{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:22:53Z","timestamp":1790716973015,"version":"4.1.0"},"reference-count":200,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jot.2024.11.003","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T23:47:34Z","timestamp":1737416854000},"page":"373-387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Gut-bone axis perturbation: Mechanisms and interventions via gut microbiota as a primary driver of osteoporosis"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5533-2500","authenticated-orcid":false,"given":"Jingyuan","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Yin","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avery Chik-Him","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9521-7768","authenticated-orcid":false,"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-9694","authenticated-orcid":false,"given":"Long","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.jot.2024.11.003_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23169465","article-title":"Current status of the diagnosis and management of osteoporosis","volume":"23","author":"Aibar-Almaz\u00e1n","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00774-020-01162-6","article-title":"Osteoclast differentiation by RANKL and OPG signaling pathways","volume":"39","author":"Udagawa","year":"2021","journal-title":"J Bone Miner Metabol"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/03008207.2017.1290085","article-title":"Osteoblast-osteoclast interactions","volume":"59","author":"Chen","year":"2018","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.jot.2024.11.003_bib4","series-title":"Radionuclide and hybrid bone imaging","first-page":"29","article-title":"Physiology of bone formation, remodeling, and metabolism","author":"Kini","year":"2012"},{"key":"10.1016\/j.jot.2024.11.003_bib5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fcimb.2020.00160","article-title":"Gut microbiome reveals specific dysbiosis in primary osteoporosis","volume":"10","author":"Xu","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"issue":"9","key":"10.1016\/j.jot.2024.11.003_bib6","doi-asserted-by":"crossref","first-page":"8583","DOI":"10.18632\/aging.103168","article-title":"Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis","volume":"12","author":"He","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"8","key":"10.1016\/j.jot.2024.11.003_bib7","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1210\/me.2014-1108","article-title":"Minireview: gut microbiota: the neglected endocrine organ","volume":"28","author":"Clarke","year":"2014","journal-title":"Mol Endocrinol"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.5582\/irdr.2018.01055","article-title":"The impact of the intestinal microbiome on bone health","volume":"7","author":"Zhang","year":"2018","journal-title":"Intractable Rare Dis Res"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tem.2014.11.004","article-title":"Effects of the gut microbiota on bone mass","volume":"26","author":"Ohlsson","year":"2015","journal-title":"Trends Endocrinol Metabol"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/10408398.2021.1944975","article-title":"Dietary interventions for better management of osteoporosis: an overview","volume":"63","author":"Guo","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"6","key":"10.1016\/j.jot.2024.11.003_bib11","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s00774-022-01375-x","article-title":"Fecal microbiota transplantation as a promising treatment option for osteoporosis","volume":"40","author":"Zhang","year":"2022","journal-title":"J Bone Miner Metabol"},{"issue":"25","key":"10.1016\/j.jot.2024.11.003_bib12","doi-asserted-by":"crossref","first-page":"7510","DOI":"10.1080\/10408398.2022.2047005","article-title":"The regulative effect and repercussion of probiotics and prebiotics on osteoporosis: involvement of brain-gut-bone axis","volume":"63","author":"Zhang","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jot.2024.11.003_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1120457","article-title":"Overview on postmenopausal osteoporosis and periodontitis: the therapeutic potential of phytoestrogens against alveolar bone loss","volume":"14","author":"Jayusman","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jot.2024.11.003_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3686749","article-title":"The interplay between immune system and microbiota in osteoporosis","volume":"2020","author":"Locantore","year":"2020","journal-title":"Mediat Inflamm"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the gut microbiota in immunity and inflammatory disease","volume":"13","author":"Kamada","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jot.2024.11.003_bib16","article-title":"Gut microbiota and bone diseases: a growing partnership","volume":"13","author":"Chen","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jot.2024.11.003_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.puhe.2019.11.001","article-title":"Association of obesity with bone mineral density and osteoporosis in adults: a systematic review and meta-analysis","volume":"180","author":"Qiao","year":"2020","journal-title":"Publ Health"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1359\/jbmr.071020","article-title":"A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men","volume":"23","author":"Riggs","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010349","article-title":"Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells","volume":"21","author":"Qadir","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib20","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1055\/s-0038-1660790","article-title":"Osteoporosis: current concepts","volume":"6","author":"Akkawi","year":"2018","journal-title":"Joints"},{"issue":"7","key":"10.1016\/j.jot.2024.11.003_bib21","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm1593","article-title":"Skeletal remodeling in health and disease","volume":"13","author":"Zaidi","year":"2007","journal-title":"Nat Med"},{"issue":"9773","key":"10.1016\/j.jot.2024.11.003_bib22","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.jot.2024.11.003_bib23","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3892\/etm.2021.10815","article-title":"Osteoporosis therapies and their mechanisms of action","volume":"22","author":"Kim","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jot.2024.11.003_bib24","article-title":"Editorial: bone inside-out and outside-in signals: control of body homeostasis","volume":"13","author":"Sankar","year":"2022","journal-title":"Front Endocrinol"},{"issue":"5778","key":"10.1016\/j.jot.2024.11.003_bib25","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.1124234","article-title":"Metagenomic analysis of the human distal gut microbiome","volume":"312","author":"Gill","year":"2006","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1080\/19490976.2017.1290757","article-title":"Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease","volume":"8","author":"Weingarden","year":"2017","journal-title":"Gut Microb"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/nyas.14107","article-title":"Gut microbiome and its role in obesity and insulin resistance","volume":"1461","author":"Lee","year":"2020","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/nu10030365","article-title":"The western diet-microbiome-host interaction and its role in metabolic disease","volume":"10","author":"Zin\u00f6cker","year":"2018","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib30","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s13668-020-00342-0","article-title":"Food insecurity, malnutrition, and the microbiome","volume":"9","author":"Christian","year":"2020","journal-title":"Curr Nutr Rep"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib31","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.cgh.2018.10.002","article-title":"The gut-brain Axis and the microbiome: mechanisms and clinical implications","volume":"17","author":"Osadchiy","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13046-021-01845-6","article-title":"Gut microbiota influence tumor development and Alter interactions with the human immune system","volume":"40","author":"Ge","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib33","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/CIRCRESAHA.120.316242","article-title":"Gut microbiota and cardiovascular disease","volume":"127","author":"Witkowski","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.jot.2024.11.003_bib34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bone.2018.03.024","article-title":"Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice","volume":"118","author":"McCabe","year":"2019","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cell.2014.09.022","article-title":"Advancing the microbiome research community","volume":"159","author":"Huttenhower","year":"2014","journal-title":"Cell"},{"issue":"124","key":"10.1016\/j.jot.2024.11.003_bib36","first-page":"51","article-title":"Microbe-microbe and host-microbe interactions drive microbiome dysbiosis and inflammatory processes","volume":"23","author":"Proal","year":"2017","journal-title":"Discov Med"},{"key":"10.1016\/j.jot.2024.11.003_bib37","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.3450","article-title":"Diversity analysis of gut microbiota in osteoporosis and osteopenia patients","volume":"5","author":"Wang","year":"2017","journal-title":"PeerJ"},{"issue":"12","key":"10.1016\/j.jot.2024.11.003_bib38","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.tips.2021.09.003","article-title":"Gut microbiome-oriented therapy for metabolic diseases: challenges and opportunities towards clinical translation","volume":"42","author":"Zhang","year":"2021","journal-title":"Trends Pharmacol Sci"},{"issue":"17","key":"10.1016\/j.jot.2024.11.003_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179452","article-title":"The human gut microbiota: a key mediator of osteoporosis and osteogenesis","volume":"22","author":"Seely","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib40","first-page":"267","article-title":"Effects of calcium on the structure of intestinal microbiota in ovariectomized rats","volume":"50","author":"Wang","year":"2021","journal-title":"Wei Sheng Yan Jiu"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib41","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00223-017-0339-3","article-title":"Prebiotics, bone and mineral metabolism","volume":"102","author":"Whisner","year":"2018","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib42","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/jbmr.3947","article-title":"Involvement of the gut microbiota and barrier function in glucocorticoid-induced osteoporosis","volume":"35","author":"Schepper","year":"2020","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2024.11.003_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115317","article-title":"The role of gut microbiota in bone homeostasis","volume":"135","author":"Behera","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.jot.2024.11.003_bib44","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.3389\/fimmu.2020.02101","article-title":"Intestinal barrier breakdown and mucosal microbiota disturbance in neuromyelitis optical spectrum disorders","volume":"11","author":"Cui","year":"2020","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.jot.2024.11.003_bib45","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1091\/mbc.E20-12-0775","article-title":"Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2","volume":"32","author":"Raya-Sandino","year":"2021","journal-title":"Mol Biol Cell"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib46","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12967-023-04091-w","article-title":"Intestinal barrier functions in hematologic and oncologic diseases","volume":"21","author":"Haroun","year":"2023","journal-title":"J Transl Med"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib47","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1423-0127-19-28","article-title":"The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues","volume":"19","author":"Zupan","year":"2012","journal-title":"J Biomed Sci"},{"issue":"12","key":"10.1016\/j.jot.2024.11.003_bib48","doi-asserted-by":"crossref","first-page":"7844","DOI":"10.1039\/C9FO01650C","article-title":"Effects of Clostridium butyricum and Enterococcus faecalis on growth performance, immune function, intestinal morphology, volatile fatty acids, and intestinal flora in a piglet model","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/nu11020308","article-title":"Monobutyrin reduces liver cholesterol and improves intestinal barrier function in rats fed high-fat diets","volume":"11","author":"Nguyen","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jot.2024.11.003_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109201","article-title":"Probiotic Lactobacillus strains from Mongolia improve calcium transport and uptake by intestinal cells in vitro","volume":"133","author":"Raveschot","year":"2020","journal-title":"Food Res Int"},{"issue":"11","key":"10.1016\/j.jot.2024.11.003_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/nu12113542","article-title":"Effect of xylo-oligosaccharides supplementation by drinking water on the bone properties and related calcium transporters in growing mice","volume":"12","author":"Gao","year":"2020","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.jot.2024.11.003_bib52","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S2213-8587(21)00119-4","article-title":"Nutritional intake and bone health","volume":"9","author":"Rizzoli","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jot.2024.11.003_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.570083","article-title":"The challenge by multiple environmental and biological factors induce inflammation in aging: their role in the promotion of chronic disease","volume":"11","author":"Bachmann","year":"2020","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.jot.2024.11.003_bib54","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1042\/CS20150046","article-title":"Age-associated modifications of intestinal permeability and innate immunity in human small intestine","volume":"129","author":"Man","year":"2015","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib55","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.134092","article-title":"Gut permeability, inflammation, and bone density across the menopause transition","volume":"5","author":"Shieh","year":"2020","journal-title":"JCI Insight"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib56","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/jbmr.3635","article-title":"Probiotic Lactobacillus reuteri prevents postantibiotic bone loss by reducing intestinal dysbiosis and preventing barrier disruption","volume":"34","author":"Schepper","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/nu12041185","article-title":"Intestinal permeability, inflammation and the role of nutrients","volume":"12","author":"Farr\u00e9","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib58","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5056\/jnm14084","article-title":"Role of corticotropin-releasing factor in gastrointestinal permeability","volume":"21","author":"Rodi\u00f1o-Janeiro","year":"2015","journal-title":"J Neurogastroenterol Motil"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib59","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrd3669","article-title":"Inflammatory bone loss: pathogenesis and therapeutic intervention","volume":"11","author":"Redlich","year":"2012","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib60","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s00223-017-0321-0","article-title":"From osteoimmunology to osteomicrobiology: how the microbiota and the immune system regulate bone","volume":"102","author":"Hsu","year":"2018","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib61","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1042\/CS20210778","article-title":"Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage\/WNT\/ERK signaling pathway","volume":"136","author":"Liang","year":"2022","journal-title":"Clin Sci (Lond)"},{"issue":"21","key":"10.1016\/j.jot.2024.11.003_bib62","doi-asserted-by":"crossref","first-page":"11648","DOI":"10.1073\/pnas.1917597117","article-title":"Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin","volume":"117","author":"Wang","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"32","key":"10.1016\/j.jot.2024.11.003_bib63","doi-asserted-by":"crossref","first-page":"19376","DOI":"10.1073\/pnas.2000047117","article-title":"Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor","volume":"117","author":"Scott","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.jot.2024.11.003_bib64","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100451R","article-title":"Gut microbiota and bone metabolism","volume":"35","author":"Lu","year":"2021","journal-title":"Faseb J"},{"issue":"6","key":"10.1016\/j.jot.2024.11.003_bib65","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/gutjnl-2020-323071","article-title":"Gut microbiota-derived metabolites as central regulators in metabolic disorders","volume":"70","author":"Agus","year":"2021","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib66","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41430-021-00991-6","article-title":"Role of the gut microbiome in chronic diseases: a narrative review","volume":"76","author":"Vijay","year":"2022","journal-title":"Eur J Clin Nutr"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/foods12051023","article-title":"The interplay of dietary fibers and intestinal microbiota affects type 2 diabetes by generating short-chain fatty acids","volume":"12","author":"Mazhar","year":"2023","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib68","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ Microbiol"},{"key":"10.1016\/j.jot.2024.11.003_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114348","article-title":"Fructus Ligustri Lucidi aqueous extract promotes calcium balance and short-chain fatty acids production in ovariectomized rats","volume":"279","author":"Chen","year":"2021","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib70","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/CIRCRESAHA.119.316448","article-title":"Gut microbiota-derived short-chain fatty acids promote poststroke recovery in aged mice","volume":"127","author":"Lee","year":"2020","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib71","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/mi.2014.44","article-title":"Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway","volume":"8","author":"Park","year":"2015","journal-title":"Mucosal Immunol"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib72","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41467-017-02490-4","article-title":"Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss","volume":"9","author":"Lucas","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib73","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.intimp.2006.08.015","article-title":"Anti-inflammatory effects of short chain fatty acids in IFN-gamma-stimulated RAW 264.7 murine macrophage cells: involvement of NF-kappaB and ERK signaling pathways","volume":"7","author":"Park","year":"2007","journal-title":"Int Immunopharm"},{"key":"10.1016\/j.jot.2024.11.003_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102196","article-title":"Targeting the gut microbiota-related metabolites for osteoporosis: the inextricable connection of gut-bone axis","volume":"94","author":"Zhang","year":"2024","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jot.2024.11.003_bib75","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phrs.2015.12.007","article-title":"Pharmacology of bile acid receptors: evolution of bile acids from simple detergents to complex signaling molecules","volume":"104","author":"Copple","year":"2016","journal-title":"Pharmacol Res"},{"issue":"10","key":"10.1016\/j.jot.2024.11.003_bib76","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/jbmr.1961","article-title":"Positive regulation of osteogenesis by bile acid through FXR","volume":"28","author":"Cho","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2024.11.003_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106943","article-title":"Bile acid metabolism regulatory network orchestrates bone homeostasis","volume":"196","author":"Xiang","year":"2023","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jot.2024.11.003_bib78","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.biopha.2018.08.093","article-title":"Activation of TGR5 promotes osteoblastic cell differentiation and mineralization","volume":"108","author":"Wang","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib79","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/jbmr.3652","article-title":"Dual targeting of bile acid receptor-1 (TGR5) and farnesoid X receptor (FXR) prevents estrogen-dependent bone loss in mice","volume":"34","author":"Li","year":"2019","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2024.11.003_bib80","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3389\/fphys.2017.00319","article-title":"The crosstalk between the gut microbiota and mitochondria during exercise","volume":"8","author":"Clark","year":"2017","journal-title":"Front Physiol"},{"key":"10.1016\/j.jot.2024.11.003_bib81","article-title":"Role of vitamin K in intestinal health","volume":"12","author":"Lai","year":"2021","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.jot.2024.11.003_bib82","doi-asserted-by":"crossref","DOI":"10.3390\/nu12123625","article-title":"Vitamin K and osteoporosis","volume":"12","author":"Fusaro","year":"2020","journal-title":"Nutrients"},{"issue":"18","key":"10.1016\/j.jot.2024.11.003_bib83","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1080\/10408398.2016.1211616","article-title":"Effect of vitamin K in bone metabolism and vascular calcification: a review of mechanisms of action and evidences","volume":"57","author":"Villa","year":"2017","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib84","doi-asserted-by":"crossref","first-page":"200","DOI":"10.11138\/ccmbm\/2017.14.1.200","article-title":"Vitamin K and bone","volume":"14","author":"Fusaro","year":"2017","journal-title":"Clin Cases Miner Bone Metab"},{"issue":"12","key":"10.1016\/j.jot.2024.11.003_bib85","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1007\/s00198-022-06557-x","article-title":"The potential mechanism of the microbiota-gut-bone axis in osteoporosis: a review","volume":"33","author":"He","year":"2022","journal-title":"Osteoporos Int"},{"issue":"16","key":"10.1016\/j.jot.2024.11.003_bib86","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.21037\/atm-20-5307","article-title":"The role of gut microbiota metabolite trimethylamine N-oxide in functional impairment of bone marrow mesenchymal stem cells in osteoporosis disease","volume":"8","author":"Lin","year":"2020","journal-title":"Ann Transl Med"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib87","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00592-019-01312-x","article-title":"Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles","volume":"56","author":"Abdul Rahim","year":"2019","journal-title":"Acta Diabetol"},{"issue":"7","key":"10.1016\/j.jot.2024.11.003_bib88","article-title":"Polyamines and gut mucosal homeostasis","volume":"2","author":"Timmons","year":"2012","journal-title":"J Gastrointest Dig Syst"},{"key":"10.1016\/j.jot.2024.11.003_bib89","article-title":"Proteus mirabilis vesicles induce mitochondrial apoptosis by regulating miR96-5p\/abca1 to inhibit osteoclastogenesis and bone loss","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jot.2024.11.003_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138309","article-title":"Engineered bacterial extracellular vesicles for osteoporosis therapy","volume":"450","author":"Liu","year":"2022","journal-title":"Chem Eng J"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib91","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/cmi.2011.26","article-title":"MicroRNA in TLR signaling and endotoxin tolerance","volume":"8","author":"Nahid","year":"2011","journal-title":"Cell Mol Immunol"},{"issue":"9","key":"10.1016\/j.jot.2024.11.003_bib92","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.1021\/acsomega.0c05590","article-title":"Understanding the antibacterial resistance: computational explorations in bacterial membranes","volume":"6","author":"Matamoros-Recio","year":"2021","journal-title":"ACS Omega"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib93","doi-asserted-by":"crossref","DOI":"10.3390\/toxins13050352","article-title":"Sodium butyrate more effectively mitigates the negative effects of high-concentrate diet in dairy cows than sodium \u03b2-hydroxybutyrate via reducing free bacterial cell wall components in rumen fluid and plasma","volume":"13","author":"Wu","year":"2021","journal-title":"Toxins"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib94","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","article-title":"Gut microbiome and health: mechanistic insights","volume":"71","author":"de Vos","year":"2022","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib95","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/08830185.2017.1397656","article-title":"TLRs\/NLRs: shaping the landscape of host immunity","volume":"37","author":"Dolasia","year":"2018","journal-title":"Int Rev Immunol"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib96","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrrheum.2014.219","article-title":"Osteoimmunology in 2014: two-faced immunology-from osteogenesis to bone resorption","volume":"11","author":"Takayanagi","year":"2015","journal-title":"Nat Rev Rheumatol"},{"issue":"7","key":"10.1016\/j.jot.2024.11.003_bib97","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.4049\/jimmunol.170.7.3688","article-title":"Lipopolysaccharide promotes the survival of osteoclasts via Toll-like receptor 4, but cytokine production of osteoclasts in response to lipopolysaccharide is different from that of macrophages","volume":"170","author":"Itoh","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jot.2024.11.003_bib98","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cellimm.2017.05.003","article-title":"Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2 signaling","volume":"317","author":"Ohlsson","year":"2017","journal-title":"Cell Immunol"},{"issue":"10","key":"10.1016\/j.jot.2024.11.003_bib99","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41577-019-0178-8","article-title":"Osteoimmunology: evolving concepts in bone-immune interactions in health and disease","volume":"19","author":"Tsukasaki","year":"2019","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.jot.2024.11.003_bib100","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/jbmr.1588","article-title":"The gut microbiota regulates bone mass in mice","volume":"27","author":"Sj\u00f6gren","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2024.11.003_bib101","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/521957","article-title":"Functional and phenotypic plasticity of CD4(+) T cell subsets","volume":"2015","author":"Caza","year":"2015","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.jot.2024.11.003_bib102","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3389\/fimmu.2018.00657","article-title":"Immunoporosis: immunology of osteoporosis-role of T cells","volume":"9","author":"Srivastava","year":"2018","journal-title":"Front Immunol"},{"issue":"235","key":"10.1016\/j.jot.2024.11.003_bib103","doi-asserted-by":"crossref","first-page":"235ra60","DOI":"10.1126\/scitranslmed.3007764","article-title":"T cell costimulation molecules CD80\/86 inhibit osteoclast differentiation by inducing the Ido\/tryptophan pathway","volume":"6","author":"Bozec","year":"2014","journal-title":"Sci Transl Med"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib104","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11914-017-0356-1","article-title":"T regulatory cells in bone remodelling","volume":"15","author":"Bozec","year":"2017","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.jot.2024.11.003_bib105","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12979-020-00202-z","article-title":"The correlation between the Th17\/Treg cell balance and bone health","volume":"17","author":"Zhu","year":"2020","journal-title":"Immun Ageing"},{"key":"10.1016\/j.jot.2024.11.003_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2022.116540","article-title":"Cytokine-mediated immunomodulation of osteoclastogenesis","volume":"164","author":"Zhou","year":"2022","journal-title":"Bone"},{"issue":"48","key":"10.1016\/j.jot.2024.11.003_bib107","doi-asserted-by":"crossref","first-page":"83419","DOI":"10.18632\/oncotarget.21379","article-title":"Mesenchymal stem cells inhibit RANK-RANKL interactions between osteoclasts and Th17 cells via osteoprotegerin activity","volume":"8","author":"Cho","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib108","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.archoralbio.2014.09.002","article-title":"Association study between salivary levels of interferon (IFN)-gamma, interleukin (IL)-17, IL-21, and IL-22 with chronic periodontitis","volume":"60","author":"Isaza-Guzm\u00e1n","year":"2015","journal-title":"Arch Oral Biol"},{"issue":"12","key":"10.1016\/j.jot.2024.11.003_bib109","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/j.1365-2362.2011.02545.x","article-title":"Effects of inflammatory and anti-inflammatory cytokines on the bone","volume":"41","author":"Schett","year":"2011","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jot.2024.11.003_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112975","article-title":"Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg\/Th17 axis","volume":"150","author":"Sun","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"10.1016\/j.jot.2024.11.003_bib111","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/19490976.2019.1589281","article-title":"Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota","volume":"10","author":"Jang","year":"2019","journal-title":"Gut Microb"},{"issue":"6","key":"10.1016\/j.jot.2024.11.003_bib112","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.immuni.2018.10.013","article-title":"The microbial metabolite butyrate stimulates bone formation via T regulatory cell-mediated regulation of WNT10B expression","volume":"49","author":"Tyagi","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.jot.2024.11.003_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106112","article-title":"Vitamin D and microbiota: two sides of the same coin in the immunomodulatory aspects","volume":"79","author":"Malaguarnera","year":"2020","journal-title":"Int Immunopharm"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib114","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1677\/jme.0.0260079","article-title":"Osteoporosis, genetics and hormones","volume":"26","author":"Rizzoli","year":"2001","journal-title":"J Mol Endocrinol"},{"issue":"8","key":"10.1016\/j.jot.2024.11.003_bib115","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nrrheum.2012.112","article-title":"Bone: modulation of IGF-1 might prevent osteoporosis","volume":"8","author":"Carney","year":"2012","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib116","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1038\/s41598-017-06126-x","article-title":"Commensal gut microbiota immunomodulatory actions in bone marrow and liver have catabolic effects on skeletal homeostasis in health","volume":"7","author":"Novince","year":"2017","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib117","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10620-015-3598-8","article-title":"Association of serotonin transporter promoter polymorphism (5HTTLPR) with microscopic colitis and ulcerative colitis: time to Be AsSERTive?","volume":"60","author":"Goldner","year":"2015","journal-title":"Dig Dis Sci"},{"issue":"15","key":"10.1016\/j.jot.2024.11.003_bib118","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.febslet.2015.05.054","article-title":"The roles of peripheral serotonin in metabolic homeostasis","volume":"589","author":"El-Merahbi","year":"2015","journal-title":"FEBS Lett"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib119","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.4049\/jimmunol.1201133","article-title":"Serotonin skews human macrophage polarization through HTR2B and HTR7","volume":"190","author":"de las Casas-Engel","year":"2013","journal-title":"J Immunol"},{"issue":"8","key":"10.1016\/j.jot.2024.11.003_bib120","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a031237","article-title":"Regulation of bone remodeling by parathyroid hormone","volume":"8","author":"Wein","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib121","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/cphy.c140071","article-title":"PTH and vitamin D","volume":"6","author":"Khundmiri","year":"2016","journal-title":"Compr Physiol"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib122","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1172\/JCI133473","article-title":"Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota","volume":"130","author":"Li","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jot.2024.11.003_bib123","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.semcdb.2021.06.024","article-title":"Alliances of the gut and bone axis","volume":"123","author":"Hansen","year":"2022","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jot.2024.11.003_bib124","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jot.2022.02.001","article-title":"Targeting the GLP-1\/GLP-1R axis to treat osteoarthritis: a new opportunity?","volume":"32","author":"Meurot","year":"2022","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jot.2024.11.003_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115654","article-title":"Recent advance of small-molecule drugs for clinical treatment of osteoporosis: a review","volume":"259","author":"Zhang","year":"2023","journal-title":"Eur J Med Chem"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib126","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.maturitas.2015.07.003","article-title":"Bone biology, signaling pathways, and therapeutic targets for osteoporosis","volume":"82","author":"I\u00f1iguez-Ariza","year":"2015","journal-title":"Maturitas"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib127","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00198-019-04855-5","article-title":"Gut microbiota composition and bone mineral loss-epidemiologic evidence from individuals in Wuhan, China","volume":"30","author":"Li","year":"2019","journal-title":"Osteoporos Int"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib128","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ecl.2013.09.004","article-title":"Osteoporosis-associated fracture and diabetes","volume":"43","author":"Kurra","year":"2014","journal-title":"Endocrinol Metab Clin N Am"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib129","doi-asserted-by":"crossref","first-page":"438","DOI":"10.14336\/AD.2019.0523","article-title":"Gut microbiome and osteoporosis","volume":"11","author":"Ding","year":"2020","journal-title":"Aging Dis"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib130","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4161\/gmic.21288","article-title":"Collateral effects of antibiotics on mammalian gut microbiomes","volume":"3","author":"Looft","year":"2012","journal-title":"Gut Microb"},{"issue":"10","key":"10.1016\/j.jot.2024.11.003_bib131","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1172\/JCI72333","article-title":"Antibiotics and the gut microbiota","volume":"124","author":"Modi","year":"2014","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib132","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00223-007-9011-7","article-title":"Acute effects of different phosphorus sources on calcium and bone metabolism in young women: a whole-foods approach","volume":"80","author":"Karp","year":"2007","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib133","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/jn\/nxy008","article-title":"Dietary fermentable fibers attenuate chronic kidney disease in mice by protecting the intestinal barrier","volume":"148","author":"Hung","year":"2018","journal-title":"J Nutr"},{"issue":"44","key":"10.1016\/j.jot.2024.11.003_bib134","doi-asserted-by":"crossref","first-page":"12476","DOI":"10.1021\/acs.jafc.0c04976","article-title":"Increased intestinal permeability in older subjects impacts the beneficial effects of dietary polyphenols by modulating their bioavailability","volume":"68","author":"Hidalgo-Liberona","year":"2020","journal-title":"J Agric Food Chem"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib135","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26030537","article-title":"Anthocyanins, microbiome and health benefits in aging","volume":"26","author":"Hair","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib136","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41538-022-00145-3","article-title":"Dietary supplementation with biogenic selenium nanoparticles alleviate oxidative stress-induced intestinal barrier dysfunction","volume":"6","author":"Qiao","year":"2022","journal-title":"npj Sci Food"},{"key":"10.1016\/j.jot.2024.11.003_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2024.109701","article-title":"Blackcurrants shape gut microbiota profile and reduce risk of postmenopausal osteoporosis via the gut-bone axis: evidence from a pilot randomized controlled trial","volume":"133","author":"Nosal","year":"2024","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jot.2024.11.003_bib138","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biopha.2017.12.042","article-title":"Osteoporosis is associated with metabolic syndrome induced by high-carbohydrate high-fat diet in a rat model","volume":"98","author":"Wong","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"12","key":"10.1016\/j.jot.2024.11.003_bib139","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.nutres.2013.08.006","article-title":"Bone quality and strength are greater in growing male rats fed fructose compared with glucose","volume":"33","author":"Bass","year":"2013","journal-title":"Nutr Res"},{"issue":"7","key":"10.1016\/j.jot.2024.11.003_bib140","doi-asserted-by":"crossref","DOI":"10.3390\/nu12071986","article-title":"Nutrients and dietary patterns related to osteoporosis","volume":"12","author":"Mu\u00f1oz-Garach","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib141","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2295432","article-title":"Diets intervene osteoporosis via gut-bone axis","volume":"16","author":"Zhang","year":"2024","journal-title":"Gut Microb"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib142","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1186\/s12889-017-4966-4","article-title":"Education and exercise program improves osteoporosis knowledge and changes calcium and vitamin D dietary intake in community dwelling elderly","volume":"17","author":"Park","year":"2017","journal-title":"BMC Publ Health"},{"key":"10.1016\/j.jot.2024.11.003_bib143","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jot.2022.09.010","article-title":"Recommendations on the post-acute management of the osteoporotic fracture - patients with \"very-high\" Re-fracture risk","volume":"37","author":"Wong","year":"2022","journal-title":"J Orthop Translat"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib144","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.3390\/ijerph110504745","article-title":"Microorganisms with claimed probiotic properties: an overview of recent literature","volume":"11","author":"Fijan","year":"2014","journal-title":"Int J Environ Res Publ Health"},{"key":"10.1016\/j.jot.2024.11.003_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154767","article-title":"FOS\/GOS attenuates high-fat diet induced bone loss via reversing microbiota dysbiosis, high intestinal permeability and systemic inflammation in mice","volume":"119","author":"Zhang","year":"2021","journal-title":"Metabolism"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib146","doi-asserted-by":"crossref","first-page":"G1025","DOI":"10.1152\/ajpgi.90227.2008","article-title":"Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function","volume":"295","author":"Ewaschuk","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib147","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s12602-019-09532-x","article-title":"Effects of the use of a combination of two Bacillus species on performance, egg quality, small intestinal mucosal morphology, and cecal microbiota profile in aging laying hens","volume":"12","author":"Yang","year":"2020","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib148","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s13568-020-01150-z","article-title":"Effects of Bacillus subtilis on growth performance, serum parameters, digestive enzyme, intestinal morphology, and colonic microbiota in piglets","volume":"10","author":"Deng","year":"2020","journal-title":"Amb Express"},{"key":"10.1016\/j.jot.2024.11.003_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108168","article-title":"Advances in pathogenesis and therapeutic strategies for osteoporosis","volume":"237","author":"Song","year":"2022","journal-title":"Pharmacol Ther"},{"issue":"7","key":"10.1016\/j.jot.2024.11.003_bib150","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1089\/jmf.2011.0296","article-title":"Yacon flour and Bifidobacterium longum modulate bone health in rats","volume":"15","author":"Rodrigues","year":"2012","journal-title":"J Med Food"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib151","doi-asserted-by":"crossref","first-page":"E591","DOI":"10.1152\/ajpendo.00412.2020","article-title":"Mild stimulatory effect of a probiotic mix on bone mass when treatment is initiated 1.5 weeks after ovariectomy in mice","volume":"320","author":"Ohlsson","year":"2021","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib152","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1530\/JOE-21-0408","article-title":"A probiotic mix partially protects against castration-induced bone loss in male mice","volume":"254","author":"Lawenius","year":"2022","journal-title":"J Endocrinol"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib153","doi-asserted-by":"crossref","first-page":"E344","DOI":"10.1152\/ajpendo.00366.2021","article-title":"Development of a synbiotic that protects against ovariectomy-induced trabecular bone loss","volume":"322","author":"Lawenius","year":"2022","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib154","first-page":"965","article-title":"Bifidobacterium lactis Probio-M8 improves bone metabolism in patients with postmenopausal osteoporosis, possibly by modulating the gut microbiota","volume":"62","author":"Zhao","year":"2023","journal-title":"Eur J Nutr"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib155","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/s41598-020-80536-2","article-title":"Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice","volume":"11","author":"Sapra","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jot.2024.11.003_bib156","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bonr.2018.02.001","article-title":"Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance","volume":"8","author":"Dar","year":"2018","journal-title":"BoneKEy Rep"},{"issue":"11","key":"10.1016\/j.jot.2024.11.003_bib157","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/jcp.24636","article-title":"Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model","volume":"229","author":"Britton","year":"2014","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib158","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41522-022-00348-2","article-title":"One-year supplementation with Lactobacillus reuteri ATCC PTA 6475 counteracts a degradation of gut microbiota in older women with low bone mineral density","volume":"8","author":"Li","year":"2022","journal-title":"npj Biofilms Microbiomes"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib159","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/joim.12805","article-title":"Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical trial","volume":"284","author":"Nilsson","year":"2018","journal-title":"J Intern Med"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib160","doi-asserted-by":"crossref","first-page":"e154","DOI":"10.1016\/S2665-9913(19)30068-2","article-title":"Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre trial","volume":"1","author":"Jansson","year":"2019","journal-title":"Lancet Rheumatol"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib161","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41591-019-0439-x","article-title":"The pros, cons, and many unknowns of probiotics","volume":"25","author":"Suez","year":"2019","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib162","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1111\/1541-4337.12554","article-title":"Updates on understanding of probiotic lactic acid bacteria responses to environmental stresses and highlights on proteomic analyses","volume":"19","author":"Mbye","year":"2020","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"9","key":"10.1016\/j.jot.2024.11.003_bib163","doi-asserted-by":"crossref","DOI":"10.3390\/nu13093211","article-title":"Effects and mechanisms of probiotics, prebiotics, synbiotics, and postbiotics on metabolic diseases targeting gut microbiota: a narrative review","volume":"13","author":"Li","year":"2021","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.jot.2024.11.003_bib164","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202004831","article-title":"Extracellular vesicles from child gut microbiota enter into bone to preserve bone mass and strength","volume":"8","author":"Liu","year":"2021","journal-title":"Adv Sci"},{"key":"10.1016\/j.jot.2024.11.003_bib165","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2023.111047","article-title":"Bone-targeted engineered bacterial extracellular vesicles delivering miRNA to treat osteoporosis","volume":"267","author":"Liu","year":"2023","journal-title":"Composites Part B"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib166","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00223-021-00911-7","article-title":"Gut microbiota dysbiosis as one cause of osteoporosis by impairing intestinal barrier function","volume":"110","author":"Wang","year":"2022","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jot.2024.11.003_bib167","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jot.2022.08.003","article-title":"Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function","volume":"37","author":"Zhang","year":"2022","journal-title":"J Orthop Translat"},{"issue":"7","key":"10.1016\/j.jot.2024.11.003_bib168","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/apt.13969","article-title":"Randomised clinical trial: faecal microbiota transplantation for recurrent Clostridum difficile infection - fresh, or frozen, or lyophilised microbiota from a small pool of healthy donors delivered by colonoscopy","volume":"45","author":"Jiang","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib169","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/jama.2018.20046","article-title":"Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial","volume":"321","author":"Costello","year":"2019","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.jot.2024.11.003_bib170","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.4014\/jmb.2002.02044","article-title":"Fecal microbiota transplantation (FMT) alleviates experimental colitis in mice by gut microbiota regulation","volume":"30","author":"Zhang","year":"2020","journal-title":"J Microbiol Biotechnol"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib171","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1017\/S1751731118001611","article-title":"Early intervention with faecal microbiota transplantation: an effective means to improve growth performance and the intestinal development of suckling piglets","volume":"13","author":"Cheng","year":"2019","journal-title":"Animal"},{"key":"10.1016\/j.jot.2024.11.003_bib172","article-title":"Effects of resistance and balance exercises for athletic ability and quality of life in people with osteoporotic vertebral fracture: systematic review and meta-analysis of randomized control trials","volume":"10","author":"Li","year":"2023","journal-title":"Front Med"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib173","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00198-017-4339-y","article-title":"Exercise to improve functional outcomes in persons with osteoporosis: a systematic review and meta-analysis","volume":"29","author":"Varahra","year":"2018","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jot.2024.11.003_bib174","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jot.2017.06.001","article-title":"The effect of Chinese martial arts Tai Chi Chuan on prevention of osteoporosis: a systematic review","volume":"12","author":"Chow","year":"2018","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jot.2024.11.003_bib175","article-title":"Exercise for osteoporosis: a literature review of pathology and mechanism","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.jot.2024.11.003_bib176","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41574-019-0170-1","article-title":"Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity","volume":"15","author":"Pagnotti","year":"2019","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib177","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/s12967-022-03700-4","article-title":"A narrative review of the moderating effects and repercussion of exercise intervention on osteoporosis: ingenious involvement of gut microbiota and its metabolites","volume":"20","author":"Zhang","year":"2022","journal-title":"J Transl Med"},{"key":"10.1016\/j.jot.2024.11.003_bib178","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jot.2022.03.003","article-title":"Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35\/NF\u03baB p65 pathway","volume":"35","author":"Shi","year":"2022","journal-title":"J Orthop Translat"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib179","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bjpt.2018.11.011","article-title":"Exercise for the prevention of osteoporosis in postmenopausal women: an evidence-based guide to the optimal prescription","volume":"23","author":"Daly","year":"2019","journal-title":"Braz J Phys Ther"},{"issue":"3","key":"10.1016\/j.jot.2024.11.003_bib180","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1249\/JSR.0000000000000940","article-title":"Type, intensity, and duration of exercise as regulator of gut microbiome profile","volume":"21","author":"Suryani","year":"2022","journal-title":"Curr Sports Med Rep"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib181","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jshs.2019.05.002","article-title":"Exercise induces tissue hypoxia and HIF-1\u03b1 redistribution in the small intestine","volume":"9","author":"Wu","year":"2020","journal-title":"J Sport Health Sci"},{"issue":"6","key":"10.1016\/j.jot.2024.11.003_bib182","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1152\/japplphysiol.00536.2015","article-title":"Intestinal epithelial barrier function and tight junction proteins with heat and exercise","volume":"120","author":"Dokladny","year":"2016","journal-title":"J Appl Physiol"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib183","doi-asserted-by":"crossref","first-page":"G512","DOI":"10.1152\/ajpgi.00232.2020","article-title":"Exercise and intestinal permeability: another form of exercise-induced hormesis?","volume":"319","author":"Keirns","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jot.2024.11.003_bib184","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.3389\/fmicb.2018.02323","article-title":"Six-week endurance exercise alters gut metagenome that is not reflected in systemic metabolism in over-weight women","volume":"9","author":"Munukka","year":"2018","journal-title":"Front Microbiol"},{"issue":"12","key":"10.1016\/j.jot.2024.11.003_bib185","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1136\/gutjnl-2013-306541","article-title":"Exercise and associated dietary extremes impact on gut microbial diversity","volume":"63","author":"Clarke","year":"2014","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib186","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1271\/bbb.70474","article-title":"Voluntary running exercise alters microbiota composition and increases n-butyrate concentration in the rat cecum","volume":"72","author":"Matsumoto","year":"2008","journal-title":"Biosci Biotechnol Biochem"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib187","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1249\/MSS.0000000000001495","article-title":"Exercise alters gut microbiota composition and function in lean and obese humans","volume":"50","author":"Allen","year":"2018","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"10.1016\/j.jot.2024.11.003_bib188","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbi.2005.04.003","article-title":"Influence of exercise training and age on CD14+ cell-surface expression of toll-like receptor 2 and 4","volume":"19","author":"Stewart","year":"2005","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jot.2024.11.003_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111398","article-title":"The impact of exercise training on inflammatory markers in postmenopausal women: a systemic review and meta-analysis","volume":"150","author":"Khalafi","year":"2021","journal-title":"Exp Gerontol"},{"issue":"6","key":"10.1016\/j.jot.2024.11.003_bib190","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3109\/08820139.2011.575425","article-title":"Effect of moderate exercise on IgA levels and lymphocyte count in mouse intestine","volume":"40","author":"Viloria","year":"2011","journal-title":"Immunol Invest"},{"issue":"8","key":"10.1016\/j.jot.2024.11.003_bib191","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.it.2015.06.006","article-title":"The bilateral responsiveness between intestinal microbes and IgA","volume":"36","author":"Macpherson","year":"2015","journal-title":"Trends Immunol"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib192","first-page":"10","article-title":"Effect of aerobic and anaerobic exercise on estrogen level, fat mass, and muscle mass among postmenopausal osteoporotic females","volume":"13","author":"Razzak","year":"2019","journal-title":"Int J Health Sci"},{"issue":"1","key":"10.1016\/j.jot.2024.11.003_bib193","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00421-012-2410-0","article-title":"The effect of 12 weeks of resistance training on hormones of bone formation in young sedentary women","volume":"113","author":"Moghadasi","year":"2013","journal-title":"Eur J Appl Physiol"},{"issue":"10","key":"10.1016\/j.jot.2024.11.003_bib194","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s40618-020-01251-3","article-title":"Endogenous transient doping: physical exercise acutely increases testosterone levels-results from a meta-analysis","volume":"43","author":"D'Andrea","year":"2020","journal-title":"J Endocrinol Invest"},{"issue":"2","key":"10.1016\/j.jot.2024.11.003_bib195","doi-asserted-by":"crossref","first-page":"149","DOI":"10.11005\/jbm.2023.30.2.149","article-title":"Position statement: exercise guidelines for osteoporosis management and fall prevention in osteoporosis patients","volume":"30","author":"Bae","year":"2023","journal-title":"J Bone Metab"},{"issue":"7","key":"10.1016\/j.jot.2024.11.003_bib196","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.numecd.2020.02.020","article-title":"Efficacy of dietary intervention or in combination with exercise on primary prevention of cardiovascular disease: a systematic review","volume":"30","author":"Abbate","year":"2020","journal-title":"Nutr Metabol Cardiovasc Dis"},{"key":"10.1016\/j.jot.2024.11.003_bib197","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2023.137104","article-title":"Swimming training combined with fecal microbial transplantation protects motor functions in rats with spinal cord injury by improving the intestinal system","volume":"799","author":"Ouyang","year":"2023","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jot.2024.11.003_bib198","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.exger.2018.12.005","article-title":"Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: role of microbiome","volume":"115","author":"Abraham","year":"2019","journal-title":"Exp Gerontol"},{"issue":"4","key":"10.1016\/j.jot.2024.11.003_bib199","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cmet.2020.08.012","article-title":"Warmth prevents bone loss through the gut microbiota","volume":"32","author":"Chevalier","year":"2020","journal-title":"Cell Metabol"},{"issue":"9","key":"10.1016\/j.jot.2024.11.003_bib200","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202004831","article-title":"Extracellular vesicles from child gut microbiota enter into bone to preserve bone mass and strength","volume":"8","author":"Liu","year":"2021","journal-title":"Adv Sci"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24001487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X24001487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T16:51:06Z","timestamp":1742230266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X24001487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":200,"alternative-id":["S2214031X24001487"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2024.11.003","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut-bone axis perturbation: Mechanisms and interventions via gut microbiota as a primary driver of osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2024.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}