{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:41:28Z","timestamp":1793288488907,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M690494"],"award-info":[{"award-number":["2021M690494"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013099","name":"Scientific Research Fund of Liaoning Provincial Education Department","doi-asserted-by":"publisher","award":["LJKQZ2021169"],"award-info":[{"award-number":["LJKQZ2021169"]}],"id":[{"id":"10.13039\/501100013099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jot.2025.01.005","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T17:48:22Z","timestamp":1742060902000},"page":"198-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Internal fixation with biodegradable high purity magnesium screws in the treatment of ankle fracture"],"prefix":"10.1016","volume":"51","author":[{"given":"De-Wei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Liang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Wei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Bo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2025.01.005_bib1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2340\/17453674.2022.2071","article-title":"Ankle fractures in Finland: 118,929 operatively treated between 1987 and 2019","volume":"93","author":"Happonen","year":"2022","journal-title":"Acta Orthop"},{"key":"10.1016\/j.jot.2025.01.005_bib2","first-page":"9","article-title":"The global status of research in ankle fracture: a bibliometric and visualized study","author":"Zeng","year":"2022","journal-title":"Front Surgery"},{"issue":"12","key":"10.1016\/j.jot.2025.01.005_bib3","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1016\/j.injury.2020.10.093","article-title":"Ankle fractures in the elderly: current concepts","volume":"51","author":"Pearce","year":"2020","journal-title":"Injury"},{"key":"10.1016\/j.jot.2025.01.005_bib4","article-title":"Use of cast immobilisation versus removable brace in adults with an ankle fracture: multicentre randomised controlled trial","volume":"n1506","author":"Kearney","year":"2021","journal-title":"Bmj"},{"issue":"8","key":"10.1016\/j.jot.2025.01.005_bib5","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1302\/2058-5241.6.200138","article-title":"Current management of trimalleolar ankle fractures","volume":"6","author":"Pfl\u00fcGER","year":"2021","journal-title":"EFORT Open Reviews"},{"issue":"1","key":"10.1016\/j.jot.2025.01.005_bib6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2106\/JBJS.17.01658","article-title":"Techniques and considerations for the operative treatment of ankle fractures in the elderly","volume":"101","author":"Konopitski","year":"2019","journal-title":"J Bone Joint Surg"},{"issue":"3","key":"10.1016\/j.jot.2025.01.005_bib7","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s11845-022-03071-1","article-title":"Magnesium implants in orthopaedic surgery create a diagnostic conundrum: a radiology case series and literature review","volume":"192","author":"Anderson","year":"2022","journal-title":"Ir J Med Sci"},{"issue":"4","key":"10.1016\/j.jot.2025.01.005_bib8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.fas.2018.05.006","article-title":"The burden of hardware removal in ankle fractures: how common is it, why do we do it and what is the cost? A ten-year review","volume":"25","author":"Fenelon","year":"2019","journal-title":"Foot Ankle Surg"},{"issue":"8","key":"10.1016\/j.jot.2025.01.005_bib9","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/j.jma.2022.07.011","article-title":"Improving the Young's modulus of Mg via alloying and compositing \u2013 a short review","volume":"10","author":"Shi","year":"2022","journal-title":"J Magnesium Alloys"},{"issue":"5","key":"10.1016\/j.jot.2025.01.005_bib10","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jseint.2021.04.014","article-title":"Predicting secondary surgery after operative fixation of olecranon fractures: a model using data from 800 patients","volume":"5","author":"Midtgaard","year":"2021","journal-title":"JSES Int"},{"issue":"6","key":"10.1016\/j.jot.2025.01.005_bib11","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jat.3590","article-title":"Effect of titanium ions on the Hippo\/YAP signaling pathway in regulating biological behaviors of MC3T3\u2010E1 osteoblasts","volume":"38","author":"Zhu","year":"2018","journal-title":"J Appl Toxicol"},{"issue":"1","key":"10.1016\/j.jot.2025.01.005_bib12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/s13018-021-02665-2","article-title":"Titanium alloy cannulated screws and biodegradable magnesium alloy bionic cannulated screws for treatment of femoral neck fractures: a finite element analysis","volume":"16","author":"Ding","year":"2021","journal-title":"J Orthop Surg Res"},{"issue":"4","key":"10.1016\/j.jot.2025.01.005_bib13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3390\/biom11040506","article-title":"The effects of calcium, magnesium, phosphorus, fluoride, and lead on bone tissue","volume":"11","author":"Ciosek","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jot.2025.01.005_bib14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jot.2022.09.013","article-title":"Development of degradable magnesium-based metal implants and their function in promoting bone metabolism (A review)","volume":"36","author":"Shan","year":"2022","journal-title":"J Orthop Translat"},{"issue":"8","key":"10.1016\/j.jot.2025.01.005_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201902443","article-title":"Biodegradable magnesium\u2010based implants in orthopedics\u2014a general review and perspectives","volume":"7","author":"Wang","year":"2020","journal-title":"Adv Sci"},{"key":"10.1016\/j.jot.2025.01.005_bib16","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.actbio.2017.08.051","article-title":"Ion channel functional protein kinase TRPM7 regulates Mg ions to promote the osteoinduction of human osteoblast via PI3K pathway: in vitro simulation of the bone-repairing effect of Mg-based alloy implant","volume":"63","author":"Zhang","year":"2017","journal-title":"Acta Biomater"},{"issue":"10","key":"10.1016\/j.jot.2025.01.005_bib17","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/nm.4162","article-title":"Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats","volume":"22","author":"Zhang","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.jot.2025.01.005_bib18","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.actbio.2021.08.040","article-title":"Fatigue and dynamic biodegradation behavior of additively manufactured Mg scaffolds","volume":"135","author":"Wang","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2025.01.005_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jot.2022.03.004","article-title":"Biodegradable magnesium implant enhances angiogenesis and alleviates medication-related osteonecrosis of the jaw in rats","volume":"33","author":"Zhu","year":"2022","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jot.2025.01.005_bib20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jot.2023.08.003","article-title":"The novel magnesium\u2013titanium hybrid cannulated screws for the treatment of vertical femoral neck fractures: biomechanical evaluation","volume":"42","author":"Zhang","year":"2023","journal-title":"J Orthop Translat"},{"issue":"2","key":"10.1016\/j.jot.2025.01.005_bib21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/mco2.59","article-title":"Biodegradable magnesium\u2010based biomaterials: an overview of challenges and opportunities","volume":"2","author":"Amukarimi","year":"2021","journal-title":"MedComm"},{"key":"10.1016\/j.jot.2025.01.005_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jot.2020.11.007","article-title":"Effectiveness and safety of biodegradable Mg-Nd-Zn-Zr alloy screws for the treatment of medial malleolar fractures","volume":"27","author":"Xie","year":"2021","journal-title":"J Orthop Translat"},{"issue":"8","key":"10.1016\/j.jot.2025.01.005_bib23","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1016\/j.msec.2013.08.008","article-title":"Enhanced biocorrosion resistance and biocompatibility of degradable Mg\u2013Nd\u2013Zn\u2013Zr alloy by brushite coating","volume":"33","author":"Niu","year":"2013","journal-title":"Mater Sci Eng C"},{"key":"10.1016\/j.jot.2025.01.005_bib24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.biomaterials.2016.10.017","article-title":"Current status on clinical applications of magnesium-based orthopaedic implants: a review from clinical translational perspective","volume":"112","author":"Zhao","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2025.01.005_bib25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jot.2021.06.002","article-title":"Immobilization of bioactive vascular endothelial growth factor onto Ca-deficient hydroxyapatite-coated Mg by covalent bonding using polydopamine","volume":"30","author":"Li","year":"2021","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jot.2025.01.005_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jot.2023.05.003","article-title":"Polymer bilayer-Micro arc oxidation surface coating on pure magnesium for bone implantation","volume":"40","author":"Dong","year":"2023","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jot.2025.01.005_bib27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jot.2019.01.004","article-title":"Treatment of trauma-induced femoral head necrosis with biodegradable pure Mg screw-fixed pedicle iliac bone flap","volume":"17","author":"Chen","year":"2019","journal-title":"J Orthop Translat"},{"issue":"8","key":"10.1016\/j.jot.2025.01.005_bib28","article-title":"High-purity weight-bearing magnesium screw: translational application in the healing of femoral neck fracture","volume":"23","author":"Huang","year":"2020","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.jot.2025.01.005_bib29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biomaterials.2015.06.031","article-title":"In vitro and in vivo studies on the degradation of high-purity Mg (99.99wt.%) screw with femoral intracondylar fractured rabbit model","volume":"6","author":"Han","year":"2015","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jot.2025.01.005_bib30","first-page":"9","article-title":"Bioabsorbable magnesium screw versus conventional titanium screw fixation for medial malleolar fractures","volume":"21","author":"May","year":"2020","journal-title":"J Orthop Translat"},{"issue":"4","key":"10.1016\/j.jot.2025.01.005_bib31","first-page":"e2519","article-title":"Isolated lateral malleolar fracture treated with a bioabsorbable magnesium compression screw","volume":"10","author":"Acar","year":"2018","journal-title":"Cureus J Med Sci"},{"key":"10.1016\/j.jot.2025.01.005_bib32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jmst.2022.08.036","article-title":"High-purity Mg and Mg-1Ca alloys: comparative assessment of the merits regarding degradation, osteogenesis, and biosafety for orthopedic applications","volume":"140","author":"Sui","year":"2023","journal-title":"J Mater Sci Technol"},{"key":"10.1016\/j.jot.2025.01.005_bib33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jmst.2022.12.004","article-title":"Perceiving the connection between the bone healing process and biodegradation of biodegradable metal implants through precise bioadaptability principle","volume":"147","author":"Zheng","year":"2023","journal-title":"J Mater Sci Technol"},{"issue":"34","key":"10.1016\/j.jot.2025.01.005_bib34","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000016898","article-title":"Finite element analysis of spiral plate and Herbert screw fixation for treatment of midshaft clavicle fractures","volume":"98","author":"Zhang","year":"2019","journal-title":"Medicine"},{"issue":"6","key":"10.1016\/j.jot.2025.01.005_bib35","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.jma.2022.02.013","article-title":"Recent progress in Mg-based alloys as a novel bioabsorbable biomaterials for orthopedic applications","volume":"10","author":"Xing","year":"2022","journal-title":"J Magnesium Alloys"},{"issue":"1","key":"10.1016\/j.jot.2025.01.005_bib36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.biomaterials.2015.11.038","article-title":"Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head","volume":"8","author":"Zhao","year":"2016","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.jot.2025.01.005_bib37","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2174\/1381612826666201113100245","article-title":"Recent advances in molecular hydrogen research reducing exercise-induced oxidative stress and inflammation","volume":"27","author":"Nogueira","year":"2021","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jot.2025.01.005_bib38","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1016\/j.csbj.2021.07.005","article-title":"Magnesium ions regulate mesenchymal stem cells population and osteogenic differentiation: a fuzzy agent-based modeling approach","volume":"19","author":"Nourisa","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"issue":"2","key":"10.1016\/j.jot.2025.01.005_bib39","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s12011-020-02183-y","article-title":"Insights into the role of magnesium ions in affecting osteogenic differentiation of mesenchymal stem cells","volume":"199","author":"Qi","year":"2020","journal-title":"Biol Trace Elem Res"},{"issue":"7","key":"10.1016\/j.jot.2025.01.005_bib40","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.3390\/pharmaceutics14071481","article-title":"A degradable and osteogenic Mg-based MAO-MT-PLGA drug\/ion delivery system for treating an osteoporotic fracture","volume":"14","author":"Liu","year":"2022","journal-title":"Pharmaceutics"},{"issue":"29","key":"10.1016\/j.jot.2025.01.005_bib41","first-page":"1","article-title":"Comprehensive review of additively manufactured biodegradable magnesium implants for repairing bone defects from biomechanical and biodegradable perspectives","volume":"11","year":"2022","journal-title":"Front Chem"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X25000063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X25000063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T12:20:22Z","timestamp":1764418822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X25000063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":41,"alternative-id":["S2214031X25000063"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2025.01.005","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Internal fixation with biodegradable high purity magnesium screws in the treatment of ankle fracture","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2025.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}