{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:11:14Z","timestamp":1783015874103,"version":"3.54.6"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402797"],"award-info":[{"award-number":["82402797"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070255"],"award-info":[{"award-number":["82070255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971077"],"award-info":[{"award-number":["31971077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000797"],"award-info":[{"award-number":["82000797"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102244"],"award-info":[{"award-number":["82102244"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472493"],"award-info":[{"award-number":["82472493"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jot.2025.101039","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:45:08Z","timestamp":1768221908000},"page":"101039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6300-0154","authenticated-orcid":false,"given":"Zhenyu","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanqi","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcheng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changnan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10469","key":"10.1016\/j.jot.2025.101039_bib1","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1016\/S0140-6736(24)01446-6","article-title":"The burden of diseases, injuries, and risk factors by state in the USA, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"404","author":"GuboD","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jot.2025.101039_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100978","article-title":"Intervertebral disc ageing and degeneration: the antiapoptotic effect of oestrogen","volume":"57","author":"Yang","year":"2020","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jot.2025.101039_bib3","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.2147\/JPR.S501083","article-title":"Impact of socioeconomic status on the risk of intervertebral disc degeneration and low back pain in the European population and the mediating role of obesity-related traits: evidence from a Mendelian randomization study","volume":"18","author":"Long","year":"2025","journal-title":"J Pain Res"},{"issue":"10440","key":"10.1016\/j.jot.2025.101039_bib4","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/S0140-6736(24)00685-8","article-title":"Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the global burden of disease study 2021","volume":"403","author":"Collaborators","year":"2024","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jot.2025.101039_bib5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.arr.2007.08.001","article-title":"The cell biology of intervertebral disc aging and degeneration","volume":"6","author":"Zhao","year":"2007","journal-title":"Ageing Res Rev"},{"issue":"4","key":"10.1016\/j.jot.2025.101039_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/jsp2.70011","article-title":"Targeting nucleus pulposus cell death in the treatment of intervertebral disc degeneration","volume":"7","author":"Sun","year":"2024","journal-title":"JOR Spine"},{"issue":"11","key":"10.1016\/j.jot.2025.101039_bib7","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1080\/15548627.2021.1872227","article-title":"HIF1A alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy","volume":"17","author":"He","year":"2021","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.jot.2025.101039_bib8","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s12276-022-00753-9","article-title":"Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-beta-mediated Smad2\/3 phosphorylation","volume":"54","author":"Chen","year":"2022","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jot.2025.101039_bib9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jare.2024.06.010","article-title":"Pyroptosis: a spoiler of peaceful coexistence between cells in degenerative bone and joint diseases","volume":"71","author":"Li","year":"2025","journal-title":"J Adv Res"},{"issue":"2","key":"10.1016\/j.jot.2025.101039_bib10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s12276-022-00729-9","article-title":"Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis","volume":"54","author":"Zhang","year":"2022","journal-title":"Exp Mol Med"},{"issue":"1","key":"10.1016\/j.jot.2025.101039_bib11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41413-024-00317-9","article-title":"Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx","volume":"12","author":"Xiang","year":"2024","journal-title":"Bone Res"},{"issue":"1","key":"10.1016\/j.jot.2025.101039_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41583-018-0093-1","article-title":"Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases","volume":"20","author":"Yuan","year":"2019","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"10.1016\/j.jot.2025.101039_bib13","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell Mol Immunol"},{"issue":"3","key":"10.1016\/j.jot.2025.101039_bib14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.immuni.2013.06.018","article-title":"The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism","volume":"39","author":"Murphy","year":"2013","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jot.2025.101039_bib15","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.cell.2014.04.019","article-title":"RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis","volume":"157","author":"Rickard","year":"2014","journal-title":"Cell"},{"issue":"20","key":"10.1016\/j.jot.2025.101039_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015292","article-title":"Role of necroptosis in intervertebral disc degeneration","volume":"24","author":"Khaleque","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.jot.2025.101039_bib17","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s10495-017-1358-2","article-title":"RIPK1\/RIPK3\/MLKL-mediated necroptosis contributes to compression-induced rat nucleus pulposus cells death","volume":"22","author":"Chen","year":"2017","journal-title":"Apoptosis"},{"issue":"11","key":"10.1016\/j.jot.2025.101039_bib18","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1038\/nm.3739","article-title":"Ubiquitination in disease pathogenesis and treatment","volume":"20","author":"Popovic","year":"2014","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.jot.2025.101039_bib19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/cr.2016.40","article-title":"Ubiquitin signaling in immune responses","volume":"26","author":"Hu","year":"2016","journal-title":"Cell Res"},{"key":"10.1016\/j.jot.2025.101039_bib20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","article-title":"The ubiquitin system","volume":"67","author":"Hershko","year":"1998","journal-title":"Annu Rev Biochem"},{"issue":"5809","key":"10.1016\/j.jot.2025.101039_bib21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.1127085","article-title":"Proteasome-independent functions of ubiquitin in endocytosis and signaling","volume":"315","author":"Mukhopadhyay","year":"2007","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.jot.2025.101039_bib22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/CIRCRESAHA.125.326520","article-title":"TRIM16 mediates K63-Linked ubiquitination of DAB2 to facilitate vascular calcification","volume":"137","author":"Lan","year":"2025","journal-title":"Circ Res"},{"issue":"17","key":"10.1016\/j.jot.2025.101039_bib23","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1093\/nar\/gkm615","article-title":"Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification","volume":"35","author":"Notenboom","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.jot.2025.101039_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00011-024-01979-1","article-title":"Mediation of macrophage M1 polarization dynamics change by ubiquitin-autophagy-pathway regulated NLRP3 inflammasomes in PD-1 inhibitor-related myocardial inflammatory injury","volume":"74","author":"Chen","year":"2025","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jot.2025.101039_bib25","article-title":"Dexmedetomidine mitigated NLRP3-Mediated neuroinflammation via the ubiquitin-autophagy pathway to improve perioperative neurocognitive disorder in mice","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Pharmacol"},{"issue":"2","key":"10.1016\/j.jot.2025.101039_bib26","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41418-021-00922-9","article-title":"The role of Ubiquitination in Apoptosis and Necroptosis","volume":"29","author":"Roberts","year":"2022","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.jot.2025.101039_bib27","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1038\/s41467-021-23474-5","article-title":"Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance","volume":"12","author":"Garcia","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.jot.2025.101039_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/CIRCULATIONAHA.118.038379","article-title":"RIPK1 expression associates with inflammation in early atherosclerosis in humans and can be therapeutically silenced to reduce NF-\u03baB activation and atherogenesis in mice","volume":"143","author":"Karunakaran","year":"2021","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jot.2025.101039_bib29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00401-024-02722-0","article-title":"Regulated cell death and its role in Alzheimer's disease and amyotrophic lateral sclerosis","volume":"147","author":"Thal","year":"2024","journal-title":"Acta Neuropathol"},{"issue":"1","key":"10.1016\/j.jot.2025.101039_bib30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.joca.2013.10.019","article-title":"Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study","volume":"22","author":"Teraguchi","year":"2014","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"10.1016\/j.jot.2025.101039_bib31","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00223-015-9986-4","article-title":"Prevalence and pattern of radiographic intervertebral disc degeneration in Vietnamese: a population-based study","volume":"96","author":"Ho-Pham","year":"2015","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jot.2025.101039_bib32","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2147\/JPR.S132769","article-title":"Treatment of chronic low back pain - new approaches on the horizon","volume":"10","author":"Knezevic","year":"2017","journal-title":"J Pain Res"},{"issue":"21","key":"10.1016\/j.jot.2025.101039_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/cells11213508","article-title":"Targeting ferroptosis holds potential for intervertebral disc degeneration therapy","volume":"11","author":"Chen","year":"2022","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.jot.2025.101039_bib34","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1038\/s41418-023-01190-5","article-title":"N6-methyladenosine hypomethylation of circGPATCH2L regulates DNA damage and apoptosis through TRIM28 in intervertebral disc degeneration","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jot.2025.101039_bib35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev-physiol-020518-114320","article-title":"Cell death in the lung: the apoptosis-necroptosis axis","volume":"81","author":"Sauler","year":"2019","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"10.1016\/j.jot.2025.101039_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis","volume":"16","author":"Cai","year":"2014","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jot.2025.101039_bib37","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3389\/fcell.2020.00817","article-title":"Plasma membrane pores drive inflammatory cell death","volume":"8","author":"Kolbrink","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"10.1016\/j.jot.2025.101039_bib38","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/s41418-023-01121-4","article-title":"MLKL deficiency protects against low-grade, sterile inflammation in aged mice","volume":"30","author":"Tovey Crutchfield","year":"2023","journal-title":"Cell Death Differ"},{"issue":"9","key":"10.1016\/j.jot.2025.101039_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/biom14091192","article-title":"Significance of necroptosis in cartilage degeneration","volume":"14","author":"Khaleque","year":"2024","journal-title":"Biomolecules"},{"issue":"10","key":"10.1016\/j.jot.2025.101039_bib40","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41419-019-1930-5","article-title":"Evidence of necroptosis in osteoarthritic disease: investigation of blunt mechanical impact as possible trigger in regulated necrosis","volume":"10","author":"Riegger","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jot.2025.101039_bib41","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3389\/fcell.2020.00685","article-title":"Inhibiting heat shock protein 90 protects nucleus pulposus-derived stem\/progenitor cells from compression-induced necroptosis and apoptosis","volume":"8","author":"Hu","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"5\u20136","key":"10.1016\/j.jot.2025.101039_bib42","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10495-018-1455-x","article-title":"Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis","volume":"23","author":"Chen","year":"2018","journal-title":"Apoptosis"},{"issue":"3","key":"10.1016\/j.jot.2025.101039_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.261","article-title":"Protein posttranslational modifications in health and diseases: functions, regulatory mechanisms, and therapeutic implications","volume":"4","author":"Zhong","year":"2023","journal-title":"MedComm"},{"issue":"6","key":"10.1016\/j.jot.2025.101039_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70226","article-title":"Lactylation: from homeostasis to pathological implications and therapeutic strategies","volume":"6","author":"Chen","year":"2025","journal-title":"MedComm"},{"issue":"12","key":"10.1016\/j.jot.2025.101039_bib45","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.tplants.2018.09.004","article-title":"Protein language: post-translational modifications talking to each other","volume":"23","author":"Vu","year":"2018","journal-title":"Trends Plant Sci"},{"issue":"5","key":"10.1016\/j.jot.2025.101039_bib46","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202311171","article-title":"The emerging roles of non-canonical ubiquitination in proteostasis and beyond","volume":"223","author":"Akizuki","year":"2024","journal-title":"J Cell Biol"},{"issue":"2","key":"10.1016\/j.jot.2025.101039_bib47","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.it.2021.12.005","article-title":"K63 ubiquitination in immune signaling","volume":"43","author":"Madiraju","year":"2022","journal-title":"Trends Immunol"},{"issue":"4","key":"10.1016\/j.jot.2025.101039_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/biom15040549","article-title":"The role of post-translational modifications in necroptosis","volume":"15","author":"Xiao","year":"2025","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.jot.2025.101039_bib49","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1038\/s41467-019-12033-8","article-title":"K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation","volume":"10","author":"Tang","year":"2019","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.jot.2025.101039_bib50","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/s41418-020-00629-3","article-title":"Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death","volume":"28","author":"Kist","year":"2021","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.jot.2025.101039_bib51","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00018-024-05487-7","article-title":"SPOP-mediated RIPK3 destabilization desensitizes LPS\/sMAC\/zVAD-induced necroptotic cell death","volume":"81","author":"Lee","year":"2024","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"10.1016\/j.jot.2025.101039_bib52","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41418-022-00934-z","article-title":"MLKL ubiquitylation: more than a makeover","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.jot.2025.101039_bib53","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41419-024-06447-6","article-title":"LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL","volume":"15","author":"Weinelt","year":"2024","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.jot.2025.101039_bib54","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41418-021-00924-7","article-title":"Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes","volume":"29","author":"Yoon","year":"2022","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.jot.2025.101039_bib55","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/febs.16255","article-title":"Surviving death: emerging concepts of RIPK3 and MLKL ubiquitination in the regulation of necroptosis","volume":"290","author":"Karlowitz","year":"2023","journal-title":"FEBS J"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X25002001?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X25002001?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T07:28:31Z","timestamp":1773991711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X25002001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":55,"alternative-id":["S2214031X25002001"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2025.101039","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2025.101039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}],"article-number":"101039"}}