{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:16:25Z","timestamp":1783113385017,"version":"3.54.6"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402788"],"award-info":[{"award-number":["82402788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82250710175"],"award-info":[{"award-number":["82250710175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82261160395"],"award-info":[{"award-number":["82261160395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230081"],"award-info":[{"award-number":["82230081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82430078"],"award-info":[{"award-number":["82430078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302748"],"award-info":[{"award-number":["82302748"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2025ZD0550400"],"award-info":[{"award-number":["2025ZD0550400"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012449","name":"Southern University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jot.2026.101113","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:20:11Z","timestamp":1778275211000},"page":"101113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Talin1 loss activates DRG neurons to accelerate bone remodeling and fracture healing in mice"],"prefix":"10.1016","volume":"58","author":[{"given":"Qinnan","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghao","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangtai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zecai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7155-5044","authenticated-orcid":false,"given":"Sixiong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyue","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6069-880X","authenticated-orcid":false,"given":"Chu","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaochuan","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7712-9449","authenticated-orcid":false,"given":"Lei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4269-2450","authenticated-orcid":false,"given":"Guozhi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2026.101113_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102372","article-title":"Sensory nerve regulation of bone homeostasis: emerging therapeutic opportunities for bone-related diseases","volume":"99","author":"Chen","year":"2024","journal-title":"Ageing Res Rev"},{"issue":"4","key":"10.1016\/j.jot.2026.101113_bib2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cell.2019.06.022","article-title":"Cutaneous TRPV1(+) neurons trigger protective innate type 17 anticipatory immunity","volume":"178","author":"Cohen","year":"2019","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.jot.2026.101113_bib3","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/j.cell.2024.04.027","article-title":"Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity","volume":"187","author":"Wu","year":"2024","journal-title":"Cell"},{"issue":"7843","key":"10.1016\/j.jot.2026.101113_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41586-020-03057-y","article-title":"Nociceptive nerves regulate haematopoietic stem cell mobilization","volume":"589","author":"Gao","year":"2021","journal-title":"Nature"},{"issue":"8008","key":"10.1016\/j.jot.2026.101113_bib5","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41586-024-07237-y","article-title":"CGRP sensory neurons promote tissue healing via neutrophils and macrophages","volume":"628","author":"Lu","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jot.2026.101113_bib6","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neuroscience.2011.01.039","article-title":"The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A","volume":"178","author":"Castaneda-Corral","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.jot.2026.101113_bib7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuroscience.2018.01.047","article-title":"The changing sensory and sympathetic innervation of the young, adult and aging mouse femur","volume":"387","author":"Chartier","year":"2018","journal-title":"Neuroscience"},{"issue":"10","key":"10.1016\/j.jot.2026.101113_bib8","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/j.celrep.2016.08.002","article-title":"NGF-TrkA signaling by sensory nerves coordinates the vascularization and ossification of developing endochondral bone","volume":"16","author":"Tomlinson","year":"2016","journal-title":"Cell Rep"},{"issue":"7450","key":"10.1016\/j.jot.2026.101113_bib9","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nature12115","article-title":"Sema3A regulates bone-mass accrual through sensory innervations","volume":"497","author":"Fukuda","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jot.2026.101113_bib10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41467-018-08097-7","article-title":"Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis","volume":"10","author":"Chen","year":"2019","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.jot.2026.101113_bib11","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1172\/JCI128428","article-title":"Fracture repair requires TrkA signaling by skeletal sensory nerves","volume":"129","author":"Li","year":"2019","journal-title":"J Clin Investig"},{"issue":"11","key":"10.1016\/j.jot.2026.101113_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl5716","article-title":"NGF-p75 signaling coordinates skeletal cell migration during bone repair","volume":"8","author":"Xu","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.jot.2026.101113_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jot.2024.10.008","article-title":"Accelerated fracture healing accompanied with traumatic brain injury: a review of clinical studies, animal models and potential mechanisms","volume":"50","author":"Jin","year":"2025","journal-title":"J Orthop Translat"},{"issue":"1","key":"10.1016\/j.jot.2026.101113_bib14","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1038\/s41467-021-25143-z","article-title":"NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma","volume":"12","author":"Lee","year":"2021","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.jot.2026.101113_bib15","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/nm.4162","article-title":"Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats","volume":"22","author":"Zhang","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.jot.2026.101113_bib16","article-title":"CGRP regulates the age-related switch between osteoblast and adipocyte differentiation","volume":"9","author":"Li","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"10.1016\/j.jot.2026.101113_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/biom13050838","article-title":"Research progress in calcitonin gene-related peptide and bone repair","volume":"13","author":"Wang","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jot.2026.101113_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jot.2025.01.010","article-title":"Identification and function of periosteal skeletal stem cells in skeletal development, homeostasis, and disease","volume":"51","author":"Shi","year":"2025","journal-title":"J Orthop Translat"},{"issue":"2","key":"10.1016\/j.jot.2026.101113_bib19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bone.2009.04.203","article-title":"Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro","volume":"45","author":"Wang","year":"2009","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.jot.2026.101113_bib20","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1079>3.0.CO;2-Y","article-title":"Disruption of the talin gene arrests mouse development at the gastrulation stage","volume":"219","author":"Monkley","year":"2000","journal-title":"Dev Dyn"},{"issue":"13","key":"10.1016\/j.jot.2026.101113_bib21","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1084\/jem.20071800","article-title":"Talin is required for integrin-mediated platelet function in hemostasis and thrombosis","volume":"204","author":"Petrich","year":"2007","journal-title":"J Exp Med"},{"issue":"4","key":"10.1016\/j.jot.2026.101113_bib22","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1128\/MCB.00790-12","article-title":"Talin1 and Rap1 are critical for osteoclast function","volume":"33","author":"Zou","year":"2013","journal-title":"Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.jot.2026.101113_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2192623","article-title":"Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity","volume":"15","author":"Latour","year":"2023","journal-title":"Gut Microbes"},{"issue":"10","key":"10.1016\/j.jot.2026.101113_bib24","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41419-023-06235-8","article-title":"Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate beta-cell proliferation and mass in mice","volume":"14","author":"Hou","year":"2023","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.jot.2026.101113_bib25","doi-asserted-by":"crossref","first-page":"465","DOI":"10.7150\/thno.123532","article-title":"The talin1-p53 axis inhibits osteocyte senescence to promote bone mass and mediate skeletal adaptation to mechanical stimulation","volume":"16","author":"Huang","year":"2026","journal-title":"Theranostics"},{"key":"10.1016\/j.jot.2026.101113_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcn.2015.03.011","article-title":"Full length talin stimulates integrin activation and axon regeneration","volume":"68","author":"Tan","year":"2015","journal-title":"Mol Cell Neurosci"},{"issue":"22","key":"10.1016\/j.jot.2026.101113_bib27","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1523\/JNEUROSCI.2456-20.2021","article-title":"The integrin signaling network promotes axon regeneration via the src-ephexin-rhoa GTPase signaling axis","volume":"41","author":"Sakai","year":"2021","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.jot.2026.101113_bib28","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s43587-021-00165-w","article-title":"Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis","volume":"2","author":"Wu","year":"2022","journal-title":"Nat Aging"},{"key":"10.1016\/j.jot.2026.101113_bib29","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbi.2024.01.002","article-title":"Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn","volume":"117","author":"Shan","year":"2024","journal-title":"Brain Behav Immun"},{"issue":"1","key":"10.1016\/j.jot.2026.101113_bib30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s13578-021-00679-1","article-title":"The mechanism of annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons","volume":"11","author":"Zhang","year":"2021","journal-title":"Cell Biosci"},{"issue":"6","key":"10.1016\/j.jot.2026.101113_bib31","article-title":"Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: implications for nociception","volume":"6","author":"Dvorakova","year":"2025","journal-title":"Cell Rep Med"},{"issue":"531","key":"10.1016\/j.jot.2026.101113_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw6471","article-title":"Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates","volume":"12","author":"Wang","year":"2020","journal-title":"Sci Transl Med"},{"issue":"44","key":"10.1016\/j.jot.2026.101113_bib33","article-title":"The Sirt1-Piezo1 axis promotes bone formation and repair in mice","volume":"12","author":"Gan","year":"2025","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"10.1016\/j.jot.2026.101113_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101639","article-title":"Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling","volume":"298","author":"Yan","year":"2022","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jot.2026.101113_bib35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jot.2023.05.005","article-title":"Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4(CreERT2) versus Aggrecan(CreERT2) transgene in mice","volume":"41","author":"Yao","year":"2023","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jot.2026.101113_bib36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jot.2025.01.006","article-title":"Targeting Piezo1 channel to alleviate intervertebral disc degeneration","volume":"51","author":"Li","year":"2025","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jot.2026.101113_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41413-019-0073-8","article-title":"Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice","volume":"8","author":"Cao","year":"2020","journal-title":"Bone Res"},{"key":"10.1016\/j.jot.2026.101113_bib38","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jot.2022.03.008","article-title":"Osteocyte beta1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice","volume":"34","author":"Qin","year":"2022","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jot.2026.101113_bib39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jot.2023.05.001","article-title":"Osteocyte beta3 integrin promotes bone mass accrual and force-induced bone formation in mice","volume":"40","author":"Qin","year":"2023","journal-title":"J Orthop Translat"},{"issue":"1","key":"10.1016\/j.jot.2026.101113_bib40","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1080\/10717544.2020.1748759","article-title":"Localized co-delivery of CNTF and FK506 using a thermosensitive hydrogel for retina ganglion cells protection after traumatic optic nerve injury","volume":"27","author":"Wang","year":"2020","journal-title":"Drug Deliv"},{"issue":"3","key":"10.1016\/j.jot.2026.101113_bib41","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1007\/s12035-023-03637-9","article-title":"Transcriptomic analysis of the rat dorsal root ganglion after fracture","volume":"61","author":"Gu","year":"2024","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jot.2026.101113_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcn.2015.03.011","article-title":"Full length talin stimulates integrin activation and axon regeneration","volume":"68","author":"Tan","year":"2015","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"10.1016\/j.jot.2026.101113_bib43","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1038\/s41467-023-38241-x","article-title":"Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis","volume":"14","author":"Obeidat","year":"2023","journal-title":"Nat Commun"},{"issue":"23","key":"10.1016\/j.jot.2026.101113_bib44","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1016\/j.neuron.2021.09.004","article-title":"The cellular and molecular basis of somatosensory neuron development","volume":"109","author":"Meltzer","year":"2021","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/j.jot.2026.101113_bib45","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1097\/j.pain.0000000000003181","article-title":"Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice","volume":"165","author":"Wu","year":"2024","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.jot.2026.101113_bib46","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41467-019-13839-2","article-title":"Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain","volume":"11","author":"Yu","year":"2020","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.jot.2026.101113_bib47","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1-Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jot.2026.101113_bib48","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jot.2024.08.016","article-title":"Role of oxidative stress in mitochondrial dysfunction and their implications in intervertebral disc degeneration: mechanisms and therapeutic strategies","volume":"49","author":"Zhou","year":"2024","journal-title":"J Orthop Translat"},{"issue":"12","key":"10.1016\/j.jot.2026.101113_bib49","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.cmet.2022.09.025","article-title":"Skeletal interoception in bone homeostasis and pain","volume":"34","author":"Lv","year":"2022","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.jot.2026.101113_bib50","article-title":"Implantable electrical stimulation at dorsal root ganglions accelerates osteoporotic fracture healing via calcitonin gene-related peptide","volume":"9","author":"Mi","year":"2022","journal-title":"Adv Sci (Weinh)"},{"issue":"30","key":"10.1016\/j.jot.2026.101113_bib51","doi-asserted-by":"crossref","first-page":"E6250","DOI":"10.1073\/pnas.1701416114","article-title":"Loss of mouse cardiomyocyte talin-1 and talin-2 leads to beta-1 integrin reduction, costameric instability, and dilated cardiomyopathy","volume":"114","author":"Manso","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jot.2026.101113_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118760","article-title":"Effect of mitochondrial dysfunction on neuropathic pain","volume":"193","author":"Li","year":"2025","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/j.jot.2026.101113_bib53","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12974-025-03456-w","article-title":"Nanozymes in neuropathic pain: strategies bridging oxidative stress, mitochondrial repair, and neuroimmune modulation for targeted therapy","volume":"22","author":"Mohsin","year":"2025","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.jot.2026.101113_bib54","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1038\/s41467-020-18753-6","article-title":"PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth","volume":"11","author":"Guo","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jot.2026.101113_bib55","first-page":"2","article-title":"Extracellular matrix stiffness regulates mitochondrial dynamics through PINCH-1- and kindlin-2-mediated signalling","author":"Keng","year":"2021","journal-title":"Current Research in Cell Biology"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26000690?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26000690?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:24:15Z","timestamp":1783110255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X26000690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":55,"alternative-id":["S2214031X26000690"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2026.101113","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Talin1 loss activates DRG neurons to accelerate bone remodeling and fracture healing in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2026.101113","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}],"article-number":"101113"}}