{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:55:11Z","timestamp":1791262511087,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172491"],"award-info":[{"award-number":["82172491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012562"],"award-info":[{"award-number":["2022A1515012562"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["20231800940422"],"award-info":[{"award-number":["20231800940422"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jot.2025.04.016","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T13:35:40Z","timestamp":1754055340000},"page":"360-375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Upregulation of ACSL1 in synovial macrophages promotes lipid peroxidation via the I\u03baB\/NF-\u03baB pathway to accelerate osteoarthritis"],"prefix":"10.1016","volume":"55","author":[{"given":"Zihao","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7992-0163","authenticated-orcid":false,"given":"Junyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2294-5411","authenticated-orcid":false,"given":"Daozhang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9991","key":"10.1016\/j.jot.2025.04.016_bib1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jot.2025.04.016_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","article-title":"Mechanisms and therapeutic implications of cellular senescence in osteoarthritis","volume":"17","author":"Coryell","year":"2021","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"10.1016\/j.jot.2025.04.016_bib3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/rheumatology\/key274","article-title":"Knee effusion volume assessed by magnetic resonance imaging and progression of knee osteoarthritis: data from the Osteoarthritis Initiative","volume":"58","author":"Wang","year":"2019","journal-title":"Rheumatology"},{"issue":"3","key":"10.1016\/j.jot.2025.04.016_bib4","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.joca.2015.09.013","article-title":"Synovitis and the risk of knee osteoarthritis: the MOST Study","volume":"24","author":"Felson","year":"2016","journal-title":"Osteoarthr Cartil"},{"issue":"7","key":"10.1016\/j.jot.2025.04.016_bib5","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.jot.2025.04.016_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13075-018-1798-2","article-title":"Synovial fluid monocyte\/macrophage subsets and their correlation to patient-reported outcomes in osteoarthritic patients: a cohort study","volume":"21","author":"G\u00f3mez-Aristiz\u00e1bal","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jot.2025.04.016_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108176","article-title":"Macrophage immunometabolism in inflammatory bowel diseases: from pathogenesis to therapy","volume":"238","author":"Pan","year":"2022","journal-title":"Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.jot.2025.04.016_bib8","first-page":"358","article-title":"Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor","volume":"1864","author":"Singh","year":"2019","journal-title":"Biochim Biophys Acta BBA - Mol Cell Biol Lipids."},{"issue":"1","key":"10.1016\/j.jot.2025.04.016_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/CIRCRESAHA.117.311307","article-title":"Mitochondrial reactive oxygen species in lipotoxic hearts induce post-translational modifications of AKAP121, DRP1, and OPA1 that promote mitochondrial fission","volume":"122","author":"Tsushima","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jot.2025.04.016_bib10","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.scitotenv.2018.12.007","article-title":"Prenatal exposure to ambient fine particulate matter induces dysregulations of lipid metabolism in adipose tissue in male offspring","volume":"657","author":"Xie","year":"2019","journal-title":"Sci Total Environ"},{"issue":"41","key":"10.1016\/j.jot.2025.04.016_bib11","doi-asserted-by":"crossref","first-page":"27816","DOI":"10.1074\/jbc.M109.022467","article-title":"Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and \u03b2-oxidation and alters phospholipid fatty acid composition","volume":"284","author":"Li","year":"2009","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.jot.2025.04.016_bib12","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.cmet.2020.10.010","article-title":"TANK-binding kinase 1 regulates the localization of acyl-CoA synthetase ACSL1 to control hepatic fatty acid oxidation","volume":"32","author":"Huh","year":"2020","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.jot.2025.04.016_bib13","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1038\/s41467-021-22471-y","article-title":"Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1","volume":"12","author":"Beatty","year":"2021","journal-title":"Nat Commun"},{"issue":"8006","key":"10.1016\/j.jot.2025.04.016_bib14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41586-024-07185-7","article-title":"APOE4\/4 is linked to damaging lipid droplets in Alzheimer's disease microglia","volume":"628","author":"Haney","year":"2024","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.jot.2025.04.016_bib15","doi-asserted-by":"crossref","first-page":"715S","DOI":"10.1093\/ajcn\/57.5.715S","article-title":"Lipid peroxidation: its mechanism, measurement, and significance","volume":"57","author":"Halliwell","year":"1993","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.jot.2025.04.016_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1042\/EBC20190058","article-title":"Modification of proteins by reactive lipid oxidation products and biochemical effects of lipoxidation","volume":"64","author":"Spickett","year":"2020","journal-title":"Essays Biochem"},{"issue":"6","key":"10.1016\/j.jot.2025.04.016_bib17","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1038\/s41418-019-0470-y","article-title":"Mitochondrial 4-HNE derived from MAO-A promotes mitoCa2+ overload in chronic postischemic cardiac remodeling","volume":"27","author":"Santin","year":"2020","journal-title":"Cell Death Differ"},{"issue":"22","key":"10.1016\/j.jot.2025.04.016_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214373","article-title":"4-Hydroxynonenal modulates blood\u2013brain barrier permeability in vitro through changes in lipid composition and oxidative status of endothelial cells and astrocytes","volume":"23","author":"Cindri\u0107","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2025.04.016_bib19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.freeradbiomed.2018.11.037","article-title":"Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, exacerbates colonic inflammation through activation of Toll-like receptor 4 signaling","volume":"131","author":"Wang","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jot.2025.04.016_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/5937326","article-title":"4-Hydroxy-Trans-2-Nonenal in the regulation of anti-oxidative and pro-inflammatory signaling pathways","volume":"2019","author":"Sonowal","year":"2019","journal-title":"Oxid Med Cell Longev"},{"issue":"9","key":"10.1016\/j.jot.2025.04.016_bib21","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"10.1016\/j.jot.2025.04.016_bib22","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/annrheumdis-2021-221513","article-title":"Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7","volume":"81","author":"Zhang","year":"2022","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.jot.2025.04.016_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/s12967-023-04173-9","article-title":"Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages","volume":"21","author":"Lu","year":"2023","journal-title":"J Transl Med"},{"issue":"4","key":"10.1016\/j.jot.2025.04.016_bib24","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology."},{"key":"10.1016\/j.jot.2025.04.016_bib25","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative \u2013 recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jot.2025.04.016_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.83069","article-title":"Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis","volume":"12","author":"Yao","year":"2023","journal-title":"eLife"},{"issue":"10","key":"10.1016\/j.jot.2025.04.016_bib27","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/annrheumdis-2018-213450","article-title":"Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2","volume":"77","author":"Zhang","year":"2018","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"10.1016\/j.jot.2025.04.016_bib28","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat Immunol"},{"issue":"9","key":"10.1016\/j.jot.2025.04.016_bib29","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.joca.2016.04.010","article-title":"Direct in vivo evidence of activated macrophages in human osteoarthritis","volume":"24","author":"Kraus","year":"2016","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"10.1016\/j.jot.2025.04.016_bib30","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.joca.2019.12.002","article-title":"Association between Bone marrow lesions & synovitis and symptoms in symptomatic knee osteoarthritis","volume":"28","author":"Perry","year":"2020","journal-title":"Osteoarthr Cartil"},{"issue":"11","key":"10.1016\/j.jot.2025.04.016_bib31","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41584-018-0095-4","article-title":"Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management","volume":"14","author":"Marshall","year":"2018","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"10.1016\/j.jot.2025.04.016_bib32","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.joca.2018.12.012","article-title":"Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis","volume":"27","author":"Wyatt","year":"2019","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"10.1016\/j.jot.2025.04.016_bib33","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.joca.2020.12.025","article-title":"Identification of a distinct lipidomic profile in the osteoarthritic synovial membrane by mass spectrometry imaging","volume":"29","author":"Rocha","year":"2021","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.jot.2025.04.016_bib34","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13075-019-1914-y","article-title":"Distinct fatty acid signatures in infrapatellar fat pad and synovial fluid of patients with osteoarthritis versus rheumatoid arthritis","volume":"21","author":"Mustonen","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jot.2025.04.016_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.857135","article-title":"Lipidomic profiling in synovial tissue","volume":"9","author":"Coras","year":"2022","journal-title":"Front Med"},{"key":"10.1016\/j.jot.2025.04.016_bib36","article-title":"Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis development","volume":"2023","author":"Hu","year":"2023","journal-title":"bioRxiv"},{"issue":"731","key":"10.1016\/j.jot.2025.04.016_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf4590","article-title":"Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology","volume":"16","author":"Tang","year":"2024","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jot.2025.04.016_bib38","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jot.2022.02.007","article-title":"An osteoarthritis subtype characterized by synovial lipid metabolism disorder and fibroblast-like synoviocyte dysfunction","volume":"33","author":"Cao","year":"2022","journal-title":"Journal of Orthopaedic Translation"},{"key":"10.1016\/j.jot.2025.04.016_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155334","article-title":"Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis","author":"Dong","year":"2023","journal-title":"Metab - Clin Exp [Internet]"},{"issue":"5","key":"10.1016\/j.jot.2025.04.016_bib40","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.joca.2020.01.007","article-title":"Macrophages regulate the progression of osteoarthritis","volume":"28","author":"Zhang","year":"2020","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.jot.2025.04.016_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67730-y","article-title":"Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis","volume":"10","author":"Chou","year":"2020","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.jot.2025.04.016_bib42","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1136\/annrheumdis-2016-210426","article-title":"CCL2\/CCR2, but not CCL5\/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis","volume":"76","author":"Raghu","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jot.2025.04.016_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122036","article-title":"Activated macrophage membrane-coated nanoparticles relieve osteoarthritis-induced synovitis and joint damage","volume":"295","author":"Zhou","year":"2023","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.jot.2025.04.016_bib44","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/art.42505","article-title":"Noncanonical pyroptosis triggered by macrophage-derived extracellular vesicles in chondrocytes leading to cartilage catabolism in osteoarthritis","volume":"75","author":"Ebata","year":"2023","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"10.1016\/j.jot.2025.04.016_bib45","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00281-019-00762-3","article-title":"An emerging role for Toll-like receptors at the neuroimmune interface in osteoarthritis","volume":"41","author":"Miller","year":"2019","journal-title":"Semin Immunopathol"},{"issue":"4","key":"10.1016\/j.jot.2025.04.016_bib46","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.3390\/ijms24044120","article-title":"Healthy and osteoarthritis-affected joints facing the cellular crosstalk","volume":"24","author":"Semenistaja","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2025.04.016_bib47","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13075-016-0983-4","article-title":"From osteoarthritic synovium to synovial-derived cells characterization: synovial macrophages are key effector cells","volume":"18","author":"Manferdini","year":"2016","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"10.1016\/j.jot.2025.04.016_bib48","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.joca.2014.05.021","article-title":"Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state","volume":"22","author":"Fahy","year":"2014","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jot.2025.04.016_bib49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2018.08.038","article-title":"Reactive oxygen species, aging and articular cartilage homeostasis","volume":"132","author":"Bolduc","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jot.2025.04.016_bib50","article-title":"Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols","volume":"129","author":"Ansari","year":"2020","journal-title":"Biomed Pharmacother Biomedecine Pharmacother"},{"issue":"8","key":"10.1016\/j.jot.2025.04.016_bib51","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1136\/annrheumdis-2019-216911","article-title":"TGF\u03b2 attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination","volume":"79","author":"Wang","year":"2020","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.jot.2025.04.016_bib52","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3109\/10715762.2010.498477","article-title":"Chemistry and biochemistry of lipid peroxidation products","volume":"44","author":"Gu\u00e9raud","year":"2010","journal-title":"Free Radic Res"},{"issue":"1","key":"10.1016\/j.jot.2025.04.016_bib53","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bbrc.2005.08.072","article-title":"Lipid peroxidation: mechanisms, inhibition, and biological effects","volume":"338","author":"Niki","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jot.2025.04.016_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jot.2025.04.016_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174397","article-title":"ACSL family: the regulatory mechanisms and therapeutic implications in cancer","volume":"909","author":"Quan","year":"2021","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"10.1016\/j.jot.2025.04.016_bib56","doi-asserted-by":"crossref","first-page":"E737","DOI":"10.1152\/ajpendo.00112.2006","article-title":"Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo","volume":"291","author":"Parkes","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X25000750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X25000750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:14:26Z","timestamp":1778523266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X25000750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":56,"alternative-id":["S2214031X25000750"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2025.04.016","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upregulation of ACSL1 in synovial macrophages promotes lipid peroxidation via the I\u03baB\/NF-\u03baB pathway to accelerate osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2025.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}