{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:16:07Z","timestamp":1773155767009,"version":"3.50.1"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jot.2024.06.015","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T08:14:45Z","timestamp":1719476085000},"page":"176-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Sargassum polysaccharide attenuates osteoarthritis in rats and is associated with the up-regulation of the ITG\u03b21-PI3K-AKT signaling pathway"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-7007","authenticated-orcid":false,"given":"Yanzhi","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-5852","authenticated-orcid":false,"given":"Rui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-3097","authenticated-orcid":false,"given":"Haiping","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8155-6278","authenticated-orcid":false,"given":"Lujiao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jintong","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qixian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fucheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kefeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jot.2024.06.015_bib1","first-page":"293","article-title":"Osteoarthritis: pathology, diagnosis, and treatment options","volume":"104","author":"Abramoff","year":"2020","journal-title":"Med Clin"},{"issue":"10182","key":"10.1016\/j.jot.2024.06.015_bib2","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet (London, England)"},{"issue":"13","key":"10.1016\/j.jot.2024.06.015_bib3","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1001\/jama.2022.1980","article-title":"What is osteoarthritis?","volume":"327","author":"Yue","year":"2022","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.jot.2024.06.015_bib4","first-page":"2507","article-title":"Prevalence of symptomatic knee, hand, and hip osteoarthritis in Greece. The ESORDIG study","volume":"33","author":"Andrianakos","year":"2006","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jot.2024.06.015_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2020.100587","article-title":"Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies","volume":"29-30","author":"Cui","year":"2020","journal-title":"EClinicalMedicine"},{"issue":"1","key":"10.1016\/j.jot.2024.06.015_bib6","first-page":"15","article-title":"Why is osteoarthritis an age-related disease?, Best practice & research","volume":"24","author":"Shane Anderson","year":"2010","journal-title":"Clin Rheumatol"},{"issue":"3","key":"10.1016\/j.jot.2024.06.015_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.5604\/15093492.1240791","article-title":"Genetic and epigenetic interactions in the etiopathogenesis of osteoarthritis. Selected molecular factors in OA etiopathogenesis","volume":"19","author":"Snochowska","year":"2017","journal-title":"Ortop Traumatol Rehabil"},{"issue":"6","key":"10.1016\/j.jot.2024.06.015_bib8","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jbspin.2013.09.007","article-title":"Is osteoarthritis a metabolic disease?","volume":"80","author":"Sellam","year":"2013","journal-title":"Joint Bone Spine"},{"issue":"5","key":"10.1016\/j.jot.2024.06.015_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052767","article-title":"Gender-related aspects in osteoarthritis development and progression: a review","volume":"23","author":"Peshkova","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.jot.2024.06.015_bib10","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/01.bot.0000246468.80635.ef","article-title":"Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease","volume":"20","author":"Brown","year":"2006","journal-title":"J Orthop Trauma"},{"issue":"6","key":"10.1016\/j.jot.2024.06.015_bib11","doi-asserted-by":"crossref","DOI":"10.1177\/23259671211004554","article-title":"Association of sports participation with osteoarthritis: a systematic review and meta-analysis","volume":"9","author":"Bestwick-Stevenson","year":"2021","journal-title":"Orthopaedic journal of sports medicine"},{"issue":"6","key":"10.1016\/j.jot.2024.06.015_bib12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jpain.2018.11.012","article-title":"Racial-ethnic differences in osteoarthritis pain and disability: a meta-analysis","volume":"20","author":"Vaughn","year":"2019","journal-title":"J Pain"},{"issue":"3","key":"10.1016\/j.jot.2024.06.015_bib13","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/BOR.0000000000000161","article-title":"State of the evidence","volume":"27","author":"Allen","year":"2015","journal-title":"Curr Opin Rheumatol"},{"issue":"9859","key":"10.1016\/j.jot.2024.06.015_bib14","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet (London, England)"},{"issue":"8","key":"10.1016\/j.jot.2024.06.015_bib15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/17425247.2019.1635117","article-title":"Biodegradable polymers: an update on drug delivery in bone and cartilage diseases","volume":"16","author":"Lima","year":"2019","journal-title":"Expet Opin Drug Deliv"},{"issue":"11","key":"10.1016\/j.jot.2024.06.015_bib16","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"Suppl 1","key":"10.1016\/j.jot.2024.06.015_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40266-019-00660-1","article-title":"Safety of oral non-selective non-steroidal anti-inflammatory drugs in osteoarthritis: what does the literature say?","volume":"36","author":"Cooper","year":"2019","journal-title":"Drugs Aging"},{"issue":"9","key":"10.1016\/j.jot.2024.06.015_bib18","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41569-020-0366-z","article-title":"Cardiovascular effects and safety of (non-aspirin) NSAIDs","volume":"17","author":"Schjerning","year":"2020","journal-title":"Nat Rev Cardiol"},{"issue":"5b","key":"10.1016\/j.jot.2024.06.015_bib19","doi-asserted-by":"crossref","first-page":"13s","DOI":"10.1016\/S0002-9343(99)00113-8","article-title":"Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications","volume":"106","author":"Whelton","year":"1999","journal-title":"Am J Med"},{"issue":"6","key":"10.1016\/j.jot.2024.06.015_bib20","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1526-4637.2012.01394.x","article-title":"Evidence-based knee injections for the management of arthritis","volume":"13","author":"Cheng","year":"2012","journal-title":"Pain Med"},{"issue":"1","key":"10.1016\/j.jot.2024.06.015_bib21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40169-017-0180-3","article-title":"Recent advances in hyaluronic acid based therapy for osteoarthritis","volume":"7","author":"Bowman","year":"2018","journal-title":"Clin Transl Med"},{"issue":"4","key":"10.1016\/j.jot.2024.06.015_bib22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3390\/antiox9040348","article-title":"Unraveling natural products\u2019 role in osteoarthritis management-an overview","volume":"9","author":"Deligiannidou","year":"2020","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jot.2024.06.015_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10020265","article-title":"Emerging natural-product-based treatments for the management of osteoarthritis","volume":"10","author":"P\u00e9rez-Lozano","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jot.2024.06.015_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.arr.2017.12.006","article-title":"Cartilage regeneration and ageing: targeting cellular plasticity in osteoarthritis","volume":"42","author":"Varela-Eirin","year":"2018","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jot.2024.06.015_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120650","article-title":"Advances in mechanically robust and biomimetic polysaccharide-based constructs for cartilage tissue engineering","volume":"308","author":"Baei","year":"2023","journal-title":"Carbohydr Polym"},{"issue":"1","key":"10.1016\/j.jot.2024.06.015_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/art.39819","volume":"69","author":"Roman-Blas","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jot.2024.06.015_bib27","doi-asserted-by":"crossref","first-page":"c4675","DOI":"10.1136\/bmj.c4675","article-title":"Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis","volume":"341","author":"Wandel","year":"2010","journal-title":"BMJ (Clinical research ed.)"},{"issue":"3","key":"10.1016\/j.jot.2024.06.015_bib28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3390\/md21030172","article-title":"Applications of antioxidant secondary metabolites of sargassum spp","volume":"21","author":"Catarino","year":"2023","journal-title":"Mar Drugs"},{"key":"10.1016\/j.jot.2024.06.015_bib29","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.carbpol.2018.06.060","article-title":"Sargassum polysaccharide inhibits inflammatory response in PCV2 infected-RAW264.7 cells by regulating histone acetylation","volume":"200","author":"Chen","year":"2018","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.jot.2024.06.015_bib30","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.carbpol.2014.01.073","article-title":"Chemical characterization, antioxidant and antitumor activity of sulfated polysaccharide from Sargassum horneri","volume":"105","author":"Shao","year":"2014","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.jot.2024.06.015_bib31","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijbiomac.2019.03.178","article-title":"Antioxidant properties of a sulfated polysaccharide isolated from an enzymatic digest of Sargassum thunbergii","volume":"132","author":"Kang","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jot.2024.06.015_bib32","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.ijbiomac.2019.08.069","article-title":"Physicochemical characterization, potential antioxidant and hypoglycemic activity of polysaccharide from Sargassum pallidum","volume":"139","author":"Cao","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jot.2024.06.015_bib33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.carbpol.2017.04.083","article-title":"Sulphated polysaccharide isolated from Sargassum vulgare: characterization and hypolipidemic effects","volume":"170","author":"Kolsi","year":"2017","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.jot.2024.06.015_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jot.2019.03.002","article-title":"Sargassum integerrimum inhibits oestrogen deficiency and hyperlipidaemia-induced bone loss by upregulating nuclear factor (erythroid-derived 2)-like 2 in female rats","volume":"19","author":"Wu","year":"2019","journal-title":"Journal of orthopaedic translation"},{"key":"10.1016\/j.jot.2024.06.015_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2023.117749","article-title":"Isolation and characterization of a novel homopolysaccharide (SFP-1) from Sargassum fusiforme: promising anti-osteoporosis activity by modulating adipo-osteogenic differentiation","volume":"207","author":"Deng","year":"2024","journal-title":"Ind Crop Prod"},{"issue":"3","key":"10.1016\/j.jot.2024.06.015_bib36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1056\/NEJMoa0900158","article-title":"Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210","volume":"362","author":"Smits","year":"2010","journal-title":"N Engl J Med"},{"issue":"7725","key":"10.1016\/j.jot.2024.06.015_bib37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-018-0554-8","article-title":"Discovery of a periosteal stem cell mediating intramembranous bone formation","volume":"562","author":"Debnath","year":"2018","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jot.2024.06.015_bib38","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0306-9877(96)90066-3","article-title":"Glucosamine for wound healing","volume":"47","author":"McCarty","year":"1996","journal-title":"Med Hypotheses"},{"issue":"5","key":"10.1016\/j.jot.2024.06.015_bib39","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1345\/aph.17235","article-title":"Glucosamine","volume":"32","author":"Barclay","year":"1998","journal-title":"Ann Pharmacother"},{"issue":"3","key":"10.1016\/j.jot.2024.06.015_bib40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.7150\/ijms.17469","article-title":"Changes of articular cartilage and subchondral bone after extracorporeal shockwave therapy in osteoarthritis of the knee","volume":"14","author":"Wang","year":"2017","journal-title":"Int J Med Sci"},{"issue":"10","key":"10.1016\/j.jot.2024.06.015_bib41","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.3390\/antiox12101832","article-title":"A novel polysaccharide from sargassum weizhouense: extraction optimization, structural characterization, antiviral and antioxidant effects","volume":"12","author":"Zhao","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jot.2024.06.015_bib42","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ijbiomac.2020.12.126","article-title":"Sargassum fusiforme polysaccharide partly replaces acarbose against type 2 diabetes in rats","volume":"170","author":"Li","year":"2021","journal-title":"Int J Biol Macromol"},{"issue":"8","key":"10.1016\/j.jot.2024.06.015_bib43","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.3390\/ijms19082308","article-title":"Sargassum serratifolium extract attenuates interleukin-1\u03b2-induced oxidative stress and inflammatory response in chondrocytes by suppressing the activation of NF-\u03baB, p38 MAPK, and PI3K\/akt","volume":"19","author":"Park","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jot.2024.06.015_bib44","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3390\/ijerph15061173","article-title":"Activation of the Nrf2\/HO-1 signaling pathway contributes to the protective effects of sargassum serratifolium extract against oxidative stress-induced DNA damage and apoptosis in SW1353 human chondrocytes","volume":"15","author":"Park","year":"2018","journal-title":"Int J Environ Res Publ Health"},{"key":"10.1016\/j.jot.2024.06.015_bib45","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ijbiomac.2022.12.153","article-title":"A review focusing on the benefits of plant-derived polysaccharides for osteoarthritis","volume":"228","author":"Kuang","year":"2023","journal-title":"Int J Biol Macromol"},{"issue":"5","key":"10.1016\/j.jot.2024.06.015_bib46","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1039\/C8FO02565G","article-title":"Supplementation with compound polysaccharides contributes to the development and metabolic activity of young rat intestinal microbiota","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct"},{"issue":"13","key":"10.1016\/j.jot.2024.06.015_bib47","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.3390\/foods11131991","article-title":"Flaxseed polysaccharide alters colonic gene expression of lipid metabolism and energy metabolism in obese rats","volume":"11","author":"Wei","year":"2022","journal-title":"Foods"},{"issue":"4","key":"10.1016\/j.jot.2024.06.015_bib48","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1152\/physrev.00036.2018","article-title":"Cell adhesion by integrins","volume":"99","author":"Bachmann","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jot.2024.06.015_bib49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2014.08.007","article-title":"Integrins and chondrocyte-matrix interactions in articular cartilage, Matrix biology","volume":"39","author":"Loeser","year":"2014","journal-title":"journal of the International Society for Matrix Biology"},{"key":"10.1016\/j.jot.2024.06.015_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-540-78771-6_1","article-title":"Diverse roles of integrin receptors in articular cartilage","volume":"197","author":"Shakibaei","year":"2008","journal-title":"Adv Anat Embryol Cell Biol"},{"issue":"19","key":"10.1016\/j.jot.2024.06.015_bib51","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1101\/gad.277003","article-title":"Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis","volume":"17","author":"Aszodi","year":"2003","journal-title":"Gene Dev"},{"issue":"3","key":"10.1016\/j.jot.2024.06.015_bib52","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/(SICI)1097-0177(199711)210:3<249::AID-AJA6>3.0.CO;2-G","article-title":"Chondrocyte survival and differentiation in situ are integrin mediated","volume":"210","author":"Hirsch","year":"1997","journal-title":"Dev Dynam : an official publication of the American Association of Anatomists"},{"issue":"4","key":"10.1016\/j.jot.2024.06.015_bib53","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3892\/ijmm.2015.2114","article-title":"Integrin-\u03b21 regulates chondrocyte proliferation and apoptosis through the upregulation of GIT1 expression","volume":"35","author":"Zhang","year":"2015","journal-title":"Int J Mol Med"},{"issue":"4","key":"10.1016\/j.jot.2024.06.015_bib54","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1159\/000430253","article-title":"Integrin \u03b21 gene therapy enhances in vitro creation of tissue-engineered cartilage under periodic mechanical stress","volume":"37","author":"Liang","year":"2015","journal-title":"Cell Physiol Biochem : international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"issue":"9","key":"10.1016\/j.jot.2024.06.015_bib55","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.7150\/ijbs.83024","article-title":"Upregulated desmin\/integrin \u03b21\/MAPK axis promotes elastic cartilage regeneration with increased ECM mechanical strength","volume":"19","author":"Zhang","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"10","key":"10.1016\/j.jot.2024.06.015_bib56","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.3390\/ijms23105593","article-title":"Activation of focal adhesion kinase restores simulated microgravity-induced inhibition of osteoblast differentiation via wnt\/\u0392-catenin pathway","volume":"23","author":"Fan","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jot.2024.06.015_bib57","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1159\/000354495","article-title":"Periodic mechanical stress stimulates the FAK mitogenic signal in rat chondrocytes through ERK1\/2 activity","volume":"32","author":"Liang","year":"2013","journal-title":"Cell Physiol Biochem : international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"issue":"11","key":"10.1016\/j.jot.2024.06.015_bib58","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.7863\/ultra.14.10016","article-title":"Low-intensity pulsed ultrasound treatment at an early osteoarthritis stage protects rabbit cartilage from damage via the integrin\/focal adhesion kinase\/mitogen-activated protein kinase signaling pathway","volume":"34","author":"Xia","year":"2015","journal-title":"J Ultrasound Med : official journal of the American Institute of Ultrasound in Medicine"},{"key":"10.1016\/j.jot.2024.06.015_bib59","doi-asserted-by":"crossref","first-page":"d982","DOI":"10.2741\/1114","article-title":"Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility","volume":"8","author":"Hanks","year":"2003","journal-title":"Front Biosci : a journal and virtual library"},{"issue":"7","key":"10.1016\/j.jot.2024.06.015_bib60","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.ultrasmedbio.2014.03.002","article-title":"Effects of low-intensity pulsed ultrasound on integrin-FAK-PI3K\/Akt mechanochemical transduction in rabbit osteoarthritis chondrocytes","volume":"40","author":"Cheng","year":"2014","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.jot.2024.06.015_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110852","article-title":"Focal adhesion kinase (FAK): its structure, characteristics, and signaling in skeletal system","volume":"111","author":"Huang","year":"2023","journal-title":"Cell Signal"},{"issue":"4","key":"10.1016\/j.jot.2024.06.015_bib62","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.joca.2020.02.027","article-title":"The PI3K\/AKT\/mTOR signaling pathway in osteoarthritis: a narrative review","volume":"28","author":"Sun","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.jot.2024.06.015_bib63","first-page":"30","article-title":"KLF14 targets ITGB1 to inhibit the progression of cervical cancer via the PI3K\/AKT signalling pathway, Discover","volume":"13","author":"Lyu","year":"2022","journal-title":"Oncology"},{"issue":"2","key":"10.1016\/j.jot.2024.06.015_bib64","doi-asserted-by":"crossref","first-page":"293","DOI":"10.7150\/jca.25163","article-title":"Chinese herbal medicine wenxia changfu formula reverses cell adhesion-mediated drug resistance via the integrin \u03b21-PI3K-AKT pathway in lung cancer","volume":"10","author":"Zhang","year":"2019","journal-title":"J Cancer"},{"issue":"6","key":"10.1016\/j.jot.2024.06.015_bib65","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s10529-020-02839-8","article-title":"Semi-synthetic product dihydroartemisinin inhibited fibronectin-1 and integrin-\u03b21 and interfered with the migration of HCCLM6 cells via PI3K-AKT pathway","volume":"42","author":"Wu","year":"2020","journal-title":"Biotechnol Lett"},{"issue":"8","key":"10.1016\/j.jot.2024.06.015_bib66","doi-asserted-by":"crossref","first-page":"10668","DOI":"10.1096\/fj.202000043R","article-title":"THBS4 promotes HCC progression by regulating ITGB1 via FAK\/PI3K\/AKT pathway","volume":"34","author":"Guo","year":"2020","journal-title":"Faseb J"},{"issue":"18\u201319","key":"10.1016\/j.jot.2024.06.015_bib67","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.lfs.2013.09.002","article-title":"A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin \u03b21\/FAK\/PI3K\/AKT\/\u03b2-catenin signaling","volume":"93","author":"Qin","year":"2013","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.jot.2024.06.015_bib68","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/onc.2012.547","article-title":"In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated \u03b21 integrin and induction of FAK\/PI3K\/Akt motility signaling","volume":"33","author":"Casar","year":"2014","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.jot.2024.06.015_bib69","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1440-169X.2010.01209.x","article-title":"Myofibroblasts protect myoblasts from intrinsic apoptosis associated with differentiation via \u03b21 integrin-PI3K\/Akt pathway","volume":"52","author":"Zhang","year":"2010","journal-title":"Dev Growth Differ"},{"key":"10.1016\/j.jot.2024.06.015_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109079","article-title":"SCO-spondin-derived peptide NX210 rescues neurons from cerebral ischemia\/reperfusion injury through modulating the Integrin-\u03b21 mediated PI3K\/Akt pathway","volume":"111","author":"Yang","year":"2022","journal-title":"Int Immunopharm"},{"key":"10.1016\/j.jot.2024.06.015_bib77","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jot.2023.11.007","article-title":"JD-312 - A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression","volume":"44","author":"Gao","year":"2024","journal-title":"Journal of orthopaedic translation"},{"issue":"9","key":"10.1016\/j.jot.2024.06.015_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0275072","article-title":"Hcmv-miR-UL148D regulates the staurosporine-induced apoptosis by targeting the Endoplasmic Reticulum to Nucleus signaling 1(ERN1)","volume":"17","author":"Pandeya","year":"2022","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jot.2024.06.015_bib72","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/cbf.3698","article-title":"Possible effects of fibroblast growth factor 21 on vascular calcification via suppressing activating transcription factor 4 mediated apoptosis and osteogenic transformation in rats","volume":"40","author":"Shi","year":"2022","journal-title":"Cell Biochem Funct"},{"issue":"9","key":"10.1016\/j.jot.2024.06.015_bib73","first-page":"1132","article-title":"Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification, Apoptosis","volume":"18","author":"Duan","year":"2013","journal-title":"an international journal on programmed cell death"},{"issue":"5","key":"10.1016\/j.jot.2024.06.015_bib74","doi-asserted-by":"crossref","first-page":"R128","DOI":"10.1186\/cc7088","article-title":"Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis","volume":"12","author":"Weber","year":"2008","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.jot.2024.06.015_bib75","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jinf.2011.12.006","article-title":"Apoptosis markers soluble Fas (sFas), Fas Ligand (FasL) and sFas\/FasL ratio in patients with bacteremia: a prospective cohort study","volume":"64","author":"Huttunen","year":"2012","journal-title":"J Infect"},{"issue":"8","key":"10.1016\/j.jot.2024.06.015_bib76","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa052771","article-title":"Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis","volume":"354","author":"Clegg","year":"2006","journal-title":"N Engl J Med"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T15:59:56Z","timestamp":1722095996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X24000688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":77,"alternative-id":["S2214031X24000688"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2024.06.015","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sargassum polysaccharide attenuates osteoarthritis in rats and is associated with the up-regulation of the ITG\u03b21-PI3K-AKT signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2024.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}