{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:00:06Z","timestamp":1793649606341,"version":"4.5.1"},"reference-count":235,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jot.2026.101064","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T10:56:05Z","timestamp":1771844165000},"page":"101064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Gut microbiota and bone aging: Focusing on the gut-X axis modes"],"prefix":"10.1016","volume":"57","author":[{"given":"Yuan-Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7080-263X","authenticated-orcid":false,"given":"Jia-Can","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2026.101064_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102382","article-title":"Trends and cross-country inequalities in the global burden of osteoarthritis, 1990-2019: a population-based study","volume":"99","author":"Cao","year":"2024","journal-title":"Ageing Res Rev"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41413-023-00303-7","article-title":"Aging impairs the osteocytic regulation of collagen integrity and bone quality","volume":"12","author":"Schurman","year":"2024","journal-title":"Bone Res"},{"issue":"14","key":"10.1016\/j.jot.2026.101064_bib3","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1039\/D1FO00825K","article-title":"Low dietary choline intake is associated with the risk of osteoporosis in elderly individuals: a population-based study","volume":"12","author":"Zhang","year":"2021","journal-title":"Food Funct"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib4","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/s41467-022-29191-x","article-title":"Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox","volume":"13","author":"Wang","year":"2022","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.jot.2026.101064_bib5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s12603-022-1748-1","article-title":"Dietary protein intake in relation to the risk of osteoporosis in middle-aged and older individuals: a cross-sectional study","volume":"26","author":"Zhang","year":"2022","journal-title":"J Nutr Health Aging"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib6","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1002\/fsn3.4070","article-title":"Linking the relationship between dietary folic acid intake and risk of osteoporosis among middle-aged and older people: a nationwide population-based study","volume":"12","author":"Zhang","year":"2024","journal-title":"Food Sci Nutr"},{"key":"10.1016\/j.jot.2026.101064_bib7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2147\/CIA.S291071","article-title":"Prevalence, characteristics, and associated risk factors of the elderly with hip fractures: a cross-sectional analysis of NHANES 2005-2010","volume":"16","author":"Zhang","year":"2021","journal-title":"Clin Interv Aging"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib8","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/13548506.2022.2119482","article-title":"Short report: relationship between self-reported sleep characteristics and falls-associated fractures in elderly individuals: a population-based study","volume":"28","author":"Zhang","year":"2023","journal-title":"Psychol Health Med"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-021-00713-z","article-title":"A new immunometabolic perspective of intervertebral disc degeneration","volume":"18","author":"Francisco","year":"2022","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1136\/annrheumdis-2021-222020","article-title":"EULAR recommendations regarding lifestyle behaviours and work participation to prevent progression of rheumatic and musculoskeletal diseases","volume":"82","author":"Gwinnutt","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jot.2026.101064_bib11","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-068033","article-title":"Fracture risk reduction and safety by osteoporosis treatment compared with placebo or active comparator in postmenopausal women: systematic review, network meta-analysis, and meta-regression analysis of randomised clinical trials","volume":"381","author":"H\u00e4ndel","year":"2023","journal-title":"Bmj"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib12","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/s12967-022-03700-4","article-title":"A narrative review of the moderating effects and repercussion of exercise intervention on osteoporosis: ingenious involvement of gut microbiota and its metabolites","volume":"20","author":"Zhang","year":"2022","journal-title":"J Transl Med"},{"issue":"25","key":"10.1016\/j.jot.2026.101064_bib13","doi-asserted-by":"crossref","first-page":"7510","DOI":"10.1080\/10408398.2022.2047005","article-title":"The regulative effect and repercussion of probiotics and prebiotics on osteoporosis: involvement of brain-gut-bone axis","volume":"63","author":"Zhang","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"13","key":"10.1016\/j.jot.2026.101064_bib14","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1039\/D0FO03468A","article-title":"The modulatory effect and implication of gut microbiota on osteoporosis: from the perspective of \"brain-gut-bone\" axis","volume":"12","author":"Zhang","year":"2021","journal-title":"Food Funct"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib15","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2263207","article-title":"Progress of linking gut microbiota and musculoskeletal health: casualty, mechanisms, and translational values","volume":"15","author":"Wang","year":"2023","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib16","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2295432","article-title":"Diets intervene osteoporosis via gut-bone axis","volume":"16","author":"Zhang","year":"2024","journal-title":"Gut Microbes"},{"issue":"7","key":"10.1016\/j.jot.2026.101064_bib17","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/s41591-020-0963-8","article-title":"Microbiome and health implications for ethnic minorities after enforced lifestyle changes","volume":"26","author":"Keohane","year":"2020","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib18","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2290331","article-title":"Targeting gut microbiota in aging-related cardiovascular dysfunction: focus on the mechanisms","volume":"15","author":"Liu","year":"2023","journal-title":"Gut Microbes"},{"issue":"12","key":"10.1016\/j.jot.2026.101064_bib19","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1001\/jamapsychiatry.2021.2573","article-title":"Perturbations in gut Microbiota composition in psychiatric disorders: a review and meta-analysis","volume":"78","author":"Nikolova","year":"2021","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib20","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2201155","article-title":"The emerging role of the small intestinal microbiota in human health and disease","volume":"15","author":"Ruigrok","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jot.2026.101064_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102196","article-title":"Targeting the gut microbiota-related metabolites for osteoporosis: the inextricable connection of gut-bone axis","volume":"94","author":"Zhang","year":"2024","journal-title":"Ageing Res Rev"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib22","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2068365","article-title":"Communication between the gut microbiota and peripheral nervous system in health and chronic disease","volume":"14","author":"Cook","year":"2022","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2186671","article-title":"Microbiota-directed biotherapeutics: considerations for quality and functional assessment","volume":"15","author":"Fekete","year":"2023","journal-title":"Gut Microbes"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib24","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1136\/gutjnl-2020-323715","article-title":"Dietary macronutrients and the gut microbiome: a precision nutrition approach to improve cardiometabolic health","volume":"71","author":"Jardon","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.jot.2026.101064_bib25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jare.2021.09.005","article-title":"Interplay of gut microbiota and oxidative stress: perspective on neurodegeneration and neuroprotection","volume":"38","author":"Shandilya","year":"2022","journal-title":"J Adv Res"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11040950","article-title":"The preventive effects of probiotic Prevotella histicola on the bone loss of mice with ovariectomy-mediated osteoporosis","volume":"11","author":"Zhang","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.jot.2026.101064_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101608","article-title":"Osteocytes in bone aging: advances, challenges, and future perspectives","volume":"77","author":"Cui","year":"2022","journal-title":"Ageing Res Rev"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13846","article-title":"Piezo1 opposes age-associated cortical bone loss","volume":"22","author":"Li","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.jot.2026.101064_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pcad.2023.02.006","article-title":"Musculoskeletal exercise: its role in promoting health and longevity","volume":"77","author":"D'Onofrio","year":"2023","journal-title":"Prog Cardiovasc Dis"},{"issue":"3","key":"10.1016\/j.jot.2026.101064_bib30","doi-asserted-by":"crossref","first-page":"592","DOI":"10.14336\/AD.2022.0831","article-title":"How are aging and osteoarthritis related?","volume":"14","author":"Wakale","year":"2023","journal-title":"Aging Dis"},{"issue":"12","key":"10.1016\/j.jot.2026.101064_bib31","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1007\/s00198-022-06557-x","article-title":"The potential mechanism of the microbiota-gut-bone axis in osteoporosis: a review","volume":"33","author":"He","year":"2022","journal-title":"Osteoporos Int"},{"issue":"8","key":"10.1016\/j.jot.2026.101064_bib32","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1172\/JCI128521","article-title":"The gut-bone axis: how bacterial metabolites bridge the distance","volume":"129","author":"Zaiss","year":"2019","journal-title":"J Clin Investig"},{"issue":"8","key":"10.1016\/j.jot.2026.101064_bib33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41584-020-0454-9","article-title":"Revisiting the gut-joint axis: links between gut inflammation and spondyloarthritis","volume":"16","author":"Gracey","year":"2020","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib34","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00586-022-07152-8","article-title":"Gut-disc axis: a cause of intervertebral disc degeneration and low back pain?","volume":"31","author":"Li","year":"2022","journal-title":"Eur Spine J"},{"key":"10.1016\/j.jot.2026.101064_bib35","first-page":"46","article-title":"Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function","volume":"37","author":"Zhang","year":"2022","journal-title":"J Orthop Transl"},{"key":"10.1016\/j.jot.2026.101064_bib36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.semcdb.2021.06.024","article-title":"Alliances of the gut and bone axis","volume":"123","author":"Hansen","year":"2022","journal-title":"Semin Cell Dev Biol"},{"issue":"3","key":"10.1016\/j.jot.2026.101064_bib37","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/JLB.3MR0321-755R","article-title":"The microbiota-gut-bone axis and bone health","volume":"110","author":"Tu","year":"2021","journal-title":"J Leukoc Biol"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib38","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/lam.13333","article-title":"Gut-organ axis: a microbial outreach and networking","volume":"72","author":"Ahlawat","year":"2021","journal-title":"Lett Appl Microbiol"},{"issue":"5","key":"10.1016\/j.jot.2026.101064_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112299","article-title":"Specific host metabolite and gut microbiome alterations are associated with bone loss during spaceflight","volume":"42","author":"Bedree","year":"2023","journal-title":"Cell Rep"},{"issue":"29","key":"10.1016\/j.jot.2026.101064_bib40","doi-asserted-by":"crossref","first-page":"9816","DOI":"10.1080\/10408398.2022.2076064","article-title":"Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases","volume":"63","author":"Li","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"33","key":"10.1016\/j.jot.2026.101064_bib41","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1021\/acs.jafc.8b01466","article-title":"Microbiome-Metabolomics analysis of the impacts of long-term dietary advanced-glycation-end-product consumption on C57BL\/6 mouse fecal microbiota and metabolites","volume":"66","author":"Qu","year":"2018","journal-title":"J Agric Food Chem"},{"issue":"49","key":"10.1016\/j.jot.2026.101064_bib42","doi-asserted-by":"crossref","first-page":"13728","DOI":"10.1021\/acs.jafc.9b04410","article-title":"Chemical cross-linking controls in vitro fecal fermentation rate of high-amylose maize starches and regulates Gut Microbiota composition","volume":"67","author":"Wang","year":"2019","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jot.2026.101064_bib43","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.83142","article-title":"Bone circuitry and interorgan skeletal crosstalk","volume":"12","author":"Zaidi","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.jot.2026.101064_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106943","article-title":"Bile acid metabolism regulatory network orchestrates bone homeostasis","volume":"196","author":"Xiang","year":"2023","journal-title":"Pharmacol Res"},{"issue":"3","key":"10.1016\/j.jot.2026.101064_bib49","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12954","article-title":"Gut microbially produced tryptophan metabolite melatonin ameliorates osteoporosis via modulating SCFA and TMAO metabolism","volume":"76","author":"Chen","year":"2024","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jot.2026.101064_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106930","article-title":"Estrogen deficiency induces bone loss through the gut microbiota","volume":"196","author":"Guan","year":"2023","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13099-023-00553-0","article-title":"Gut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis","volume":"15","author":"Wang","year":"2023","journal-title":"Gut Pathog"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib53","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00198-020-05728-y","article-title":"Association between gut microbiota, bone metabolism, and fracture risk in postmenopausal Japanese women","volume":"32","author":"Ozaki","year":"2021","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jot.2026.101064_bib54","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.17416","article-title":"Gut microbiota alterations in postmenopausal women with osteoporosis and osteopenia from Shanghai, China","volume":"12","author":"Ji","year":"2024","journal-title":"PeerJ"},{"issue":"5","key":"10.1016\/j.jot.2026.101064_bib55","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00198-019-04855-5","article-title":"Gut microbiota composition and bone mineral loss-epidemiologic evidence from individuals in Wuhan, China","volume":"30","author":"Li","year":"2019","journal-title":"Osteoporos Int"},{"issue":"9","key":"10.1016\/j.jot.2026.101064_bib76","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/art.41729","article-title":"Association between Gut Microbiota and symptomatic hand osteoarthritis: data from the Xiangya osteoarthritis study","volume":"73","author":"Wei","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jot.2026.101064_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104892","article-title":"Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohorts","volume":"98","author":"Wei","year":"2023","journal-title":"EBioMedicine"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib79","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2023-003529","article-title":"Gut-joint axis in knee synovitis: gut fungal dysbiosis and altered fungi-bacteria correlation network identified in a community-based study","volume":"9","author":"Jiang","year":"2023","journal-title":"RMD Open"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib80","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1186\/s12967-024-05374-6","article-title":"Distinct characteristics of the gut virome in patients with osteoarthritis and gouty arthritis","volume":"22","author":"Chen","year":"2024","journal-title":"J Transl Med"},{"issue":"23","key":"10.1016\/j.jot.2026.101064_bib82","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1042\/CS20201224","article-title":"Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice","volume":"134","author":"Guan","year":"2020","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib83","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/art.42687","article-title":"Sex-Linked discrepancies in C57BL6\/J Mouse Osteoarthritis are associated with the gut microbiome and are transferrable by microbiome transplantation","volume":"76","author":"Schlupp","year":"2024","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jot.2026.101064_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155480","article-title":"The Sanbi Decoction alleviates intervertebral disc degeneration in rats through intestinal flora and serum metabolic homeostasis modulation","volume":"127","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.jot.2026.101064_bib108","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/os.13626","article-title":"The effect of gut Microbiota on the progression of intervertebral disc degeneration","volume":"15","author":"Yao","year":"2023","journal-title":"Orthop Surg"},{"key":"10.1016\/j.jot.2026.101064_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102130","article-title":"Dementia, osteoporosis and fragility fractures: intricate epidemiological relationships, plausible biological connections, and twisted clinical practices","volume":"93","author":"Ruggiero","year":"2024","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jot.2026.101064_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102234","article-title":"The role and mechanism of RNA-binding proteins in bone metabolism and osteoporosis","volume":"96","author":"Wu","year":"2024","journal-title":"Ageing Res Rev"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib47","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.54734","article-title":"Denosumab and the risk of diabetes in patients treated for osteoporosis","volume":"7","author":"Huang","year":"2024","journal-title":"JAMA Netw Open"},{"issue":"5","key":"10.1016\/j.jot.2026.101064_bib48","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/ard-2023-224941","article-title":"Associations of residential greenness with bone mineral density and osteoporosis: the modifying effect of genetic susceptibility","volume":"83","author":"Tan","year":"2024","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib50","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.14336\/AD.2023.0425","article-title":"Association between dysbiosis in the gut Microbiota of primary osteoporosis patients and bone loss","volume":"14","author":"Waldbaum","year":"2023","journal-title":"Aging Dis"},{"issue":"Pt 2","key":"10.1016\/j.jot.2026.101064_bib56","article-title":"High-altitude exposure decreases bone mineral density and its relationship with gut microbiota: results from the China multi-ethnic cohort (CMEC) study","volume":"215","author":"Zuo","year":"2022","journal-title":"Environ Res"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib57","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41522-022-00348-2","article-title":"One-year supplementation with Lactobacillus reuteri ATCC PTA 6475 counteracts a degradation of gut microbiota in older women with low bone mineral density","volume":"8","author":"Li","year":"2022","journal-title":"npj Biofilms Microbiomes"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib58","first-page":"965","article-title":"Bifidobacterium lactis Probio-M8 improves bone metabolism in patients with postmenopausal osteoporosis, possibly by modulating the gut microbiota","volume":"62","author":"Zhao","year":"2023","journal-title":"Eur J Nutr"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib59","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1038\/s41467-023-42005-y","article-title":"Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways","volume":"14","author":"Lin","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jot.2026.101064_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154767","article-title":"FOS\/GOS attenuates high-fat diet induced bone loss via reversing microbiota dysbiosis, high intestinal permeability and systemic inflammation in mice","volume":"119","author":"Zhang","year":"2021","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib61","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/ajcn\/nqab194","article-title":"An emerging role of Prevotella histicola on estrogen deficiency-induced bone loss through the gut microbiota-bone axis in postmenopausal women and in ovariectomized mice","volume":"114","author":"Wang","year":"2021","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib65","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41413-021-00147-z","article-title":"Subchondral bone microenvironment in osteoarthritis and pain","volume":"9","author":"Hu","year":"2021","journal-title":"Bone Res"},{"issue":"14","key":"10.1016\/j.jot.2026.101064_bib66","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo7868","article-title":"Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression","volume":"9","author":"Zhang","year":"2023","journal-title":"Sci Adv"},{"issue":"12","key":"10.1016\/j.jot.2026.101064_bib67","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13517","article-title":"Single-cell RNA sequencing in osteoarthritis","volume":"56","author":"Gu","year":"2023","journal-title":"Cell Prolif"},{"issue":"3","key":"10.1016\/j.jot.2026.101064_bib68","first-page":"1029","article-title":"Perspectives on osteoarthritis treatment with mesenchymal stem cells and Radix Achyranthis bidentatae","volume":"15","author":"An","year":"2024","journal-title":"Aging Dis"},{"issue":"5","key":"10.1016\/j.jot.2026.101064_bib69","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/s41401-021-00747-9","article-title":"Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK\/c-fos\/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion","volume":"43","author":"Fang","year":"2022","journal-title":"Acta Pharmacol Sin"},{"issue":"12","key":"10.1016\/j.jot.2026.101064_bib70","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13518","article-title":"Endothelial Stat3 activation promotes osteoarthritis development","volume":"56","author":"Li","year":"2023","journal-title":"Cell Prolif"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib71","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41392-023-01330-w","article-title":"Osteoarthritis: pathogenic signaling pathways and therapeutic targets","volume":"8","author":"Yao","year":"2023","journal-title":"Signal Transduct Targeted Ther"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib72","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13075-021-02427-9","article-title":"The gut microbiota in osteoarthritis: where do we stand and what can we do?","volume":"23","author":"Hao","year":"2021","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"10.1016\/j.jot.2026.101064_bib73","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.joca.2021.08.003","article-title":"The causal role of gut microbiota in development of osteoarthritis","volume":"29","author":"Yu","year":"2021","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jot.2026.101064_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100946","article-title":"Gut microbiota and osteoarthritis management: an expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)","volume":"55","author":"Biver","year":"2019","journal-title":"Ageing Res Rev"},{"issue":"706","key":"10.1016\/j.jot.2026.101064_bib75","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn4722","article-title":"Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes","volume":"15","author":"Thompson","year":"2023","journal-title":"Sci Transl Med"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib78","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/art.42009","article-title":"Association between Gut Microbiota and elevated serum urate in two independent cohorts","volume":"74","author":"Wei","year":"2022","journal-title":"Arthritis Rheumatol"},{"issue":"8","key":"10.1016\/j.jot.2026.101064_bib81","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.scib.2023.03.024","article-title":"The gut microbiome-joint axis in osteoarthritis","volume":"68","author":"Wei","year":"2023","journal-title":"Sci Bull (Beijing)"},{"issue":"9","key":"10.1016\/j.jot.2026.101064_bib84","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1039\/D3FO00775H","article-title":"Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics","volume":"14","author":"Mi","year":"2023","journal-title":"Food Funct"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib85","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.joca.2021.01.012","article-title":"The microbiome mediates epiphyseal bone loss and metabolomic changes after acute joint trauma in mice","volume":"29","author":"Hahn","year":"2021","journal-title":"Osteoarthr Cartil"},{"issue":"17","key":"10.1016\/j.jot.2026.101064_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176424","article-title":"Antibiotic treatment prior to injury improves post-traumatic osteoarthritis outcomes in mice","volume":"21","author":"Mendez","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.jot.2026.101064_bib89","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.95997","article-title":"Targeting the gut microbiome to treat the osteoarthritis of obesity","volume":"3","author":"Schott","year":"2018","journal-title":"JCI Insight"},{"issue":"6742","key":"10.1016\/j.jot.2026.101064_bib90","doi-asserted-by":"crossref","DOI":"10.1126\/science.adt0548","article-title":"Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling","volume":"388","author":"Yang","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.jot.2026.101064_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101902","article-title":"Epigenetic modifications of inflammation in intervertebral disc degeneration","volume":"87","author":"Kang","year":"2023","journal-title":"Ageing Res Rev"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib92","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.spinee.2023.10.021","article-title":"Causal associations between modifiable risk factors and intervertebral disc degeneration","volume":"24","author":"Guo","year":"2024","journal-title":"Spine J"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib93","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.spinee.2024.02.001","article-title":"Risk factors associated with low-grade virulent infection in intervertebral disc degeneration: a systematic review and meta-analysis","volume":"24","author":"Zhang","year":"2024","journal-title":"Spine J"},{"issue":"5","key":"10.1016\/j.jot.2026.101064_bib94","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1007\/s00586-024-08162-4","article-title":"Serum periostin levels correlate with severity of intervertebral disc degeneration","volume":"33","author":"Morimoto","year":"2024","journal-title":"Eur Spine J"},{"key":"10.1016\/j.jot.2026.101064_bib95","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.wneu.2019.03.238","article-title":"Three-Dimensional printing-assisted cervical anterior bilateral pedicle screw fixation of artificial vertebral body for cervical tuberculosis","volume":"127","author":"Zhang","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.jot.2026.101064_bib96","article-title":"Causal relationship between basal metabolic rate and intervertebral disc degeneration: a Mendelian randomization study","author":"Liu","year":"20243393352","journal-title":"Eur Spine J"},{"key":"10.1016\/j.jot.2026.101064_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107119","article-title":"Bioenergetic dysfunction in the pathogenesis of intervertebral disc degeneration","volume":"202","author":"Song","year":"2024","journal-title":"Pharmacol Res"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib98","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41584-022-00783-7","article-title":"Mechanisms and clinical implications of intervertebral disc calcification","volume":"18","author":"Zehra","year":"2022","journal-title":"Nat Rev Rheumatol"},{"issue":"19","key":"10.1016\/j.jot.2026.101064_bib99","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202313248","article-title":"Catalytic nanodots-driven pyroptosis suppression in Nucleus Pulposus for antioxidant intervention of intervertebral disc degeneration","volume":"36","author":"Sun","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.jot.2026.101064_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101733","article-title":"The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration","volume":"81","author":"Sun","year":"2022","journal-title":"Ageing Res Rev"},{"issue":"21","key":"10.1016\/j.jot.2026.101064_bib101","article-title":"Glycolysis-derived lactate induces ACSL4 expression and lactylation to activate ferroptosis during intervertebral disc degeneration","volume":"12","author":"Sun","year":"2025","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib102","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1186\/s13018-023-04081-0","article-title":"Gut microbiota and intervertebral disc degeneration: a bidirectional two-sample Mendelian randomization study","volume":"18","author":"Geng","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.jot.2026.101064_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107131","article-title":"Polystyrene micro-\/nanoplastics induced hematopoietic damages via the crosstalk of gut microbiota, metabolites, and cytokines","volume":"161","author":"Jing","year":"2022","journal-title":"Environ Int"},{"issue":"5","key":"10.1016\/j.jot.2026.101064_bib104","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1007\/s00586-023-08059-8","article-title":"Genetic analysis of the causal relationship between gut microbiota and intervertebral disc degeneration: a two-sample Mendelian randomized study","volume":"33","author":"Zheng","year":"2024","journal-title":"Eur Spine J"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib105","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1007\/s00586-024-08131-x","article-title":"Causal associations between gut microbiota with intervertebral disk degeneration, low back pain, and sciatica: a Mendelian randomization study","volume":"33","author":"Fang","year":"2024","journal-title":"Eur Spine J"},{"key":"10.1016\/j.jot.2026.101064_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154998","article-title":"Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells","volume":"119","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib109","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.134092","article-title":"Gut permeability, inflammation, and bone density across the menopause transition","volume":"5","author":"Shieh","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jot.2026.101064_bib110","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12979-018-0135-6","article-title":"Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota","volume":"15","author":"van Beek","year":"2018","journal-title":"Immun Ageing"},{"issue":"7722","key":"10.1016\/j.jot.2026.101064_bib111","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41586-018-0482-7","article-title":"Coupling of bone resorption and formation by RANKL reverse signalling","volume":"561","author":"Ikebuchi","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jot.2026.101064_bib112","first-page":"132","article-title":"Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT\/GSK-3\u03b2\/\u03b2-catenin signaling","volume":"40","author":"Zhong","year":"2023","journal-title":"J Orthop Transl"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib113","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s12276-022-00749-5","article-title":"Single-cell RNA sequencing analysis of human bone-marrow-derived mesenchymal stem cells and functional subpopulation identification","volume":"54","author":"Xie","year":"2022","journal-title":"Exp Mol Med"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib114","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41392-023-01338-2","article-title":"Characterization of mesenchymal stem cells in human fetal bone marrow by single-cell transcriptomic and functional analysis","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.jot.2026.101064_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126524","article-title":"Enhancing the effectiveness of Alkaline Phosphatase and bone matrix proteins by tunable metal-organic composite for accelerated mineralization","volume":"252","author":"Sekar Jeyakumar","year":"2023","journal-title":"Int J Biol Macromol"},{"issue":"10","key":"10.1016\/j.jot.2026.101064_bib116","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41584-021-00682-3","article-title":"The endothelium-bone axis in development, homeostasis and bone and joint disease","volume":"17","author":"Tuckermann","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jot.2026.101064_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101510","article-title":"Iron homeostasis and organismal aging","volume":"72","author":"Zeidan","year":"2021","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jot.2026.101064_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101680","article-title":"Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process","volume":"80","author":"Zhang","year":"2022","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jot.2026.101064_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117108","article-title":"Secondary hyperparathyroidism: predictors and relationship with vitamin D status, bone turnover markers and bone mineral density","volume":"184","author":"Fitzpatrick","year":"2024","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.jot.2026.101064_bib120","article-title":"Therapeutic avenues in bone repair: harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss","volume":"5","author":"Lewis","year":"2024","journal-title":"Cell Rep Med"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib121","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1038\/s41467-021-26302-y","article-title":"Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors","volume":"12","author":"Xia","year":"2021","journal-title":"Nat Commun"},{"issue":"29","key":"10.1016\/j.jot.2026.101064_bib122","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1523\/JNEUROSCI.0404-23.2023","article-title":"Metastatic infiltration of nervous tissue and periosteal nerve sprouting in multiple myeloma-induced bone pain in mice and human","volume":"43","author":"Diaz-delCastillo","year":"2023","journal-title":"J Neurosci"},{"issue":"26","key":"10.1016\/j.jot.2026.101064_bib123","doi-asserted-by":"crossref","first-page":"12263","DOI":"10.7150\/thno.53009","article-title":"Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib124","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/jbmr\/zjad014","article-title":"Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus","volume":"39","author":"Walle","year":"2024","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib125","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41413-022-00240-x","article-title":"Hallmarks of peripheral nerve function in bone regeneration","volume":"11","author":"Tao","year":"2023","journal-title":"Bone Res"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib126","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/med.22031","article-title":"Emerging roles of nerve-bone axis in modulating skeletal system","volume":"44","author":"Li","year":"2024","journal-title":"Med Res Rev"},{"key":"10.1016\/j.jot.2026.101064_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108174","article-title":"The roles of N6-methyladenosine methylation in the regulation of bone development, bone remodeling and osteoporosis","volume":"238","author":"Li","year":"2022","journal-title":"Pharmacol Ther"},{"issue":"9","key":"10.1016\/j.jot.2026.101064_bib128","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s12276-021-00667-y","article-title":"Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells","volume":"53","author":"Lee","year":"2021","journal-title":"Exp Mol Med"},{"issue":"10","key":"10.1016\/j.jot.2026.101064_bib129","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s11427-021-2103-5","article-title":"Interactions between central nervous system and peripheral metabolic organs","volume":"65","author":"Zeng","year":"2022","journal-title":"Sci China Life Sci"},{"issue":"7032","key":"10.1016\/j.jot.2026.101064_bib130","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature03398","article-title":"Leptin regulation of bone resorption by the sympathetic nervous system and CART","volume":"434","author":"Elefteriou","year":"2005","journal-title":"Nature"},{"issue":"33","key":"10.1016\/j.jot.2026.101064_bib131","article-title":"Neuropeptide Y-Mediated gut Microbiota alterations aggravate Postmenopausal osteoporosis","volume":"10","author":"Chen","year":"2023","journal-title":"Adv Sci (Weinh)"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib132","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2256043","article-title":"Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling","volume":"15","author":"Danhof","year":"2023","journal-title":"Gut Microbes"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib133","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1161\/STROKEAHA.118.024685","article-title":"Screening and treatment for osteoporosis after stroke","volume":"50","author":"Kapoor","year":"2019","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.jot.2026.101064_bib134","doi-asserted-by":"crossref","first-page":"123","DOI":"10.5312\/wjo.v10.i3.123","article-title":"Linkage of microbiota and osteoporosis: a mini literature review","volume":"10","author":"Yatsonsky","year":"2019","journal-title":"World J Orthoped"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib135","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2127446","article-title":"Dietary isoflavones Alter Gut Microbiota and lipopolysaccharide biosynthesis to reduce inflammation","volume":"14","author":"Ghimire","year":"2022","journal-title":"Gut Microbes"},{"issue":"12","key":"10.1016\/j.jot.2026.101064_bib136","doi-asserted-by":"crossref","DOI":"10.1172\/JCI157340","article-title":"The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone","volume":"132","author":"Pal","year":"2022","journal-title":"J Clin Investig"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib137","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1172\/JCI133473","article-title":"Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota","volume":"130","author":"Li","year":"2020","journal-title":"J Clin Investig"},{"issue":"17","key":"10.1016\/j.jot.2026.101064_bib138","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159406","article-title":"Low-dose IL-2 shapes a tolerogenic gut microbiota that improves autoimmunity and gut inflammation","volume":"7","author":"Tchitchek","year":"2022","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib139","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41422-023-00918-9","article-title":"The roles and regulatory mechanisms of TGF-\u03b2 and BMP signaling in bone and cartilage development, homeostasis and disease","volume":"34","author":"Wu","year":"2024","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib140","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/JPER.20-0055","article-title":"Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17\/Treg imbalance","volume":"92","author":"Cafferata","year":"2021","journal-title":"J Periodontol"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib141","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143137","article-title":"Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells","volume":"131","author":"Yu","year":"2021","journal-title":"J Clin Investig"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib142","doi-asserted-by":"crossref","first-page":"156","DOI":"10.15252\/embr.201744421","article-title":"Regulatory T cells are expanded by Teriparatide treatment in humans and mediate intermittent PTH-induced bone anabolism in mice","volume":"19","author":"Yu","year":"2018","journal-title":"EMBO Rep"},{"issue":"8","key":"10.1016\/j.jot.2026.101064_bib143","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/jcpe.13671","article-title":"A vitronectin-derived peptide prevents and restores alveolar bone loss by modulating bone re-modelling and expression of RANKL and IL-17A","volume":"49","author":"Lee","year":"2022","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jot.2026.101064_bib144","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bonr.2018.02.001","article-title":"Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance","volume":"8","author":"Dar","year":"2018","journal-title":"Bone Rep"},{"issue":"14","key":"10.1016\/j.jot.2026.101064_bib145","doi-asserted-by":"crossref","first-page":"7969","DOI":"10.1021\/acs.jafc.4c00281","article-title":"Konjac oligosaccharides alleviated ovariectomy-induced bone loss through Gut Microbiota modulation and Treg\/Th17 regulation","volume":"72","author":"Ai","year":"2024","journal-title":"J Agric Food Chem"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib146","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s11914-020-00629-9","article-title":"Gut Microbiota in bone health and diabetes","volume":"19","author":"Knudsen","year":"2021","journal-title":"Curr Osteoporos Rep"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib147","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jcjd.2019.10.006","article-title":"Interplay between Gut Microbiota and gastrointestinal peptides: potential outcomes on the regulation of glucose control","volume":"44","author":"Lupien-Meilleur","year":"2020","journal-title":"Can J Diabetes"},{"issue":"8","key":"10.1016\/j.jot.2026.101064_bib148","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1080\/10408398.2016.1252712","article-title":"Gut: a key player in the pathogenesis of type 2 diabetes?","volume":"58","author":"Muscogiuri","year":"2018","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"7","key":"10.1016\/j.jot.2026.101064_bib149","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13245","article-title":"Altered gut microbiota and metabolites profile are associated with reduced bone metabolism in ethanol-induced osteoporosis","volume":"55","author":"Liu","year":"2022","journal-title":"Cell Prolif"},{"issue":"183","key":"10.1016\/j.jot.2026.101064_bib150","doi-asserted-by":"crossref","first-page":"655","DOI":"10.24976\/Discov.Med.202436183.62","article-title":"Incretins beyond the pancreas: exploring the impact of GIP and GLP-1\/2 on bone remodeling","volume":"36","author":"Zhao","year":"2024","journal-title":"Discov Med"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib151","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s00223-023-01150-8","article-title":"Narrative review of effects of glucagon-like Peptide-1 receptor agonists on bone health in people living with obesity","volume":"114","author":"Herrou","year":"2024","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib152","doi-asserted-by":"crossref","DOI":"10.1093\/ejendo\/lvac004","article-title":"GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells","volume":"188","author":"Hansen","year":"2023","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jot.2026.101064_bib153","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bone.2016.07.014","article-title":"Glucose-dependent insulinotropic polypeptide (GIP) dose-dependently reduces osteoclast differentiation and resorption","volume":"91","author":"Mabilleau","year":"2016","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib154","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1080\/19490976.2017.1371893","article-title":"Mechanisms of gut microbiota-mediated bone remodeling","volume":"9","author":"Yan","year":"2018","journal-title":"Gut Microbes"},{"issue":"10","key":"10.1016\/j.jot.2026.101064_bib155","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1172\/JCI64906","article-title":"FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin","volume":"122","author":"Kode","year":"2012","journal-title":"J Clin Investig"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib156","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nm.2388","article-title":"Lrp5 functions in bone to regulate bone mass","volume":"17","author":"Cui","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.jot.2026.101064_bib157","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-med-090710-133426","article-title":"Regulation of bone mass by serotonin: molecular biology and therapeutic implications","volume":"62","author":"Karsenty","year":"2011","journal-title":"Annu Rev Med"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib158","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1302\/2046-3758.101.BJR-2020-0273.R1","article-title":"The role of gut microbiota in bone homeostasis","volume":"10","author":"Li","year":"2021","journal-title":"Bone Joint Res"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib159","doi-asserted-by":"crossref","DOI":"10.1111\/1751-7915.14485","article-title":"Grape seed extract prevents oestrogen deficiency-induced bone loss by modulating the gut microbiota and metabolites","volume":"17","author":"Lu","year":"2024","journal-title":"Microb Biotechnol"},{"key":"10.1016\/j.jot.2026.101064_bib160","article-title":"Microbial tryptophan metabolites ameliorate ovariectomy-induced bone loss by repairing intestinal AhR-Mediated gut-bone signaling pathway","author":"Chen","year":"2024","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib161","first-page":"46","article-title":"Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles","volume":"9","author":"Wu","year":"2022","journal-title":"Mil Med Res"},{"key":"10.1016\/j.jot.2026.101064_bib162","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1389638","article-title":"Gut microbes differ in postmenopausal women responding to prunes to maintain hip bone mineral density","volume":"11","author":"Simpson","year":"2024","journal-title":"Front Nutr"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib163","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm1511","article-title":"Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis","volume":"8","author":"He","year":"2022","journal-title":"Sci Adv"},{"issue":"15","key":"10.1016\/j.jot.2026.101064_bib164","doi-asserted-by":"crossref","DOI":"10.3390\/foods12152958","article-title":"Protective effect of long-term fermented soybeans with abundant Bacillus subtilis on glucose and bone metabolism and memory function in ovariectomized rats: modulation of the Gut Microbiota","volume":"12","author":"Yang","year":"2023","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib165","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41467-017-02490-4","article-title":"Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss","volume":"9","author":"Lucas","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib166","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12951-022-01320-0","article-title":"The ketone body \u03b2-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation","volume":"20","author":"Wu","year":"2022","journal-title":"J Nanobiotechnol"},{"issue":"16","key":"10.1016\/j.jot.2026.101064_bib167","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.21037\/atm-20-5307","article-title":"The role of gut microbiota metabolite trimethylamine N-oxide in functional impairment of bone marrow mesenchymal stem cells in osteoporosis disease","volume":"8","author":"Lin","year":"2020","journal-title":"Ann Transl Med"},{"issue":"8","key":"10.1016\/j.jot.2026.101064_bib168","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13638","article-title":"Cholestyramine alleviates bone and muscle loss in irritable bowel syndrome via regulating bile acid metabolism","volume":"57","author":"Chen","year":"2024","journal-title":"Cell Prolif"},{"issue":"10","key":"10.1016\/j.jot.2026.101064_bib169","doi-asserted-by":"crossref","DOI":"10.3390\/nu12103161","article-title":"Metabolomic associations with serum bone turnover markers","volume":"12","author":"Bellissimo","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jot.2026.101064_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107121","article-title":"Gut Clostridium sporogenes-derived indole propionic acid suppresses osteoclast formation by activating pregnane X receptor","volume":"202","author":"Peng","year":"2024","journal-title":"Pharmacol Res"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib171","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00223-017-0331-y","article-title":"Gut Microbiota, immune system, and bone","volume":"102","author":"D'Amelio","year":"2018","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib172","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202400474","article-title":"Extracellular vesicles in gut-bone axis: novel insights and therapeutic opportunities for osteoporosis","volume":"5","author":"Liu","year":"2025","journal-title":"Small Sci"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib173","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2489069","article-title":"Bacterial extracellular vesicles in osteoarthritis: a new bridge of the gut-joint axis","volume":"17","author":"Niu","year":"2025","journal-title":"Gut Microbes"},{"issue":"33","key":"10.1016\/j.jot.2026.101064_bib174","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202500746","article-title":"Self-Replenishable metabolically augmented synbiotic microspheres Remodel gut-bone homeostasis","volume":"37","author":"Chen","year":"2025","journal-title":"Adv Mater"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib175","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.immuni.2018.10.013","article-title":"The microbial metabolite butyrate stimulates bone formation via T regulatory cell-mediated regulation of WNT10B expression","volume":"49","author":"Tyagi","year":"2018","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.jot.2026.101064_bib176","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13075","article-title":"Probiotics ameliorate alveolar bone loss by regulating gut microbiota","volume":"54","author":"Jia","year":"2021","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jot.2026.101064_bib177","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bone.2018.03.024","article-title":"Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice","volume":"118","author":"McCabe","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.jot.2026.101064_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110331","article-title":"The influence of gut microbiome on bone health and related dietary strategies against bone dysfunctions","volume":"144","author":"Peng","year":"2021","journal-title":"Food Res Int"},{"issue":"8","key":"10.1016\/j.jot.2026.101064_bib179","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvae117","article-title":"Emerging insights into the endocrine regulation of bone homeostasis by Gut Microbiome","volume":"8","author":"Hansdah","year":"2024","journal-title":"J Endocr Soc"},{"issue":"9","key":"10.1016\/j.jot.2026.101064_bib180","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S2213-8587(21)00119-4","article-title":"Nutritional intake and bone health","volume":"9","author":"Rizzoli","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib181","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ajcnut.2023.05.007","article-title":"Associations of midlife dietary patterns with incident dementia and brain structure: findings from the UK biobank study","volume":"118","author":"Zhang","year":"2023","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib182","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1007\/s00394-017-1490-3","article-title":"Adherence to Mediterranean diet in relation to bone mineral density and risk of fracture: a systematic review and meta-analysis of observational studies","volume":"57","author":"Malmir","year":"2018","journal-title":"Eur J Nutr"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib183","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40520-024-02721-x","article-title":"Role of fermented dairy products in the health benefits of a mediterranean diet","volume":"36","author":"Rizzoli","year":"2024","journal-title":"Aging Clin Exp Res"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib184","doi-asserted-by":"crossref","DOI":"10.3390\/nu12041096","article-title":"You are what you eat-the relationship between diet, Microbiota, and metabolic Disorders-A review","volume":"12","author":"Moszak","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jot.2026.101064_bib185","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117874","article-title":"Extraction, characterization of aloe polysaccharides and the in-depth analysis of its prebiotic effects on mice gut microbiota","volume":"261","author":"Liu","year":"2021","journal-title":"Carbohydr Polym"},{"issue":"47","key":"10.1016\/j.jot.2026.101064_bib186","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1607235113","article-title":"Gut microbiota induce IGF-1 and promote bone formation and growth","volume":"113","author":"Yan","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.jot.2026.101064_bib62","doi-asserted-by":"crossref","first-page":"629","DOI":"10.14336\/AD.2019.0613","article-title":"Lactulose suppresses osteoclastogenesis and ameliorates Estrogen deficiency-induced bone loss in mice","volume":"11","author":"Chen","year":"2020","journal-title":"Aging Dis"},{"key":"10.1016\/j.jot.2026.101064_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110923","article-title":"Puerarin improves the bone micro-environment to inhibit OVX-induced osteoporosis via modulating SCFAs released by the gut microbiota and repairing intestinal mucosal integrity","volume":"132","author":"Li","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"10.1016\/j.jot.2026.101064_bib64","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900861","article-title":"Tuna bone powder alleviates glucocorticoid-induced osteoporosis via coregulation of the NF-\u03baB and Wnt\/\u03b2-Catenin signaling pathways and modulation of Gut Microbiota composition and metabolism","volume":"64","author":"Li","year":"2020","journal-title":"Mol Nutr Food Res"},{"issue":"Pt 2","key":"10.1016\/j.jot.2026.101064_bib87","article-title":"Modulation of gut microbiota by crude mulberry polysaccharide attenuates knee osteoarthritis progression in rats","volume":"262","author":"Zheng","year":"2024","journal-title":"Int J Biol Macromol"},{"issue":"7","key":"10.1016\/j.jot.2026.101064_bib187","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.25658","article-title":"Vegetarian dietary patterns and cardiometabolic risk in people with or at high risk of cardiovascular disease: a systematic review and meta-analysis","volume":"6","author":"Wang","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jot.2026.101064_bib188","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2024.100687","article-title":"Unraveling the role of serum metabolites in the relationship between plant-based diets and bone health in community-dwelling older adults","volume":"8","author":"Zheng","year":"2024","journal-title":"Curr Res Food Sci"},{"issue":"3","key":"10.1016\/j.jot.2026.101064_bib189","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1053\/j.gastro.2022.05.037","article-title":"Mediterranean-Like dietary pattern associations with gut Microbiome composition and subclinical gastrointestinal inflammation","volume":"163","author":"Turpin","year":"2022","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib190","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/advances\/nmab077","article-title":"Fueling gut microbes: a review of the interaction between diet, exercise, and the gut Microbiota in athletes","volume":"12","author":"Hughes","year":"2021","journal-title":"Adv Nutr"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib191","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2023.10.012","article-title":"High soluble fiber promotes colorectal tumorigenesis through modulating Gut Microbiota and metabolites in mice","volume":"166","author":"Yang","year":"2024","journal-title":"Gastroenterology"},{"issue":"50","key":"10.1016\/j.jot.2026.101064_bib192","doi-asserted-by":"crossref","first-page":"15747","DOI":"10.1021\/acs.jafc.2c04354","article-title":"Oryzanol ameliorates DSS-stimulated gut barrier damage via targeting the gut Microbiota accompanied by the TLR4\/NF-\u03baB\/NLRP3 Cascade response in vivo","volume":"70","author":"Xia","year":"2022","journal-title":"J Agric Food Chem"},{"issue":"3","key":"10.1016\/j.jot.2026.101064_bib193","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00028.2020","article-title":"Microbiota on biotics: probiotics, prebiotics, and synbiotics to optimize growth and metabolism","volume":"319","author":"Edwards","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jot.2026.101064_bib194","doi-asserted-by":"crossref","DOI":"10.1007\/s12602-024-10306-3","article-title":"Evaluating the role of probiotics, prebiotics, and synbiotics supplementation in age-related musculoskeletal disorders in older adults: a systematic review","author":"Lashkarbolouk","year":"20251753495","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10.1016\/j.jot.2026.101064_bib195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.930511","article-title":"Lactobacillus (LA-1) and butyrate inhibit osteoarthritis by controlling autophagy and inflammatory cell death of chondrocytes","volume":"13","author":"Cho","year":"2022","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib196","article-title":"Lactobacillus acidophilus mitigates osteoarthritis-associated pain, cartilage disintegration and gut Microbiota dysbiosis in an experimental Murine OA model","volume":"10","author":"I","year":"2022","journal-title":"Biomedicines"},{"issue":"14","key":"10.1016\/j.jot.2026.101064_bib197","doi-asserted-by":"crossref","first-page":"7734","DOI":"10.1021\/jf2013716","article-title":"Antiosteoporotic effects of Lactobacillus -fermented soy skim milk on bone mineral density and the microstructure of femoral bone in ovariectomized mice","volume":"59","author":"Chiang","year":"2011","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jot.2026.101064_bib198","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.nut.2018.02.013","article-title":"Bacillus clausii inhibits bone loss by skewing Treg-Th17 cell equilibrium in postmenopausal osteoporotic mice model","volume":"54","author":"Dar","year":"2018","journal-title":"Nutrition"},{"key":"10.1016\/j.jot.2026.101064_bib199","article-title":"Lactobacillus plantarum attenuates glucocorticoid-induced osteoporosis by altering the composition of rat gut microbiota and serum metabolic profile","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.jot.2026.101064_bib200","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s00394-024-03400-3","article-title":"The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17\/Treg","volume":"63","author":"Zhu","year":"2024","journal-title":"Eur J Nutr"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib201","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jtcme.2023.06.002","article-title":"Gut-joint axis: oral probiotic ameliorates Osteoarthritis","volume":"14","author":"Amin","year":"2024","journal-title":"J Tradit Complement Med"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib202","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25010143","article-title":"The complex interplay between the gut microbiome and osteoarthritis: a systematic review on potential correlations and therapeutic approaches","volume":"25","author":"Marchese","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.jot.2026.101064_bib203","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00862-25","article-title":"Bifidobacterium animalis subsp. lactis Probio-M8 enhances chondroitin efficacy for knee osteoarthritis in postmenopausal women via the gut-joint axis","volume":"10","author":"Wang","year":"2025","journal-title":"mSystems"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib204","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.tjnut.2024.02.011","article-title":"Age-related gut Microbiota transplantation disrupts myocardial energy homeostasis and induces oxidative damage","volume":"154","author":"Xu","year":"2024","journal-title":"J Nutr"},{"key":"10.1016\/j.jot.2026.101064_bib205","article-title":"Fecal Microbiota transplantation Attenuates frailty via gut-muscle axis in old mice","author":"Zhu","year":"20241621180","journal-title":"Aging Dis"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib206","doi-asserted-by":"crossref","DOI":"10.1128\/cmr.00060-22","article-title":"Fecal microbiota transplantation: current challenges and future landscapes","volume":"37","author":"Yadegar","year":"2024","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"10.1016\/j.jot.2026.101064_bib207","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/fft2.34","article-title":"Transplanting fecal material from wild-type mice fed black raspberries alters the immune system of recipient mice","volume":"1","author":"Huang","year":"2020","journal-title":"Food Front"},{"issue":"7837","key":"10.1016\/j.jot.2026.101064_bib208","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-2971-8","article-title":"The gut microbiota is associated with immune cell dynamics in humans","volume":"588","author":"Schluter","year":"2020","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib209","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/gutjnl-2016-313017","article-title":"European consensus conference on faecal microbiota transplantation in clinical practice","volume":"66","author":"Cammarota","year":"2017","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.jot.2026.101064_bib210","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.cgh.2024.10.001","article-title":"Gut Microbiota features in relation to fecal Microbiota transplantation outcome in ulcerative colitis: a systematic review and meta-analysis","volume":"23","author":"B\u00e9nard","year":"2025","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.jot.2026.101064_bib211","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.14309\/ajg.0000000000000198","article-title":"Efficacy of fecal microbiota transplantation in irritable bowel syndrome: a systematic review and meta-analysis","volume":"114","author":"Xu","year":"2019","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib212","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s00774-022-01375-x","article-title":"Fecal microbiota transplantation as a promising treatment option for osteoporosis","volume":"40","author":"Zhang","year":"2022","journal-title":"J Bone Miner Metabol"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib213","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s40168-025-02118-6","article-title":"Fecal microbiota transplantation for hypertension: an exploratory, multicenter, randomized, blinded, placebo-controlled trial","volume":"13","author":"Fan","year":"2025","journal-title":"Microbiome"},{"issue":"10","key":"10.1016\/j.jot.2026.101064_bib214","doi-asserted-by":"crossref","DOI":"10.7326\/ANNALS-25-03648-JC","article-title":"In primary CDI, fecal microbiota transplantation was noninferior to vancomycin for clinical cure at 14 d without recurrence at 60 d","volume":"178","author":"Sacks","year":"2025","journal-title":"Ann Intern Med"},{"issue":"10","key":"10.1016\/j.jot.2026.101064_bib215","doi-asserted-by":"crossref","DOI":"10.2196\/30131","article-title":"Modulation of bone and joint biomarkers, Gut Microbiota, and inflammation status by synbiotic supplementation and weight-bearing exercise: human Study protocol for a randomized controlled trial","volume":"10","author":"Ilesanmi-Oyelere","year":"2021","journal-title":"JMIR Res Protoc"},{"issue":"7","key":"10.1016\/j.jot.2026.101064_bib216","doi-asserted-by":"crossref","DOI":"10.3390\/nu16071070","article-title":"Effects of exercise on gut Microbiota of adults: a systematic review and meta-analysis","volume":"16","author":"Min","year":"2024","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.jot.2026.101064_bib217","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1302\/2046-3758.711.BJR-2018-0075.R2","article-title":"Transcriptome analysis of osteoblasts in an ovariectomized mouse model in response to physical exercise","volume":"7","author":"Hsu","year":"2018","journal-title":"Bone Joint Res"},{"issue":"11","key":"10.1016\/j.jot.2026.101064_bib218","doi-asserted-by":"crossref","DOI":"10.3390\/nu11112826","article-title":"Impact of vitamin D on physical efficiency and exercise Performance-A review","volume":"11","author":"Wici\u0144ski","year":"2019","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jot.2026.101064_bib88","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.joim.2022.01.004","article-title":"Effects of different courses of moxibustion treatment on intestinal flora and inflammation of a rat model of knee osteoarthritis","volume":"20","author":"Jia","year":"2022","journal-title":"J Integr Med"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib219","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2024.04.004","article-title":"Gut microbial alterations in arginine metabolism determine bone mechanical adaptation","volume":"36","author":"Wang","year":"2024","journal-title":"Cell Metab"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib220","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1039\/D4FO04430D","article-title":"The interaction between various food components and intestinal microbiota improves human health through the gut-X axis: independently or synergistically","volume":"16","author":"Li","year":"2025","journal-title":"Food Funct"},{"issue":"9","key":"10.1016\/j.jot.2026.101064_bib221","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1136\/annrheumdis-2014-206323","article-title":"Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis","volume":"74","author":"Ciccia","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jot.2026.101064_bib222","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117239","article-title":"Investigating the link between gut microbiome and bone mineral density: the role of genetic factors","volume":"188","author":"Gao","year":"2024","journal-title":"Bone"},{"key":"10.1016\/j.jot.2026.101064_bib223","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118099","article-title":"Modulation of gut microbiota by chondroitin sulfate calcium complex during alleviation of osteoporosis in ovariectomized rats","volume":"266","author":"Shen","year":"2021","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.jot.2026.101064_bib224","article-title":"The brain-gut-bone axis in neurodegenerative diseases: insights, challenges, and future prospects","author":"Li","year":"2024","journal-title":"Adv Sci (Weinh)"},{"issue":"16","key":"10.1016\/j.jot.2026.101064_bib225","doi-asserted-by":"crossref","first-page":"7642","DOI":"10.1039\/D3FO01840G","article-title":"Diallyl trisulfide ameliorates bone loss and alters specific gut microbiota and serum metabolites in natural aging mice","volume":"14","author":"Zhang","year":"2023","journal-title":"Food Funct"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib226","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2297860","article-title":"Multi-omic approaches for host-microbiome data integration","volume":"16","author":"Chetty","year":"2024","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib227","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/imm.12645","article-title":"Communicating systems in the body: how microbiota and microglia cooperate","volume":"150","author":"Erny","year":"2017","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.jot.2026.101064_bib228","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.chom.2021.04.002","article-title":"Organoids and organs-on-chips: insights into human gut-microbe interactions","volume":"29","author":"Puschhof","year":"2021","journal-title":"Cell Host Microbe"},{"issue":"4","key":"10.1016\/j.jot.2026.101064_bib229","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/joim.12508","article-title":"The gut microbiota and metabolic disease: current understanding and future perspectives","volume":"280","author":"Arora","year":"2016","journal-title":"J Intern Med"},{"key":"10.1016\/j.jot.2026.101064_bib230","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jare.2022.12.001","article-title":"Brain modulation by the gut microbiota: from disease to therapy","volume":"53","author":"Mitra","year":"2023","journal-title":"J Adv Res"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib231","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s40168-023-01552-8","article-title":"Using the collaborative cross to identify the role of host genetics in defining the murine gut microbiome","volume":"11","author":"Nagarajan","year":"2023","journal-title":"Microbiome"},{"issue":"8","key":"10.1016\/j.jot.2026.101064_bib232","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1007\/s00394-022-02928-6","article-title":"Human gut microbiota composition and its predicted functional properties in people with western and healthy dietary patterns","volume":"61","author":"Malinowska","year":"2022","journal-title":"Eur J Nutr"},{"issue":"8","key":"10.1016\/j.jot.2026.101064_bib233","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S2468-1253(24)00053-0","article-title":"Artificial intelligence and endo-histo-omics: new dimensions of precision endoscopy and histology in inflammatory bowel disease","volume":"9","author":"Iacucci","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.jot.2026.101064_bib234","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.270","article-title":"Gut-X axis","volume":"4","author":"Lin","year":"2025","journal-title":"iMeta"},{"key":"10.1016\/j.jot.2026.101064_bib235","doi-asserted-by":"crossref","DOI":"10.2991\/978-94-6463-932-2","article-title":"Gut microbiota-mediated regulation of skeletal development: a review of mechanistic analysis and interventional strategies","author":"Liu","year":"2025","journal-title":"J Adv Res"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26000197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26000197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:32:10Z","timestamp":1778859130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X26000197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":235,"alternative-id":["S2214031X26000197"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2026.101064","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut microbiota and bone aging: Focusing on the gut-X axis modes","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2026.101064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}],"article-number":"101064"}}