{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:32:26Z","timestamp":1787841146201,"version":"build-2784847793"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2024-00507256"],"award-info":[{"award-number":["RS-2024-00507256"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009224","name":"Advanced Research Projects Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002647","name":"Sungkyunkwan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jot.2025.06.013","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:49:55Z","timestamp":1751384995000},"page":"221-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Why muscle strengthening exercises should target the quadriceps and gluteus maximus in patients with knee osteoarthritis?: Effects of knee pain on muscle volume and fatty degeneration based on AI-assisted cross-sectional analysis"],"prefix":"10.1016","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-1222","authenticated-orcid":false,"given":"Do Kyung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6883-5448","authenticated-orcid":false,"given":"Hyeon Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-8674","authenticated-orcid":false,"given":"Kyung Rae","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Pil","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3575-4123","authenticated-orcid":false,"given":"Jun-Il","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"issue":"10","key":"10.1016\/j.jot.2025.06.013_bib2","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.biocel.2013.06.024","article-title":"Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials","volume":"45","author":"Marzetti","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/s12877-024-05098-8","article-title":"Causal relationship between sarcopenia with osteoarthritis and the mediating role of obesity: a univariate, multivariate, two-step Mendelian randomization study","volume":"24","author":"Jin","year":"2024","journal-title":"BMC Geriatr"},{"issue":"5","key":"10.1016\/j.jot.2025.06.013_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/ar3467","article-title":"Mechanisms of quadriceps muscle weakness in knee joint osteoarthritis: the effects of prolonged vibration on torque and muscle activation in osteoarthritic and healthy control subjects","volume":"13","author":"Rice","year":"2011","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-89677-8","article-title":"Gonarthrosis related changes in quadriceps muscle architecture and physical function outcomes in women","volume":"15","author":"Ciftci","year":"2025","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.jot.2025.06.013_bib6","doi-asserted-by":"crossref","first-page":"766","DOI":"10.2519\/jospt.2013.4833","article-title":"Does quadriceps atrophy exist in individuals with patellofemoral pain? A systematic literature review with meta-analysis","volume":"43","author":"Giles","year":"2013","journal-title":"J Orthop Sports Phys Ther"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41598-023-50574-7","article-title":"Assessment of lower limb muscle strength can predict fall risk in patients with chronic liver disease","volume":"14","author":"Takada","year":"2024","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jot.2025.06.013_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.7326\/0003-4819-127-2-199707150-00001","article-title":"Quadriceps weakness and osteoarthritis of the knee","volume":"127","author":"Slemenda","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jot.2025.06.013_bib9","series-title":"StatPearls","article-title":"Venous insufficiency","author":"Patel","year":"2025"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1148\/radiol.212771","article-title":"Role of thigh muscle changes in knee osteoarthritis outcomes: osteoarthritis initiative data","volume":"305","author":"Mohajer","year":"2022","journal-title":"Radiology"},{"issue":"9","key":"10.1016\/j.jot.2025.06.013_bib11","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1109\/TMI.2024.3398728","article-title":"UNETR++: delving into efficient and accurate 3D medical image segmentation","volume":"43","author":"Shaker","year":"2024","journal-title":"IEEE Trans Med Imag"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib12","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1038\/s41598-024-53707-8","article-title":"Precise individual muscle segmentation in whole thigh CT scans for sarcopenia assessment using U-net transformer","volume":"14","author":"Kim","year":"2024","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.jot.2025.06.013_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0296073","article-title":"Computed tomography evaluation of skeletal muscle quality and quantity in people with morbid obesity with and without metabolic abnormality","volume":"18","author":"Oh","year":"2023","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jot.2025.06.013_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1519\/00139143-200932020-00008","article-title":"Sarcopenia--mechanisms and treatments","volume":"32","author":"Jones","year":"2009","journal-title":"J Geriatr Phys Ther"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib15","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1186\/s13018-024-05109-9","article-title":"High expression of transcription factor EGR1 is associated with postoperative muscle atrophy in patients with knee osteoarthritis undergoing total knee arthroplasty","volume":"19","author":"Liu","year":"2024","journal-title":"J Orthop Surg Res"},{"issue":"4","key":"10.1016\/j.jot.2025.06.013_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196682","article-title":"Muscle wasting in osteoarthritis model induced by anterior cruciate ligament transection","volume":"13","author":"Silva","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jot.2025.06.013_bib17","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.joca.2012.02.635","article-title":"Side differences of thigh muscle cross-sectional areas and maximal isometric muscle force in bilateral knees with the same radiographic disease stage, but unilateral frequent pain - data from the osteoarthritis initiative","volume":"20","author":"Sattler","year":"2012","journal-title":"Osteoarthr Cartil"},{"issue":"11","key":"10.1016\/j.jot.2025.06.013_bib18","doi-asserted-by":"crossref","first-page":"C932","DOI":"10.1152\/ajpcell.00014.2015","article-title":"Chronic disuse and skeletal muscle structure in older adults: sex-specific differences and relationships to contractile function","volume":"308","author":"Callahan","year":"2015","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jot.2025.06.013_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.794062","article-title":"Benefits and mechanisms of exercise training for knee osteoarthritis","volume":"12","author":"Zeng","year":"2021","journal-title":"Front Physiol"},{"issue":"6","key":"10.1016\/j.jot.2025.06.013_bib20","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1002\/jcsm.13067","article-title":"The time course of disuse muscle atrophy of the lower limb in health and disease","volume":"13","author":"Hardy","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12160-012-9353-x","article-title":"Avoidance of activities in early symptomatic knee osteoarthritis: results from the CHECK cohort","volume":"44","author":"Holla","year":"2012","journal-title":"Ann Behav Med"},{"issue":"11","key":"10.1016\/j.jot.2025.06.013_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25115715","article-title":"Inflammatory cytokine-induced muscle atrophy and weakness can Be ameliorated by an inhibition of TGF-beta-activated kinase-1","volume":"25","author":"Kanai","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"13","key":"10.1016\/j.jot.2025.06.013_bib23","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.2174\/0929867326666181129095309","article-title":"Role of pro-inflammatory cytokines in regulation of skeletal muscle metabolism: a systematic review","volume":"27","author":"Sharma","year":"2020","journal-title":"Curr Med Chem"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12010009","article-title":"Pathogenic mechanisms and therapeutic approaches in obesity-related knee osteoarthritis","volume":"12","author":"Shumnalieva","year":"2023","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.jot.2025.06.013_bib25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4085\/1062-6050-48.2.10","article-title":"Pain and effusion and quadriceps activation and strength","volume":"48","author":"Palmieri-Smith","year":"2013","journal-title":"J Athl Train"},{"issue":"3","key":"10.1016\/j.jot.2025.06.013_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13195","article-title":"The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability","volume":"225","author":"Rodrigues","year":"2019","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.jot.2025.06.013_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101463","article-title":"Shared and distinct mechanisms of skeletal muscle atrophy: a narrative review","volume":"71","author":"Wilburn","year":"2021","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jot.2025.06.013_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.673404","article-title":"Evolving roles of muscle-resident fibro-adipogenic progenitors in health, regeneration, neuromuscular disorders, and aging","volume":"12","author":"Theret","year":"2021","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s42003-023-04504-y","article-title":"MME(+) fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle","volume":"6","author":"Fitzgerald","year":"2023","journal-title":"Commun Biol"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12891-025-08347-y","article-title":"Differences in fatty infiltration in thigh muscles and physical function between people with and without knee osteoarthritis and similar body mass index: a cross-sectional study","volume":"26","author":"Aily","year":"2025","journal-title":"BMC Muscoskelet Disord"},{"issue":"4","key":"10.1016\/j.jot.2025.06.013_bib31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00296-019-04271-2","article-title":"Fatty infiltration in the thigh muscles in knee osteoarthritis: a systematic review and meta-analysis","volume":"39","author":"Pedroso","year":"2019","journal-title":"Rheumatol Int"},{"issue":"4","key":"10.1016\/j.jot.2025.06.013_bib32","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.2214\/AJR.07.2835","article-title":"Atrophy and fatty infiltration of the supraspinatus muscle: sonography versus MRI","volume":"190","author":"Khoury","year":"2008","journal-title":"AJR Am J Roentgenol"},{"issue":"5","key":"10.1016\/j.jot.2025.06.013_bib33","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/0363546506297539","article-title":"Fatty infiltration and atrophy of the rotator cuff do not improve after rotator cuff repair and correlate with poor functional outcome","volume":"35","author":"Gladstone","year":"2007","journal-title":"Am J Sports Med"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-46558-2","article-title":"Knee osteoarthritis with a high grade of Kellgren-Lawrence score is associated with a worse frailty status, KNHANES 2010-2013","volume":"13","author":"Joo","year":"2023","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5371\/hp.2022.34.1.18","article-title":"Does fracture severity of intertrochanteric fracture in elderly caused by low-energy trauma affected by gluteus muscle volume?","volume":"34","author":"Kim","year":"2022","journal-title":"Hip Pelvis"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41584-020-00523-9","article-title":"Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines","volume":"17","author":"Arden","year":"2021","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"10.1016\/j.jot.2025.06.013_bib37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1136\/bjsports-2018-099683","article-title":"Does adding hip exercises to quadriceps exercises result in superior outcomes in pain, function and quality of life for people with knee osteoarthritis? A systematic review and meta-analysis","volume":"54","author":"Hislop","year":"2020","journal-title":"Br J Sports Med"},{"issue":"9","key":"10.1016\/j.jot.2025.06.013_bib38","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s00167-013-2434-y","article-title":"Weak associations between structural changes on MRI and symptoms, function and muscle strength in relation to knee osteoarthritis","volume":"22","author":"Baert","year":"2014","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"7","key":"10.1016\/j.jot.2025.06.013_bib39","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/ard.2005.043653","article-title":"Relative impact of radiographic osteoarthritis and pain on quadriceps strength, proprioception, static postural sway and lower limb function","volume":"65","author":"Hall","year":"2006","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.jot.2025.06.013_bib40","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1097\/PHM.0000000000000262","article-title":"Is pain in one knee associated with isometric muscle strength in the contralateral limb?: data from the osteoarthritis initiative","volume":"94","author":"Steidle-Kloc","year":"2015","journal-title":"Am J Phys Med Rehabil"},{"issue":"10","key":"10.1016\/j.jot.2025.06.013_bib41","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/ard.57.10.588","article-title":"Quadriceps weakness in knee osteoarthritis: the effect on pain and disability","volume":"57","author":"O'Reilly","year":"1998","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"10.1016\/j.jot.2025.06.013_bib42","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2519\/jospt.2021.9735","article-title":"Recent injury, severe radiographic change, and lower quadriceps strength increase risk of knee pain exacerbation during walking: a within-person knee-matched study","volume":"51","author":"Liu","year":"2021","journal-title":"J Orthop Sports Phys Ther"},{"issue":"1","key":"10.1016\/j.jot.2025.06.013_bib43","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1177\/03635465231209987","article-title":"Incidence of and risk factors for arthrogenic muscle inhibition in acute anterior cruciate ligament injuries: a cross-sectional study and analysis of associated factors from the SANTI study group","volume":"52","author":"Sonnery-Cottet","year":"2024","journal-title":"Am J Sports Med"},{"issue":"3","key":"10.1016\/j.jot.2025.06.013_bib44","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/19417381231169285","article-title":"Neuromotor treatment of arthrogenic muscle inhibition after knee injury or surgery","volume":"16","author":"Dos Anjos","year":"2024","journal-title":"Sports Health"},{"issue":"6","key":"10.1016\/j.jot.2025.06.013_bib45","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1123\/jsr.2020-0479","article-title":"Mechanisms of arthrogenic muscle inhibition","volume":"31","author":"Lepley","year":"2022","journal-title":"J Sport Rehabil"},{"issue":"8","key":"10.1016\/j.jot.2025.06.013_bib46","doi-asserted-by":"crossref","DOI":"10.1177\/2325967118788045","article-title":"Return to level I sports after anterior cruciate ligament reconstruction: evaluation of age, sex, and readiness to return criteria","volume":"6","author":"Webster","year":"2018","journal-title":"Orthop J Sports Med"},{"issue":"5","key":"10.1016\/j.jot.2025.06.013_bib47","doi-asserted-by":"crossref","DOI":"10.1177\/23259671251317208","article-title":"A guideline for validated return-to-sport testing in everyday clinical practice: a focused review on the validity, reliability, and feasibility of tests estimating the risk of reinjury after ACL reconstruction","volume":"13","author":"Mengis","year":"2025","journal-title":"Orthop J Sports Med"},{"key":"10.1016\/j.jot.2025.06.013_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/ksa.12588","article-title":"Return to preinjury pivoting sports after anterior cruciate ligament reconstruction is different between males and females, as are the patient-reported reasons","author":"Ebert","year":"2025","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.jot.2025.06.013_bib49","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1016\/j.knee.2024.03.003","article-title":"Factors influencing outcome following total knee arthroplasty","volume":"47","author":"Al-Dadah","year":"2024","journal-title":"Knee"},{"issue":"2","key":"10.1016\/j.jot.2025.06.013_bib50","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.arth.2020.07.084","article-title":"20-Year minimum outcomes and survival rate of high-flexion versus standard total knee arthroplasty","volume":"36","author":"Kim","year":"2021","journal-title":"J Arthroplast"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X25001068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X25001068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:51:16Z","timestamp":1779450676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X25001068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":50,"alternative-id":["S2214031X25001068"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2025.06.013","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Why muscle strengthening exercises should target the quadriceps and gluteus maximus in patients with knee osteoarthritis?: Effects of knee pain on muscle volume and fatty degeneration based on AI-assisted cross-sectional analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2025.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}