{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:10:50Z","timestamp":1793725850416,"version":"4.6.1"},"reference-count":231,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jot.2024.07.008","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T18:42:12Z","timestamp":1725475332000},"page":"217-231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Emerging role of liver-bone axis in osteoporosis"],"prefix":"10.1016","volume":"48","author":[{"given":"Hongliang","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2713-2156","authenticated-orcid":false,"given":"Bin","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00198-018-4414-z","article-title":"Estrogen therapy for osteoporosis in the modern era","volume":"29","author":"Levin","year":"2018","journal-title":"Osteoporos Int"},{"issue":"9","key":"10.1016\/j.jot.2024.07.008_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11092382","article-title":"Secondary osteoporosis and metabolic bone diseases","volume":"11","author":"Sobh","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.jot.2024.07.008_bib3","first-page":"1017","article-title":"Epidemiology and management of osteoporosis in the People's Republic of China: current perspectives","volume":"10","author":"Lin","year":"2015","journal-title":"Clin Interv Aging"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41368-022-00175-3","article-title":"Loss of KDM4B impairs osteogenic differentiation of OMSCs and promotes oral bone aging","volume":"14","author":"Deng","year":"2022","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.jot.2024.07.008_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/421746","article-title":"Biology of bone tissue: structure, function, and factors that influence bone cells","volume":"2015","author":"Florencio-Silva","year":"2015","journal-title":"BioMed Res Int"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/jcp.2007.048868","article-title":"The cell biology of bone metabolism","volume":"61","author":"Datta","year":"2008","journal-title":"J Clin Pathol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib7","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/0004563218759371","article-title":"The bone remodelling cycle","volume":"55","author":"Kenkre","year":"2018","journal-title":"Ann Clin Biochem"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/md17060317","article-title":"Magma seawater inhibits hepatic lipid accumulation through suppression of lipogenic enzymes regulated by SREBPs in thioacetamide-injected rats","volume":"17","author":"Woo","year":"2019","journal-title":"Mar Drugs"},{"key":"10.1016\/j.jot.2024.07.008_bib9","article-title":"The roles of hepatokine and osteokine in liver-bone crosstalk: advance in basic and clinical aspects","volume":"14","author":"Li","year":"2023","journal-title":"Front Endocrinol"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib10","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1681\/ASN.2013060569","article-title":"Hepatectomy-related hypophosphatemia: a novel phosphaturic factor in the liver-kidney axis","volume":"25","author":"Nomura","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib11","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s11655-017-2810-4","article-title":"Liver-adipose tissue crosstalk: a key player in the pathogenesis of glucolipid metabolic disease","volume":"23","author":"Ye","year":"2017","journal-title":"Chin J Integr Med"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.tem.2018.01.002","article-title":"Bilirubin in the liver-gut signaling Axis","volume":"29","author":"Hamoud","year":"2018","journal-title":"Trends Endocrinol Metabol"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib13","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3350\/cmh.2020.0174","article-title":"Liver-lung axes in alcohol-related liver disease","volume":"26","author":"Arteel","year":"2020","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.jot.2024.07.008_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108915","article-title":"Organ and brain crosstalk: the liver-brain axis in gastrointestinal, liver, and pancreatic diseases","volume":"205","author":"Matsubara","year":"2022","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib15","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s00204-013-1191-5","article-title":"Chronic CCl4 intoxication causes liver and bone damage similar to the human pathology of hepatic osteodystrophy: a mouse model to analyse the liver-bone axis","volume":"88","author":"Nussler","year":"2014","journal-title":"Arch Toxicol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib16","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cmet.2022.02.006","article-title":"Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression","volume":"34","author":"Lu","year":"2022","journal-title":"Cell Metabol"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40360-022-00568-4","article-title":"Acute bone damage through liver-bone axis induced by thioacetamide in rats","volume":"23","author":"Jin","year":"2022","journal-title":"BMC Pharmacol Toxicol"},{"key":"10.1016\/j.jot.2024.07.008_bib18","article-title":"Liver-bone crosstalk in non-alcoholic fatty liver disease: clinical implications and underlying pathophysiology","volume":"14","author":"Zhao","year":"2023","journal-title":"Front Endocrinol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib19","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","article-title":"Endocrine regulation of energy metabolism by the skeleton","volume":"130","author":"Lee","year":"2007","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib20","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.cmet.2024.03.006","article-title":"An integrated multi-omics analysis reveals osteokines involved in global regulation","volume":"36","author":"Liang","year":"2024","journal-title":"Cell Metabol"},{"issue":"10","key":"10.1016\/j.jot.2024.07.008_bib21","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1080\/15548627.2020.1839286","article-title":"Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3","volume":"17","author":"Liu","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.jot.2024.07.008_bib22","doi-asserted-by":"crossref","DOI":"10.1177\/2042018819888824","article-title":"Reduced physical activity in young and older adults: metabolic and musculoskeletal implications","volume":"10","author":"Bowden Davies","year":"2019","journal-title":"Ther Adv Endocrinol Metab"},{"key":"10.1016\/j.jot.2024.07.008_bib23","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3389\/fendo.2019.00861","article-title":"Aging and imaging assessment of body composition: from fat to facts","volume":"10","author":"Ponti","year":"2019","journal-title":"Front Endocrinol"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib24","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2023.101133","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"29","author":"Rinella","year":"2024","journal-title":"Ann Hepatol"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1530\/EJE-19-0699","article-title":"Increased risk of low bone mineral density in patients with non-alcoholic fatty liver disease: a cohort study","volume":"182","author":"Shen","year":"2020","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s40618-023-02130-3","article-title":"Micro-scale vertebral features in postmenopausal women with alcohol-associated and metabolic-associated fatty liver disease: ex vivo bone quality analyses","volume":"47","author":"Jadzic","year":"2024","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.jot.2024.07.008_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.857110","article-title":"Relationship between non-alcoholic fatty liver disease and degree of hepatic steatosis and bone mineral density","volume":"13","author":"Xie","year":"2022","journal-title":"Front Endocrinol"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib29","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00774-016-0807-2","article-title":"Nonalcoholic fatty liver disease and osteoporosis: a systematic review and meta-analysis","volume":"35","author":"Upala","year":"2017","journal-title":"J Bone Miner Metabol"},{"issue":"7","key":"10.1016\/j.jot.2024.07.008_bib30","doi-asserted-by":"crossref","first-page":"66","DOI":"10.14715\/cmb\/2019.65.7.12","article-title":"SIRT2 deficiency prevents age-related bone loss in rats by inhibiting osteoclastogenesis","volume":"65","author":"Jing","year":"2019","journal-title":"Cell Mol Biol"},{"key":"10.1016\/j.jot.2024.07.008_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100961","article-title":"SIRT2: controversy and multiple roles in disease and physiology","volume":"55","author":"Wang","year":"2019","journal-title":"Ageing Res Rev"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/s42255-023-00803-0","article-title":"SIRT2 regulates extracellular vesicle-mediated liver-bone communication","volume":"5","author":"Lin","year":"2023","journal-title":"Nat Metab"},{"issue":"21","key":"10.1016\/j.jot.2024.07.008_bib33","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1093\/hmg\/ddx298","article-title":"The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes","volume":"26","author":"Lemos","year":"2017","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41598-017-00035-9","article-title":"Sirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1101\/gad.180406.111","article-title":"Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system","volume":"26","author":"Krishnan","year":"2012","journal-title":"Genes Dev"},{"key":"10.1016\/j.jot.2024.07.008_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122431","article-title":"The role of Sirtuin 2 in liver - an extensive and complex biological process","volume":"339","author":"Li","year":"2024","journal-title":"Life Sci"},{"issue":"12","key":"10.1016\/j.jot.2024.07.008_bib37","first-page":"1304","article-title":"Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress","volume":"33","author":"Wang","year":"2014","journal-title":"EMBO J"},{"issue":"48","key":"10.1016\/j.jot.2024.07.008_bib38","doi-asserted-by":"crossref","first-page":"6325","DOI":"10.1021\/acs.biochem.7b00859","article-title":"Resveratrol exerts antioxidant effects by activating SIRT2 to deacetylate Prx1","volume":"56","author":"Pan","year":"2017","journal-title":"Biochemistry"},{"issue":"Pt 24","key":"10.1016\/j.jot.2024.07.008_bib39","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1242\/jcs.073783","article-title":"SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310","volume":"123","author":"Rothgiesser","year":"2010","journal-title":"J Cell Sci"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib40","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s10753-018-0881-9","article-title":"Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis","volume":"42","author":"Wang","year":"2019","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib41","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.cmet.2020.01.009","article-title":"An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance","volume":"31","author":"He","year":"2020","journal-title":"Cell Metabol"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib42","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1172\/JCI88574","article-title":"Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2","volume":"127","author":"Yang","year":"2017","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib43","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41420-022-01048-8","article-title":"BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis","volume":"8","author":"Xu","year":"2022","journal-title":"Cell Death Dis"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib44","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cmet.2015.09.010","article-title":"A liver-bone endocrine relay by IGFBP1 promotes osteoclastogenesis and mediates FGF21-induced bone resorption","volume":"22","author":"Wang","year":"2015","journal-title":"Cell Metabol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib45","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cmet.2016.02.001","article-title":"A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and type 2 diabetic subjects","volume":"23","author":"Talukdar","year":"2016","journal-title":"Cell Metabol"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib46","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1113\/EP088351","article-title":"Age-related bone loss is associated with FGF21 but not IGFBP1 in healthy adults","volume":"105","author":"Lee","year":"2020","journal-title":"Exp Physiol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib47","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1677\/JOE-09-0431","article-title":"The GH\/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis","volume":"205","author":"Perrini","year":"2010","journal-title":"J Endocrinol"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib48","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nrendo.2013.67","article-title":"The GH\/IGF-1 axis in ageing and longevity","volume":"9","author":"Junnila","year":"2013","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib49","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1097\/GRF.0000000000000572","article-title":"Bone health and osteoporosis prevention and treatment","volume":"63","author":"Munoz","year":"2020","journal-title":"Clin Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.jot.2024.07.008_bib50","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1359\/jbmr.1999.14.9.1473","article-title":"On the estrogen-bone relationship and postmenopausal bone loss: a new model","volume":"14","author":"Frost","year":"1999","journal-title":"J Bone Miner Res"},{"issue":"Suppl 6","key":"10.1016\/j.jot.2024.07.008_bib51","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1515\/jpem-2000-s619","article-title":"Estrogen, bone, growth and sex: a sea change in conventional wisdom","volume":"13","author":"Grumbach","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"Suppl 1","key":"10.1016\/j.jot.2024.07.008_bib52","first-page":"E31","article-title":"Estrogens maintain bone mass by regulating expression of genes controlling function and life span in mature osteoclasts","volume":"1173","author":"Imai","year":"2009","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib53","first-page":"719","article-title":"Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity","volume":"104","author":"Kousteni","year":"2001","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib54","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/er.2009-0024","article-title":"From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis","volume":"31","author":"Manolagas","year":"2010","journal-title":"Endocr Rev"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030552","article-title":"Oxidative stress in human pathology and aging: molecular mechanisms and perspectives","volume":"11","author":"Hajam","year":"2022","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib56","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.jot.2024.07.008_bib57","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.freeradbiomed.2022.12.102","article-title":"17beta-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation","volume":"195","author":"Yang","year":"2023","journal-title":"Free Radic Biol Med"},{"issue":"Suppl","key":"10.1016\/j.jot.2024.07.008_bib58","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/0378-5122(96)01015-8","article-title":"Estrogen and bone metabolism","volume":"23","author":"Vaananen","year":"1996","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031376","article-title":"Osteoporosis due to hormone imbalance: an overview of the effects of estrogen deficiency and glucocorticoid overuse on bone turnover","volume":"23","author":"Cheng","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.jot.2024.07.008_bib60","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nm1096-1132","article-title":"Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta","volume":"2","author":"Hughes","year":"1996","journal-title":"Nat Med"},{"issue":"18","key":"10.1016\/j.jot.2024.07.008_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184420","article-title":"miR-34a-5p increases hepatic triglycerides and total cholesterol levels by regulating ACSL1 protein expression in laying hens","volume":"20","author":"Tian","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib62","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/hep.510290307","article-title":"Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats","volume":"29","author":"Yasuda","year":"1999","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.jot.2024.07.008_bib63","article-title":"Sex differences in chronic liver disease and benign liver lesions","volume":"5","author":"Cooper","year":"2023","journal-title":"JHEP Rep"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib64","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00198-020-05665-w","article-title":"Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up","volume":"32","author":"Rikkonen","year":"2021","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jot.2024.07.008_bib65","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2147\/JIR.S344009","article-title":"The potential role of serum IGF-1 and leptin as biomarkers: towards screening for and diagnosing postmenopausal osteoporosis","volume":"15","author":"Zhang","year":"2022","journal-title":"J Inflamm Res"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib66","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.diabet.2018.10.001","article-title":"Association between non-alcoholic fatty liver disease and bone turnover biomarkers in post-menopausal women with type 2 diabetes","volume":"45","author":"Mantovani","year":"2019","journal-title":"Diabetes Metab"},{"issue":"10","key":"10.1016\/j.jot.2024.07.008_bib67","first-page":"971","article-title":"Markers of autoimmune liver diseases in postmenopausal women with osteoporosis","volume":"65","author":"Demirdal","year":"2010","journal-title":"Clinics"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib68","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12011-019-01867-4","article-title":"The effect of abnormal iron metabolism on osteoporosis","volume":"195","author":"Che","year":"2020","journal-title":"Biol Trace Elem Res"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib69","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s10753-014-9982-2","article-title":"Effects of mouse hepcidin 1 treatment on osteoclast differentiation and intracellular iron concentration","volume":"38","author":"Zhao","year":"2015","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib70","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3892\/etm.2015.2484","article-title":"Reducing iron accumulation: a potential approach for the prevention and treatment of postmenopausal osteoporosis","volume":"10","author":"Chen","year":"2015","journal-title":"Exp Ther Med"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib71","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.gene.2012.09.060","article-title":"Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element","volume":"511","author":"Hou","year":"2012","journal-title":"Gene"},{"issue":"14","key":"10.1016\/j.jot.2024.07.008_bib72","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.3748\/wjg.v23.i14.2613","article-title":"Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis","volume":"23","author":"Kukla","year":"2017","journal-title":"World J Gastroenterol"},{"issue":"13","key":"10.1016\/j.jot.2024.07.008_bib73","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.3748\/wjg.v16.i13.1639","article-title":"Hepatic osteodystrophy and liver cirrhosis","volume":"16","author":"Goral","year":"2010","journal-title":"World J Gastroenterol"},{"issue":"17","key":"10.1016\/j.jot.2024.07.008_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20174270","article-title":"Bone diseases in patients with chronic liver disease","volume":"20","author":"Jeong","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib75","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s00198-019-04870-6","article-title":"Bone microarchitecture and bone turnover in hepatic cirrhosis","volume":"30","author":"Wakolbinger","year":"2019","journal-title":"Osteoporos Int"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib76","first-page":"16","article-title":"Regulation of 5-hydroxytryptamine1A receptor function in rat hippocampus by short- and long-term administration of 5-hydroxytryptamine1A agonist and antidepressants","volume":"260","author":"Newman","year":"1992","journal-title":"J Pharmacol Exp Therapeut"},{"issue":"51","key":"10.1016\/j.jot.2024.07.008_bib77","first-page":"814","article-title":"Serum concentrations of insulin-like growth factor-I (IGF-I) in patients with liver cirrhosis","volume":"50","author":"Vyzantiadis","year":"2003","journal-title":"Hepato-Gastroenterology"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib78","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S1665-2681(19)31009-9","article-title":"IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosis","volume":"12","author":"Ronsoni","year":"2013","journal-title":"Ann Hepatol"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib79","first-page":"245","article-title":"Serum insulin like growth factor-1 (IGF-1) and insulin like growth factor binding protein-3 (IGFBP-3) levels in liver cirrhosis","volume":"18","author":"Colako\u011flu","year":"2007","journal-title":"Turk J Gastroenterol"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib80","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1172\/JCI0215463","article-title":"Circulating levels of IGF-1 directly regulate bone growth and density","volume":"110","author":"Yakar","year":"2002","journal-title":"J Clin Invest"},{"issue":"23","key":"10.1016\/j.jot.2024.07.008_bib81","doi-asserted-by":"crossref","first-page":"7312","DOI":"10.3748\/wjg.v20.i23.7312","article-title":"Pathogenesis of liver cirrhosis","volume":"20","author":"Zhou","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"8","key":"10.1016\/j.jot.2024.07.008_bib82","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.18632\/aging.101529","article-title":"Inverse relationship between serum hsCRP concentration and hand grip strength in older adults: a nationwide population-based study","volume":"10","author":"Kim","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jot.2024.07.008_bib83","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.708959","article-title":"Crosstalk between plasma cytokines, inflammation, and liver damage as a new strategy to monitoring NAFLD progression","volume":"12","author":"Fontes-Cal","year":"2021","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101611","article-title":"Regulation of bone mass in inflammatory diseases","volume":"36","author":"Adami","year":"2022","journal-title":"Best Pract Res Clin Endocrinol Metabol"},{"key":"10.1016\/j.jot.2024.07.008_bib85","article-title":"Sclerostin and osteocalcin: candidate bone-produced hormones","volume":"12","author":"Wang","year":"2021","journal-title":"Front Endocrinol"},{"issue":"13","key":"10.1016\/j.jot.2024.07.008_bib86","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1073\/pnas.0711119105","article-title":"Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice","volume":"105","author":"Ferron","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib87","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.bone.2011.04.017","article-title":"Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice","volume":"50","author":"Ferron","year":"2012","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib88","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1210\/en.2012-2144","article-title":"Osteocalcin reverses endoplasmic reticulum stress and improves impaired insulin sensitivity secondary to diet-induced obesity through nuclear factor-kappaB signaling pathway","volume":"154","author":"Zhou","year":"2013","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib89","first-page":"124","article-title":"Plasma osteocalcin levels in liver cirrhosis","volume":"23","author":"Capra","year":"1991","journal-title":"Ital J Gastroenterol"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-014-9931-y","article-title":"Osteocalcin: an osteoblast-derived polypeptide hormone that modulates whole body energy metabolism","volume":"96","author":"Brennan-Speranza","year":"2015","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib91","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1038\/s41467-021-25673-6","article-title":"Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin","volume":"12","author":"Mao","year":"2021","journal-title":"Nat Commun"},{"issue":"13","key":"10.1016\/j.jot.2024.07.008_bib92","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1096\/fj.05-4221fje","article-title":"Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation","volume":"19","author":"Poole","year":"2005","journal-title":"Faseb J"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib93","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1210\/en.2007-0270","article-title":"Targeting the Wnt\/beta-catenin pathway to regulate bone formation in the adult skeleton","volume":"148","author":"Baron","year":"2007","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib94","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/joa.13621","article-title":"The altered osteocytic expression of connexin 43 and sclerostin in human cadaveric donors with alcoholic liver cirrhosis: potential treatment targets","volume":"240","author":"Jadzic","year":"2022","journal-title":"J Anat"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib95","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00774-013-0524-z","article-title":"Effect of liver dysfunction on circulating sclerostin","volume":"32","author":"Rhee","year":"2014","journal-title":"J Bone Miner Metabol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib96","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1093\/alcalc\/ags136","article-title":"Serum sclerostin in alcoholics: a pilot study","volume":"48","author":"Gonz\u00e1lez-Reimers","year":"2013","journal-title":"Alcohol Alcohol"},{"issue":"1\u20132","key":"10.1016\/j.jot.2024.07.008_bib97","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00508-019-01595-8","article-title":"Serum levels of sclerostin reflect altered bone microarchitecture in patients with hepatic cirrhosis","volume":"132","author":"Wakolbinger","year":"2020","journal-title":"Wien Klin Wochenschr"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00198-011-1787-7","article-title":"Alcohol and bone: review of dose effects and mechanisms","volume":"23","author":"Maurel","year":"2012","journal-title":"Osteoporos Int"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib99","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0169-6009(90)90113-T","article-title":"Decreased serum osteocalcin levels in patients with liver cirrhosis","volume":"8","author":"Pietschmann","year":"1990","journal-title":"Bone Miner"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib100","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1053\/j.gastro.2010.10.014","article-title":"Bone disease in patients with primary sclerosing cholangitis","volume":"140","author":"Angulo","year":"2011","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.jot.2024.07.008_bib101","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s11604-016-0573-z","article-title":"Diffusion-weighted MRI for detection of hepatic osteodystrophy in primary sclerosing cholangitis: a comparison study with dual-energy X-ray absorptiometry","volume":"34","author":"Keller","year":"2016","journal-title":"Jpn J Radiol"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib102","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1055\/s-0038-1660790","article-title":"Osteoporosis: current concepts","volume":"6","author":"Akkawi","year":"2018","journal-title":"Joints"},{"issue":"18","key":"10.1016\/j.jot.2024.07.008_bib103","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810705","article-title":"The role of vitamin D and vitamin D binding protein in chronic liver diseases","volume":"23","author":"Pop","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2024.07.008_bib104","article-title":"The role of Th17 cells in endocrine organs: involvement of the gut, adipose tissue, liver and bone","volume":"13","author":"Zi","year":"2022","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib105","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.jhep.2018.12.035","article-title":"Th17 cell frequency is associated with low bone mass in primary sclerosing cholangitis","volume":"70","author":"Schmidt","year":"2019","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib106","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/hep.510280315","article-title":"Bone mineral density, serum insulin-like growth factor I, and bone turnover markers in viral cirrhosis","volume":"28","author":"Gallego-Rojo","year":"1998","journal-title":"Hepatology"},{"issue":"50","key":"10.1016\/j.jot.2024.07.008_bib107","doi-asserted-by":"crossref","first-page":"e2276","DOI":"10.1097\/MD.0000000000002276","article-title":"Association between chronic hepatitis B virus infection and risk of osteoporosis: a nationwide population-based study","volume":"94","author":"Chen","year":"2015","journal-title":"Medicine (Baltim)"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib108","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4103\/sjg.SJG_452_16","article-title":"Hepatitis C virus infection and risk of osteoporosis: a meta-analysis","volume":"23","author":"Wijarnpreecha","year":"2017","journal-title":"Saudi J Gastroenterol"},{"issue":"16","key":"10.1016\/j.jot.2024.07.008_bib109","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000019719","article-title":"Association between hepatitis B virus infection and risk of osteoporosis: a systematic review and meta-analysis: a protocol for systematic review","volume":"99","author":"Xie","year":"2020","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.jot.2024.07.008_bib110","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1120083","article-title":"Seropositive for hepatitis B and C viruses is associated with the risk of decreased bone mineral density in adults: an analysis of studies from the NHANES database","volume":"10","author":"Tao","year":"2023","journal-title":"Front Med"},{"issue":"9","key":"10.1016\/j.jot.2024.07.008_bib111","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1210\/jc.2004-0077","article-title":"Osteoporosis, mineral metabolism, and serum soluble tumor necrosis factor receptor p55 in viral cirrhosis","volume":"89","author":"Gonzalez-Calvin","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib112","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1038\/s41598-019-41674-4","article-title":"Crosssectional assessment of bone mass density in adults with hepatitis B virus and hepatitis C virus infection","volume":"9","author":"Chen","year":"2019","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib113","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jhep.2014.04.001","article-title":"Risk of hip fracture associated with untreated and treated chronic hepatitis B virus infection","volume":"61","author":"Byrne","year":"2014","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib114","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1053\/j.gastro.2007.03.039","article-title":"Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma","volume":"132","author":"Kim","year":"2007","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib115","first-page":"126","article-title":"The effect of hepatitis B virus infection on hepcidin expression in hepatitis B patients","volume":"43","author":"Wang","year":"2013","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.jot.2024.07.008_bib116","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fendo.2019.00302","article-title":"Relationship between vertebral fractures, bone mineral density, and osteometabolic profile in HIV and hepatitis B and C-infected patients treated with ART","volume":"10","author":"Dalla Grana","year":"2019","journal-title":"Front Endocrinol"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib117","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/hep.29800","article-title":"Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance","volume":"67","author":"Terrault","year":"2018","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.jot.2024.07.008_bib118","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib119","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.jot.2024.07.008_bib120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24087517","article-title":"Osteosarcopenia in NAFLD\/MAFLD: an underappreciated clinical problem in chronic liver disease","volume":"24","author":"Musio","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib121","doi-asserted-by":"crossref","first-page":"e283","DOI":"10.1038\/emm.2016.123","article-title":"Gene-metabolite network analysis in different nonalcoholic fatty liver disease phenotypes","volume":"49","author":"Liu","year":"2017","journal-title":"Exp Mol Med"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib122","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrgastro.2016.147","article-title":"NAFLD and diabetes mellitus","volume":"14","author":"Tilg","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib123","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3858\/emm.2010.42.6.045","article-title":"Msx2 mediates the inhibitory action of TNF-alpha on osteoblast differentiation","volume":"42","author":"Lee","year":"2010","journal-title":"Exp Mol Med"},{"issue":"7","key":"10.1016\/j.jot.2024.07.008_bib124","doi-asserted-by":"crossref","first-page":"e0182202","DOI":"10.1371\/journal.pone.0182202","article-title":"Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jot.2024.07.008_bib125","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.2147\/CIA.S170533","article-title":"Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis","volume":"13","author":"Filip","year":"2018","journal-title":"Clin Interv Aging"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib126","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/apa.13685","article-title":"Insulin-like growth factor 1 and metabolic parameters are associated with nonalcoholic fatty liver disease in obese children and adolescents","volume":"106","author":"Liang","year":"2017","journal-title":"Acta Paediatr"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib127","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12020-019-01982-1","article-title":"Insulin-like growth factor-1 and non-alcoholic fatty liver disease: a systemic review and meta-analysis","volume":"65","author":"Yao","year":"2019","journal-title":"Endocrine"},{"issue":"7","key":"10.1016\/j.jot.2024.07.008_bib128","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071447","article-title":"The role of growth hormone and insulin-like growth factor-I in the liver","volume":"18","author":"Takahashi","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2024.07.008_bib129","doi-asserted-by":"crossref","DOI":"10.1038\/srep34605","article-title":"IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner","volume":"6","author":"Nishizawa","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib130","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1053\/j.gastro.2010.04.054","article-title":"Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease","volume":"139","author":"Dushay","year":"2010","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib131","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.07.003","article-title":"Fibroblast growth factor 21 as a biomarker for NAFLD: integrating pathobiology into clinical practice","volume":"53","author":"Morris-Stiff","year":"2010","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib132","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1084\/jem.193.3.399","article-title":"Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin","volume":"193","author":"Ishijima","year":"2001","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib133","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/MPG.0000000000001768","article-title":"Serum osteocalcin levels in children with nonalcoholic fatty liver disease","volume":"66","author":"Amin","year":"2018","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib134","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jhep.2020.07.030","article-title":"Targeting NFATc4 attenuates non-alcoholic steatohepatitis in mice","volume":"73","author":"Du","year":"2020","journal-title":"J Hepatol"},{"issue":"8","key":"10.1016\/j.jot.2024.07.008_bib135","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1007\/s00125-011-2170-0","article-title":"Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice","volume":"54","author":"Kiefer","year":"2011","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib136","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/jcp.24278","article-title":"Osteocalcin: skeletal and extra-skeletal effects","volume":"228","author":"Neve","year":"2013","journal-title":"J Cell Physiol"},{"issue":"8","key":"10.1016\/j.jot.2024.07.008_bib137","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3109\/00365513.2011.604427","article-title":"Serum osteocalcin levels in patients with nonalcoholic fatty liver disease: association with ballooning degeneration","volume":"71","author":"Yilmaz","year":"2011","journal-title":"Scand J Clin Lab Invest"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib138","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab011","article-title":"Explaining divergent observations regarding osteocalcin\/GPRC6A endocrine signaling","volume":"162","author":"Pi","year":"2021","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib139","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00774-015-0687-x","article-title":"Circulating sclerostin and Dickkopf-1 levels in patients with nonalcoholic fatty liver disease","volume":"34","author":"Polyzos","year":"2016","journal-title":"J Bone Miner Metabol"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib140","doi-asserted-by":"crossref","first-page":"E271","DOI":"10.1152\/ajpendo.00092.2013","article-title":"Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity","volume":"305","author":"Lau","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jot.2024.07.008_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101349","article-title":"The hepatocyte IKK:NF-kappaB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis","volume":"54","author":"Heida","year":"2021","journal-title":"Mol Metabol"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib142","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12664-016-0652-1","article-title":"Bone health and vitamin D status in alcoholic liver disease","volume":"35","author":"Kizilgul","year":"2016","journal-title":"Indian J Gastroenterol"},{"issue":"8","key":"10.1016\/j.jot.2024.07.008_bib143","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/stem.2392","article-title":"Chronic high dose alcohol induces osteopenia via activation of mTOR signaling in bone marrow mesenchymal stem cells","volume":"34","author":"Liu","year":"2016","journal-title":"Stem Cell"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib144","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/alcalc\/agx006","article-title":"Alcohol induces cellular senescence and impairs osteogenic potential in bone marrow-derived mesenchymal stem cells","volume":"52","author":"Chen","year":"2017","journal-title":"Alcohol Alcohol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib145","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cld.2016.02.002","article-title":"Spectrum of alcoholic liver disease","volume":"20","author":"Chacko","year":"2016","journal-title":"Clin Liver Dis"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib146","first-page":"703","article-title":"Effects of alcohol and liver cirrhosis on the GH-IGF-I axis","volume":"30","author":"Santolaria","year":"1995","journal-title":"Alcohol Alcohol"},{"issue":"7","key":"10.1016\/j.jot.2024.07.008_bib147","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/BF03343879","article-title":"Decreased IGF-I bioavailability after ethanol abuse in alcoholics: partial restitution after short-term abstinence","volume":"24","author":"Rojdmark","year":"2001","journal-title":"J Endocrinol Invest"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib148","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0741-8329(00)00090-2","article-title":"Alterations of IGF-binding proteins in patients with alcoholic liver cirrhosis","volume":"21","author":"Nedi\u0107","year":"2000","journal-title":"Alcohol"},{"issue":"21","key":"10.1016\/j.jot.2024.07.008_bib149","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.2174\/1381612043383764","article-title":"The anabolic effects of GH\/IGF system on bone","volume":"10","author":"Kasukawa","year":"2004","journal-title":"Curr Pharmaceut Des"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib150","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s11914-023-00826-2","article-title":"Osteocyte mechanotransduction in orthodontic tooth movement","volume":"21","author":"Seddiqi","year":"2023","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.jot.2024.07.008_bib151","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2021.106552","article-title":"Pathophysiological role of prostaglandin E synthases in liver diseases","volume":"154","author":"Xu","year":"2021","journal-title":"Prostag Other Lipid Mediat"},{"issue":"9","key":"10.1016\/j.jot.2024.07.008_bib152","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/s41374-021-00531-7","article-title":"Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury","volume":"101","author":"Pan","year":"2021","journal-title":"Lab Invest"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib153","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2023.13079","article-title":"Inhibition of TP signaling promotes endometriosis growth and neovascularization","volume":"28","author":"Furue","year":"2023","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib154","doi-asserted-by":"crossref","first-page":"45","DOI":"10.17219\/acem\/67561","article-title":"IL-6, IL-1beta, and TNF-alpha only in combination influence the osteoporotic phenotype in Crohn's patients via bone formation and bone resorption","volume":"27","author":"Blaschke","year":"2018","journal-title":"Adv Clin Exp Med"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1590\/0103-6440201600545","article-title":"Effect of 15% alcohol dependence on alveolar bone loss and TNF-alpha secretion in Wistar rats","volume":"27","author":"Wagner","year":"2016","journal-title":"Braz Dent J"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib156","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1478-3231.2005.01073.x","article-title":"Osteoprotegerin and RANKL in alcoholic liver cirrhosis","volume":"25","author":"F\u00e1brega","year":"2005","journal-title":"Liver Int"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib157","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/alcalc\/agl004","article-title":"Serum osteoprotegerin and RANKL levels in chronic alcoholic liver disease","volume":"41","author":"Garc\u00eda-Valdecasas-Campelo","year":"2006","journal-title":"Alcohol Alcohol"},{"issue":"12","key":"10.1016\/j.jot.2024.07.008_bib158","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1210\/endo.142.12.8536","article-title":"Minireview: the OPG\/RANKL\/RANK system","volume":"142","author":"Khosla","year":"2001","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib159","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF03346365","article-title":"Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol","volume":"31","author":"Santori","year":"2008","journal-title":"J Endocrinol Invest"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib160","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/acer.13063","article-title":"Osteoprotegerin levels decrease in abstinent alcohol-dependent patients","volume":"40","author":"Malik","year":"2016","journal-title":"Alcohol Clin Exp Res"},{"issue":"13","key":"10.1016\/j.jot.2024.07.008_bib161","doi-asserted-by":"crossref","DOI":"10.3390\/nu14132574","article-title":"Sclerostin in excessive drinkers: relationships with liver function and body composition","volume":"14","author":"Mart\u00edn Gonz\u00e1lez","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib162","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1210\/jc.2007-0737","article-title":"The relationship between alcohol consumption and cortisol secretion in an aging cohort","volume":"93","author":"Badrick","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib163","first-page":"345","article-title":"Alcohol and bone disease","volume":"25","author":"Rico","year":"1990","journal-title":"Alcohol Alcohol"},{"issue":"9","key":"10.1016\/j.jot.2024.07.008_bib164","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.4254\/wjh.v7.i9.1258","article-title":"Bone changes in alcoholic liver disease","volume":"7","author":"Gonz\u00e1lez-Reimers","year":"2015","journal-title":"World J Hepatol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib165","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s12072-010-9194-2","article-title":"Disturbances of parathyroid hormone-vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study","volume":"4","author":"Miroliaee","year":"2010","journal-title":"Hepatol Int"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib166","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1210\/er.2012-1012","article-title":"The roles of vitamin D in skeletal muscle: form, function, and metabolism","volume":"34","author":"Girgis","year":"2013","journal-title":"Endocr Rev"},{"issue":"11","key":"10.1016\/j.jot.2024.07.008_bib167","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/gerona\/gls068","article-title":"The role of androgens and estrogens on healthy aging and longevity","volume":"67","author":"Horstman","year":"2012","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib168","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/andr.13526","article-title":"The chronic alcohol consumption influences the gonadal axis in men: results from a meta-analysis","volume":"12","author":"Santi","year":"2024","journal-title":"Andrology"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib169","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1007\/s12640-023-00674-z","article-title":"Biological pathways associated with vitamins in autism spectrum disorder","volume":"41","author":"Gusso","year":"2023","journal-title":"Neurotox Res"},{"issue":"2\u20133","key":"10.1016\/j.jot.2024.07.008_bib170","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.toxlet.2009.08.023","article-title":"Excess iron inhibits osteoblast metabolism","volume":"191","author":"Yamasaki","year":"2009","journal-title":"Toxicol Lett"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib171","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s11926-008-0020-y","article-title":"Calcium and vitamin D: skeletal and extraskeletal health","volume":"10","author":"Khazai","year":"2008","journal-title":"Curr Rheumatol Rep"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib172","doi-asserted-by":"crossref","DOI":"10.3390\/nu9060617","article-title":"Long-Term dexamethasone exposure down-regulates hepatic TFR1 and reduces liver iron concentration in rats","volume":"9","author":"Li","year":"2017","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib173","doi-asserted-by":"crossref","first-page":"R95","DOI":"10.1530\/JOE-16-0657","article-title":"High-density lipoprotein (HDL) metabolism and bone mass","volume":"233","author":"Papachristou","year":"2017","journal-title":"J Endocrinol"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib174","first-page":"1107","article-title":"Determination of genotypes of human aldehyde dehydrogenase ALDH2 locus","volume":"35","author":"Yoshida","year":"1983","journal-title":"Am J Hum Genet"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib175","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jhep.2019.06.018","article-title":"ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles","volume":"71","author":"Seo","year":"2019","journal-title":"J Hepatol"},{"key":"10.1016\/j.jot.2024.07.008_bib176","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2023.07.002","article-title":"SLC3A2, as an indirect target gene of ALDH2, exacerbates alcohol-associated liver cancer via the sphingolipid biosynthesis pathway","volume":"206","author":"Xia","year":"2023","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib177","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/alcalc\/agp038","article-title":"Osteopenia in alcoholics: effect of alcohol abstinence","volume":"44","author":"Alvisa-Negr\u00edn","year":"2009","journal-title":"Alcohol Alcohol"},{"issue":"12","key":"10.1016\/j.jot.2024.07.008_bib178","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1111\/j.1530-0277.2012.01834.x","article-title":"Markers of bone resorption and formation during abstinence in male alcoholic patients","volume":"36","author":"Malik","year":"2012","journal-title":"Alcohol Clin Exp Res"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib179","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/myc.12889","article-title":"Molecular epidemiology and in vitro antifungal susceptibility of Trichophyton schoenleinii, agent of tinea capitis favosa","volume":"62","author":"Gao","year":"2019","journal-title":"Mycoses"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib180","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1053\/j.gastro.2010.06.013","article-title":"Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment","volume":"139","author":"Pietrangelo","year":"2010","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.jot.2024.07.008_bib181","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s00198-010-1456-2","article-title":"Bone status in a mouse model of genetic hemochromatosis","volume":"22","author":"Guggenbuhl","year":"2011","journal-title":"Osteoporos Int"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib182","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00198-008-0701-4","article-title":"Association between iron overload and osteoporosis in patients with hereditary hemochromatosis","volume":"20","author":"Valenti","year":"2009","journal-title":"Osteoporos Int"},{"issue":"6","key":"10.1016\/j.jot.2024.07.008_bib183","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s00223-014-9845-8","article-title":"Hepcidin1 knockout mice display defects in bone microarchitecture and changes of bone formation markers","volume":"94","author":"Shen","year":"2014","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib184","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jhep.2016.03.007","article-title":"Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1\/Tfr2\/hepcidin axis","volume":"65","author":"Bao","year":"2016","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib185","doi-asserted-by":"crossref","first-page":"G171","DOI":"10.1152\/ajpgi.00291.2015","article-title":"Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2","volume":"310","author":"Rishi","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jot.2024.07.008_bib186","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bone.2016.09.023","article-title":"The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss","volume":"94","author":"Xu","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.jot.2024.07.008_bib187","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X20939405","article-title":"Bone and joint complications in patients with hereditary hemochromatosis: a cross-sectional study of 93 patients","volume":"12","author":"Nguyen","year":"2020","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib188","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/gim.2017.121","article-title":"Clinical penetrance in hereditary hemochromatosis: estimates of the cumulative incidence of severe liver disease among HFE C282Y homozygotes","volume":"20","author":"Grosse","year":"2018","journal-title":"Genet Med"},{"issue":"9541","key":"10.1016\/j.jot.2024.07.008_bib189","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"Gryseels","year":"2006","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib190","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","volume":"4","author":"McManus","year":"2018","journal-title":"Schistosomiasis. Nat Rev Dis Primers"},{"issue":"10163","key":"10.1016\/j.jot.2024.07.008_bib191","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/S0140-6736(18)33008-3","article-title":"Schistosomiasis","volume":"392","author":"Barnett","year":"2018","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib192","doi-asserted-by":"crossref","first-page":"e1009462","DOI":"10.1371\/journal.ppat.1009462","article-title":"Schistosome infection promotes osteoclast-mediated bone loss","volume":"17","author":"Li","year":"2021","journal-title":"PLoS Pathog"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib193","doi-asserted-by":"crossref","first-page":"534","DOI":"10.4269\/ajtmh.2005.72.534","article-title":"Impact of parasitic infections and dietary intake on child growth in the schistosomiasis-endemic Dongting Lake Region, China","volume":"72","author":"Zhou","year":"2005","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib194","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1038\/s41467-019-12606-7","article-title":"Genome-wide CRISPR\/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC","volume":"10","author":"Wei","year":"2019","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.jot.2024.07.008_bib195","first-page":"1177","article-title":"\u809d\u764c\u60a3\u8005\u9aa8\u4ee3\u8c22\u751f\u5316\u6307\u6807\u4e0e\u9aa8\u8d28\u758f\u677e\u7684\u4e34\u5e8a\u7814\u7a76","volume":"19","author":"\u4ed8\u58eb\u6b66","year":"2013","journal-title":"\u4e2d\u56fd\u9aa8\u8d28\u758f\u677e\u6742\u5fd7"},{"issue":"9","key":"10.1016\/j.jot.2024.07.008_bib196","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.7150\/thno.49819","article-title":"SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma","volume":"11","author":"Lin","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jot.2024.07.008_bib197","article-title":"SPTBN1 prevents primary osteoporosis by modulating osteoblasts proliferation and differentiation and blood vessels formation in bone","volume":"9","author":"Xu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jot.2024.07.008_bib198","doi-asserted-by":"crossref","unstructured":"Jung, J. and Q. Wu, Revealing the organ-specific expression of SPTBN1 using single-cell RNA sequencing analysis. bioRxiv, 2023(Preprint).doi:10.1101\/2023.06.01.543198.","DOI":"10.1101\/2023.06.01.543198"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib199","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-023-00250-3","article-title":"A mutation in the ZNF687 gene that is responsible for the severe form of Paget's disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model","volume":"11","author":"Russo","year":"2023","journal-title":"Bone Res"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib200","first-page":"1021","article-title":"Evaluation of osteopontin as a biomarker in hepatocellular carcinomas in Egyptian patients with chronic HCV cirrhosis","volume":"19","author":"Abdel-Hafiz","year":"2018","journal-title":"Asian Pac J Cancer Prev APJCP"},{"issue":"7","key":"10.1016\/j.jot.2024.07.008_bib201","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1016\/j.transproceed.2021.07.049","article-title":"Bone disease and liver transplantation: a review","volume":"53","author":"Rodr\u00edguez-Aguilar","year":"2021","journal-title":"Transplant Proc"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib202","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2023.2230871","article-title":"Risk factors for fractures following liver transplantation: a population-based cohort study","volume":"55","author":"Chang","year":"2023","journal-title":"Ann Med"},{"issue":"7","key":"10.1016\/j.jot.2024.07.008_bib203","doi-asserted-by":"crossref","DOI":"10.3390\/life13071438","article-title":"Changes in serum bone metabolism markers after living donor liver transplantation (LDLT) and their association with fracture occurrences","volume":"13","author":"Kuo","year":"2023","journal-title":"Life"},{"issue":"8","key":"10.1016\/j.jot.2024.07.008_bib204","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/lt.24458","article-title":"Bone mineral density predicts posttransplant survival among hepatocellular carcinoma liver transplant recipients","volume":"22","author":"Sharma","year":"2016","journal-title":"Liver Transplant"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib205","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s00268-019-05206-5","article-title":"Prognostic impact of osteopenia in patients who underwent living donor liver transplantation for hepatocellular carcinoma","volume":"44","author":"Toshima","year":"2020","journal-title":"World J Surg"},{"issue":"2","key":"10.1016\/j.jot.2024.07.008_bib206","doi-asserted-by":"crossref","first-page":"367","DOI":"10.14309\/ajg.0000000000002507","article-title":"Osteoporosis and fragility fractures in patients with cirrhosis evaluated for liver transplantation: identification of high-risk patients based on computed tomography at evaluation","volume":"119","author":"Nachef","year":"2023","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib207","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/hmg\/ddad173","article-title":"Comparison of pharmaceutical properties and biological activity of prednisolone, deflazacort, and vamorolone in DMD disease models","volume":"33","author":"Liu","year":"2023","journal-title":"Hum Mol Genet"},{"issue":"19","key":"10.1016\/j.jot.2024.07.008_bib208","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1002\/cncr.25960","article-title":"Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors","volume":"117","author":"Uchino","year":"2011","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib209","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S1499-3872(16)60173-X","article-title":"Bone metastases from hepatocellular carcinoma: clinical features and prognostic factors","volume":"16","author":"Lu","year":"2017","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"5","key":"10.1016\/j.jot.2024.07.008_bib210","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/jcb.10726","article-title":"IGF-I and MAP kinase involvement in the stimulatory effects of LNCaP prostate cancer cell conditioned media on cell proliferation and protein synthesis in MC3T3-E1 osteoblastic cells","volume":"90","author":"Bhattacharyya","year":"2003","journal-title":"J Cell Biochem"},{"issue":"12","key":"10.1016\/j.jot.2024.07.008_bib211","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1359\/JBMR.050802","article-title":"Influence of BMPs on the formation of osteoblastic lesions in metastatic prostate cancer","volume":"20","author":"Feeley","year":"2005","journal-title":"J Bone Miner Res"},{"issue":"23","key":"10.1016\/j.jot.2024.07.008_bib212","doi-asserted-by":"crossref","first-page":"10921","DOI":"10.1158\/0008-5472.CAN-05-1809","article-title":"Vascular endothelial growth factor contributes to prostate cancer-mediated osteoblastic activity","volume":"65","author":"Kitagawa","year":"2005","journal-title":"Cancer Res"},{"issue":"3 Suppl","key":"10.1016\/j.jot.2024.07.008_bib213","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/cncr.11129","article-title":"Role of endothelin-1 in osteoblastic bone metastases","volume":"97","author":"Guise","year":"2003","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib214","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/157016107781024082","article-title":"The endothelin axis: a novel target for pharmacotherapy of female malignancies","volume":"5","author":"Smollich","year":"2007","journal-title":"Curr Vasc Pharmacol"},{"issue":"7","key":"10.1016\/j.jot.2024.07.008_bib215","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/mc.23538","article-title":"LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition","volume":"62","author":"Zhang","year":"2023","journal-title":"Mol Carcinog"},{"issue":"3","key":"10.1016\/j.jot.2024.07.008_bib216","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41418-022-01071-3","article-title":"HSP90beta promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-kappaB signaling","volume":"30","author":"Cheng","year":"2023","journal-title":"Cell Death Differ"},{"issue":"14","key":"10.1016\/j.jot.2024.07.008_bib217","doi-asserted-by":"crossref","DOI":"10.1242\/dev.200633","article-title":"Postnatal eye size in mice is controlled by SREBP2-mediated transcriptional repression of Lrp2 and Bmp2","volume":"149","author":"Mai","year":"2022","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib218","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12951-023-01871-w","article-title":"Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration","volume":"21","author":"Yang","year":"2023","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib219","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/hep.31673","article-title":"H19 promotes HCC bone metastasis through reducing osteoprotegerin expression in a protein phosphatase 1 catalytic subunit alpha\/p38 mitogen-activated protein kinase-dependent manner and sponging microRNA 200b-3p","volume":"74","author":"Huang","year":"2021","journal-title":"Hepatology"},{"issue":"17","key":"10.1016\/j.jot.2024.07.008_bib220","doi-asserted-by":"crossref","first-page":"e2207080","DOI":"10.1002\/advs.202207080","article-title":"Bone lesion-derived extracellular vesicles fuel prometastatic cascades in hepatocellular carcinoma by transferring ALKBH5-targeting miR-3190-5p","volume":"10","author":"Han","year":"2023","journal-title":"Adv Sci"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib221","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.7150\/ijbs.73570","article-title":"N(6)-Methyladenosine modification of ANLN enhances hepatocellular carcinoma bone metastasis","volume":"19","author":"Zheng","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib222","doi-asserted-by":"crossref","first-page":"5","DOI":"10.5603\/EP.a2023.0012","article-title":"Guidelines for the diagnosis and management of osteoporosis in Poland. Update 2022","volume":"74","author":"G\u0142uszko","year":"2023","journal-title":"Endokrynol Pol"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib223","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1080\/10717544.2022.2111479","article-title":"Human serum albumin-based nanoparticles alter raloxifene administration and improve bioavailability","volume":"29","author":"Yang","year":"2022","journal-title":"Drug Deliv"},{"issue":"10","key":"10.1016\/j.jot.2024.07.008_bib224","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s00198-021-05900-y","article-title":"The clinician's guide to prevention and treatment of osteoporosis","volume":"33","author":"LeBoff","year":"2022","journal-title":"Osteoporos Int"},{"issue":"1","key":"10.1016\/j.jot.2024.07.008_bib225","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/jbmr.5650060108","article-title":"Effects of testosterone and venesection on spinal and peripheral bone mineral in six hypogonadal men with hemochromatosis","volume":"6","author":"Diamond","year":"1991","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2024.07.008_bib226","article-title":"Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis","volume":"111S","author":"LeBoff","year":"2020","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib227","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00198-017-4356-x","article-title":"Tocotrienol supplementation suppressed bone resorption and oxidative stress in postmenopausal osteopenic women: a 12-week randomized double-blinded placebo-controlled trial","volume":"29","author":"Shen","year":"2018","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jot.2024.07.008_bib228","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3361309","article-title":"Effects of GLP-1 receptor agonists on bone mineral density in patients with type 2 diabetes mellitus: a 52-week clinical study","volume":"2021","author":"Cai","year":"2021","journal-title":"BioMed Res Int"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib229","doi-asserted-by":"crossref","first-page":"319","DOI":"10.5603\/EP.a2021.0031","article-title":"Evaluation of the risk of fracture in type 2 diabetes mellitus patients with incretins: an updated meta-analysis","volume":"72","author":"Kong","year":"2021","journal-title":"Endokrynol Pol"},{"key":"10.1016\/j.jot.2024.07.008_bib230","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172661","article-title":"Farnesoid X nuclear receptor agonists for the treatment of nonalcoholic steatohepatitis","volume":"863","author":"Venetsanaki","year":"2019","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"10.1016\/j.jot.2024.07.008_bib231","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/jbmr.3652","article-title":"Dual targeting of bile acid receptor-1 (TGR5) and farnesoid X receptor (FXR) prevents estrogen-dependent bone loss in mice","volume":"34","author":"Li","year":"2019","journal-title":"J Bone Miner Res"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T19:42:22Z","timestamp":1732736542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X24000767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":231,"alternative-id":["S2214031X24000767"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2024.07.008","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging role of liver-bone axis in osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2024.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}