{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:31:28Z","timestamp":1793233888513,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","award":["ZNYB2023008"],"award-info":[{"award-number":["ZNYB2023008"]}],"id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016359","name":"Zhongnan Hospital of Wuhan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672168"],"award-info":[{"award-number":["81672168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jot.2024.06.001","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T03:26:57Z","timestamp":1719545217000},"page":"207-222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes"],"prefix":"10.1016","volume":"47","author":[{"given":"Rui","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunkun","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenggang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anmin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8520-566X","authenticated-orcid":false,"given":"Jiaming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-664X","authenticated-orcid":false,"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10182","key":"10.1016\/j.jot.2024.06.001_bib1","first-page":"1745","volume":"393","author":"Hunter","year":"2019","journal-title":"Osteoarthritis. Lancet"},{"issue":"9463","key":"10.1016\/j.jot.2024.06.001_bib2","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0140-6736(05)71086-2","article-title":"Pathogenesis and management of pain in osteoarthritis","volume":"365","author":"Dieppe","year":"2005","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jot.2024.06.001_bib3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.semarthrit.2013.07.003","article-title":"Health economics in the field of osteoarthritis: an expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)","volume":"43","author":"Hiligsmann","year":"2013","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.jot.2024.06.001_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2018.08.038","article-title":"Reactive oxygen species, aging and articular cartilage homeostasis","volume":"132","author":"Bolduc","year":"2019","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"10.1016\/j.jot.2024.06.001_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072358","article-title":"The role of chondrocyte Hypertrophy and senescence in osteoarthritis initiation and progression","volume":"21","author":"Rim","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jot.2024.06.001_bib6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/jor.24457","article-title":"Role of inflammation and the immune system in the progression of osteoarthritis","volume":"38","author":"Woodell-May","year":"2020","journal-title":"J Orthop Res"},{"issue":"1","key":"10.1016\/j.jot.2024.06.001_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2741\/s443","article-title":"PAMP-DAMPs interactions mediates development and progression of multiple sclerosis","volume":"8","author":"Hern\u00e1ndez-Pedro","year":"2016","journal-title":"Front Biosci (Schol Ed)"},{"issue":"5","key":"10.1016\/j.jot.2024.06.001_bib8","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.4049\/jimmunol.1201630","article-title":"TRIF-mediated TLR3 and TLR4 signaling is negatively regulated by ADAM15","volume":"190","author":"Ahmed","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.jot.2024.06.001_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113113","article-title":"STING, a promising target for small molecular immune modulator: a review","volume":"211","author":"Liu","year":"2021","journal-title":"Eur J Med Chem"},{"issue":"1","key":"10.1016\/j.jot.2024.06.001_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s13046-021-02017-2","article-title":"A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy","volume":"40","author":"De Waele","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"issue":"6","key":"10.1016\/j.jot.2024.06.001_bib11","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.cytogfr.2014.06.006","article-title":"The mechanism of double-stranded DNA sensing through the cGAS-STING pathway","volume":"25","author":"Shu","year":"2014","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jot.2024.06.001_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1202797","article-title":"STING signaling promotes apoptosis, Necrosis, and cell Death: an Overview and Update","volume":"2018","author":"Liu","year":"2018","journal-title":"Mediators Inflamm"},{"issue":"1","key":"10.1016\/j.jot.2024.06.001_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin Immunol"},{"issue":"8","key":"10.1016\/j.jot.2024.06.001_bib14","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat Immunol"},{"issue":"7","key":"10.1016\/j.jot.2024.06.001_bib15","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.addr.2007.11.005","article-title":"TLR3: interferon induction by double-stranded RNA including poly(I:C)","volume":"60","author":"Matsumoto","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"issue":"8","key":"10.1016\/j.jot.2024.06.001_bib16","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.joca.2021.04.017","article-title":"Targeting STING attenuates ROS induced intervertebral disc degeneration","volume":"29","author":"Guo","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"issue":"19","key":"10.1016\/j.jot.2024.06.001_bib17","doi-asserted-by":"crossref","first-page":"8664","DOI":"10.18632\/aging.102354","article-title":"Decreased RIPK1 expression in chondrocytes alleviates osteoarthritis via the TRIF\/MyD88-RIPK1-TRAF2 negative feedback loop","volume":"11","author":"Liang","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"7","key":"10.1016\/j.jot.2024.06.001_bib18","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/abbs\/gmaa051","article-title":"TBK1, a central kinase in innate immune sensing of nucleic acids and beyond","volume":"52","author":"Zhou","year":"2020","journal-title":"Acta Biochim Biophys Sin"},{"issue":"1","key":"10.1016\/j.jot.2024.06.001_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autrev.2013.06.004","article-title":"Innate and adaptive immunity in inflammatory bowel disease","volume":"13","author":"Geremia","year":"2014","journal-title":"Autoimmun Rev"},{"issue":"6","key":"10.1016\/j.jot.2024.06.001_bib20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.molmed.2016.04.006","article-title":"Human TBK1: a Gatekeeper of neuroinflammation","volume":"22","author":"Ahmad","year":"2016","journal-title":"Trends Mol Med"},{"issue":"1","key":"10.1016\/j.jot.2024.06.001_bib21","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1080\/21655979.2021.2018976","article-title":"Silence of TANK-binding kinase 1 (TBK1) regulates extracellular matrix degradation of chondrocyte in osteoarthritis by janus kinase (JAK)-signal transducer of activators of transcription (STAT) signaling","volume":"13","author":"Sun","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.jot.2024.06.001_bib22","article-title":"TBK1-medicated DRP1 phosphorylation orchestrates mitochondrial dynamics and autophagy activation in osteoarthritis","author":"Hu","year":"2022","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"10.1016\/j.jot.2024.06.001_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165997","article-title":"Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy","volume":"1867","author":"Gao","year":"2021","journal-title":"Biochim Biophys Acta, Mol Basis Dis"},{"issue":"7","key":"10.1016\/j.jot.2024.06.001_bib24","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3727\/096504021X16161478258040","article-title":"TBK1 inhibitor exerts Antiproliferative effect on glioblastoma Multiforme cells","volume":"28","author":"Scuderi","year":"2021","journal-title":"Oncol Res"},{"issue":"6","key":"10.1016\/j.jot.2024.06.001_bib25","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.jot.2024.06.001_bib26","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jot.2024.06.001_bib27","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fnmol.2017.00284","article-title":"Methods used to evaluate pain Behaviors in Rodents","volume":"10","author":"Deuis","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.jot.2024.06.001_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110289","article-title":"Cystathionine-\u03b3-lyase attenuates inflammatory response and pain of osteoarthritis","volume":"120","author":"Wei","year":"2023","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"10.1016\/j.jot.2024.06.001_bib29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/art.40730","article-title":"Evidence for Genetic contribution to Variation in Posttraumatic osteoarthritis in mice","volume":"71","author":"Chinzei","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"Suppl 3","key":"10.1016\/j.jot.2024.06.001_bib30","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.jot.2024.06.001_bib31","doi-asserted-by":"crossref","first-page":"336","DOI":"10.5483\/BMBRep.2019.52.5.072","article-title":"Induction of pro-inflammatory cytokines by 29-kDa FN-f via cGAS\/STING pathway","volume":"52","author":"Hwang","year":"2019","journal-title":"BMB Rep"},{"issue":"11","key":"10.1016\/j.jot.2024.06.001_bib32","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1136\/ard.2007.079574","article-title":"Differential Toll-like receptor-dependent collagenase expression in chondrocytes","volume":"67","author":"Zhang","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jot.2024.06.001_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.634822","article-title":"Chondro-protective effects of Shikimic acid on osteoarthritis via Restoring Impaired autophagy and suppressing the MAPK\/NF-\u03baB signaling pathway","volume":"12","author":"You","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jot.2024.06.001_bib34","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bcp.2019.02.030","article-title":"Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression","volume":"165","author":"Herrero-Beaumont","year":"2019","journal-title":"Biochem Pharmacol"},{"issue":"8","key":"10.1016\/j.jot.2024.06.001_bib36","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s13238-017-0377-7","article-title":"The minor collagens in articular cartilage","volume":"8","author":"Luo","year":"2017","journal-title":"Protein Cell"},{"issue":"3","key":"10.1016\/j.jot.2024.06.001_bib37","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/1529-0131(200003)43:3<673::AID-ANR25>3.0.CO;2-8","article-title":"Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1)","volume":"43","author":"Dahlberg","year":"2000","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.jot.2024.06.001_bib38","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/ncprheum0841","article-title":"Drug insight: aggrecanases as therapeutic targets for osteoarthritis","volume":"4","author":"Fosang","year":"2008","journal-title":"Nat Clin Pract Rheumatol"},{"issue":"8","key":"10.1016\/j.jot.2024.06.001_bib39","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.joca.2015.02.778","article-title":"Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification","volume":"23","author":"Larkin","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jot.2024.06.001_bib40","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cytogfr.2018.10.002","article-title":"Pro-inflammatory cytokines: the link between obesity and osteoarthritis","volume":"44","author":"Wang","year":"2018","journal-title":"Cytokine Growth Factor Rev"},{"issue":"5","key":"10.1016\/j.jot.2024.06.001_bib41","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.joca.2018.02.901","article-title":"NLRP3 as a potentially novel biomarker for the management of osteoarthritis","volume":"26","author":"McAllister","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"10.1016\/j.jot.2024.06.001_bib42","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","article-title":"The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis","volume":"6","author":"Sellam","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jot.2024.06.001_bib43","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.09.025","article-title":"Redox and NF-\u03baB signaling in osteoarthritis","volume":"132","author":"Lepetsos","year":"2019","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.jot.2024.06.001_bib44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1474-9728.2002.00008.x","article-title":"The role of chondrocyte senescence in osteoarthritis","volume":"1","author":"Price","year":"2002","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.jot.2024.06.001_bib45","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","article-title":"Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors","volume":"120","author":"Campisi","year":"2005","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jot.2024.06.001_bib46","doi-asserted-by":"crossref","DOI":"10.1186\/ar4494","article-title":"p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis","volume":"16","author":"Philipot","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.jot.2024.06.001_bib47","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tcb.2018.02.001","article-title":"Hallmarks of cellular senescence","volume":"28","author":"Hernandez-Segura","year":"2018","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jot.2024.06.001_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.779177","article-title":"SIRT1: a potential therapeutic target in autoimmune diseases","volume":"12","author":"Shen","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jot.2024.06.001_bib49","article-title":"Regulation of SIRT1 and its roles in inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jot.2024.06.001_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1060721","article-title":"Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K\/AKT\/mTOR signaling pathway and enhancement of autophagy","volume":"13","author":"Lu","year":"2022","journal-title":"Front Endocrinol"},{"issue":"5633","key":"10.1016\/j.jot.2024.06.001_bib51","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1087262","article-title":"Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway","volume":"301","author":"Yamamoto","year":"2003","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.jot.2024.06.001_bib52","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nri1900","article-title":"IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors","volume":"6","author":"Honda","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"6227","key":"10.1016\/j.jot.2024.06.001_bib53","doi-asserted-by":"crossref","first-page":"aaa2630","DOI":"10.1126\/science.aaa2630","article-title":"Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347","author":"Liu","year":"2015","journal-title":"Science"},{"issue":"7213","key":"10.1016\/j.jot.2024.06.001_bib54","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jot.2024.06.001_bib55","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.immuni.2008.09.003","article-title":"The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation","volume":"29","author":"Zhong","year":"2008","journal-title":"Immunity"},{"issue":"6121","key":"10.1016\/j.jot.2024.06.001_bib56","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"issue":"6121","key":"10.1016\/j.jot.2024.06.001_bib57","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1229963","article-title":"Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA","volume":"339","author":"Wu","year":"2013","journal-title":"Science"},{"issue":"7265","key":"10.1016\/j.jot.2024.06.001_bib58","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jot.2024.06.001_bib59","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41419-020-03341-9","article-title":"STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-\u03baB signaling pathway","volume":"12","author":"Guo","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jot.2024.06.001_bib60","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.3389\/fimmu.2020.01776","article-title":"HDAC6 mediates poly (I:C)-Induced TBK1 and Akt phosphorylation in Macrophages","volume":"11","author":"Wang","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jot.2024.06.001_bib61","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.biopha.2017.10.130","article-title":"Aqueous extract of Codium fragile alleviates osteoarthritis through the MAPK\/NF-\u03baB pathways in IL-1\u03b2-induced rat primary chondrocytes and a rat osteoarthritis model","volume":"97","author":"Moon","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"10.1016\/j.jot.2024.06.001_bib62","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/138945010791011938","article-title":"NF-kappaB signaling: multiple angles to target OA","volume":"11","author":"Marcu","year":"2010","journal-title":"Curr Drug Targets"},{"issue":"3","key":"10.1016\/j.jot.2024.06.001_bib63","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.joca.2009.11.005","article-title":"MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation","volume":"18","author":"Sondergaard","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"10.1016\/j.jot.2024.06.001_bib64","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.joca.2009.02.003","article-title":"Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells","volume":"17","author":"Ushita","year":"2009","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T15:58:47Z","timestamp":1722095927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X24000494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":63,"alternative-id":["S2214031X24000494"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2024.06.001","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2024.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}