{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:23:27Z","timestamp":1791563007785,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jot.2024.08.007","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T14:57:39Z","timestamp":1724770659000},"page":"204-216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Memantine attenuates the development of osteoarthritis by blocking NMDA receptor mediated calcium overload and chondrocyte senescence"],"prefix":"10.1016","volume":"48","author":[{"given":"Qingmei","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-6097","authenticated-orcid":false,"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jot.2024.08.007_bib1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","article-title":"Ageing and the pathogenesis of osteoarthritis","volume":"12","author":"Loeser","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jot.2024.08.007_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101413","article-title":"Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications","volume":"70","author":"Xie","year":"2021","journal-title":"Ageing Res Rev"},{"issue":"2","key":"10.1016\/j.jot.2024.08.007_bib3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.joca.2021.11.002","article-title":"Novel role of estrogen receptor-\u03b1 on regulating chondrocyte phenotype and response to mechanical loading","volume":"30","author":"Wang","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.jot.2024.08.007_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","article-title":"Mechanisms and therapeutic implications of cellular senescence in osteoarthritis","volume":"17","author":"Coryell","year":"2021","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"10.1016\/j.jot.2024.08.007_bib5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.jot.2024.08.007_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2020.113409","article-title":"Galantamine-Memantine combination in the treatment of Alzheimer's disease and beyond","volume":"293","author":"Koola","year":"2020","journal-title":"Psychiatr Res"},{"issue":"7702","key":"10.1016\/j.jot.2024.08.007_bib7","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41586-018-0039-9","article-title":"Mechanism of NMDA receptor channel block by MK-801 and memantine","volume":"556","author":"Song","year":"2018","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jot.2024.08.007_bib8","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1152\/physrev.00041.2020","article-title":"Mitochondrial calcium exchange in physiology and disease","volume":"102","author":"Garbincius","year":"2022","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jot.2024.08.007_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jare.2022.01.004","article-title":"Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx","volume":"41","author":"Wang","year":"2022","journal-title":"J Adv Res"},{"issue":"3\u20134","key":"10.1016\/j.jot.2024.08.007_bib10","first-page":"273","article-title":"NMDA receptor expression and roles in human articular chondrocyte mechanotransduction","volume":"41","author":"Salter","year":"2004","journal-title":"Biorheology"},{"key":"10.1016\/j.jot.2024.08.007_bib11","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.biopha.2017.04.054","article-title":"Memantine inhibits degradation of the articular cartilage extracellular matrix induced by advanced glycation end products (AGEs)","volume":"91","author":"Zhao","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/j.jot.2024.08.007_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13075-020-2129-y","article-title":"Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior","volume":"22","author":"Li","year":"2020","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.jot.2024.08.007_bib13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00018-022-04325-y","article-title":"Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology","volume":"79","author":"Lurette","year":"2022","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"10.1016\/j.jot.2024.08.007_bib39","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.gendis.2022.12.016","article-title":"DLX5 promotes Col10a1 expression and chondrocyte hypertrophy and is involved in osteoarthritis progression","volume":"10","author":"Chen","year":"2023","journal-title":"Genes Dis"},{"issue":"13","key":"10.1016\/j.jot.2024.08.007_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/cells12131726","article-title":"The highs and lows of memantine-an autophagy and mitophagy inducing agent that protects mitochondria","volume":"12","author":"de Wet","year":"2023","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.jot.2024.08.007_bib15","doi-asserted-by":"crossref","first-page":"870","DOI":"10.2353\/ajpath.2010.090452","article-title":"Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice","volume":"176","author":"Martinez-Coria","year":"2010","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.jot.2024.08.007_bib16","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/ard-2022-223470","article-title":"Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours","volume":"82","author":"Courties","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jot.2024.08.007_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbi.2022.02.015","article-title":"Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK\/PGC-1\u03b1-mediated mitochondrial biogenesis and suppression of neuroinflammation","volume":"102","author":"Sun","year":"2022","journal-title":"Brain Behav Immun"},{"issue":"2","key":"10.1016\/j.jot.2024.08.007_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12945","article-title":"Melatonin is a potential novel analgesic agent for osteoarthritis: evidence from cohort studies in humans and preclinical research in rats","volume":"76","author":"Li","year":"2024","journal-title":"J Pineal Res"},{"issue":"2","key":"10.1016\/j.jot.2024.08.007_bib19","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201228R","article-title":"In vitro study to identify ligand-independent function of estrogen receptor-\u03b1 in suppressing DNA damage-induced chondrocyte senescence","volume":"37","author":"Zhang","year":"2023","journal-title":"Faseb j"},{"issue":"4","key":"10.1016\/j.jot.2024.08.007_bib20","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1136\/annrheumdis-2021-221380","article-title":"Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis","volume":"81","author":"Wang","year":"2022","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.jot.2024.08.007_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007226","article-title":"The effect of memantine, an antagonist of the NMDA glutamate receptor, in in vitro and in vivo infections by Trypanosoma cruzi","volume":"13","author":"Santos Souza","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"22","key":"10.1016\/j.jot.2024.08.007_bib22","doi-asserted-by":"crossref","first-page":"10202","DOI":"10.1073\/pnas.0913897107","article-title":"Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways","volume":"107","author":"Otsuki","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.jot.2024.08.007_bib23","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.1038\/s41467-022-33744-5","article-title":"Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development","volume":"13","author":"Nagata","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jot.2024.08.007_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41392-023-01330-w","article-title":"Osteoarthritis: pathogenic signaling pathways and therapeutic targets","volume":"8","author":"Yao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"14","key":"10.1016\/j.jot.2024.08.007_bib25","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1056\/NEJMoa013128","article-title":"Memantine in moderate-to-severe Alzheimer's disease","volume":"348","author":"Reisberg","year":"2003","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jot.2024.08.007_bib26","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s11481-011-9337-9","article-title":"Low-dose memantine attenuated morphine addictive behavior through its anti-inflammation and neurotrophic effects in rats","volume":"7","author":"Chen","year":"2012","journal-title":"J Neuroimmune Pharmacol"},{"issue":"11","key":"10.1016\/j.jot.2024.08.007_bib27","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.joca.2009.05.006","article-title":"Intra-articular magnesium sulfate (MgSO4) reduces experimental osteoarthritis and nociception: association with attenuation of N-methyl-D-aspartate (NMDA) receptor subunit 1 phosphorylation and apoptosis in rat chondrocytes","volume":"17","author":"Lee","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"10.1016\/j.jot.2024.08.007_bib28","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.joca.2009.02.002","article-title":"Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression","volume":"17","author":"Piepoli","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"10.1016\/j.jot.2024.08.007_bib29","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.joca.2018.06.015","article-title":"Altered N-methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes","volume":"26","author":"Kalev-Zylinska","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jot.2024.08.007_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2020.101986","article-title":"NMDA receptor-independent LTP in mammalian nervous system","volume":"200","author":"Alkadhi","year":"2021","journal-title":"Prog Neurobiol"},{"issue":"11","key":"10.1016\/j.jot.2024.08.007_bib31","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1517\/17425255.2012.712686","article-title":"Pharmacokinetic and pharmacodynamic considerations for NMDA receptor antagonists in the treatment of chronic neuropathic pain","volume":"8","author":"Niesters","year":"2012","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"10182","key":"10.1016\/j.jot.2024.08.007_bib32","first-page":"1745","volume":"393","author":"Hunter","year":"2019","journal-title":"Osteoarthritis. Lancet"},{"issue":"11","key":"10.1016\/j.jot.2024.08.007_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141886","article-title":"Reduces synovial inflammation and pain in experimental osteoarthritis","volume":"10","author":"Calado","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jot.2024.08.007_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2147\/JPR.S333454","article-title":"Transcranial direct current stimulation alleviates the chronic pain of osteoarthritis by modulating NMDA receptors in midbrain periaqueductal gray in rats","volume":"15","author":"Li","year":"2022","journal-title":"J Pain Res"},{"key":"10.1016\/j.jot.2024.08.007_bib35","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.2147\/JPR.S367982","article-title":"Role of N-Methyl-D-Aspartate receptor NR2B subunit in inflammatory arthritis-induced chronic pain and peripheral sensitized neuropathic pain: a systematic review","volume":"15","author":"Meng","year":"2022","journal-title":"J Pain Res"},{"issue":"5","key":"10.1016\/j.jot.2024.08.007_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/hup.2841","article-title":"Evaluation of memantine's efficacy and safety in the treatment of children with autism spectrum disorder: a systematic review and meta-analysis","volume":"37","author":"Elnaiem","year":"2022","journal-title":"Hum Psychopharmacol"},{"issue":"1","key":"10.1016\/j.jot.2024.08.007_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41413-023-00248-x","article-title":"Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-\u03b1","volume":"11","author":"Wang","year":"2023","journal-title":"Bone Res"},{"issue":"1","key":"10.1016\/j.jot.2024.08.007_bib38","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/19336950.2021.1903184","article-title":"Mechanosensory and mechanotransductive processes mediated by ion channels in articular chondrocytes: potential therapeutic targets for osteoarthritis","volume":"15","author":"Zhang","year":"2021","journal-title":"Channels"}],"updated-by":[{"DOI":"10.1016\/j.jot.2025.02.005","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000}}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24000949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T22:10:07Z","timestamp":1742335807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X24000949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":39,"alternative-id":["S2214031X24000949"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2024.08.007","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Memantine attenuates the development of osteoarthritis by blocking NMDA receptor mediated calcium overload and chondrocyte senescence","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2024.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}