{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:12:10Z","timestamp":1788786730843,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004853","name":"The Chinese University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["06170366"],"award-info":[{"award-number":["06170366"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jot.2024.11.001","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T23:54:21Z","timestamp":1737503661000},"page":"329-336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Bone microarchitecture assessed by 3D high-resolution peripheral quantitative computed tomography (HR-pQCT) as predictor of fracture risk in patients with glucocorticoid-induced osteoporosis"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-9390","authenticated-orcid":false,"given":"Ho","family":"So","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Francis","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze-Lok","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Wing Yin","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violet Ka Lai","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitty Yan","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley King Yee","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack Jock Wai","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal Ying","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6410-8852","authenticated-orcid":false,"given":"Lai-Shan","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jot.2024.11.001_bib1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1056\/NEJMcp1012926","article-title":"Clinical practice. Glucocorticoid-induced bone disease","volume":"365","author":"Weinstein","year":"2011","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jot.2024.11.001_bib2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/BOR.0000000000000608","article-title":"Glucocorticoid-induced osteoporosis update","volume":"31","author":"Adami","year":"2019","journal-title":"Curr Opin Rheumatol"},{"issue":"5","key":"10.1016\/j.jot.2024.11.001_bib3","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1210\/jc.2008-1578","article-title":"Age dependence of early symptomatic vertebral fracture with high-dose glucocorticoid treatment for collagen vascular diseases","volume":"94","author":"Tatsuno","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.jot.2024.11.001_bib4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/BOR.0000000000000885","article-title":"Osteoporosis epidemiology using international cohorts","volume":"34","author":"Lorentzon","year":"2022","journal-title":"Curr Opin Rheumatol"},{"issue":"2","key":"10.1016\/j.jot.2024.11.001_bib5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00223-004-0205-y","article-title":"A histomorphometric study of cortical bone of the iliac crest in patients treated with glucocorticoids","volume":"77","author":"Vedi","year":"2005","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"10.1016\/j.jot.2024.11.001_bib6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1359\/jbmr.2001.16.1.97","article-title":"Comparison of trabecular bone microarchitecture and remodeling in glucocorticoid-induced and postmenopausal osteoporosis","volume":"16","author":"Dalle Carbonare","year":"2001","journal-title":"J Bone Miner Res"},{"issue":"6","key":"10.1016\/j.jot.2024.11.001_bib7","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s00198-018-4473-1","article-title":"Incidence of fractures among patients with rheumatoid arthritis: a systematic review and meta-analysis","volume":"29","author":"Jin","year":"2018","journal-title":"Osteoporos Int"},{"issue":"10","key":"10.1016\/j.jot.2024.11.001_bib8","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.3390\/ijms23105804","article-title":"Bone involvement in systemic lupus erythematosus","volume":"23","author":"Rella","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.jot.2024.11.001_bib9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/1756-185X.12405","article-title":"Prevalence and associated factors of reduced bone mineral density in patients with idiopathic inflammatory myopathies","volume":"19","author":"So","year":"2016","journal-title":"International Journal of Rheumatic Diseases"},{"issue":"7","key":"10.1016\/j.jot.2024.11.001_bib10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41584-024-01120-w","article-title":"Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases","volume":"20","author":"Buttgereit","year":"2024","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"10.1016\/j.jot.2024.11.001_bib11","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.bone.2009.12.015","article-title":"Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in postmenopausal women","volume":"46","author":"Vilayphiou","year":"2010","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.jot.2024.11.001_bib12","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1001\/jama.299.12.1468","article-title":"Osteoporosis and fractures: missing the bridge?","volume":"299","author":"Cheung","year":"2008","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.jot.2024.11.001_bib13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S2213-8587(18)30308-5","article-title":"Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study","volume":"7","author":"Samelson","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9","key":"10.1016\/j.jot.2024.11.001_bib14","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1210\/jc.2018-00490","article-title":"Bone mass, microstructure, and strength can discriminate vertebral fracture in patients on long-term steroid treatment","volume":"103","author":"Shen","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.jot.2024.11.001_bib15","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","article-title":"Vertebral fracture assessment using a semiquantitative technique","volume":"8","author":"Genant","year":"1993","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.jot.2024.11.001_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2818.1997.1340694.x","article-title":"A new method for the model-independent assessment of thickness in three-dimensional images","volume":"185","author":"Hildebrand","year":"1997","journal-title":"J Microsc"},{"issue":"3","key":"10.1016\/j.jot.2024.11.001_bib17","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bone.2010.05.034","article-title":"Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT","volume":"47","author":"Burghardt","year":"2010","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.jot.2024.11.001_bib18","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0021-9290(98)00177-8","article-title":"The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques","volume":"32","author":"Turner","year":"1999","journal-title":"J Biomech"},{"issue":"6","key":"10.1016\/j.jot.2024.11.001_bib19","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S8756-3282(02)00736-6","article-title":"Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images","volume":"30","author":"Pistoia","year":"2002","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.jot.2024.11.001_bib20","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/jbmr.3105","article-title":"Bone microarchitecture assessed by HR-pQCT as predictor of fracture risk in postmenopausal women: the OFELY study","volume":"32","author":"Sornay-Rendu","year":"2017","journal-title":"J Bone Miner Res"},{"issue":"2","key":"10.1016\/j.jot.2024.11.001_bib21","first-page":"516","article-title":"Cortical bone area predicts incident fractures independently of areal bone mineral density in older men","volume":"102","author":"Ohlsson","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.jot.2024.11.001_bib22","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/jbmr.3433","article-title":"Volumetric bone mineral density and failure load of distal limbs predict incident clinical fracture independent HR-pQCT BMD and failure load predicts incident clinical fracture of FRAX and clinical risk factors among older men","volume":"33","author":"Langsetmo","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"8","key":"10.1016\/j.jot.2024.11.001_bib23","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/jbmr.3451","article-title":"Prediction of fractures in men using bone microarchitectural parameters assessed by high-resolution peripheral quantitative computed tomography-the prospective STRAMBO study","volume":"33","author":"Szulc","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"2","key":"10.1016\/j.jot.2024.11.001_bib24","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jbmr.3299","article-title":"Evaluation of radius microstructure and areal bone mineral density improves fracture prediction in postmenopausal women","volume":"33","author":"Biver","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10.1016\/j.jot.2024.11.001_bib25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00198-006-0278-8","article-title":"Bone microarchitecture in males with corticosteroid-induced osteoporosis","volume":"18","author":"Chappard","year":"2007","journal-title":"Osteoporos Int"},{"issue":"2","key":"10.1016\/j.jot.2024.11.001_bib26","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1172\/JCI2799","article-title":"Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone","volume":"102","author":"Weinstein","year":"1998","journal-title":"The Journal of clinical investigation"},{"issue":"4","key":"10.1016\/j.jot.2024.11.001_bib27","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1210\/en.2003-0990","article-title":"Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength","volume":"145","author":"O'Brien","year":"2004","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/j.jot.2024.11.001_bib28","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1210\/jc.2014-2177","article-title":"Abnormalities in cortical bone, trabecular plates, and stiffness in postmenopausal women treated with glucocorticoids","volume":"99","author":"Sutter","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.jot.2024.11.001_bib29","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/jbmr.2221","article-title":"Alterations of bone density, microstructure, and strength of the distal radius in male patients with rheumatoid arthritis: a case-control study with HR-pQCT","volume":"29","author":"Zhu","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10.1016\/j.jot.2024.11.001_bib30","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/jbmr.1793","article-title":"Structure and strength of the distal radius in female patients with rheumatoid arthritis: a case-control study","volume":"28","author":"Zhu","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"6","key":"10.1016\/j.jot.2024.11.001_bib31","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/jbmr.319","article-title":"Cross-sectional analysis of the association between fragility fractures and bone microarchitecture in older men: the STRAMBO study","volume":"26","author":"Szulc","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"10","key":"10.1016\/j.jot.2024.11.001_bib32","doi-asserted-by":"crossref","first-page":"E1918","DOI":"10.1210\/jc.2012-1968","article-title":"Microarchitectural abnormalities are more severe in postmenopausal women with vertebral compared to nonvertebral fractures","volume":"97","author":"Stein","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.jot.2024.11.001_bib33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1359\/jbmr.081004","article-title":"Association between change in BMD and fragility fracture in women and men","volume":"24","author":"Berger","year":"2009","journal-title":"J Bone Miner Res"},{"issue":"7","key":"10.1016\/j.jot.2024.11.001_bib34","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1359\/JBMR.050215","article-title":"Femoral neck bone loss predicts fracture risk independent of baseline BMD","volume":"20","author":"Nguyen","year":"2005","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10.1016\/j.jot.2024.11.001_bib35","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1210\/jc.2011-2871","article-title":"Rate of bone density change does not enhance fracture prediction in routine clinical practice","volume":"97","author":"Leslie","year":"2012","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"issue":"2","key":"10.1016\/j.jot.2024.11.001_bib36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1001\/archinte.167.2.155","article-title":"Cauley J.A., et al. Evaluating the value of repeat bone mineral density measurement and prediction of fractures in older women: the study of osteoporotic fractures","volume":"167","author":"Hillier","year":"2007","journal-title":"Arch Intern Med"},{"issue":"9","key":"10.1016\/j.jot.2024.11.001_bib37","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s00198-009-1102-z","article-title":"Bone loss and the risk of non-vertebral fractures in women and men: the Troms\u00f8 study","volume":"21","author":"Ahmed","year":"2010","journal-title":"Osteoporos Int"},{"issue":"4","key":"10.1016\/j.jot.2024.11.001_bib38","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jbmr.3347","article-title":"Lower bone density, impaired microarchitecture, and strength predict future fragility fracture in postmenopausal women: 5-year follow-up of the calgary CaMos cohort","volume":"33","author":"Burt","year":"2018","journal-title":"J Bone Miner Res"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24001426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24001426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T12:20:47Z","timestamp":1764418847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X24001426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":38,"alternative-id":["S2214031X24001426"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2024.11.001","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone microarchitecture assessed by 3D high-resolution peripheral quantitative computed tomography (HR-pQCT) as predictor of fracture risk in patients with glucocorticoid-induced osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2024.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}