{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:45:48Z","timestamp":1791377148202,"version":"4.3.2"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009363","name":"Osteosynthesis and Trauma Care Foundation","doi-asserted-by":"publisher","award":["2022-RWSL"],"award-info":[{"award-number":["2022-RWSL"]}],"id":[{"id":"10.13039\/100009363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022720","name":"Health Bureau","doi-asserted-by":"publisher","award":["22210142"],"award-info":[{"award-number":["22210142"]}],"id":[{"id":"10.13039\/100022720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jot.2023.12.006","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T20:22:28Z","timestamp":1709842948000},"page":"24-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Implants coating strategies for antibacterial treatment in fracture and defect models: A systematic review of animal studies"],"prefix":"10.1016","volume":"45","author":[{"given":"Baoqi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Thebault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0994-8335","authenticated-orcid":false,"given":"B\u00e9atrice","family":"Labat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5774-106X","authenticated-orcid":false,"given":"Guy","family":"Ladam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-4650","authenticated-orcid":false,"given":"Volker","family":"Alt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7221-3783","authenticated-orcid":false,"given":"Markus","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Brochausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Jantsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Ip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-8255","authenticated-orcid":false,"given":"Wing-Hoi","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui Yee Sharon","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-6627","authenticated-orcid":false,"given":"Ronald Man Yeung","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jot.2023.12.006_bib1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.copbio.2011.02.005","article-title":"Infection and tissue engineering in segmental bone defects - a mini review","volume":"22","author":"Nair","year":"2011","journal-title":"Curr Opin Biotechnol"},{"issue":"3","key":"10.1016\/j.jot.2023.12.006_bib2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.injury.2017.08.040","article-title":"Fracture-related infection: a consensus on definition from an international expert group","volume":"49","author":"Metsemakers","year":"2018","journal-title":"Injury"},{"issue":"9","key":"10.1016\/j.jot.2023.12.006_bib3","doi-asserted-by":"crossref","first-page":"e580","DOI":"10.1016\/S2666-7568(21)00172-0","article-title":"Global, regional, and national burden of bone fractures in 204 countries and territories, 1990\u20132019: a systematic analysis from the Global Burden of Disease Study 2019","volume":"2","author":"Wu","year":"2021","journal-title":"Lancet Healthy Longev"},{"issue":"12","key":"10.1016\/j.jot.2023.12.006_bib4","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1007\/s00198-022-06473-0","article-title":"The imminent risk of a fracture-existing worldwide data: a systematic review and meta-analysis","volume":"33","author":"Wong","year":"2022","journal-title":"Osteoporos Int"},{"issue":"6","key":"10.1016\/j.jot.2023.12.006_bib5","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1016\/j.injury.2022.03.029","article-title":"Open lower limb fractures in the elderly","volume":"53","author":"Lancaster","year":"2022","journal-title":"Injury"},{"issue":"3","key":"10.1016\/j.jot.2023.12.006_bib6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.injury.2016.09.019","article-title":"Infection after fracture fixation: current surgical and microbiological concepts","volume":"49","author":"Metsemakers","year":"2018","journal-title":"Injury"},{"issue":"12","key":"10.1016\/j.jot.2023.12.006_bib7","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.injury.2011.10.015","article-title":"Prevalence of complications of open tibial shaft fractures stratified as per the Gustilo-Anderson classification","volume":"42","author":"Papakostidis","year":"2011","journal-title":"Injury"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41572-022-00396-0","article-title":"Fracture-related infection","volume":"8","author":"Moriarty","year":"2022","journal-title":"Nat Rev Dis Prim"},{"issue":"12","key":"10.1016\/j.jot.2023.12.006_bib9","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.3390\/antibiotics11121822","article-title":"Strategies to mitigate and treat orthopaedic device-associated infections","volume":"11","author":"Kennedy","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.jot.2023.12.006_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.00061","article-title":"Reconstruction of large skeletal defects: current clinical therapeutic strategies and future directions using 3D printing","volume":"8","author":"Vidal","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jot.2023.12.006_bib11","first-page":"261","article-title":"Bioactive glass coatings on metallic implants for biomedical applications","volume":"4","author":"Oliver","year":"2019","journal-title":"Bioact Mater"},{"issue":"44","key":"10.1016\/j.jot.2023.12.006_bib43","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb0025","article-title":"Antibacterial infection and immune-evasive coating for orthopedic implants","volume":"6","author":"Chae","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.jot.2023.12.006_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120446","article-title":"Fusion peptide engineered \"statically-versatile\" titanium implant simultaneously enhancing anti-infection, vascularization and osseointegration","volume":"264","author":"Chen","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2023.12.006_bib36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.apmt.2019.06.012","article-title":"3D printed dual-functional biomaterial with self-assembly micro-nano surface and enriched nano argentum for antibalctorial and bone regeneration","volume":"17","author":"Li","year":"2019","journal-title":"Appl Mater Today"},{"issue":"2","key":"10.1016\/j.jot.2023.12.006_bib44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/0885328217713356","article-title":"Antimicrobial and bone-forming activity of a copper coated implant in a rabbit model","volume":"32","author":"Prinz","year":"2017","journal-title":"J Biomater Appl"},{"issue":"5","key":"10.1016\/j.jot.2023.12.006_bib49","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.biomaterials.2011.10.038","article-title":"Hydrophobic polycationic coatings that inhibit biofilms and support bone healing during infection","volume":"33","author":"Schaer","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2023.12.006_bib46","doi-asserted-by":"crossref","first-page":"178","DOI":"10.22203\/eCM.v035a13","article-title":"Chlorhexidine-releasing implant coating on intramedullary nail reduces infection in a rat model","volume":"35","author":"Shiels","year":"2018","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.jot.2023.12.006_bib38","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1638508","article-title":"Controlled release of vancomycin and tigecycline from an orthopaedic implant coating prevents Staphylococcus aureus infection in an open fracture animal model","volume":"2019","author":"Stavrakis","year":"2019","journal-title":"BioMed Res Int"},{"issue":"15","key":"10.1016\/j.jot.2023.12.006_bib47","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.2106\/JBJS.K.00886","article-title":"Vancomycin-modified implant surface inhibits biofilm formation and supports bone-healing in an infected osteotomy model in sheep: a proof-of-concept study","volume":"94","author":"Stewart","year":"2012","journal-title":"J Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib40","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1080\/10717544.2021.1960924","article-title":"Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction","volume":"28","author":"Sun","year":"2021","journal-title":"Drug Deliv"},{"issue":"12","key":"10.1016\/j.jot.2023.12.006_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115940","article-title":"Lysostaphin-coated titan-implants preventing localized osteitis by Staphylococcus aureus in a mouse model","volume":"9","author":"Windolf","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jot.2023.12.006_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.110782","article-title":"Rapid construction of polyetheretherketone (PEEK) biological implants incorporated with brushite (CaHPO(4)\u00b72H(2)O) and antibiotics for anti-infection and enhanced osseointegration","volume":"111","author":"Xue","year":"2020","journal-title":"Mater Sci Eng C"},{"key":"10.1016\/j.jot.2023.12.006_bib42","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.actbio.2018.08.015","article-title":"Dual-functional 3D-printed composite scaffold for inhibiting bacterial infection and promoting bone regeneration in infected bone defect models","volume":"79","author":"Yang","year":"2018","journal-title":"Acta Biomater"},{"issue":"3","key":"10.1016\/j.jot.2023.12.006_bib37","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s10856-013-5115-y","article-title":"Osteogenic activity of silver-loaded coral hydroxyapatite and its investigation in vivo","volume":"25","author":"Zhang","year":"2014","journal-title":"J Mater Sci Mater Med"},{"issue":"2","key":"10.1016\/j.jot.2023.12.006_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/jfb13020078","article-title":"Cu(2+) release from polylactic acid coating on titanium reduces bone implant-related infection","volume":"13","author":"Zhang","year":"2022","journal-title":"J Funct Biomater"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12891-023-06210-6","article-title":"Comparative analysis of pathogen distribution in patients with fracture-related infection and periprosthetic joint infection: a retrospective study","volume":"24","author":"Ma","year":"2023","journal-title":"BMC Muscoskel Disord"},{"issue":"8","key":"10.1016\/j.jot.2023.12.006_bib13","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3390\/antibiotics10080921","article-title":"Is there a difference in microbiological epidemiology and effective empiric antimicrobial therapy comparing fracture-related infection and periprosthetic joint infection? A retrospective comparative study","volume":"10","author":"Rupp","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.jot.2023.12.006_bib14","article-title":"Epidemiology and drug resistance of fracture-related infection of the long bones of the extremities: a retrospective study at the largest trauma center in southwest China","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Microbiol"},{"issue":"3","key":"10.1016\/j.jot.2023.12.006_bib15","doi-asserted-by":"crossref","DOI":"10.1177\/10225536221118512","article-title":"Microbiology of fracture related infections","volume":"30","author":"Graan","year":"2022","journal-title":"J Orthop Surg"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib16","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1038\/s41598-023-28270-3","article-title":"Retrospective analysis of drug resistance characteristics and infection related risk factors of multidrug-resistant organisms (MDROs) isolated from the orthopedics department of a tertiary hospital","volume":"13","author":"Yang","year":"2023","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jot.2023.12.006_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ajic.2009.06.010","article-title":"Surgical site infections: causative pathogens and associated outcomes","volume":"38","author":"Weigelt","year":"2010","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.jot.2023.12.006_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/phar.2806","article-title":"Current therapies and challenges for the treatment of Staphylococcus aureus biofilm-related infections","author":"Tran","year":"2023","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jot.2023.12.006_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2020.102228","article-title":"Bacterial adhesion on orthopedic implants","volume":"283","author":"Filipovi\u0107","year":"2020","journal-title":"Adv Colloid Interface Sci"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.micro.55.1.165","article-title":"Quorum sensing in bacteria","volume":"55","author":"Miller","year":"2001","journal-title":"Annu Rev Microbiol"},{"issue":"7680","key":"10.1016\/j.jot.2023.12.006_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature24624","article-title":"Progress in and promise of bacterial quorum sensing research","volume":"551","author":"Whiteley","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jot.2023.12.006_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.638085","article-title":"Mechanisms of antibiotic failure during Staphylococcus aureus osteomyelitis","volume":"12","author":"Gimza","year":"2021","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.jot.2023.12.006_bib23","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00590-021-02956-8","article-title":"Current concepts in the prevention, diagnosis and treatment of fracture-related infection (FRI)","volume":"31","author":"Iliadis","year":"2021","journal-title":"Eur J Orthop Surg Traumatol"},{"issue":"13","key":"10.1016\/j.jot.2023.12.006_bib24","article-title":"Biomaterials against bone infection","volume":"9","author":"Vallet-Reg\u00ed","year":"2020","journal-title":"Adv Healthcare Mater"},{"issue":"10","key":"10.1016\/j.jot.2023.12.006_bib25","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1302\/2046-3758.1110.BJR-2021-0495.R3","article-title":"Current therapeutic interventions combating biofilm-related infections in orthopaedics : a systematic review of in vivo animal studies","volume":"11","author":"Li","year":"2022","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.jot.2023.12.006_bib26","article-title":"Antibacterial coatings on orthopedic implants","volume":"19","author":"Chen","year":"2023","journal-title":"Mater Today Bio"},{"issue":"19","key":"10.1016\/j.jot.2023.12.006_bib27","article-title":"Surface design for antibacterial materials: from fundamentals to advanced strategies","volume":"8","author":"Li","year":"2021","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jot.2023.12.006_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.apsusc.2018.04.184","article-title":"Synthesis of efficient bacterial adhesion-resistant coatings by one-step polydopamine-assisted deposition of branched polyethylenimine-g-poly(sulfobetaine methacrylate) copolymers","volume":"450","author":"Ran","year":"2018","journal-title":"Appl Surf Sci"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ijpharm.2014.11.015","article-title":"A polycarboxylic\/amino functionalized hyaluronic acid derivative for the production of pH sensible hydrogels in the prevention of bacterial adhesion on biomedical surfaces","volume":"478","author":"Palumbo","year":"2015","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1021\/acsami.2c15102","article-title":"Construction of hierarchical micro\/nanostructured ZnO\/Cu-ZnMOFs@SA superhydrophobic composite coatings with excellent multifunctionality of anticorrosion, blood-repelling, and antimicrobial properties","volume":"15","author":"Zhang","year":"2023","journal-title":"ACS Appl Mater Interfaces"},{"issue":"4","key":"10.1016\/j.jot.2023.12.006_bib31","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1128\/AAC.02934-15","article-title":"Preventing implant-associated infections by silver coating","volume":"60","author":"Kuehl","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"10.1016\/j.jot.2023.12.006_bib32","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1021\/am3010847","article-title":"Noneluting enzymatic antibiofilm coatings","volume":"4","author":"Pavlukhina","year":"2012","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.jot.2023.12.006_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111062","article-title":"Functional behavior of chitosan\/gelatin\/silica-gentamicin coatings by electrophoretic deposition on surgical grade stainless steel","volume":"115","author":"Aydemir","year":"2020","journal-title":"Mater Sci Eng C"},{"issue":"12","key":"10.1016\/j.jot.2023.12.006_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202799","article-title":"Engineering multifunctional polyether ether ketone implant: mechanics-adaptability, biominerialization, immunoregulation, anti-infection, osteointegration, and osteogenesis","volume":"12","author":"Ma","year":"2023","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.jot.2023.12.006_bib35","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbac107","article-title":"Layer-by-layer assembly of procyanidin and collagen promotes mesenchymal stem cell proliferation and osteogenic differentiation in vitro and in vivo","volume":"10","author":"Bai","year":"2023","journal-title":"Regen Biomater"},{"key":"10.1016\/j.jot.2023.12.006_bib50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1469-0691.2005.01162.x","article-title":"Methicillin-resistant Staphylococcus aureus: clinical manifestations and antimicrobial therapy","volume":"11","author":"Cunha","year":"2005","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jot.2023.12.006_bib51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jot.2023.05.003","article-title":"Polymer bilayer-Micro arc oxidation surface coating on pure magnesium for bone implantation","volume":"40","author":"Dong","year":"2023","journal-title":"J Orthop Translat"},{"issue":"4","key":"10.1016\/j.jot.2023.12.006_bib52","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3390\/antibiotics12040742","article-title":"New antibiotics for Staphylococcus aureus infection: an update from the world association of infectious diseases and immunological disorders (WAidid) and the Italian society of anti-infective therapy (SITA)","volume":"12","author":"Esposito","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.jot.2023.12.006_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.934485","article-title":"The microbiological etiology of fracture-related infection","volume":"12","author":"Depypere","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jot.2023.12.006_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101488","article-title":"Osteoporosis is a novel risk factor of infections and sepsis: a cohort study","volume":"49","author":"Zhang","year":"2022","journal-title":"Eclinicalmedicine"},{"issue":"2","key":"10.1016\/j.jot.2023.12.006_bib55","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1302\/2046-3758.112.BJR-2021-0299.R1","article-title":"Fracture-related infection in osteoporotic bone causes more severe infection and further delays healing","volume":"11","author":"Li","year":"2022","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.jot.2023.12.006_bib56","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.actbio.2023.03.044","article-title":"Hydrogel delivery of DNase I and liposomal vancomycin to eradicate fracture-related methicillin-resistant staphylococcus aureus infection and support osteoporotic fracture healing","volume":"164","author":"Li","year":"2023","journal-title":"Acta Biomater"},{"issue":"6","key":"10.1016\/j.jot.2023.12.006_bib57","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.1021\/acsomega.8b00769","article-title":"Role of the surface nanoscale roughness of stainless steel on bacterial adhesion and microcolony formation","volume":"3","author":"Wu","year":"2018","journal-title":"ACS Omega"},{"issue":"4","key":"10.1016\/j.jot.2023.12.006_bib58","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.biomaterials.2009.09.081","article-title":"The relationship between the nanostructure of titanium surfaces and bacterial attachment","volume":"31","author":"Puckett","year":"2010","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.jot.2023.12.006_bib59","doi-asserted-by":"crossref","first-page":"10664","DOI":"10.1021\/acsnano.5b04231","article-title":"Bioinspired hierarchical surface structures with tunable wettability for regulating bacteria adhesion","volume":"9","author":"Dou","year":"2015","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib60","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1021\/acsbiomaterials.6b00579","article-title":"Poly(ethylene glycol)-based coatings combining low-biofouling and quorum-sensing inhibiting properties to reduce bacterial colonization","volume":"3","author":"Ozcelik","year":"2017","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.jot.2023.12.006_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120366","article-title":"Hyaluronic acid-based hydrogel coatings on Ti6Al4V implantable biomaterial with multifunctional antibacterial activity","volume":"301","author":"Andrade del Olmo","year":"2023","journal-title":"Carbohydr Polym"},{"issue":"6","key":"10.1016\/j.jot.2023.12.006_bib62","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1021\/acsami.9b22206","article-title":"Multifunctional antibacterial materials comprising water dispersible random copolymers containing a fluorinated block and their application in catheters","volume":"12","author":"Li","year":"2020","journal-title":"ACS Appl Mater Interfaces"},{"issue":"25","key":"10.1016\/j.jot.2023.12.006_bib63","doi-asserted-by":"crossref","first-page":"21181","DOI":"10.1021\/acsami.7b05230","article-title":"Universal coating from electrostatic self-assembly to prevent multidrug-resistant bacterial colonization on medical devices and solid surfaces","volume":"9","author":"Zheng","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"issue":"8","key":"10.1016\/j.jot.2023.12.006_bib64","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1016\/j.actbio.2014.03.037","article-title":"Implant osseointegration and the role of microroughness and nanostructures: lessons for spine implants","volume":"10","author":"Gittens","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2023.12.006_bib65","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jot.2018.09.001","article-title":"Surface treatment strategies to combat implant-related infection from the beginning","volume":"17","author":"Wang","year":"2019","journal-title":"J Orthop Translat"},{"issue":"4","key":"10.1016\/j.jot.2023.12.006_bib66","first-page":"849","article-title":"New antimicrobial strategies based on metal complexes","volume":"2","author":"Claudel","year":"2020","journal-title":"Chemistry (Easton)"},{"key":"10.1016\/j.jot.2023.12.006_bib67","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.jallcom.2017.08.078","article-title":"Advances in the induction of osteogenesis by zinc surface modification based on titanium alloy substrates for medical implants","volume":"726","author":"Gao","year":"2017","journal-title":"J Alloys Compd"},{"issue":"5","key":"10.1016\/j.jot.2023.12.006_bib68","doi-asserted-by":"crossref","first-page":"H1821","DOI":"10.1152\/ajpheart.01015.2001","article-title":"Copper-induced vascular endothelial growth factor expression and wound healing","volume":"282","author":"Sen","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"10.1016\/j.jot.2023.12.006_bib69","first-page":"2569","article-title":"Antibacterial metals and alloys for potential biomedical implants","volume":"6","author":"Zhang","year":"2021","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2023.12.006_bib70","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.jconrel.2020.10.038","article-title":"Controlled drug delivery systems in eradicating bacterial biofilm-associated infections","volume":"329","author":"Liu","year":"2021","journal-title":"J Contr Release"},{"issue":"24","key":"10.1016\/j.jot.2023.12.006_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413212","article-title":"Application of antimicrobial peptides on biomedical implants: three ways to pursue peptide coatings","volume":"22","author":"Drexelius","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jot.2023.12.006_bib72","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1021\/la503911m","article-title":"Antibacterial and antibiofilm surfaces through polydopamine-assisted immobilization of lysostaphin as an antibacterial enzyme","volume":"31","author":"Yeroslavsky","year":"2015","journal-title":"Langmuir"},{"issue":"3","key":"10.1016\/j.jot.2023.12.006_bib73","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.02508-16","article-title":"Control of biofilm formation: antibiotics and beyond","volume":"83","author":"Algburi","year":"2017","journal-title":"Appl Environ Microbiol"},{"issue":"7","key":"10.1016\/j.jot.2023.12.006_bib74","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.1021\/acsami.1c19337","article-title":"Dopamine assisted self-cleaning, antifouling, and antibacterial coating via dynamic covalent interactions","volume":"14","author":"Asha","year":"2022","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.jot.2023.12.006_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.783816","article-title":"Multifunctional coatings of titanium implants toward promoting osseointegration and preventing infection: recent developments","volume":"9","author":"Lu","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"issue":"4822","key":"10.1016\/j.jot.2023.12.006_bib76","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1126\/science.3629258","article-title":"Biomaterial-centered infections - microbial adhesion versus tissue integration","volume":"237","author":"Gristina","year":"1987","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib77","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: mechanisms and interventions","volume":"11","author":"Einhorn","year":"2015","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"10.1016\/j.jot.2023.12.006_bib78","doi-asserted-by":"crossref","first-page":"E1662","DOI":"10.1002\/term.2593","article-title":"The cytokines and micro-environment of fracture haematoma: current evidence","volume":"12","author":"Walters","year":"2018","journal-title":"J Tissue Eng Regen Med"},{"issue":"2","key":"10.1016\/j.jot.2023.12.006_bib79","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/jor.23460","article-title":"Fracture healing physiology and the quest for therapies for delayed healing and nonunion","volume":"35","author":"Kostenuik","year":"2017","journal-title":"J Orthop Res"},{"issue":"10","key":"10.1016\/j.jot.2023.12.006_bib80","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1002\/jor.24422","article-title":"Impact of bacterial infections on osteogenesis: evidence from in vivo studies","volume":"37","author":"Croes","year":"2019","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jot.2023.12.006_bib81","first-page":"14","article-title":"The role of TNF-\u03b1 in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment","author":"Li","year":"2023","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.jot.2023.12.006_bib82","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1089\/ten.teb.2014.0677","article-title":"Boon and bane of inflammation in bone tissue regeneration and its link with angiogenesis","volume":"21","author":"Schmidt-Bleek","year":"2015","journal-title":"Tissue Eng Part B"},{"key":"10.1016\/j.jot.2023.12.006_bib83","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2015.00085","article-title":"Vs. Osteoblast: relationship and consequences in osteomyelitis","volume":"5","author":"Josse","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"issue":"3\u20134","key":"10.1016\/j.jot.2023.12.006_bib84","first-page":"205","article-title":"Infections from biomaterials and implants - a race for the surface","volume":"14","author":"Gristina","year":"1989","journal-title":"Med Prog Technol"},{"key":"10.1016\/j.jot.2023.12.006_bib85","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.biomaterials.2018.07.017","article-title":"Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives","volume":"180","author":"Ho-Shui-Ling","year":"2018","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.jot.2023.12.006_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031128","article-title":"Strategies for bone regeneration: from graft to tissue engineering","volume":"22","author":"Battafarano","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2023.12.006_bib87","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2014.50","article-title":"Contaminated open fracture and crush injury: a murine model","volume":"3","author":"Gilbert","year":"2015","journal-title":"Bone Res"},{"issue":"3","key":"10.1016\/j.jot.2023.12.006_bib88","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/ar292","article-title":"Angiogenesis in the pathogenesis of inflammatory joint and lung diseases","volume":"3","author":"Walsh","year":"2001","journal-title":"Arthritis Res"},{"issue":"2","key":"10.1016\/j.jot.2023.12.006_bib89","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrd.2015.2","article-title":"Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis","volume":"15","author":"Kreuger","year":"2016","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib90","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s42003-023-04515-9","article-title":"Differential angiogenesis of bone and muscle endothelium in aging and inflammatory processes","volume":"6","author":"Arrigoni","year":"2023","journal-title":"Commun Biol"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib91","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0192623307310949","article-title":"Biocompatibility: meeting a key functional requirement of next-generation medical devices","volume":"36","author":"Helmus","year":"2008","journal-title":"Toxicol Pathol"},{"issue":"5","key":"10.1016\/j.jot.2023.12.006_bib92","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.3892\/etm.2021.10750","article-title":"Biocompatibility assessment of biomaterials used in orthopedic devices: an overview (Review)","volume":"22","author":"Huzum","year":"2021","journal-title":"Exp Ther Med"},{"issue":"15","key":"10.1016\/j.jot.2023.12.006_bib93","doi-asserted-by":"crossref","first-page":"12724","DOI":"10.1021\/acsomega.1c07225","article-title":"Alkaline phosphatase activity of serum affects osteogenic differentiation cultures","volume":"7","author":"Ansari","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.jot.2023.12.006_bib94","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.thromres.2020.07.027","article-title":"In vitro hemocompatibility testing of medical devices","volume":"195","author":"Nalezinkov\u00e1","year":"2020","journal-title":"Thromb Res"},{"issue":"9","key":"10.1016\/j.jot.2023.12.006_bib95","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1021\/acs.chemrestox.5b00258","article-title":"Concentration ranges of antibacterial cations for showing the highest antibacterial efficacy but the least cytotoxicity against mammalian cells: implications for a new antibacterial mechanism","volume":"28","author":"Ning","year":"2015","journal-title":"Chem Res Toxicol"},{"issue":"3","key":"10.1016\/j.jot.2023.12.006_bib96","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1590\/S1678-77572010000300011","article-title":"Time- and concentration-dependent cytotoxicity of antibiotics used in endodontic therapy","volume":"18","author":"Ferreira","year":"2010","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.jot.2023.12.006_bib97","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jot.2023.08.006","article-title":"Biomaterial-based scaffolds in promotion of cartilage regeneration: recent advances and emerging applications","volume":"41","author":"Liang","year":"2023","journal-title":"J Orthop Translat"},{"issue":"2","key":"10.1016\/j.jot.2023.12.006_bib98","doi-asserted-by":"crossref","first-page":"184","DOI":"10.21037\/qims.2016.04.01","article-title":"The imaging of osteomyelitis","volume":"6","author":"Lee","year":"2016","journal-title":"Quant Imag Med Surg"},{"issue":"2","key":"10.1016\/j.jot.2023.12.006_bib99","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1055\/s-0029-1214160","article-title":"Radiographic imaging in osteomyelitis: the role of plain radiography, computed tomography, ultrasonography, magnetic resonance imaging, and scintigraphy","volume":"23","author":"Pineda","year":"2009","journal-title":"Semin Plast Surg"},{"key":"10.1016\/j.jot.2023.12.006_bib100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fcimb.2015.00085","article-title":"Staphylococcus aureus vs. Osteoblast: relationship and consequences in osteomyelitis","volume":"5","author":"Josse","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"10.1016\/j.jot.2023.12.006_bib101","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00415-18","article-title":"Novel insights into Staphylococcus aureus deep bone infections: the involvement of osteocytes","volume":"9","author":"Yang","year":"2018","journal-title":"mBio"},{"issue":"3","key":"10.1016\/j.jot.2023.12.006_bib102","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/emmm.201100123","article-title":"Return of the Trojan horse: intracellular phenotype switching and immune evasion by Staphylococcus aureus","volume":"3","author":"Garzoni","year":"2011","journal-title":"EMBO Mol Med"},{"issue":"1","key":"10.1016\/j.jot.2023.12.006_bib103","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001409","article-title":"A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages","volume":"3","author":"Kubica","year":"2008","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jot.2023.12.006_bib104","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s11914-018-0423-2","article-title":"The role of the immune cells in fracture healing","volume":"16","author":"Baht","year":"2018","journal-title":"Curr Osteoporos Rep"},{"issue":"12","key":"10.1016\/j.jot.2023.12.006_bib105","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.4049\/jimmunol.1701574","article-title":"Innate immunity to Staphylococcus aureus: evolving paradigms in soft tissue and invasive infections","volume":"200","author":"Brandt","year":"2018","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.jot.2023.12.006_bib106","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1172\/JCI93356","article-title":"Inflammatory osteolysis: a conspiracy against bone","volume":"127","author":"Mbalaviele","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jot.2023.12.006_bib107","article-title":"Does the incorporation of zinc into TiO(2) on titanium surfaces increase bactericidal activity? A systematic review and meta-analysis","author":"Silva Lima Mendes","year":"2022","journal-title":"J Prosthet Dent"},{"issue":"5","key":"10.1016\/j.jot.2023.12.006_bib108","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1021\/acsbiomaterials.1c01307","article-title":"In vivo antibacterial efficacy of antimicrobial peptides modified metallic Implants\u2500Systematic review and meta-analysis","volume":"8","author":"Sandhu","year":"2022","journal-title":"ACS Biomater Sci Eng"},{"issue":"12","key":"10.1016\/j.jot.2023.12.006_bib109","article-title":"In vivo antibacterial efficacy of nanopatterns on titanium implant surface: a systematic review of the literature","volume":"10","author":"Sun","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.jot.2023.12.006_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117487","article-title":"Surface functionalization of chitosan as a coating material for orthopaedic applications: a comprehensive review","volume":"255","author":"Kumari","year":"2021","journal-title":"Carbohydr Polym"},{"issue":"22","key":"10.1016\/j.jot.2023.12.006_bib111","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25225471","article-title":"Gentamicin-coated tibia nail in fractures and nonunion to reduce fracture-related infections: a systematic review","volume":"25","author":"De Meo","year":"2020","journal-title":"Molecules"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:45:18Z","timestamp":1761993918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X24000020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":111,"alternative-id":["S2214031X24000020"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2023.12.006","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implants coating strategies for antibacterial treatment in fracture and defect models: A systematic review of animal studies","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2023.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}