{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:48:14Z","timestamp":1793296094923,"version":"4.5.0"},"reference-count":195,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82427809"],"award-info":[{"award-number":["82427809"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20374"],"award-info":[{"award-number":["U24A20374"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["KJZD20230923114612025"],"award-info":[{"award-number":["KJZD20230923114612025"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220531100408019"],"award-info":[{"award-number":["JCYJ20220531100408019"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["RCJC20231211090028053"],"award-info":[{"award-number":["RCJC20231211090028053"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jot.2025.08.008","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:31:32Z","timestamp":1757100692000},"page":"75-93","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["3D bioprinting bone\/cartilage organoids: construction, applications, and challenges"],"prefix":"10.1016","volume":"55","author":[{"given":"Deju","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruipeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3151-0607","authenticated-orcid":false,"given":"Cairong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8648-6595","authenticated-orcid":false,"given":"Yuxiao","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s42114-024-01115-x","article-title":"Advances in self-powered biomaterials for bone defect repair","volume":"8","author":"Shen","year":"2024","journal-title":"Advanced Composites and Hybrid Materials"},{"key":"10.1016\/j.jot.2025.08.008_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2024.103169","article-title":"Age-related bone diseases: role of inflammaging","volume":"143","author":"Bi","year":"2024","journal-title":"J Autoimmun"},{"issue":"17","key":"10.1016\/j.jot.2025.08.008_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303794","article-title":"Intra\u2010articular injectable biomaterials for cartilage repair and regeneration","volume":"13","author":"Kalairaj","year":"2024","journal-title":"Adv Healthcare Mater"},{"issue":"6742","key":"10.1016\/j.jot.2025.08.008_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/science.adt0548","article-title":"Osteoarthritis treatment via the GLP-1\u2013mediated gut-joint axis targets intestinal FXR signaling","volume":"388","author":"Yang","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.jot.2025.08.008_bib5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jot.2024.12.004","article-title":"T cell related osteoimmunology in fracture healing: potential targets for augmenting bone regeneration","volume":"51","author":"Wang","year":"2025","journal-title":"Journal of Orthopaedic Translation"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41413-024-00332-w","article-title":"Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections","volume":"12","author":"Qin","year":"2024","journal-title":"Bone Research"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/biot.202400699","article-title":"Osteochondral tissue engineering: scaffold materials, fabrication techniques and applications","volume":"20","author":"Wang","year":"2025","journal-title":"Biotechnol J"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib8","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1186\/s12967-024-05809-0","article-title":"Recent advances in layer-by-layer assembly scaffolds for co-delivery of bioactive molecules for bone regeneration: an updated review","volume":"22","author":"Liu","year":"2024","journal-title":"J Transl Med"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41591-024-03489-3","article-title":"Clinical applications of human organoids","volume":"31","author":"Verstegen","year":"2025","journal-title":"Nat Med"},{"issue":"8","key":"10.1016\/j.jot.2025.08.008_bib10","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.stem.2024.05.007","article-title":"Bioengineered human colon organoids with in vivo-like cellular complexity and function","volume":"31","author":"Mitrofanova","year":"2024","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.jot.2025.08.008_bib11","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.tibtech.2024.11.021","article-title":"Vascularized human brain organoids: current possibilities and prospects","volume":"43","author":"Kistemaker","year":"2025","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.jot.2025.08.008_bib12","doi-asserted-by":"crossref","DOI":"10.1177\/20417314241232502","article-title":"Advanced lung organoids for respiratory system and pulmonary disease modeling","volume":"15","author":"Joo","year":"2024","journal-title":"J Tissue Eng"},{"key":"10.1016\/j.jot.2025.08.008_bib13","first-page":"1","article-title":"Emerging biotechnologies for engineering liver organoids","volume":"45","author":"Zhao","year":"2025","journal-title":"Bioact Mater"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib14","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/adb4a1","article-title":"Application progress of bio-manufacturing technology in kidney organoids","volume":"17","author":"Mao","year":"2025","journal-title":"Biofabrication"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib15","doi-asserted-by":"crossref","DOI":"10.26599\/NR.2025.94907084","article-title":"3D bioprinted advanced cartilage organoids with engineered magnetic nanoparticles polarized-BMSCs\/alginate\/gelatin for cartilage tissue regeneration","volume":"18","author":"Ding","year":"2025","journal-title":"Nano Res"},{"issue":"5","key":"10.1016\/j.jot.2025.08.008_bib16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.stemcr.2024.03.009","article-title":"Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility","volume":"19","author":"Pamies","year":"2024","journal-title":"Stem Cell Rep"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib17","doi-asserted-by":"crossref","first-page":"682","DOI":"10.7150\/thno.105840","article-title":"Standardization and consensus in the development and application of bone organoids","volume":"15","author":"Wang","year":"2025","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib18","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.stem.2024.01.012","article-title":"A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment","volume":"31","author":"Kastenschmidt","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jot.2025.08.008_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1342340","article-title":"Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review","volume":"12","author":"Liang","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41413-024-00376-y","article-title":"Engineering bone\/cartilage organoids: strategy, progress, and application","volume":"12","author":"Bai","year":"2024","journal-title":"Bone Research"},{"issue":"22","key":"10.1016\/j.jot.2025.08.008_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400431","article-title":"Research progress in hydrogels for cartilage organoids","volume":"13","author":"Li","year":"2024","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.jot.2025.08.008_bib22","first-page":"129","article-title":"Biomaterial scaffolds in maxillofacial bone tissue engineering: a review of recent advances","volume":"33","author":"Huang","year":"2024","journal-title":"Bioact Mater"},{"issue":"34","key":"10.1016\/j.jot.2025.08.008_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202403641","article-title":"Recent advances in 3D printing of smart scaffolds for bone tissue engineering and regeneration","volume":"36","author":"Yuan","year":"2024","journal-title":"Adv Mater"},{"issue":"49","key":"10.1016\/j.jot.2025.08.008_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202408032","article-title":"3D bioprinting for engineered tissue constructs and patient\u2010specific models: current progress and prospects in clinical applications","volume":"36","author":"Lee","year":"2024","journal-title":"Adv Mater"},{"issue":"7","key":"10.1016\/j.jot.2025.08.008_bib25","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1021\/acs.chemrev.4c00070","article-title":"4D printing: a comprehensive review of technologies, materials, stimuli, design, and emerging applications","volume":"125","author":"Ding","year":"2025","journal-title":"Chem Rev"},{"key":"10.1016\/j.jot.2025.08.008_bib26","article-title":"Application and progress of 3D printed biomaterials in osteoporosis","volume":"13","author":"Wang","year":"2025","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib27","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41392-022-01194-6","article-title":"Applications of human organoids in the personalized treatment for digestive diseases","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.jot.2025.08.008_bib28","first-page":"319","article-title":"Controlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKK\u03b2\/NF-\u03baB signaling","volume":"44","author":"Chen","year":"2025","journal-title":"Bioact Mater"},{"issue":"5\u20136","key":"10.1016\/j.jot.2025.08.008_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/ten.tea.2022.0164","article-title":"ALK-5 inhibitors for efficient derivation of mesenchymal stem cells from human embryonic stem cells","volume":"29","author":"Grogan","year":"2023","journal-title":"Tissue Eng"},{"issue":"12","key":"10.1016\/j.jot.2025.08.008_bib30","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1093\/stcltm\/szac078","article-title":"Challenges facing the translation of embryonic stem cell therapy for the treatment of cartilage lesions","volume":"11","author":"Grogan","year":"2022","journal-title":"Stem Cells Translational Medicine"},{"key":"10.1016\/j.jot.2025.08.008_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107474","article-title":"ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis","volume":"209","author":"Feng","year":"2024","journal-title":"Pharmacol Res"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib32","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3390\/ijms21020581","article-title":"In vitro fabrication of hybrid bone\/cartilage complex using mouse induced pluripotent stem cells","volume":"21","author":"Limraksasin","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib33","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3390\/ijms26020804","article-title":"Fabrication of hard tissue constructs from induced pluripotent stem cells for exploring mechanisms of hereditary tooth\/skeletal dysplasia","volume":"26","author":"Kondo","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2025.08.008_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120334","article-title":"Recapitulation of cartilage\/bone formation using iPSCs via biomimetic 3D rotary culture approach for developmental engineering","volume":"260","author":"Zhang","year":"2020","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib35","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s42003-025-07658-z","article-title":"Defined culture conditions robustly maintain human stem cell pluripotency, highlighting a role for Ca2+ signaling","volume":"8","author":"Eidhof","year":"2025","journal-title":"Commun Biol"},{"issue":"5","key":"10.1016\/j.jot.2025.08.008_bib36","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.stem.2020.10.014","article-title":"CRISPR-cas tools and their application in genetic engineering of human stem cells and organoids","volume":"27","author":"Hendriks","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13287-024-03794-1","article-title":"iPSCs chondrogenic differentiation for personalized regenerative medicine: a literature review","volume":"15","author":"Ali","year":"2024","journal-title":"Stem Cell Res Ther"},{"issue":"11","key":"10.1016\/j.jot.2025.08.008_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14299","article-title":"Tissue-specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging","volume":"23","author":"Kurosawa","year":"2024","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s13287-024-03790-5","article-title":"Osteochondral organoids: current advances, applications, and upcoming challenges","volume":"15","author":"Faeed","year":"2024","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12967-024-05945-7","article-title":"Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis","volume":"23","author":"Vega-Letter","year":"2025","journal-title":"J Transl Med"},{"issue":"6","key":"10.1016\/j.jot.2025.08.008_bib41","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1242\/dev.142836","article-title":"Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone\/marrow organoid in vivo","volume":"144","author":"Pievani","year":"2017","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib42","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jcyt.2024.09.005","article-title":"Efficacy of a single dose of cryopreserved human umbilical cord mesenchymal stromal cells for the treatment of knee osteoarthritis:a randomized, controlled, double-blind pilot study","volume":"27","author":"Pico","year":"2025","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jot.2025.08.008_bib43","first-page":"339","article-title":"Periosteum-bone inspired hierarchical scaffold with endogenous piezoelectricity for neuro-vascularized bone regeneration","volume":"44","author":"Zhao","year":"2025","journal-title":"Bioact Mater"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib44","article-title":"Developmentally engineered callus organoid bioassemblies exhibit predictive in vivo long bone healing","volume":"7","author":"Nilsson","year":"2019","journal-title":"Adv Sci"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib45","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/ocr.12862","article-title":"Piezo1 promotes osteogenesis through CaMKII signalling in a rat maxillary expansion model","volume":"28","author":"He","year":"2024","journal-title":"Orthod Craniofac Res"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-021-00166-w","article-title":"Construction of developmentally inspired periosteum-like tissue for bone regeneration","volume":"10","author":"Dai","year":"2022","journal-title":"Bone Research"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202402909","article-title":"Cordycepin\u2010loaded dental pulp stem cell\u2010derived exosomes promote aged bone repair by rejuvenating senescent mesenchymal stem cells and endothelial cells","volume":"14","author":"Wang","year":"2024","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.jot.2025.08.008_bib48","first-page":"1","article-title":"Vascularization of a bone organoid using dental pulp stem cells","volume":"2023","author":"Li","year":"2023","journal-title":"Stem Cell Int"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib49","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4103\/NRR.NRR-D-23-00928","article-title":"Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins","volume":"20","author":"Hu","year":"2025","journal-title":"Neural Regeneration Research"},{"issue":"7","key":"10.1016\/j.jot.2025.08.008_bib50","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.70001","article-title":"Large\u2010scale production of expandable hepatoblast organoids and polarised hepatocyte organoids from hESCs under 3D static and dynamic suspension conditions","volume":"58","author":"Wu","year":"2025","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jot.2025.08.008_bib51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.theriogenology.2025.01.013","article-title":"Porcine endometrial epithelial organoids: generation, characterization, and the impact of stromal cells","volume":"235","author":"Li","year":"2025","journal-title":"Theriogenology"},{"issue":"25","key":"10.1016\/j.jot.2025.08.008_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202207752","article-title":"Decellularized extracellular matrix for remodeling bioengineering organoid's microenvironment","volume":"19","author":"Zhu","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.jot.2025.08.008_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112207","article-title":"Osteoformation potential of an allogenic partially demineralized bone matrix in critical-size defects in the rat calvarium","volume":"127","author":"Diallo","year":"2021","journal-title":"Mater Sci Eng C"},{"issue":"7","key":"10.1016\/j.jot.2025.08.008_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404975","article-title":"Masquelet inspired in vivo engineered extracellular matrix as functional periosteum for bone defect repair and reconstruction","volume":"14","author":"Jiang","year":"2025","journal-title":"Adv Healthcare Mater"},{"issue":"4","key":"10.1016\/j.jot.2025.08.008_bib55","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41563-021-01136-7","article-title":"Synthetic dynamic hydrogels promote degradation-independent in vitro organogenesis","volume":"21","author":"Chrisnandy","year":"2021","journal-title":"Nat Mater"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.stemcr.2024.12.001","article-title":"Chemically defined and dynamic click hydrogels support hair cell differentiation in human inner ear organoids","volume":"20","author":"Arkenberg","year":"2025","journal-title":"Stem Cell Rep"},{"issue":"7","key":"10.1016\/j.jot.2025.08.008_bib57","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1021\/acsbiomaterials.4c00574","article-title":"Hydroxyapatite nanoparticles promote the development of bone microtissues for accelerated bone regeneration by activating the FAK\/akt pathway","volume":"10","author":"Li","year":"2024","journal-title":"ACS Biomater Sci Eng"},{"issue":"30","key":"10.1016\/j.jot.2025.08.008_bib58","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202470239","article-title":"Engineering large\u2010scale self\u2010mineralizing bone organoids with bone matrix\u2010inspired hydroxyapatite hybrid bioinks","volume":"36","author":"Wang","year":"2024","journal-title":"Adv Mater"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib59","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1039\/D4TB01710B","article-title":"A composite dressing combining ultralong hydroxyapatite nanowire bio-paper and a calcium alginate hydrogel accelerates wound healing","volume":"13","author":"Zhu","year":"2025","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.jot.2025.08.008_bib60","first-page":"475","article-title":"Silicified collagen scaffold induces semaphorin 3A secretion by sensory nerves to improve in-situ bone regeneration","volume":"9","author":"Ma","year":"2022","journal-title":"Bioact Mater"},{"issue":"48","key":"10.1016\/j.jot.2025.08.008_bib61","article-title":"Stem cell\u2010recruiting injectable microgels for repairing osteoarthritis","volume":"31","author":"Lei","year":"2021","journal-title":"Adv Funct Mater"},{"issue":"7","key":"10.1016\/j.jot.2025.08.008_bib62","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/jbm.a.37694","article-title":"Fabrication of vascularized tissue\u2010engineered bone models using triaxial bioprinting","volume":"112","author":"Zhang","year":"2024","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.jot.2025.08.008_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101584","article-title":"Calcium silicate nanowires-containing multicellular bioinks for 3D bioprinting of neural-bone constructs","volume":"46","author":"Zhang","year":"2022","journal-title":"Nano Today"},{"issue":"8","key":"10.1016\/j.jot.2025.08.008_bib64","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13634","article-title":"Directed differentiation of human embryonic stem cells into parathyroid cells and establishment of parathyroid organoids","volume":"57","author":"Wang","year":"2024","journal-title":"Cell Prolif"},{"issue":"8","key":"10.1016\/j.jot.2025.08.008_bib65","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1038\/s41596-023-00847-2","article-title":"Directed differentiation of ureteric bud and collecting duct organoids from human pluripotent stem cells","volume":"18","author":"Shi","year":"2023","journal-title":"Nat Protoc"},{"issue":"5","key":"10.1016\/j.jot.2025.08.008_bib66","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/s41592-024-02172-2","article-title":"Generation of complex bone marrow organoids from human induced pluripotent stem cells","volume":"21","author":"Frenz-Wiessner","year":"2024","journal-title":"Nat Methods"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib67","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41421-024-00689-6","article-title":"Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell Discovery"},{"issue":"11","key":"10.1016\/j.jot.2025.08.008_bib68","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","article-title":"Mechanisms of bone development and repair","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"10.1016\/j.jot.2025.08.008_bib69","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202302088","article-title":"Bone organoids: recent advances and future challenges","volume":"13","author":"Zhao","year":"2023","journal-title":"Adv Healthcare Mater"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib70","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.stemcr.2016.06.004","article-title":"Immobilized WNT proteins act as a stem cell niche for tissue engineering","volume":"7","author":"Lowndes","year":"2016","journal-title":"Stem Cell Rep"},{"issue":"5","key":"10.1016\/j.jot.2025.08.008_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112509","article-title":"Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-\u03b2 signaling","volume":"42","author":"Wu","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.jot.2025.08.008_bib72","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.actbio.2020.06.046","article-title":"Engineering the cellular mechanical microenvironment to regulate stem cell chondrogenesis: insights from a microgel model","volume":"113","author":"Feng","year":"2020","journal-title":"Acta Biomater"},{"issue":"20","key":"10.1016\/j.jot.2025.08.008_bib73","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202501594","article-title":"3D printed microsphere\u2010hydrogel scaffold facilitates restoration of reinnervation in bone regeneration through programmable release of NGF\/BMP\u20102 mimetic peptides","volume":"14","author":"Zhang","year":"2025","journal-title":"Adv Healthcare Mater"},{"issue":"12","key":"10.1016\/j.jot.2025.08.008_bib74","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1016\/j.cell.2021.04.034","article-title":"Cardioids reveal self-organizing principles of human cardiogenesis","volume":"184","author":"Hofbauer","year":"2021","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.jot.2025.08.008_bib75","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1016\/j.cell.2024.05.016","article-title":"Parsing patterns: emerging roles of tissue self-organization in health and disease","volume":"187","author":"Ramos","year":"2024","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.jot.2025.08.008_bib76","doi-asserted-by":"crossref","DOI":"10.1002\/biot.202400240","article-title":"A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single\u2010cell suspension","volume":"19","author":"Kandra","year":"2024","journal-title":"Biotechnol J"},{"issue":"44","key":"10.1016\/j.jot.2025.08.008_bib77","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202410547","article-title":"Microfluidic platform for generating and releasing patient\u2010derived cancer organoids with diverse shapes: insight into shape\u2010dependent tumor growth","volume":"36","author":"Kheiri","year":"2024","journal-title":"Adv Mater"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib78","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/s41467-024-45710-4","article-title":"A microfluidic platform integrating functional vascularized organoids-on-chip","volume":"15","author":"Quintard","year":"2024","journal-title":"Nat Commun"},{"issue":"41","key":"10.1016\/j.jot.2025.08.008_bib79","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202300305","article-title":"Microfibrous scaffolds guide stem cell lumenogenesis and brain organoid engineering","volume":"35","author":"Ritzau\u2010Reid","year":"2023","journal-title":"Adv Mater"},{"issue":"6","key":"10.1016\/j.jot.2025.08.008_bib80","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.2022","article-title":"Strategies in electrospun polymer and hybrid scaffolds for enhanced cell integration and vascularization for bone tissue engineering and organoids","volume":"16","author":"Polak","year":"2024","journal-title":"WIREs Nanomedicine and Nanobiotechnology"},{"issue":"8","key":"10.1016\/j.jot.2025.08.008_bib81","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202470062","article-title":"Small joint organoids 3D bioprinting: construction strategy and application","volume":"20","author":"Zhang","year":"2024","journal-title":"Small"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib82","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202403762","article-title":"Integrating 3D bioprinting and organoids to better recapitulate the complexity of cellular microenvironments for tissue engineering","volume":"14","author":"Hu","year":"2024","journal-title":"Adv Healthcare Mater"},{"issue":"6","key":"10.1016\/j.jot.2025.08.008_bib83","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2016.02.043","article-title":"Bone and muscle endocrine functions: unexpected paradigms of inter-organ communication","volume":"164","author":"Karsenty","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jot.2025.08.008_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120627","article-title":"Recent advances in the design of implantable insulin secreting heterocellular islet organoids","volume":"269","author":"Akolpoglu","year":"2021","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.jot.2025.08.008_bib85","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202006796","article-title":"Bone\u2010on\u2010a\u2010Chip: microfluidic technologies and microphysiologic models of bone tissue","volume":"31","author":"Mansoorifar","year":"2020","journal-title":"Adv Funct Mater"},{"issue":"12","key":"10.1016\/j.jot.2025.08.008_bib86","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1016\/j.stemcr.2023.10.020","article-title":"Deriving early single-rosette brain organoids from human pluripotent stem cells","volume":"18","author":"Tidball","year":"2023","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.jot.2025.08.008_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122980","article-title":"Generation of mouse testicular organoids with highly compartmentalized tubular lumen structure and their cryopreservation","volume":"355","author":"Tan","year":"2024","journal-title":"Life Sci"},{"key":"10.1016\/j.jot.2025.08.008_bib88","doi-asserted-by":"crossref","first-page":"tkae070","DOI":"10.1093\/burnst\/tkae070","article-title":"The empowering influence of air-liquid interface culture on skin organoid hair follicle development","volume":"13","author":"Sun","year":"2025","journal-title":"Burns & Trauma"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib89","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/adac90","article-title":"In vivo vessel connection of pre-vascularised 3D-bioprinted gingival connective tissue substitutes","volume":"17","author":"Smirani","year":"2025","journal-title":"Biofabrication"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib90","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s10456-025-09972-w","article-title":"Isolated human adipose microvessels retain native microvessel structure and recapitulate sprouting angiogenesis","volume":"28","author":"Moss","year":"2025","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jot.2025.08.008_bib91","article-title":"Generation of vascularized brain organoids to study neurovascular interactions","volume":"11","author":"Ju","year":"2022","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib92","doi-asserted-by":"crossref","DOI":"10.1088\/2516-1091\/ab5637","article-title":"Vascularization in tissue engineering: fundamentals and state-of-art","volume":"2","author":"Yang","year":"2020","journal-title":"Prog Biomed Eng"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib93","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.stemcr.2018.01.041","article-title":"Renal subcapsular transplantation of PSC-derived kidney organoids induces neo-vasculogenesis and significant glomerular and tubular maturation in vivo","volume":"10","author":"van den Berg","year":"2018","journal-title":"Stem Cell Rep"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acsbiomaterials.4c01824","article-title":"Sacrificial templating for accelerating clinical translation of engineered organs","volume":"11","author":"Malkani","year":"2024","journal-title":"ACS Biomater Sci Eng"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib95","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ac6bbe","article-title":"Engineered assistive materials for 3D bioprinting: support baths and sacrificial inks","volume":"14","author":"Brunel","year":"2022","journal-title":"Biofabrication"},{"key":"10.1016\/j.jot.2025.08.008_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2025.214188","article-title":"Three-dimensional bioprinting utilizing sacrificial material support and longitudinal printability evaluation through volumetric imaging","volume":"169","author":"Yang","year":"2025","journal-title":"Biomater Adv"},{"key":"10.1016\/j.jot.2025.08.008_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2022.111012","article-title":"3D printing sacrificial templates for manufacturing hydrogel constructs with channel networks","volume":"222","author":"Pan","year":"2022","journal-title":"Mater Des"},{"key":"10.1016\/j.jot.2025.08.008_bib98","article-title":"3D bioprinting of a perfusable skin-on-chip model suitable for drug testing and wound healing studies","volume":"33","author":"Maggiotto","year":"2025","journal-title":"Mater Today Bio"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib99","doi-asserted-by":"crossref","DOI":"10.1063\/1.5056188","article-title":"3D bioprinting for high-throughput screening: drug screening, disease modeling, and precision medicine applications","volume":"6","author":"Mazzocchi","year":"2019","journal-title":"Appl Phys Rev"},{"issue":"21","key":"10.1016\/j.jot.2025.08.008_bib100","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202302502","article-title":"A pillar and perfusion plate platform for robust human organoid culture and analysis","volume":"13","author":"Kang","year":"2023","journal-title":"Adv Healthcare Mater"},{"issue":"8","key":"10.1016\/j.jot.2025.08.008_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.device.2024.100420","article-title":"Ultra-small tissue-compatible organoid printer for rapid and controllable modeling of respiratory organoids","volume":"2","author":"Yang","year":"2024","journal-title":"Device"},{"issue":"8","key":"10.1016\/j.jot.2025.08.008_bib102","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1039\/D1LC00003A","article-title":"The acoustic droplet printing of functional tumor microenvironments","volume":"21","author":"Chen","year":"2021","journal-title":"Lab Chip"},{"issue":"12","key":"10.1016\/j.jot.2025.08.008_bib103","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1039\/C9LC01184F","article-title":"The emerging role of microfluidics in multi-material 3D bioprinting","volume":"20","author":"Richard","year":"2020","journal-title":"Lab Chip"},{"key":"10.1016\/j.jot.2025.08.008_bib104","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.eng.2024.01.028","article-title":"Process, material, and regulatory considerations for 3D printed medical devices and tissue constructs","volume":"36","author":"Ng","year":"2024","journal-title":"Engineering"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib105","doi-asserted-by":"crossref","DOI":"10.1080\/17452759.2024.2384662","article-title":"Recent advances in 3D bioprinting of tissues and organs for transplantation and drug screening","volume":"19","author":"Sun","year":"2024","journal-title":"Virtual Phys Prototyp"},{"issue":"6675","key":"10.1016\/j.jot.2025.08.008_bib106","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1126\/science.adi1563","article-title":"Self-enhancing sono-inks enable deep-penetration acoustic volumetric printing","volume":"382","author":"Kuang","year":"2023","journal-title":"Science"},{"issue":"19","key":"10.1016\/j.jot.2025.08.008_bib107","doi-asserted-by":"crossref","first-page":"10793","DOI":"10.1021\/acs.chemrev.0c00008","article-title":"Inkjet bioprinting of biomaterials","volume":"120","author":"Li","year":"2020","journal-title":"Chem Rev"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib108","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ada8e2","article-title":"Pneumatic conveying inkjet bioprinting for the processing of living cells","volume":"17","author":"Bo\u017cek","year":"2025","journal-title":"Biofabrication"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib109","first-page":"245","article-title":"Distinct toxicity of microplastics\/TBBPA co-exposure to bioprinted liver organoids derived from hiPSCs of healthy and patient donors","volume":"10","author":"Liang","year":"2024","journal-title":"International Journal of Bioprinting"},{"key":"10.1016\/j.jot.2025.08.008_bib110","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biomaterials.2016.06.012","article-title":"A comprehensive review on droplet-based bioprinting: past, present and future","volume":"102","author":"Gudapati","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2025.08.008_bib111","first-page":"356","article-title":"Embedded 3D bioprinting \u2013 an emerging strategy to fabricate biomimetic & large vascularized tissue constructs","volume":"32","author":"Budharaju","year":"2024","journal-title":"Bioact Mater"},{"issue":"7","key":"10.1016\/j.jot.2025.08.008_bib112","article-title":"A 3D\u2010bioprinted multiple myeloma model","volume":"11","author":"Wu","year":"2021","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.jot.2025.08.008_bib113","first-page":"257","article-title":"3-D bioprinted human-derived skin organoids accelerate full-thickness skin defects repair","volume":"42","author":"Zhang","year":"2024","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2025.08.008_bib114","first-page":"1","article-title":"Microfluidic intestinal organoid-on-a-chip uncovers therapeutic targets by recapitulating oxygen dynamics of intestinal IR injury","volume":"30","author":"Huang","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2025.08.008_bib115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jot.2024.12.003","article-title":"Role of YAP\/TAZ in bone diseases: a transductor from mechanics to biology","volume":"51","author":"Chen","year":"2025","journal-title":"Journal of Orthopaedic Translation"},{"issue":"7","key":"10.1016\/j.jot.2025.08.008_bib116","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.eng.2020.05.021","article-title":"Visible light-induced 3D bioprinting technologies and corresponding bioink materials for tissue engineering: a review","volume":"7","author":"Zheng","year":"2021","journal-title":"Engineering"},{"issue":"2\u20133","key":"10.1016\/j.jot.2025.08.008_bib117","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s00542-004-0468-2","article-title":"Laser scanning path generation considering photopolymer solidification in micro-stereolithography","volume":"11","author":"Cho","year":"2005","journal-title":"Microsyst Technol"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib118","first-page":"110","article-title":"Photo-curing 3D printing technique and its challenges","volume":"5","author":"Quan","year":"2020","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2025.08.008_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121741","article-title":"High-efficient engineering of osteo-callus organoids for rapid bone regeneration within one month","volume":"288","author":"Xie","year":"2022","journal-title":"Biomaterials"},{"issue":"49","key":"10.1016\/j.jot.2025.08.008_bib120","article-title":"Optimized photoclick (Bio)Resins for fast volumetric bioprinting","volume":"33","author":"Rizzo","year":"2021","journal-title":"Adv Mater"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib121","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/adab25","article-title":"Volumetric bioprinting of the osteoid niche","volume":"17","author":"Duquesne","year":"2025","journal-title":"Biofabrication"},{"issue":"15","key":"10.1016\/j.jot.2025.08.008_bib122","article-title":"Volumetric bioprinting of organoids and optically tuned hydrogels to build liver\u2010like metabolic biofactories","volume":"34","author":"Bernal","year":"2022","journal-title":"Adv Mater"},{"issue":"13","key":"10.1016\/j.jot.2025.08.008_bib123","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202102784","article-title":"Acoustic bioprinting of patient\u2010derived organoids for predicting cancer therapy responses","volume":"11","author":"Chen","year":"2022","journal-title":"Adv Healthcare Mater"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib124","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.tibtech.2023.09.001","article-title":"Printhead on a chip: empowering droplet-based bioprinting with microfluidics","volume":"42","author":"Zhang","year":"2024","journal-title":"Trends Biotechnol"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib125","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/abca80","article-title":"Microfluidic-assisted bioprinting of tissues and organoids at high cell concentrations","volume":"13","author":"Serex","year":"2021","journal-title":"Biofabrication"},{"issue":"10","key":"10.1016\/j.jot.2025.08.008_bib126","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw5111","article-title":"Aspiration-assisted bioprinting for precise positioning of biologics","volume":"6","author":"Ayan","year":"2020","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib127","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/abc1bf","article-title":"Aspiration-assisted bioprinting of co-cultured osteogenic spheroids for bone tissue engineering","volume":"13","author":"Heo","year":"2020","journal-title":"Biofabrication"},{"key":"10.1016\/j.jot.2025.08.008_bib128","doi-asserted-by":"crossref","DOI":"10.1089\/ten.teb.2024.0168","article-title":"Advancing cartilage tissue engineering: a review of 3D bioprinting approaches and bioink properties","author":"Boretti","year":"2024","journal-title":"Tissue Eng B Rev"},{"issue":"23","key":"10.1016\/j.jot.2025.08.008_bib129","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252312567","article-title":"Photocrosslinkable biomaterials for 3D bioprinting: mechanisms, recent advances, and future prospects","volume":"25","author":"Lai","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib130","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14671","article-title":"Structural basis of homo- and heterotrimerization of collagen I","volume":"8","author":"Sharma","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jot.2025.08.008_bib131","article-title":"Silk based bio\u2013inks for medical applications","volume":"196","author":"Anant","year":"2023","journal-title":"Eur Polym J"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib132","doi-asserted-by":"crossref","DOI":"10.1088\/2516-1091\/ad2d59","article-title":"Trends and advances in silk based 3D printing\/bioprinting towards cartilage tissue engineering and regeneration","volume":"6","author":"Singh","year":"2024","journal-title":"Prog Biomed Eng"},{"key":"10.1016\/j.jot.2025.08.008_bib133","first-page":"429","article-title":"Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor","volume":"35","author":"Shen","year":"2024","journal-title":"Bioact Mater"},{"issue":"6","key":"10.1016\/j.jot.2025.08.008_bib134","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1039\/D4TB01060D","article-title":"Collagen as a bio-ink for 3D printing: a critical review","volume":"13","author":"Debnath","year":"2025","journal-title":"J Mater Chem B"},{"issue":"26","key":"10.1016\/j.jot.2025.08.008_bib135","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300905","article-title":"Embedded bioprinting of breast tumor cells and organoids using low\u2010concentration collagen\u2010based bioinks","volume":"12","author":"Shi","year":"2023","journal-title":"Adv Healthcare Mater"},{"issue":"9","key":"10.1016\/j.jot.2025.08.008_bib136","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw2459","article-title":"Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels","volume":"5","author":"Skylar-Scott","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.jot.2025.08.008_bib137","first-page":"197","article-title":"Structural and biological engineering of 3D hydrogels for wound healing","volume":"24","author":"Norahan","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2025.08.008_bib138","first-page":"392","article-title":"3D bioprinting of high-performance hydrogel with in-situ birth of stem cell spheroids","volume":"43","author":"Zhu","year":"2025","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2025.08.008_bib139","article-title":"Alginate, hyaluronic acid, and chitosan-based 3D printing hydrogel for cartilage tissue regeneration","volume":"202","author":"Jo","year":"2024","journal-title":"Eur Polym J"},{"key":"10.1016\/j.jot.2025.08.008_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123450","article-title":"Modification, 3D printing process and application of sodium alginate based hydrogels in soft tissue engineering: a review","volume":"232","author":"Wei","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jot.2025.08.008_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2021.102436","article-title":"State-of-the-art of 3D printing technology of alginate-based hydrogels\u2014an emerging technique for industrial applications","volume":"293","author":"Mallakpour","year":"2021","journal-title":"Adv Colloid Interface Sci"},{"issue":"5","key":"10.1016\/j.jot.2025.08.008_bib142","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13465","article-title":"In vitro construction of liver organoids with biomimetic lobule structure by a multicellular 3D bioprinting strategy","volume":"56","author":"Jian","year":"2023","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jot.2025.08.008_bib143","first-page":"511","article-title":"Biomaterials\/bioinks and extrusion bioprinting","volume":"28","author":"Chen","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2025.08.008_bib144","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.actbio.2022.06.036","article-title":"Hyaluronic acid methacrylate\/pancreatic extracellular matrix as a potential 3D printing bioink for constructing islet organoids","volume":"165","author":"Wang","year":"2023","journal-title":"Acta Biomater"},{"issue":"6","key":"10.1016\/j.jot.2025.08.008_bib145","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1021\/acsbiomaterials.3c00299","article-title":"Hyaluronic acid as bioink and hydrogel scaffolds for tissue engineering applications","volume":"9","author":"Sekar","year":"2023","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.jot.2025.08.008_bib146","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128504","article-title":"The fabrication of the chitosan-based bioink for in vitro tissue repair and regeneration: a review","volume":"257","author":"Zhang","year":"2024","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib147","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1021\/acsabm.4c01476","article-title":"3D printing of a self-healing, bioactive, and dual-cross-linked polysaccharide-based composite hydrogel as a scaffold for bone tissue engineering","volume":"8","author":"Nasiripour","year":"2025","journal-title":"ACS Appl Bio Mater"},{"issue":"18","key":"10.1016\/j.jot.2025.08.008_bib148","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202100581","article-title":"Promoting long\u2010term cultivation of motor neurons for 3D neuromuscular junction formation of 3D in vitro using central\u2010nervous\u2010tissue\u2010derived bioink","volume":"10","author":"Kong","year":"2021","journal-title":"Adv Healthcare Mater"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib149","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ad51a6","article-title":"3D bioprinting platform development for high-throughput cancer organoid models construction and drug evaluation","volume":"16","author":"Dai","year":"2024","journal-title":"Biofabrication"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib150","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/s42003-021-02910-8","article-title":"Towards organoid culture without Matrigel","volume":"4","author":"Kozlowski","year":"2021","journal-title":"Commun Biol"},{"key":"10.1016\/j.jot.2025.08.008_bib151","article-title":"A vascularized in vivo melanoma model suitable for metastasis research of different tumor stages using fundamentally different bioinks","volume":"26","author":"Schmid","year":"2024","journal-title":"Mater Today Bio"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib152","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10327","article-title":"Extracellular matrix bioink boosts stemness and facilitates transplantation of intestinal organoids as a biosafe Matrigel alternative","volume":"8","author":"Xu","year":"2022","journal-title":"Bioengineering & Translational Medicine"},{"issue":"11","key":"10.1016\/j.jot.2025.08.008_bib153","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202409886","article-title":"Material\u2010mediated immunotherapy to regulate bone aging and promote bone repair","volume":"21","author":"Xue","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.jot.2025.08.008_bib154","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1117647","article-title":"Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration","volume":"11","author":"Sun","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"issue":"48","key":"10.1016\/j.jot.2025.08.008_bib155","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201910282","article-title":"PEG\/HA hybrid hydrogels for biologically and mechanically tailorable bone marrow organoids","volume":"30","author":"Vallmajo\u2010Martin","year":"2020","journal-title":"Adv Funct Mater"},{"issue":"10","key":"10.1016\/j.jot.2025.08.008_bib156","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300843","article-title":"Undifferentiated human amniotic fluid progenitor cells promote bone regeneration in vivo","volume":"14","author":"Vallmajo\u2010Martin","year":"2025","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.jot.2025.08.008_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.bprint.2022.e00247","article-title":"Enhancing cell survival in 3D printing of organoids using innovative bioinks loaded with pre-cellularized porous microscaffolds","volume":"28","author":"Rousselle","year":"2022","journal-title":"Bioprinting"},{"issue":"10","key":"10.1016\/j.jot.2025.08.008_bib158","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1021\/acsbiomaterials.6b00196","article-title":"3D-Bioprinting of polylactic acid (PLA) nanofiber\u2013alginate hydrogel bioink containing human adipose-derived stem cells","volume":"2","author":"Narayanan","year":"2016","journal-title":"ACS Biomater Sci Eng"},{"issue":"13","key":"10.1016\/j.jot.2025.08.008_bib159","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202109810","article-title":"3D printing of cell\u2010laden microgel\u2010based biphasic bioink with heterogeneous microenvironment for biomedical applications","volume":"32","author":"Fang","year":"2021","journal-title":"Adv Funct Mater"},{"issue":"16","key":"10.1016\/j.jot.2025.08.008_bib160","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1039\/D2BM00632D","article-title":"Photoclick polysaccharide-based bioinks with an extended biofabrication window for 3D embedded bioprinting","volume":"10","author":"Zhou","year":"2022","journal-title":"Biomater Sci"},{"key":"10.1016\/j.jot.2025.08.008_bib161","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.actbio.2022.08.014","article-title":"Nanocomposite bioinks for 3D bioprinting","volume":"151","author":"Cai","year":"2022","journal-title":"Acta Biomater"},{"issue":"15","key":"10.1016\/j.jot.2025.08.008_bib162","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201901798","article-title":"Dynamic bioinks to advance bioprinting","volume":"9","author":"Morgan","year":"2020","journal-title":"Adv Healthcare Mater"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib163","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/abdc86","article-title":"GelMA\/bioactive silica nanocomposite bioinks for stem cell osteogenic differentiation","volume":"13","author":"Tavares","year":"2021","journal-title":"Biofabrication"},{"key":"10.1016\/j.jot.2025.08.008_bib164","first-page":"388","article-title":"Protocol for engineering bone organoids from mesenchymal stem cells","volume":"45","author":"Wang","year":"2025","journal-title":"Bioact Mater"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib165","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ac73b9","article-title":"Long-term mechanical loading is required for the formation of 3D bioprinted functional osteocyte bone organoids","volume":"14","author":"Zhang","year":"2022","journal-title":"Biofabrication"},{"issue":"37","key":"10.1016\/j.jot.2025.08.008_bib166","doi-asserted-by":"crossref","first-page":"43492","DOI":"10.1021\/acsami.3c08550","article-title":"Engineering highly vascularized bone tissues by 3D bioprinting of granular prevascularized spheroids","volume":"15","author":"Fang","year":"2023","journal-title":"ACS Appl Mater Interfaces"},{"issue":"16","key":"10.1016\/j.jot.2025.08.008_bib167","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202501376","article-title":"3D bioprinting of prevascularized bone organoids for rapid in situ cranial bone reconstruction","volume":"14","author":"Duan","year":"2025","journal-title":"Adv Healthcare Mater"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib168","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13018-025-05604-7","article-title":"Bio-3D printing of scaffold-free ADSC-derived cartilage constructs comparable to natural cartilage in vitro","volume":"20","author":"Nonaka","year":"2025","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib169","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ac42de","article-title":"Dynamic hyaluronic acid hydrogel with covalent linked gelatin as an anti-oxidative bioink for cartilage tissue engineering","volume":"14","author":"Shi","year":"2021","journal-title":"Biofabrication"},{"key":"10.1016\/j.jot.2025.08.008_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121750","article-title":"Spatial patterning of phenotypically distinct microtissues to engineer osteochondral grafts for biological joint resurfacing","volume":"289","author":"Burdis","year":"2022","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.jot.2025.08.008_bib171","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1021\/acsbiomaterials.4c00819","article-title":"Rapidly degrading hydrogels to support biofabrication and 3D bioprinting using cartilage microtissues","volume":"10","author":"Kronemberger","year":"2024","journal-title":"ACS Biomater Sci Eng"},{"issue":"4","key":"10.1016\/j.jot.2025.08.008_bib172","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ad6e1a","article-title":"Laser-assisted bioprinting of targeted cartilaginous spheroids for high density bottom-up tissue engineering","volume":"16","author":"Hall","year":"2024","journal-title":"Biofabrication"},{"key":"10.1016\/j.jot.2025.08.008_bib173","first-page":"200","article-title":"In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units","volume":"27","author":"Yang","year":"2023","journal-title":"Bioact Mater"},{"issue":"46","key":"10.1016\/j.jot.2025.08.008_bib174","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202104159","article-title":"Bioinspired development of an in vitro engineered fracture callus for the treatment of critical long bone defects","volume":"31","author":"Bolander","year":"2021","journal-title":"Adv Funct Mater"},{"issue":"7","key":"10.1016\/j.jot.2025.08.008_bib175","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1038\/s41596-024-00971-7","article-title":"Generating human bone marrow organoids for disease modeling and drug discovery","volume":"19","author":"Olijnik","year":"2024","journal-title":"Nat Protoc"},{"issue":"5","key":"10.1016\/j.jot.2025.08.008_bib176","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/s41592-024-02172-2","article-title":"Generation of complex bone marrow organoids from human induced pluripotent stem cells","volume":"21","author":"Frenz-Wiessner","year":"2024","journal-title":"Nat Methods"},{"issue":"2","key":"10.1016\/j.jot.2025.08.008_bib177","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1158\/2159-8290.CD-22-0199","article-title":"Human bone marrow organoids for disease modeling, discovery, and validation of therapeutic targets in hematologic malignancies","volume":"13","author":"Khan","year":"2023","journal-title":"Cancer Discov"},{"issue":"10","key":"10.1016\/j.jot.2025.08.008_bib178","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.3390\/ijms23105788","article-title":"Towards 3D bioprinted spinal cord organoids","volume":"23","author":"Han","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.jot.2025.08.008_bib179","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1021\/acsnano.4c11960","article-title":"Micro\/nanobiomimetic iron-based scaffold induces vascularized bone regeneration to repair large segmental bone defect in load-bearing sites","volume":"19","author":"Yuan","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.jot.2025.08.008_bib180","article-title":"Biomaterial-assisted organoid technology for disease modeling and drug screening","volume":"30","author":"Shao","year":"2025","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.jot.2025.08.008_bib181","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177368","article-title":"Current applications, future Perspectives and challenges of Organoid technology in oral cancer research","volume":"993","author":"Wang","year":"2025","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"10.1016\/j.jot.2025.08.008_bib182","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3390\/cells12121590","article-title":"Organoids as innovative models for bone and joint diseases","volume":"12","author":"Huang","year":"2023","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.jot.2025.08.008_bib183","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.stem.2024.09.001","article-title":"A human organoid drug screen identifies \u03b12-adrenergic receptor signaling as a therapeutic target for cartilage regeneration","volume":"31","author":"Wei","year":"2024","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib184","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.274","article-title":"Organoids: the current status and biomedical applications","volume":"4","author":"Yang","year":"2023","journal-title":"MedComm"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib185","doi-asserted-by":"crossref","first-page":"6311","DOI":"10.1038\/s41467-023-41990-4","article-title":"Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation","volume":"14","author":"Robin","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jot.2025.08.008_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140483","article-title":"Protein bioactive complexes promote osteogenesis under microgravity environment","volume":"303","author":"Kabir","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jot.2025.08.008_bib187","first-page":"1","article-title":"The search for the ultimate exercise countermeasure to preserve crew health and ensure mission success in long\u2010duration spaceflight","author":"Fernandez\u2010Gonzalo","year":"2025","journal-title":"Exp Physiol"},{"issue":"3","key":"10.1016\/j.jot.2025.08.008_bib188","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.stem.2023.01.008","article-title":"Reversal of malignant ADAR1 splice isoform switching with Rebecsinib","volume":"30","author":"Crews","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"34","key":"10.1016\/j.jot.2025.08.008_bib189","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202309618","article-title":"Satellite\u2010based on\u2010orbit printing of 3D tumor models","volume":"36","author":"Mo","year":"2023","journal-title":"Adv Mater"},{"issue":"1","key":"10.1016\/j.jot.2025.08.008_bib190","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-022-00190-4","article-title":"Mechanical regulation of bone remodeling","volume":"10","author":"Wang","year":"2022","journal-title":"Bone Research"},{"issue":"4","key":"10.1016\/j.jot.2025.08.008_bib191","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s13391-025-00561-z","article-title":"3D organoid culturing devices to induce in vitro models of human intestinal inflammation","volume":"21","author":"Nam","year":"2025","journal-title":"Electron Mater Lett"},{"issue":"43","key":"10.1016\/j.jot.2025.08.008_bib192","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq6900","article-title":"Microfluidic bioprinting of tough hydrogel-based vascular conduits for functional blood vessels","volume":"8","author":"Wang","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.jot.2025.08.008_bib193","doi-asserted-by":"crossref","first-page":"25","DOI":"10.34133\/bmr.0025","article-title":"Superior induced pluripotent stem cell generation through phactr3-driven mechanomodulation of both early and late phases of cell reprogramming","volume":"28","author":"Chowdhury","year":"2024","journal-title":"Biomater Res"},{"issue":"8","key":"10.1016\/j.jot.2025.08.008_bib194","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/s41556-023-01193-x","article-title":"A fast chemical reprogramming system promotes cell identity transition through a diapause-like state","volume":"25","author":"Chen","year":"2023","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jot.2025.08.008_bib195","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/s41589-024-01799-8","article-title":"A rapid chemical reprogramming system to generate human pluripotent stem cells","volume":"21","author":"Wang","year":"2025","journal-title":"Nat Chem Biol"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X2500138X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X2500138X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:40:06Z","timestamp":1772901606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X2500138X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":195,"alternative-id":["S2214031X2500138X"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2025.08.008","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3D bioprinting bone\/cartilage organoids: construction, applications, and challenges","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2025.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}