{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:15:55Z","timestamp":1783196155589,"version":"3.54.6"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012175","name":"Zhejiang Administration Bureau of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2024ZL947"],"award-info":[{"award-number":["2024ZL947"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZCLQN25H2701"],"award-info":[{"award-number":["ZCLQN25H2701"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Ningbo Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["2023J215"],"award-info":[{"award-number":["2023J215"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jot.2026.101112","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:20:11Z","timestamp":1778275211000},"page":"101112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Deer antler polypeptides promote osteogenesis for fracture healing via activating neurosensory PGE2\/EP4\/p-CREB axis"],"prefix":"10.1016","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3816-7937","authenticated-orcid":false,"given":"Yunfan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihao","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoqiang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihe","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggan","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5987-4146","authenticated-orcid":false,"given":"Chenjie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2026.101112_bib1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2106\/JBJS.22.00478","article-title":"Return to work following intramedullary nailing of lower-limb long-bone fractures in South Africa","volume":"105","author":"Masterson","year":"2023","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jot.2026.101112_bib2","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2016.2775","article-title":"Epidemiology of fracture nonunion in 18 human bones","volume":"151","author":"Zura","year":"2016","journal-title":"JAMA Surg"},{"key":"10.1016\/j.jot.2026.101112_bib3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1080\/14712598.2024.2391491","article-title":"Clinical management and innovation in fracture non-union","volume":"24","author":"Siverino","year":"2024","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.jot.2026.101112_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.injury.2023.111243","article-title":"The burden of long bone fracture and health system response in Malawi: a scoping review","volume":"55","author":"Abbas","year":"2024","journal-title":"Injury"},{"key":"10.1016\/j.jot.2026.101112_bib5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.bone.2019.07.022","article-title":"Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice","volume":"127","author":"Coates","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.jot.2026.101112_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12904","article-title":"TGF-\u03b2\/Smad2 signalling regulates enchondral bone formation of Gli1+ periosteal cells during fracture healing","volume":"53","author":"Xia","year":"2020","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jot.2026.101112_bib7","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/jbmr.4616","article-title":"Skeletal stem\/progenitor cells in periosteum and skeletal muscle share a common molecular response to bone injury","volume":"37","author":"Julien","year":"2022","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2026.101112_bib8","article-title":"Postnatal osterix but not DMP1 lineage cells significantly contribute to intramembranous ossification in three preclinical models of bone injury","volume":"13","author":"Buettmann","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.jot.2026.101112_bib9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/jbmr\/zjae069","article-title":"Skeletal stem and progenitor cells in bone development and repair","volume":"39","author":"Trompet","year":"2024","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2026.101112_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102372","article-title":"Sensory nerve regulation of bone homeostasis: emerging therapeutic opportunities for bone-related diseases","volume":"99","author":"Chen","year":"2024","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jot.2026.101112_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107850","article-title":"Interoceptive regulation of bone homeostasis: the interplay between the nervous and skeletal systems in pathophysiology","volume":"218","author":"Xu","year":"2025","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jot.2026.101112_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1570685","article-title":"Jinkui shenqi pill accelerates osteoporotic fracture healing by promoting bone formation through neurosensory PGE2\/EP4\/p-CREB axis","volume":"16","author":"Xi","year":"2025","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jot.2026.101112_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1359\/jbmr.081002","article-title":"Reduced COX-2 expression in aged mice is associated with impaired fracture healing","volume":"24","author":"Naik","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2026.101112_bib14","first-page":"27","article-title":"Ultrasonic effect on fracture repair and prostaglandin E2 production","volume":"35","author":"Tsai","year":"1992","journal-title":"Chin J Physiol"},{"key":"10.1016\/j.jot.2026.101112_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/17453679308994530","article-title":"Effect of local prostaglandin E2 on fracture callus in rabbits","volume":"64","author":"Keller","year":"1993","journal-title":"Acta Orthop Scand"},{"key":"10.1016\/j.jot.2026.101112_bib16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF02556354","article-title":"Systemic effects of prostaglandin E2 on vertebral trabecular remodeling in beagles used in a healing study","volume":"42","author":"Norrdin","year":"1988","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jot.2026.101112_bib17","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41467-022-28203-0","article-title":"Divalent metal cations stimulate skeleton interoception for new bone formation in mouse injury models","volume":"13","author":"Qiao","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jot.2026.101112_bib18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41467-018-08097-7","article-title":"Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis","volume":"10","author":"Chen","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jot.2026.101112_bib19","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1172\/JCI131554","article-title":"Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones","volume":"130","author":"Hu","year":"2020","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jot.2026.101112_bib20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13062-024-00561-3","article-title":"Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversal","volume":"19","author":"Li","year":"2024","journal-title":"Biol Direct"},{"key":"10.1016\/j.jot.2026.101112_bib21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jep.2012.12.008","article-title":"Deer antler base as a traditional Chinese medicine: a review of its traditional uses, chemistry and pharmacology","volume":"145","author":"Wu","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jot.2026.101112_bib22","article-title":"A novel deer antler-inspired bone graft triggers rapid bone regeneration","volume":"37","author":"Li","year":"2025","journal-title":"Adv Mater"},{"key":"10.1016\/j.jot.2026.101112_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021759","article-title":"Isolation, identification, and characterization of bioactive peptides in human bone cells from tortoiseshell and deer antler gelatin","volume":"24","author":"Ho","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2026.101112_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27154756","article-title":"Peptide biomarkers discovery for seven species of deer antler using LC-MS\/MS and label-free approach","volume":"27","author":"Xue","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jot.2026.101112_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/nu14194183","article-title":"Health effects of peptides extracted from deer antler","volume":"14","author":"Xia","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jot.2026.101112_bib26","article-title":"Pilose antler peptide enhances diabetic fracture healing by modulating the CREB-Smad2\/3-Runx2 signaling axis","volume":"354","author":"Wang","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jot.2026.101112_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ph17070972","article-title":"Sika deer velvet antler peptide exerts neuroprotective effect in a parkinson's disease model via regulating oxidative damage and gut microbiota","volume":"17","author":"Liu","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jot.2026.101112_bib28","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s10735-022-10099-1","article-title":"Velvet antler polypeptide combined with calcium phosphate coating to protect peripheral nerve cells from oxidative stress","volume":"53","author":"Mao","year":"2022","journal-title":"J Mol Histol"},{"key":"10.1016\/j.jot.2026.101112_bib29","article-title":"Pilose antler Peptide-3.2KD ameliorates adriamycin-induced myocardial injury through TGF-\u03b2\/SMAD signaling pathway","volume":"8","author":"Xu","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jot.2026.101112_bib30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.31083\/j.jin2003061","article-title":"The anti-aging effect of velvet antler polypeptide is dependent on modulation of the gut microbiota and regulation of the PPAR\u03b1\/APOE4 pathway","volume":"20","author":"Liu","year":"2021","journal-title":"J Integr Neurosci"},{"key":"10.1016\/j.jot.2026.101112_bib31","doi-asserted-by":"crossref","first-page":"9752","DOI":"10.1039\/D0FO01899F","article-title":"Velvet antler polypeptide prevents the disruption of hepatic tight junctions via inhibiting oxidative stress in cholestatic mice and liver cell lines","volume":"11","author":"Li","year":"2020","journal-title":"Food Funct"},{"key":"10.1016\/j.jot.2026.101112_bib32","first-page":"5353","article-title":"Pilose antler polypeptide protects against sevoflurane-mediated neurocyte injury","volume":"18","author":"Li","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jot.2026.101112_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1289843","article-title":"Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis","volume":"10","author":"Wang","year":"2023","journal-title":"Front Med"},{"key":"10.1016\/j.jot.2026.101112_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106560","article-title":"Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy","volume":"187","author":"Carey","year":"2023","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jot.2026.101112_bib35","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.stem.2022.10.002","article-title":"Bone marrow and periosteal skeletal stem\/progenitor cells make distinct contributions to bone maintenance and repair","volume":"29","author":"Jeffery","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jot.2026.101112_bib36","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.ijbiomac.2017.03.024","article-title":"Protective effect of pilose antler peptide on carbon tetrachloride-induced hepatotoxicity in mice","volume":"99","author":"Chunhua","year":"2017","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jot.2026.101112_bib37","article-title":"The protective effect of pilose antler peptide on CUMS-induced depression through AMPK\/Sirt1\/NF-\u03baB\/NLRP3-Mediated pyroptosis","volume":"13","author":"Hu","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jot.2026.101112_bib38","doi-asserted-by":"crossref","first-page":"134","DOI":"10.21873\/invivo.13420","article-title":"Development, validation and characterization of a novel portable closed fracture device","volume":"38","author":"Zhang","year":"2024","journal-title":"In Vivo (Athens)"},{"key":"10.1016\/j.jot.2026.101112_bib39","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.92469.3","article-title":"\u03b2-catenin inhibition disrupts the homeostasis of osteogenic\/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of the femoral head","volume":"12","author":"Xia","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.jot.2026.101112_bib40","first-page":"325","article-title":"Sensory nerve EP4 facilitates heterotopic ossification by regulating angiogenesis-coupled bone formation","volume":"49","author":"Lin","year":"2024","journal-title":"J Orthop Transl"},{"key":"10.1016\/j.jot.2026.101112_bib41","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ijom.2010.10.011","article-title":"Cyclooxygenase-2 activity is important in craniofacial fracture repair","volume":"40","author":"Chikazu","year":"2011","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.jot.2026.101112_bib42","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1359\/jbmr.2002.17.6.963","article-title":"Cyclo-oxygenase 2 function is essential for bone fracture healing","volume":"17","author":"Simon","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2026.101112_bib43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13550-018-0463-8","article-title":"Bone marrow cell homing to sites of acute tibial fracture: 89zr-Oxine cell labeling with positron emission tomographic imaging in a mouse model","volume":"8","author":"Asiedu","year":"2018","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.jot.2026.101112_bib44","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1038\/s41467-024-49824-7","article-title":"The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer","volume":"15","author":"Hou","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jot.2026.101112_bib45","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s10194-025-02043-x","article-title":"Unmasking the relationship between CGRP and glutamate: from peripheral excitation to central sensitization in migraine","volume":"26","author":"Martami","year":"2025","journal-title":"J Headache Pain"},{"key":"10.1016\/j.jot.2026.101112_bib46","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11596-023-2739-0","article-title":"Lipopolysaccharide-induced trigeminal ganglion nerve fiber damage is associated with autophagy inhibition","volume":"43","author":"Li","year":"2023","journal-title":"Curr Med Sci"},{"key":"10.1016\/j.jot.2026.101112_bib47","first-page":"103","article-title":"GFAP and neuron specific enolase (NSE) in the serum of suicide attempters","volume":"36","author":"Bagheri","year":"2022","journal-title":"Med J Islam Repub Iran"},{"key":"10.1016\/j.jot.2026.101112_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202305042","article-title":"Unloading-induced skeletal interoception alters hypothalamic signaling to promote bone loss and fat metabolism","volume":"10","author":"Guo","year":"2023","journal-title":"Adv Sci"},{"key":"10.1016\/j.jot.2026.101112_bib49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00210-023-02642-y","article-title":"Well-known polypeptides of deer antler velvet with key actives: modern pharmacological advances","volume":"397","author":"Sun","year":"2024","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jot.2026.101112_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.meatsci.2023.109278","article-title":"A review on bioactive peptides derived from meat and by-products: extraction methods, biological activities, applications and limitations","volume":"204","author":"L\u00f3pez-Pedrouso","year":"2023","journal-title":"Meat Sci"},{"key":"10.1016\/j.jot.2026.101112_bib51","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2334\/josnusd.50.247","article-title":"Prostaglandins and bone: potential risks and benefits related to the use of nonsteroidal anti-inflammatory drugs in clinical dentistry","volume":"50","author":"Fracon","year":"2008","journal-title":"J Oral Sci"},{"key":"10.1016\/j.jot.2026.101112_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.107666","article-title":"Velvet antler polypeptide (VAP) protects against cerebral ischemic injury through NF-\u03baB signaling pathway in vitro","volume":"33","author":"Wu","year":"2024","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jot.2026.101112_bib53","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4103\/1008-682X.166435","article-title":"Effects of velvet antler polypeptide on sexual behavior and testosterone synthesis in aging Male mice","volume":"18","author":"Zang","year":"2016","journal-title":"Asian J Androl"},{"key":"10.1016\/j.jot.2026.101112_bib54","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/08923973.2016.1233978","article-title":"A recombinant polypeptide from velvet antler of Cervus nippon temminck exhibits similar immunomodulatory effects as its natural counterpart","volume":"38","author":"Zha","year":"2016","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.jot.2026.101112_bib55","doi-asserted-by":"crossref","first-page":"9103","DOI":"10.1016\/j.biomaterials.2013.08.024","article-title":"Effects of compatibility of deproteinized antler cancellous bone with various bioactive factors on their osteogenic potential","volume":"34","author":"Zhang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101112_bib56","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1172\/JCI128428","article-title":"Fracture repair requires TrkA signaling by skeletal sensory nerves","volume":"129","author":"Li","year":"2019","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jot.2026.101112_bib57","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.70324","article-title":"Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY","volume":"10","author":"Lv","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.jot.2026.101112_bib58","article-title":"Dorsal root ganglia control nociceptive input to the central nervous system. PLoS","volume":"21","author":"Hao","year":"2023","journal-title":"Biol Met"},{"key":"10.1016\/j.jot.2026.101112_bib59","article-title":"TRPV1 channel activated by the PGE2\/EP4 pathway mediates spinal hypersensitivity in a mouse model of vertebral endplate degeneration","volume":"2021","author":"Liu","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jot.2026.101112_bib60","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ejp.1172","article-title":"Signalling transduction events involved in agonist-induced PGE2\/EP4 receptor externalization in cultured rat dorsal root ganglion neurons","volume":"22","author":"Ma","year":"2018","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jot.2026.101112_bib61","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00223-025-01350-4","article-title":"Semaphorin 3A on osteoporosis: an overreview of the literature","volume":"116","author":"Zhang","year":"2025","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jot.2026.101112_bib62","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/jbmr.3950","article-title":"Propranolol reverses impaired fracture healing response observed with selective serotonin reuptake inhibitor treatment","volume":"35","author":"Sooyeon","year":"2020","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2026.101112_bib63","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41413-024-00321-z","article-title":"\u03b2-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture","volume":"12","author":"Huang","year":"2024","journal-title":"Bone Res"},{"key":"10.1016\/j.jot.2026.101112_bib64","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0092-8674(02)01049-8","article-title":"Leptin regulates bone formation via the sympathetic nervous system","volume":"111","author":"Takeda","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jot.2026.101112_bib65","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41413-024-00371-3","article-title":"Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head","volume":"12","author":"Shao","year":"2024","journal-title":"Bone Res"},{"key":"10.1016\/j.jot.2026.101112_bib66","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cmet.2024.09.012","article-title":"Overnutrition causes insulin resistance and metabolic disorder through increased sympathetic nervous system activity","volume":"37","author":"Sakamoto","year":"2025","journal-title":"Cell Metab"},{"key":"10.1016\/j.jot.2026.101112_bib67","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/embj.201386145","article-title":"Creb coactivators direct anabolic responses and enhance performance of skeletal muscle","volume":"33","author":"Bruno","year":"2014","journal-title":"EMBO J"},{"key":"10.1016\/j.jot.2026.101112_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103005","article-title":"Implantable electrical stimulation at dorsal root ganglions accelerates osteoporotic fracture healing via calcitonin gene-related peptide","volume":"9","author":"Mi","year":"2022","journal-title":"Adv Sci"}],"updated-by":[{"DOI":"10.1016\/j.jot.2026.101162","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000}}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26000689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26000689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:28:55Z","timestamp":1783193335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X26000689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":68,"alternative-id":["S2214031X26000689"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2026.101112","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deer antler polypeptides promote osteogenesis for fracture healing via activating neurosensory PGE2\/EP4\/p-CREB axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2026.101112","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}],"article-number":"101112"}}