{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:46:42Z","timestamp":1789494402288,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFB3804303"],"award-info":[{"award-number":["2022YFB3804303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0110704"],"award-info":[{"award-number":["2019YFA0110704"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing-Tianjing-Hebei Basic Research Cooperation Program","award":["22JCZXJC00130"],"award-info":[{"award-number":["22JCZXJC00130"]}]},{"name":"the National Key Research and Development Program of China"},{"name":"The National key research and Development Program of China"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jot.2025.05.005","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T07:56:16Z","timestamp":1749455776000},"page":"82-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Construction of cartilaginous organoids based on cartilage extracellular matrix microcarriers to promote articular cartilage regeneration through immune regulation"],"prefix":"10.1016","volume":"53","author":[{"given":"Hongyu","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6123-8374","authenticated-orcid":false,"given":"Yanbin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leijia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoye","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianting","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruichao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sice","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunkang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2740-0472","authenticated-orcid":false,"given":"Aiyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2025.05.005_bib1","article-title":"Acellular cartilage matrix biomimetic scaffold with immediate enrichment of autologous bone marrow mononuclear cells to repair articular cartilage defects","volume":"15","author":"Jia","year":"2022","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.jot.2025.05.005_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.biomaterials.2018.02.016","article-title":"Photo-crosslinkable, injectable sericin hydrogel as 3D biomimetic extracellular matrix for minimally invasive repairing cartilage","volume":"163","author":"Qi","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2025.05.005_bib3","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/s41588-020-00724-8","article-title":"MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome","volume":"52","author":"Fasciani","year":"2020","journal-title":"Nat Genet"},{"key":"10.1016\/j.jot.2025.05.005_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020419","article-title":"Inflammation-modulating hydrogels for osteoarthritis cartilage tissue engineering","volume":"9","author":"Koh","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jot.2025.05.005_bib5","first-page":"312","article-title":"Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field","volume":"22","author":"Li","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2025.05.005_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101864","article-title":"MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis","volume":"85","author":"You","year":"2023","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jot.2025.05.005_bib7","first-page":"429","article-title":"Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor","volume":"35","author":"Shen","year":"2024","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2025.05.005_bib8","first-page":"137","article-title":"Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect","volume":"38","author":"Lu","year":"2024","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2025.05.005_bib9","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1177\/0363546516652619","article-title":"Treatment of articular cartilage defects with microfracture and autologous matrix-induced chondrogenesis leads to extensive subchondral bone cyst formation in a sheep model","volume":"44","author":"Beck","year":"2016","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jot.2025.05.005_bib10","article-title":"Scaffold-based tissue engineering strategies for osteochondral repair","volume":"9","author":"Fu","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jot.2025.05.005_bib11","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1016\/j.biomaterials.2009.12.023","article-title":"Repair of meniscal cartilage white zone tears using a stem cell\/collagen-scaffold implant","volume":"31","author":"Pabbruwe","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2025.05.005_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta21060","article-title":"Autologous chondrocyte implantation in the knee: systematic review and economic evaluation","volume":"21","author":"Mistry","year":"2017","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.jot.2025.05.005_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1022368","article-title":"The potential therapeutic role of extracellular vesicles in osteoarthritis","volume":"10","author":"Zhuang","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jot.2025.05.005_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.biomaterials.2018.05.004","article-title":"Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix","volume":"173","author":"Li","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2025.05.005_bib15","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1186\/s12967-023-04591-9","article-title":"From cells to organs: progress and potential in cartilaginous organoids research","volume":"21","author":"Wang","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.jot.2025.05.005_bib16","first-page":"105","article-title":"Three-dimensional bio-printing of decellularized extracellular matrix-based bio-inks for cartilage regeneration: a systematic review","volume":"3","author":"Sahranavard","year":"2022","journal-title":"Biomater Transl"},{"key":"10.1016\/j.jot.2025.05.005_bib17","first-page":"3","article-title":"Osteochondral scaffolds for early treatment of cartilage defects in osteoarthritic joints: from bench to clinic","volume":"1","author":"Tamaddon","year":"2020","journal-title":"Biomater Transl"},{"key":"10.1016\/j.jot.2025.05.005_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/science.abp8964","article-title":"The extracellular matrix and the immune system: a mutually dependent relationship","volume":"379","author":"Sutherland","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.jot.2025.05.005_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2016.11.068","article-title":"Extracellular matrix hydrogels from decellularized tissues: structure and function","volume":"49","author":"Saldin","year":"2017","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2025.05.005_bib20","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1038\/s41467-019-12545-3","article-title":"In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration","volume":"10","author":"Zhu","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jot.2025.05.005_bib21","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbad118","article-title":"dECM restores macrophage immune homeostasis and alleviates iron overload to promote DTPI healing","volume":"11","author":"Zhang","year":"2024","journal-title":"Regen Biomater"},{"key":"10.1016\/j.jot.2025.05.005_bib22","article-title":"ECM\u2010Inspired hydrogels with ADSCs encapsulation for rheumatoid arthritis treatment","volume":"10","author":"Zhu","year":"2023","journal-title":"Adv Sci"},{"key":"10.1016\/j.jot.2025.05.005_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.actbio.2025.02.043","article-title":"Inflammation-modulating elastic decellularized extracellular matrix scaffold promotes meniscus regeneration","volume":"196","author":"Ding","year":"2025","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2025.05.005_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.actbio.2021.03.054","article-title":"Cell-free decellularized cartilage extracellular matrix scaffolds combined with interleukin 4 promote osteochondral repair through immunomodulatory macrophages: in vitro and in vivo preclinical study","volume":"127","author":"Tian","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2025.05.005_bib25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.stem.2015.02.019","article-title":"Mesenchymal cell contributions to the stem cell niche","volume":"16","author":"Kfoury","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jot.2025.05.005_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121750","article-title":"Spatial patterning of phenotypically distinct microtissues to engineer osteochondral grafts for biological joint resurfacing","volume":"289","author":"Burdis","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2025.05.005_bib27","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.joca.2011.07.005","article-title":"Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy","volume":"19","author":"Cooke","year":"2011","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jot.2025.05.005_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn8420","article-title":"Articular fibrocartilage-targeted therapy by microtubule stabilization","volume":"8","author":"Li","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.jot.2025.05.005_bib29","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41392-021-00675-4","article-title":"Generating 3D-cultured organoids for pre-clinical modeling and treatment of degenerative joint disease","volume":"6","author":"Sun","year":"2021","journal-title":"Sig Transduct Target Ther"},{"key":"10.1016\/j.jot.2025.05.005_bib30","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/s41467-023-36408-0","article-title":"Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect","volume":"14","author":"Abe","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jot.2025.05.005_bib31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.actbio.2018.07.031","article-title":"Functional tissue-engineered microtissue derived from cartilage extracellular matrix for articular cartilage regeneration","volume":"77","author":"Yin","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2025.05.005_bib32","first-page":"1932","article-title":"Hierarchical macro-microporous WPU-ECM scaffolds combined with microfracture promote in situ articular cartilage regeneration in rabbits","volume":"6","author":"Chen","year":"2021","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2025.05.005_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.actbio.2020.01.040","article-title":"The dual character of exosomes in osteoarthritis: antagonists and therapeutic agents","volume":"105","author":"Zhou","year":"2020","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2025.05.005_bib34","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.actbio.2018.04.001","article-title":"Hydrogel derived from porcine decellularized nerve tissue as a promising biomaterial for repairing peripheral nerve defects","volume":"73","author":"Lin","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2025.05.005_bib35","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jot.2025.05.005_bib36","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jot.2025.05.005_bib37","doi-asserted-by":"crossref","first-page":"17253","DOI":"10.1073\/pnas.1308887110","article-title":"Modulation of macrophage phenotype by cell shape","volume":"110","author":"McWhorter","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jot.2025.05.005_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113913","article-title":"Biomimetic immunomodulation strategies for effective tissue repair and restoration","volume":"179","author":"Villarreal-Leal","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jot.2025.05.005_bib39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jconrel.2016.01.026","article-title":"Delivery strategies to control inflammatory response: modulating M1\u2013M2 polarization in tissue engineering applications","volume":"240","author":"Alvarez","year":"2016","journal-title":"J Contr Release"},{"key":"10.1016\/j.jot.2025.05.005_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/genes13010138","article-title":"Wnt pathway extracellular components and their essential roles in bone homeostasis","volume":"13","author":"Mart\u00ednez-Gil","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.jot.2025.05.005_bib41","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1002\/jcp.24045","article-title":"Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development","volume":"227","author":"Ding","year":"2012","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jot.2025.05.005_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246275","article-title":"NF-\u03baB signaling regulates physiological and pathological chondrogenesis","volume":"20","author":"Jimi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2025.05.005_bib43","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/jbmr.222","article-title":"CCN family 2\/connective tissue growth factor (CCN2\/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP)","volume":"26","author":"Nishida","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2025.05.005_bib44","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.biomaterials.2013.11.070","article-title":"Modulation of chondrocyte functions and stiffness-dependent cartilage repair using an injectable enzymatically crosslinked hydrogel with tunable mechanical properties","volume":"35","author":"Wang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2025.05.005_bib45","article-title":"Small joint organoids 3D bioprinting: construction strategy and application","volume":"20","author":"Zhang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.jot.2025.05.005_bib46","first-page":"200","article-title":"In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units","volume":"27","author":"Yang","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2025.05.005_bib47","doi-asserted-by":"crossref","first-page":"40163","DOI":"10.1021\/acsami.0c13426","article-title":"Designer hydrogel with intelligently switchable stem-cell contact for incubating cartilaginous microtissues","volume":"12","author":"Xiahou","year":"2020","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.jot.2025.05.005_bib48","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41578-018-0023-x","article-title":"Extracellular matrix-based materials for regenerative medicine","volume":"3","author":"Hussey","year":"2018","journal-title":"Nat Rev Mater"},{"key":"10.1016\/j.jot.2025.05.005_bib49","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.tibtech.2014.06.008","article-title":"Toward in situ tissue engineering: chemokine-guided stem cell recruitment","volume":"32","author":"Andreas","year":"2014","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.jot.2025.05.005_bib50","article-title":"Living and injectable porous hydrogel microsphere with paracrine activity for cartilage regeneration","volume":"19","author":"Li","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.jot.2025.05.005_bib51","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.smim.2017.04.004","article-title":"Macrophage phenotype in response to ECM bioscaffolds","volume":"29","author":"Huleihel","year":"2017","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jot.2025.05.005_bib52","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/jbm.a.35894","article-title":"Solubilized extracellular matrix bioscaffolds derived from diverse source tissues differentially influence macrophage phenotype","volume":"105","author":"Dziki","year":"2017","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.jot.2025.05.005_bib53","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.tibtech.2012.12.004","article-title":"Extracellular matrix scaffolds for cartilage and bone regeneration","volume":"31","author":"Benders","year":"2013","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.jot.2025.05.005_bib54","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.joca.2019.12.007","article-title":"The role of macrophages in osteoarthritis and cartilage repair","volume":"28","author":"Wu","year":"2020","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jot.2025.05.005_bib55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3389\/fimmu.2020.00111","article-title":"Macrophage: a potential target on cartilage regeneration","volume":"11","author":"Fernandes","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jot.2025.05.005_bib56","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1089\/ten.teb.2016.0332","article-title":"Induced remodeling of porcine tendons to human anterior cruciate ligaments by \u03b1-GAL epitope removal and partial cross-linking","volume":"23","author":"Stone","year":"2017","journal-title":"Tissue Eng Part B Rev"},{"key":"10.1016\/j.jot.2025.05.005_bib57","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1038\/s41598-018-38342-4","article-title":"Finding an optimal corneal xenograft using comparative analysis of corneal matrix proteins across species","volume":"9","author":"Sharifi","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jot.2025.05.005_bib58","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1056\/NEJMoa2120238","article-title":"Results of two cases of pig-to-human kidney xenotransplantation","volume":"386","author":"Montgomery","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jot.2025.05.005_bib59","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(23)00775-4","article-title":"Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report","volume":"402","author":"Mohiuddin","year":"2023","journal-title":"Lancet"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X25000828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X25000828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:52:02Z","timestamp":1779450722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X25000828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":59,"alternative-id":["S2214031X25000828"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2025.05.005","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Construction of cartilaginous organoids based on cartilage extracellular matrix microcarriers to promote articular cartilage regeneration through immune regulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2025.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}