{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:25:31Z","timestamp":1788492331776,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M730809"],"award-info":[{"award-number":["2023M730809"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305265"],"award-info":[{"award-number":["82305265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024A1515010894"],"award-info":[{"award-number":["2024A1515010894"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515110723"],"award-info":[{"award-number":["2019A1515110723"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jot.2023.12.007","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T09:14:25Z","timestamp":1711530865000},"page":"197-210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Therapeutic potential of a prominent dihydroxyflavanone pinocembrin for osteolytic bone disease: In vitro and in vivo evidence"],"prefix":"10.1016","volume":"45","author":[{"given":"Guoju","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanqiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8055-9318","authenticated-orcid":false,"given":"Qunzhang","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2023.12.007_bib1","article-title":"The biology of normal bone remodelling","volume":"26","author":"Katsimbri","year":"2017","journal-title":"Eur J Cancer Care"},{"key":"10.1016\/j.jot.2023.12.007_bib2","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/jcp.26042","article-title":"The roles of signaling pathways in bone repair and regeneration","volume":"233","author":"Majidinia","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jot.2023.12.007_bib3","first-page":"347","article-title":"Biological basis of bone strength: anatomy, physiology and measurement","volume":"20","author":"Hart","year":"2020","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.jot.2023.12.007_bib4","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/GME.0000000000001831","volume":"28","year":"2021","journal-title":"Menopause News N"},{"key":"10.1016\/j.jot.2023.12.007_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cells9092073","article-title":"Osteoblast-osteoclast communication and bone homeostasis","volume":"9","author":"Kim","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jot.2023.12.007_bib6","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0140-6736(21)02646-5","article-title":"Drug therapy for osteoporosis in older adults","volume":"399","author":"Reid","year":"2022","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.jot.2023.12.007_bib7","doi-asserted-by":"crossref","first-page":"E5685","DOI":"10.3390\/ijms21165685","article-title":"Osteoclast multinucleation: review of current literature","volume":"21","author":"Kodama","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2023.12.007_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00774-020-01162-6","article-title":"Osteoclast differentiation by RANKL and OPG signaling pathways","volume":"39","author":"Udagawa","year":"2021","journal-title":"J Bone Miner Metabol"},{"key":"10.1016\/j.jot.2023.12.007_bib9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00774-020-01175-1","article-title":"Discovery of the RANKL\/RANK\/OPG system","volume":"39","author":"Yasuda","year":"2021","journal-title":"J Bone Miner Metabol"},{"key":"10.1016\/j.jot.2023.12.007_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174799","article-title":"Pinocembrin mediates antiarrhythmic e\ufb00ects in rats with isoproterenol-induced cardiac remodeling","volume":"920","author":"Chen","year":"2022","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jot.2023.12.007_bib11","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3390\/biom11081240","article-title":"Pinocembrin ameliorates skin fibrosis via inhibiting TGF-\u03b21 signaling pathway","volume":"11","author":"Li","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jot.2023.12.007_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/s12974-020-02014-w","article-title":"Pinocembrin ameliorates intermittent hypoxia-induced neuroinflammation through BNIP3-dependent mitophagy in a murine model of sleep apnea","volume":"17","author":"Gong","year":"2020","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jot.2023.12.007_bib13","article-title":"Effect of pinocembrin isolated from Alpinia zerumbet on osteoblast differentiation","volume":"73","author":"N N","year":"2020","journal-title":"Cytotechnology"},{"key":"10.1016\/j.jot.2023.12.007_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173212","article-title":"Pinocembrin alleviates glucocorticoid-induced apoptosis by activating autophagy via suppressing the PI3K\/Akt\/mTOR pathway in osteocytes","volume":"880","author":"Wang","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jot.2023.12.007_bib15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00418-018-1636-2","article-title":"Recent advances in osteoclast biology","volume":"149","author":"Ono","year":"2018","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.jot.2023.12.007_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molmed.2005.11.007","article-title":"RANKL-RANK signaling in osteoclastogenesis and bone disease","volume":"12","author":"Wada","year":"2006","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jot.2023.12.007_bib17","doi-asserted-by":"crossref","first-page":"706","DOI":"10.14348\/molcells.2017.0225","article-title":"Current understanding of RANK signaling in osteoclast differentiation and maturation","volume":"40","author":"Park","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.jot.2023.12.007_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","article-title":"The molecular understanding of osteoclast differentiation","volume":"40","author":"Asagiri","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.jot.2023.12.007_bib19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1210\/me.2007-0237","article-title":"NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP)","volume":"22","author":"Kim","year":"2008","journal-title":"Mol Endocrinol Baltim Md"},{"key":"10.1016\/j.jot.2023.12.007_bib20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/bies.950170402","article-title":"c-fos and bone loss: a proto-oncogene regulates osteoclast lineage determination","volume":"17","author":"Jacenko","year":"1995","journal-title":"BioEssays News Rev Mol Cell Dev Biol"},{"key":"10.1016\/j.jot.2023.12.007_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1196\/annals.1346.018","article-title":"The regulation of cathepsin K gene expression","volume":"1068","author":"Troen","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jot.2023.12.007_bib22","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.yexcr.2006.10.001","article-title":"RANK ligand signaling modulates the matrix metalloproteinase-9 gene expression during osteoclast differentiation","volume":"313","author":"Sundaram","year":"2007","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jot.2023.12.007_bib23","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr Biol CB"},{"key":"10.1016\/j.jot.2023.12.007_bib24","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.3390\/ijms20143576","article-title":"Reactive oxygen species in osteoclast differentiation and possible pharmaceutical targets of ROS-mediated osteoclast diseases","volume":"20","author":"Agidigbi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2023.12.007_bib25","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/abbs\/gmaa098","article-title":"ROS signaling cascades: dual regulations for osteoclast and osteoblast","volume":"52","author":"Tao","year":"2020","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1016\/j.jot.2023.12.007_bib26","doi-asserted-by":"crossref","first-page":"20030","DOI":"10.1074\/jbc.M116.731216","article-title":"NADPH oxidases are essential for macrophage differentiation","volume":"291","author":"Xu","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jot.2023.12.007_bib27","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1182\/blood-2004-09-3662","article-title":"A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation","volume":"106","author":"Lee","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jot.2023.12.007_bib28","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1089\/ars.2013.5341","article-title":"Role of heme oxygenase-1 in postnatal differentiation of stem cells: a possible cross-talk with microRNAs","volume":"20","author":"Kozakowska","year":"2014","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.jot.2023.12.007_bib29","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fphar.2014.00196","article-title":"Glutathione: new roles in redox signaling for an old antioxidant","volume":"5","author":"Aquilano","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jot.2023.12.007_bib30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.redox.2016.01.006","article-title":"Molecular regulatory mechanisms of osteoclastogenesis through cytoprotective enzymes","volume":"8","author":"Kanzaki","year":"2016","journal-title":"Redox Biol"},{"key":"10.1016\/j.jot.2023.12.007_bib31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol Mol Biol Rev MMBR"},{"key":"10.1016\/j.jot.2023.12.007_bib32","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/MMBR.68.2.320-344.2004","article-title":"ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions","volume":"68","author":"Roux","year":"2004","journal-title":"Microbiol Mol Biol Rev MMBR"},{"key":"10.1016\/j.jot.2023.12.007_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.7150\/ijbs.13814","article-title":"Selective regulation of MAPK signaling mediates RANKL-dependent osteoclast differentiation","volume":"12","author":"Lee","year":"2016","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jot.2023.12.007_bib34","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/bonekey.2015.80","article-title":"Focus on the p38 MAPK signaling pathway in bone development and maintenance","volume":"4","author":"Thouverey","year":"2015","journal-title":"BoneKEy Rep"},{"issue":"11\u20135","key":"10.1016\/j.jot.2023.12.007_bib35","article-title":"Roles for NF-kappaB and c-Fos in osteoclasts","volume":"23","author":"Boyce","year":"2005","journal-title":"J Bone Miner Metabol"},{"key":"10.1016\/j.jot.2023.12.007_bib36","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1359\/jbmr.080211","article-title":"JNK\/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts","volume":"23","author":"Ikeda","year":"2008","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"key":"10.1016\/j.jot.2023.12.007_bib37","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0006-291X(03)01294-4","article-title":"A role for alphaV integrin subunit in TGF-beta-stimulated osteoclastogenesis","volume":"307","author":"Chin","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jot.2023.12.007_bib38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3803\/EnM.2015.30.1.35","article-title":"NF-\u03baB-Mediated regulation of osteoclastogenesis","volume":"30","author":"Boyce","year":"2015","journal-title":"Endocrinol Metab"},{"key":"10.1016\/j.jot.2023.12.007_bib39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cytogfr.2008.11.007","article-title":"NF-kappaB modulators in osteolytic bone diseases","volume":"20","author":"Xu","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jot.2023.12.007_bib40","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1365-2613.2009.00661.x","article-title":"Ovariectomy-associated changes in bone mineral density and bone marrow haematopoiesis in rats","volume":"90","author":"Lei","year":"2009","journal-title":"Int J Exp Pathol"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:29:28Z","timestamp":1778858968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X24000032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":40,"alternative-id":["S2214031X24000032"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2023.12.007","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of a prominent dihydroxyflavanone pinocembrin for osteolytic bone disease: In vitro and in vivo evidence","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2023.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}