{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:18:00Z","timestamp":1783145880777,"version":"3.54.6"},"reference-count":183,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010318","name":"University of Manitoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jot.2026.101122","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:57:21Z","timestamp":1779001041000},"page":"101122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Toward next-generation hip implants: From failure mechanisms to translational design"],"prefix":"10.1016","volume":"58","author":[{"given":"Yunhua","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1605-0753","authenticated-orcid":false,"given":"Thomas","family":"Turgeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9824-4144","authenticated-orcid":false,"given":"Ian","family":"Polyzois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2026.101122_bib1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s41999-025-01213-z","article-title":"The impact of hip fracture on resilience in health-related quality of life: a cohort study","volume":"16","author":"Ek","year":"2025","journal-title":"Eur Geriatr Med"},{"key":"10.1016\/j.jot.2026.101122_bib2","article-title":"Exploring mortality risk factors and specific causes of death within 30 days after hip fracture hospitalization","volume":"14","author":"Wu","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jot.2026.101122_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jorep.2024.100429","article-title":"Navigating mortality and morbidity trends in geriatric patients post-surgical fixation of hip surgery","volume":"4","author":"Sarwath","year":"2025","journal-title":"Journal of Orthopaedic Reports"},{"key":"10.1016\/j.jot.2026.101122_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2025.105832","article-title":"Global, regional, and national burdens of hip fractures in elderly individuals from 1990 to 2021 and predictions up to 2050: a systematic analysis of the global burden of disease study 2021","volume":"133","author":"Tian","year":"2025","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.jot.2026.101122_bib5","doi-asserted-by":"crossref","first-page":"6591","DOI":"10.3390\/jcm13216591","article-title":"Challenges and long-term outcomes of cementless total hip arthroplasty in patients under 30: a 24-Year Follow-Up study with a minimum 8-Year follow-up, focused on developmental dysplasia of the hip","volume":"13","author":"Drobniewski","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.jot.2026.101122_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/jeo2.70350","article-title":"The relationship between stress shielding, bone density changes and implant migration, failure and fracture after total knee arthroplasty: a systematic review","volume":"12","author":"Senesi","year":"2025","journal-title":"J Exp Orthop"},{"key":"10.1016\/j.jot.2026.101122_bib7","article-title":"Stress transfer, stress shielding, and micro-movement analysis in the implanted femoral bone region with various hip implant stem materials: a finite element approach","volume":"41","author":"Soliman","year":"2024","journal-title":"Mater Today Commun"},{"key":"10.1016\/j.jot.2026.101122_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.actbio.2023.11.011","article-title":"The role of stiffness-matching in avoiding stress shielding-induced bone loss and stress concentration-induced skeletal reconstruction device failure","volume":"173","author":"Chmielewska","year":"2024","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2026.101122_bib9","first-page":"51","article-title":"Effectiveness of stress shielding prevention using a low young's modulus Ti-33.6Nb-4Sn stem: a 7-Year Follow-Up study","volume":"13","author":"Baba","year":"2025","journal-title":"Med Sci"},{"key":"10.1016\/j.jot.2026.101122_bib10","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1016\/j.actbio.2014.03.037","article-title":"Implant osseointegration and the role of microroughness and nanostructures: lessons for spine implants","volume":"10","author":"Gittens","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2026.101122_bib11","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/jbm.a.36829","article-title":"Role of implants surface modification in osseointegration: a systematic review","volume":"108","author":"Liu","year":"2020","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.jot.2026.101122_bib12","doi-asserted-by":"crossref","first-page":"S454","DOI":"10.1016\/j.arth.2024.06.038","article-title":"Periprosthetic fractures: a rising tide of hip arthroplasty failure noted in the American joint replacement registry and the preventative role of cemented stems","volume":"39","author":"Sassoon","year":"2024","journal-title":"J Arthroplast"},{"key":"10.1016\/j.jot.2026.101122_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1310262","article-title":"Roles of inflammatory cell infiltrate in periprosthetic osteolysis","volume":"14","author":"Panez-Toro","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jot.2026.101122_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/clinpract15030042","article-title":"A retrospective study on the incidence of periprosthetic fractures related to total hip arthroplasty and postoperative complications during hospitalization","volume":"15","author":"Niculescu","year":"2025","journal-title":"Clin Pract"},{"key":"10.1016\/j.jot.2026.101122_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2022.110552","article-title":"On the design evolution of hip implants: a review","volume":"216","author":"Guo","year":"2022","journal-title":"Mater Des"},{"key":"10.1016\/j.jot.2026.101122_bib16","doi-asserted-by":"crossref","first-page":"8773","DOI":"10.4081\/or.2021.8773","article-title":"Historical overview of hip arthroplasty: from humble beginnings to a high-tech future","volume":"13","author":"Bota","year":"2021","journal-title":"Orthop Rev"},{"key":"10.1016\/j.jot.2026.101122_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.5371\/hp.2019.31.4.179","article-title":"Total hip arthroplasty: past, present, and future. What has been achieved?","volume":"31","author":"Shon","year":"2019","journal-title":"Hip Pelvis"},{"key":"10.1016\/j.jot.2026.101122_bib18","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1302\/0301-620X.81B5.0810907","article-title":"Characteristics of bone ingrowth and interface mechanics of a new porous tantalum biomaterial","volume":"81","author":"Bobyn","year":"1999","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jot.2026.101122_bib19","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1016\/j.biomaterials.2006.04.041","article-title":"Experimental and clinical performance of porous tantalum in orthopedic surgery","volume":"27","author":"Levine","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101122_bib20","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.2106\/JBJS.L.01313","article-title":"Use of porous tantalum for acetabular reconstruction in revision hip arthroplasty","volume":"95","author":"Issack","year":"2013","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jot.2026.101122_bib21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3390\/bioengineering10070759","article-title":"Three-dimensional scaffolds for bone tissue engineering","volume":"10","author":"Chinnasami","year":"2023","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.jot.2026.101122_bib22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.biomaterials.2016.01.012","article-title":"Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: a review","volume":"83","author":"Wang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101122_bib23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jor.2022.06.013","article-title":"Functionally graded additive manufacturing for orthopedic applications","volume":"33","author":"Rouf","year":"2022","journal-title":"J Orthop"},{"key":"10.1016\/j.jot.2026.101122_bib24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s44455-025-00003-8","article-title":"A computational optimisation study of hip implant using density mapping functionally graded biomimetic TPMS-Based lattice structures","volume":"1","author":"Vafaeefar","year":"2025","journal-title":"Npj Metamaterials"},{"key":"10.1016\/j.jot.2026.101122_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e37818","article-title":"Advanced porous hip implants: a comprehensive review","volume":"10","author":"Ziaie","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jot.2026.101122_bib26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13018-022-03492-9","article-title":"Additively manufactured controlled porous orthopedic joint replacement designs to reduce bone stress shielding: a systematic review","volume":"18","author":"Safavi","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.jot.2026.101122_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1252636","article-title":"Additively manufactured porous scaffolds by design for treatment of bone defects","volume":"11","author":"Toosi","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jot.2026.101122_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijfatigue.2019.105358","article-title":"Fatigue of additive manufactured Ti-6Al-4V, part I: the effects of powder feedstock, manufacturing, and post-process conditions on the resulting microstructure and defects","volume":"132","author":"Pegues","year":"2020","journal-title":"Int J Fatig"},{"key":"10.1016\/j.jot.2026.101122_bib29","doi-asserted-by":"crossref","DOI":"10.1080\/17452759.2024.2302556","article-title":"Fatigue performance of metal additive manufacturing: a comprehensive overview","volume":"19","author":"Javidrad","year":"2024","journal-title":"Virtual Phys Prototyp"},{"key":"10.1016\/j.jot.2026.101122_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2020.100724","article-title":"Defects in additive manufactured metals and their effect on fatigue performance: a state-of-the-art review","volume":"117","author":"Sanaei","year":"2021","journal-title":"Prog Mater Sci"},{"key":"10.1016\/j.jot.2026.101122_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2023.105930","article-title":"3D printed biomedical devices and their applications: a review on state-of-the-art technologies, existing challenges, and future perspectives","volume":"143","author":"Mamo","year":"2023","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.jot.2026.101122_bib32","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1007\/s00402-022-04504-3","article-title":"Incidence and treatment of intracapsular femoral neck fractures in Germany","volume":"143","author":"Szymski","year":"2023","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.jot.2026.101122_bib33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12891-023-06140-3","article-title":"Femoral neck fractures in non-geriatric patients: femoral neck system versus cannulated cancellous screw","volume":"24","author":"Kenmegne","year":"2023","journal-title":"BMC Muscoskelet Disord"},{"key":"10.1016\/j.jot.2026.101122_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.772539","article-title":"Femoral stems with porous lattice structures: a review","volume":"9","author":"Liu","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jot.2026.101122_bib35","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s00264-023-06086-0","article-title":"Outcome and complication rate of total hip arthroplasty in patients younger than twenty years: which bearing surface should be used?","volume":"48","author":"Kang","year":"2024","journal-title":"Int Orthop"},{"key":"10.1016\/j.jot.2026.101122_bib36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jjoisr.2023.01.006","article-title":"Causes of failure after total hip arthroplasty: a narrative review of literature","volume":"1","author":"Kobayashi","year":"2023","journal-title":"Journal of Joint Surgery and Research"},{"key":"10.1016\/j.jot.2026.101122_bib37","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5435\/JAAOS-D-19-00860","article-title":"Reasons for revision: primary total hip arthroplasty mechanisms of failure","volume":"29","author":"Kelmer","year":"2021","journal-title":"JAAOS - Journal of the American Academy of Orthopaedic Surgeons"},{"key":"10.1016\/j.jot.2026.101122_bib38","first-page":"7080","article-title":"Primary total hip arthroplasty failure: aseptic loosening remains the most common cause of revision","volume":"14","author":"Feng","year":"2022","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.jot.2026.101122_bib39","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s11420-018-9641-5","article-title":"Mechanically induced periprosthetic osteolysis: a systematic review","volume":"15","author":"McArthur","year":"2019","journal-title":"HSS J"},{"key":"10.1016\/j.jot.2026.101122_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2025.02.032","article-title":"Causes of reoperations after primary total hip arthroplasty: a retrospective cohort Study over 20 years","author":"Park","year":"2025","journal-title":"J Arthroplast"},{"key":"10.1016\/j.jot.2026.101122_bib41","doi-asserted-by":"crossref","unstructured":"Zhao W-Q, Yu K-Q, Xie R-Z, Liang Y-F, Huang J-F. Risk factors for periprosthetic femoral fractures following hip arthroplasty: a systematic review and meta-analysis. Ann Med n.d.;57:2494679. https:\/\/doi.org\/10.1080\/07853890.2025.2494679.","DOI":"10.1080\/07853890.2025.2494679"},{"key":"10.1016\/j.jot.2026.101122_bib42","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12891-022-05159-2","article-title":"Periprosthetic femoral fractures in total hip arthroplasty (THA): a comparison between osteosynthesis and revision in a retrospective cohort study","volume":"23","author":"Scalici","year":"2022","journal-title":"BMC Muscoskelet Disord"},{"key":"10.1016\/j.jot.2026.101122_bib43","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.medengphy.2013.09.009","article-title":"A fatigue assessment technique for modular and pre-stressed orthopaedic implants","volume":"36","author":"Dickinson","year":"2014","journal-title":"Med Eng Phys"},{"key":"10.1016\/j.jot.2026.101122_bib44","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0142-1123(00)00052-9","article-title":"Fatigue of biomaterials: a review","volume":"22","author":"Teoh","year":"2000","journal-title":"Int J Fatig"},{"key":"10.1016\/j.jot.2026.101122_bib45","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1007\/s00402-024-05281-x","article-title":"Risk factors for femoral stem fracture following total hip arthroplasty: a systematic review and meta analysis","volume":"144","author":"Turnbull","year":"2024","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.jot.2026.101122_bib46","doi-asserted-by":"crossref","first-page":"665.e17","DOI":"10.1016\/j.arth.2010.05.021","article-title":"Fatigue fracture of a short stem hip replacement: a failure analysis with electron microscopy and review of the literature","volume":"26","author":"Ishaque","year":"2011","journal-title":"J Arthroplast"},{"key":"10.1016\/j.jot.2026.101122_bib47","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2340\/17453674.2023.13648","article-title":"Increasing risk of revision due to infection after primary total hip arthroplasty: results from the nordic arthroplasty register association","volume":"94","author":"Dale","year":"2023","journal-title":"Acta Orthop"},{"key":"10.1016\/j.jot.2026.101122_bib48","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0140-6736(12)60353-5","article-title":"Failure rates of stemmed metal-on-metal hip replacements: analysis of data from the national joint registry of England and Wales","volume":"379","author":"Smith","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jot.2026.101122_bib49","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3109\/17453670903506658","article-title":"Increasing risk of revision due to deep infection after hip arthroplasty","volume":"80","author":"Dale","year":"2009","journal-title":"Acta Orthop"},{"key":"10.1016\/j.jot.2026.101122_bib50","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.3390\/jcm8122091","article-title":"Periprosthetic osteolysis: mechanisms, prevention and treatment","volume":"8","author":"Goodman","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.jot.2026.101122_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1123753","article-title":"The dual role of autophagy in periprosthetic osteolysis","volume":"11","author":"Yin","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jot.2026.101122_bib52","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41598-020-79813-x","article-title":"Wear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening","volume":"11","author":"Vall\u00e9s","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jot.2026.101122_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/mmr.2023.13092","article-title":"Britanin inhibits titanium wear particle-induced osteolysis and osteoclastogenesis","volume":"28","author":"Kim","year":"2023","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jot.2026.101122_bib54","article-title":"Artemisinic acid attenuates osteoclast formation and titanium particle-induced osteolysis via inhibition of RANKL-Induced ROS accumulation and MAPK and NF-\u03baB signaling pathways","volume":"15","author":"Gao","year":"2024","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jot.2026.101122_bib55","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2013.0962","article-title":"Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement","volume":"11","author":"Goodman","year":"2014","journal-title":"J R Soc Interface"},{"key":"10.1016\/j.jot.2026.101122_bib56","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5371\/hp.2021.33.2.53","article-title":"Factors affecting periprosthetic bone loss after hip arthroplasty","volume":"33","author":"Lee","year":"2021","journal-title":"Hip & Pelvis"},{"key":"10.1016\/j.jot.2026.101122_bib57","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/17453674.2019.1695351","article-title":"Mechanical instability induces osteoclast differentiation independent of the presence of a fibrous tissue interface and osteocyte apoptosis in a rat model for aseptic loosening","volume":"91","author":"Madsen","year":"2020","journal-title":"Acta Orthop"},{"key":"10.1016\/j.jot.2026.101122_bib58","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/10255840701478810","article-title":"Activation pathways of osteoclasts are up-regulated by micromotions at the bone\u2013implant interface","volume":"10","author":"Stadelmann","year":"2007","journal-title":"Comput Methods Biomech Biomed Eng"},{"key":"10.1016\/j.jot.2026.101122_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-25567-7","article-title":"The release of osteoclast-stimulating factors on supraphysiological loading by osteoprogenitors coincides with expression of genes associated with inflammation and cytoskeletal arrangement","volume":"12","author":"Bratengeier","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jot.2026.101122_bib60","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1359\/jbmr.060107","article-title":"Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss","volume":"21","author":"Aguirre","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2026.101122_bib61","doi-asserted-by":"crossref","unstructured":"Mbalaviele G, Novack DV, Schett G, Teitelbaum SL. Inflammatory osteolysis: a conspiracy against bone. J Clin Investig n.d.;127:2030\u20132039. https:\/\/doi.org\/10.1172\/JCI93356.","DOI":"10.1172\/JCI93356"},{"key":"10.1016\/j.jot.2026.101122_bib62","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3389\/fcell.2020.00352","article-title":"The effects of biomaterial implant wear debris on osteoblasts","volume":"8","author":"Zhang","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jot.2026.101122_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2018.11.018","article-title":"Osseointegration and current interpretations of the bone-implant interface","volume":"84","author":"Shah","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2026.101122_bib64","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.3390\/polym14214600","article-title":"Stress shielding and bone resorption of press-fit polyether\u2013ether\u2013ketone (PEEK) hip prosthesis: a sawbone model study","volume":"14","author":"Naghavi","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.jot.2026.101122_bib65","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1002\/jor.24840","article-title":"Stress shielding at the bone-implant interface: influence of surface roughness and of the bone-implant contact ratio","volume":"39","author":"Raffa","year":"2021","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jot.2026.101122_bib66","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s00264-023-05825-7","article-title":"Stress shielding effect after total hip arthroplasty varies between combinations of stem design and stiffness\u2014a comparing biomechanical finite element analysis","volume":"47","author":"Burchard","year":"2023","journal-title":"Int Orthop"},{"key":"10.1016\/j.jot.2026.101122_bib67","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jbiomech.2017.08.017","article-title":"Improving stress shielding following total hip arthroplasty by using a femoral stem made of \u03b2 type Ti-33.6Nb-4Sn with a Young's modulus gradation","volume":"63","author":"Yamako","year":"2017","journal-title":"J Biomech"},{"key":"10.1016\/j.jot.2026.101122_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2022.105409","article-title":"Mechanical performance of additively manufactured cobalt-chromium-molybdenum auxetic meta-biomaterial bone scaffolds","volume":"134","author":"Wanniarachchi","year":"2022","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.jot.2026.101122_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.matchemphys.2023.127867","article-title":"Mechanical properties and biocompatibility of various cobalt chromium dental alloys","volume":"304","author":"Fratila","year":"2023","journal-title":"Mater Chem Phys"},{"key":"10.1016\/j.jot.2026.101122_bib70","doi-asserted-by":"crossref","first-page":"22734","DOI":"10.1039\/D1RA02355A","article-title":"Multi-scale microstructure high-strength titanium alloy lattice structure manufactured via selective laser melting","volume":"11","author":"Yang","year":"2021","journal-title":"RSC Adv"},{"key":"10.1016\/j.jot.2026.101122_bib71","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41597-023-02387-6","article-title":"Elastic modulus data for additively and conventionally manufactured variants of Ti-6Al-4V, IN718 and AISI 316 L","volume":"10","author":"Rehmer","year":"2023","journal-title":"Sci Data"},{"key":"10.1016\/j.jot.2026.101122_bib72","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s12633-019-00222-5","article-title":"Fabrication of ceramic hip implant composites: influence of silicon nitride on physical, mechanical and wear properties","volume":"12","author":"Goswami","year":"2020","journal-title":"Silicon"},{"key":"10.1016\/j.jot.2026.101122_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-022-00223-y","article-title":"Biomechanics and mechanobiology of the bone matrix","volume":"10","author":"Ma","year":"2022","journal-title":"Bone Res"},{"key":"10.1016\/j.jot.2026.101122_bib74","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0142-9612(97)00073-2","article-title":"Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation","volume":"18","author":"Rho","year":"1997","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101122_bib75","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3390\/bioengineering9120764","article-title":"The role of the innate immune system in wear debris-induced inflammatory peri-implant osteolysis in total joint arthroplasty","volume":"9","author":"Connors","year":"2022","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.jot.2026.101122_bib76","doi-asserted-by":"crossref","DOI":"10.3389\/fmats.2020.00274","article-title":"The mechanisms underlying the biological response to wear debris in periprosthetic inflammation","volume":"7","author":"Couto","year":"2020","journal-title":"Front Mater"},{"key":"10.1016\/j.jot.2026.101122_bib77","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.3390\/app14062259","article-title":"A review of the impacts of implant stiffness on fracture healing","volume":"14","author":"Mori","year":"2024","journal-title":"Appl Sci"},{"key":"10.1016\/j.jot.2026.101122_bib78","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3390\/biomed4020014","article-title":"Customized lattice structures tailored to mimic patients' bone anisotropic properties and microarchitecture for joint reconstruction applications","volume":"4","author":"El-Gizawy","year":"2024","journal-title":"BioMed"},{"key":"10.1016\/j.jot.2026.101122_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e32713","article-title":"Advances in biodegradable materials: degradation mechanisms, mechanical properties, and biocompatibility for orthopedic applications","volume":"10","author":"Hussain","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jot.2026.101122_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1617585","article-title":"Surface engineering of nano magnesium alloys for orthopedic implants: a systematic review of strategies to mitigate corrosion and promote bone regeneration","volume":"13","author":"Chaudhari","year":"2025","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jot.2026.101122_bib81","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pmatsci.2017.08.003","article-title":"Additive manufacturing of biomaterials","volume":"93","author":"Bose","year":"2018","journal-title":"Prog Mater Sci"},{"key":"10.1016\/j.jot.2026.101122_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsamd.2020.01.007","article-title":"Porous scaffolds for bone regeneration","volume":"5","author":"Abbasi","year":"2020","journal-title":"J Sci Adv Mater Devices"},{"key":"10.1016\/j.jot.2026.101122_bib83","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1562367","article-title":"An integrated experimental and analytical approach for the analysis of the mechanical interaction between metal porous scaffolds and bone: implications for stress shielding in orthopedic implants","volume":"13","author":"Ramaglia Amadasi","year":"2025","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jot.2026.101122_bib84","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.3390\/app15094827","article-title":"Biomechanical and clinical validation of a modulus-graded ti-nb-sn femoral stem for suppressing stress shielding in total hip arthroplasty","volume":"15","author":"Mori","year":"2025","journal-title":"Appl Sci"},{"key":"10.1016\/j.jot.2026.101122_bib85","first-page":"220","article-title":"Capability of auxetic femoral stems to reduce stress shielding after total hip arthroplasty","volume":"38","author":"Liu","year":"2023","journal-title":"J Orthop Transl"},{"key":"10.1016\/j.jot.2026.101122_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.compstruct.2023.117262","article-title":"Analysis of stress shielding reduction in bone fracture fixation implant using functionally graded materials","volume":"321","author":"Shahzamanian","year":"2023","journal-title":"Compos Struct"},{"key":"10.1016\/j.jot.2026.101122_bib87","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1274679","article-title":"Mechanism of regulating macrophages\/osteoclasts in attenuating wear particle-induced aseptic osteolysis","volume":"14","author":"Yin","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jot.2026.101122_bib88","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1186\/s12951-024-03049-4","article-title":"Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy","volume":"22","author":"Liu","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.jot.2026.101122_bib89","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.3390\/ma14143805","article-title":"In vitro analysis of wearing of hip joint prostheses composed of different contact materials","volume":"14","author":"Su","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.jot.2026.101122_bib90","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2016.14","article-title":"A review of UHMWPE wear-induced osteolysis: the role for early detection of the immune response","volume":"4","author":"Kandahari","year":"2016","journal-title":"Bone Res"},{"key":"10.1016\/j.jot.2026.101122_bib91","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1016\/j.biomaterials.2007.06.035","article-title":"Wear particles, periprosthetic osteolysis and the immune system","volume":"28","author":"Goodman","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101122_bib92","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1302\/2046-3758.55.BJR-2016-0086","article-title":"The pathobiology and pathology of aseptic implant failure","volume":"5","author":"Athanasou","year":"2016","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.jot.2026.101122_bib93","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.imbio.2019.08.002","article-title":"Factors influencing multinucleated giant cell formation in vitro","volume":"224","author":"Trout","year":"2019","journal-title":"Immunobiology"},{"key":"10.1016\/j.jot.2026.101122_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinbiomech.2025.106540","article-title":"Laser surface texturing for enhanced implant biocompatibility and osseointegration: a critical review of its effects on surface properties","volume":"126","author":"Ozan","year":"2025","journal-title":"Clin BioMech"},{"key":"10.1016\/j.jot.2026.101122_bib95","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1177\/0300060517732697","article-title":"Current methods of preventing aseptic loosening and improving osseointegration of titanium implants in cementless total hip arthroplasty: a review","volume":"46","author":"Apostu","year":"2018","journal-title":"J Int Med Res"},{"key":"10.1016\/j.jot.2026.101122_bib96","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1016\/j.biomaterials.2005.02.002","article-title":"Porosity of 3D biomaterial scaffolds and osteogenesis","volume":"26","author":"Karageorgiou","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101122_bib97","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.biomaterials.2009.09.063","article-title":"The effect of mean pore size on cell attachment, proliferation and migration in collagen-glycosaminoglycan scaffolds for bone tissue engineering","volume":"31","author":"Murphy","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101122_bib98","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.1021\/acsbiomaterials.3c00214","article-title":"Mechanical properties directionality and permeability of fused triply periodic minimal surface porous scaffolds fabricated by selective laser melting","volume":"9","author":"Ye","year":"2023","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.jot.2026.101122_bib99","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s10856-024-06856-1","article-title":"Understanding the relationship between pore structure and properties of triply periodic minimal surface bone scaffolds","volume":"36","author":"Sun","year":"2025","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.jot.2026.101122_bib100","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1089\/ten.tea.2023.0033","article-title":"Triply periodic minimal surface-based scaffolds for bone tissue engineering: a mechanical, in vitro and in vivo study","volume":"29","author":"Maevskaia","year":"2023","journal-title":"Tissue Eng"},{"key":"10.1016\/j.jot.2026.101122_bib101","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3390\/coatings13061091","article-title":"Bioactive calcium phosphate coatings for bone implant applications: a review","volume":"13","author":"Drevet","year":"2023","journal-title":"Coatings"},{"key":"10.1016\/j.jot.2026.101122_bib102","article-title":"Advanced surface modification techniques for titanium implants: a review of osteogenic and antibacterial strategies","volume":"13","author":"Zhang","year":"2025","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jot.2026.101122_bib103","article-title":"Implant\u2010bone\u2010interface: reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo","volume":"7","author":"Stich","year":"2021","journal-title":"Bioeng Transl Med"},{"key":"10.1016\/j.jot.2026.101122_bib104","article-title":"Investigating the early osteogenic potential of strontium doped titanium alloy surface","volume":"23","author":"Alenezi","year":"2025","journal-title":"J Appl Biomater Funct Mater"},{"key":"10.1016\/j.jot.2026.101122_bib105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1051\/sicotj\/2024003","article-title":"Collared versus collarless hydroxyapatite-coated stems for primary cementless total hip arthroplasty; a systematic review of comparative studies. Is there any difference in survival, functional, and radiographic outcomes?","volume":"10","author":"Giovanoulis","year":"2024","journal-title":"SICOT J"},{"key":"10.1016\/j.jot.2026.101122_bib106","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/00016740308540838","article-title":"Comparison of hydroxyapatite- and porous-coated stems in total hip replacement","author":"Park","year":"2003","journal-title":"Acta Orthop"},{"key":"10.1016\/j.jot.2026.101122_bib107","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.arth.2008.01.129","article-title":"A randomized trial of hydroxyapatite-coated femoral stems in total hip arthroplasty: a 13-Year Follow-Up","volume":"24","author":"Camazzola","year":"2009","journal-title":"J Arthroplast"},{"key":"10.1016\/j.jot.2026.101122_bib108","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.pnsc.2014.08.014","article-title":"Progress of biodegradable metals","volume":"24","author":"Li","year":"2014","journal-title":"Prog Nat Sci Mater Int"},{"key":"10.1016\/j.jot.2026.101122_bib109","first-page":"127","article-title":"Optimising degradation and mechanical performance of additively manufactured biodegradable Fe\u2013Mn scaffolds using design strategies based on triply periodic minimal surfaces","volume":"5","author":"Dargusch","year":"2024","journal-title":"Smart Mater Med"},{"key":"10.1016\/j.jot.2026.101122_bib110","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3390\/cryst15080671","article-title":"Recent advances in biodegradable magnesium alloys for medical implants: Evolution, innovations, and clinical translation","volume":"15","author":"Aikin","year":"2025","journal-title":"Crystals"},{"key":"10.1016\/j.jot.2026.101122_bib111","doi-asserted-by":"crossref","DOI":"10.3389\/fbiom.2022.925471","article-title":"Assessing the long-term in vivo degradation behavior of magnesium alloys - a high resolution synchrotron radiation micro computed tomography study","volume":"1","author":"Sefa","year":"2022","journal-title":"Front Biomater Sci"},{"key":"10.1016\/j.jot.2026.101122_bib112","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3390\/met15070754","article-title":"Additive manufacturing of biodegradable metallic implants by selective laser melting: current research status and application perspectives","volume":"15","author":"Gracheva","year":"2025","journal-title":"Metals"},{"key":"10.1016\/j.jot.2026.101122_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.msea.2022.143276","article-title":"Microstructural evolution and mechanical properties of pure Zn fabricated by selective laser melting","volume":"846","author":"Wang","year":"2022","journal-title":"Mater Sci Eng, A"},{"key":"10.1016\/j.jot.2026.101122_bib114","doi-asserted-by":"crossref","first-page":"rbad095","DOI":"10.1093\/rb\/rbad095","article-title":"Magnesium-based alloys with adapted interfaces for bone implants and tissue engineering","volume":"10","author":"Antoniac","year":"2023","journal-title":"Regen Biomater"},{"key":"10.1016\/j.jot.2026.101122_bib115","doi-asserted-by":"crossref","first-page":"8645","DOI":"10.1038\/s41598-021-87783-x","article-title":"Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings","volume":"11","author":"Khalili","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jot.2026.101122_bib116","article-title":"Degradation behavior, osteogenesis, and antimicrobial properties of Ga-coated ZK60 Mg alloys for medical implants","author":"Feng","year":"2025","journal-title":"J Magnesium Alloys"},{"key":"10.1016\/j.jot.2026.101122_bib117","article-title":"Bioabsorbable WE43 Mg alloy wires modified by continuous plasma-electrolytic oxidation for implant applications","author":"Ali","year":"2023","journal-title":"Part I: processing, microstructure and mechanical properties"},{"key":"10.1016\/j.jot.2026.101122_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2024.106602","article-title":"Comparison of stress distribution in fully porous and dense-core porous scaffolds in dental implantation","volume":"156","author":"Hosseini","year":"2024","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.jot.2026.101122_bib119","first-page":"135","article-title":"Porous metal materials for applications in orthopedic field: a review on mechanisms in bone healing","volume":"49","author":"Ma","year":"2024","journal-title":"J Orthop Transl"},{"key":"10.1016\/j.jot.2026.101122_bib120","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1401899","article-title":"Design of novel triply periodic minimal surface (TPMS) bone scaffold with multi-functional pores: lower stress shielding and higher mass transport capacity","volume":"12","author":"Jiang","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jot.2026.101122_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213697","article-title":"Osseointegration of functionally graded Ti6Al4V porous implants: histology of the pore network","volume":"155","author":"Deering","year":"2023","journal-title":"Biomater Adv"},{"key":"10.1016\/j.jot.2026.101122_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.tws.2024.112800","article-title":"Optimizing mass transfer performance in triply periodic minimal surface porous scaffolds through isosurface offset","volume":"208","author":"Li","year":"2025","journal-title":"Thin-Walled Struct"},{"key":"10.1016\/j.jot.2026.101122_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2025.107039","article-title":"Impact of biodegradation on the mechanical and fatigue properties of 3D-printed PLA bone scaffolds","volume":"168","author":"Bakhtiari","year":"2025","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.jot.2026.101122_bib124","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.3390\/polym16233303","article-title":"Advances and challenges in polymer-based scaffolds for bone tissue engineering: a path towards personalized regenerative medicine","volume":"16","author":"Farjaminejad","year":"2024","journal-title":"Polymers"},{"key":"10.1016\/j.jot.2026.101122_bib125","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.biomaterials.2005.10.003","article-title":"Magnesium and its alloys as orthopedic biomaterials: a review","volume":"27","author":"Staiger","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101122_bib126","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.actbio.2010.02.028","article-title":"The history of biodegradable magnesium implants: a review","volume":"6","author":"Witte","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2026.101122_bib127","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1002\/adma.201300226","article-title":"Zinc exhibits ideal physiological corrosion behavior for bioabsorbable stents","volume":"25","author":"Bowen","year":"2013","journal-title":"Adv Mater"},{"key":"10.1016\/j.jot.2026.101122_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijfatigue.2024.108531","article-title":"In vitro corrosion-fatigue behaviour of rare-earth containing magnesium WE43 in sterile complex cell culture medium","volume":"188","author":"Nachtsheim","year":"2024","journal-title":"Int J Fatig"},{"key":"10.1016\/j.jot.2026.101122_bib129","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3390\/surfaces7010007","article-title":"Impact of corrosion in simulated body fluid on fatigue characteristics of 3D-Printed polylactic acid-coated AM60 magnesium alloys","volume":"7","author":"Ashraf Talesh","year":"2024","journal-title":"Surfaces"},{"key":"10.1016\/j.jot.2026.101122_bib130","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s10033-024-01064-y","article-title":"Review on the fabrication of surface functional structures for enhancing bioactivity of titanium and titanium alloy implants","volume":"37","author":"Tang","year":"2024","journal-title":"Chin J Mech Eng"},{"key":"10.1016\/j.jot.2026.101122_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.amf.2025.200195","article-title":"Recent advancements in the surface modification of additively manufactured metallic bone implants","volume":"4","author":"Li","year":"2025","journal-title":"Additive Manufacturing Frontiers"},{"key":"10.1016\/j.jot.2026.101122_bib132","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3390\/ma18040822","article-title":"Advanced strategies for enhancing the biocompatibility and antibacterial properties of implantable structures","volume":"18","author":"Mishchenko","year":"2025","journal-title":"Materials"},{"key":"10.1016\/j.jot.2026.101122_bib133","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/21870764.2019.1669861","article-title":"Bioactive coating as a surface modification technique for biocompatible metallic implants: a review","volume":"7","author":"Priyadarshini","year":"2019","journal-title":"J Asian Ceram Soc"},{"key":"10.1016\/j.jot.2026.101122_bib134","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1269223","article-title":"Modification of titanium orthopedic implants with bioactive glass: a systematic review of in vivo and in vitro studies","volume":"11","author":"Liang","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jot.2026.101122_bib135","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00590-023-03622-x","article-title":"A review of wear debris in thumb base joint implants","volume":"34","author":"Mangan","year":"2024","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"10.1016\/j.jot.2026.101122_bib136","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/prosthesis7010021","article-title":"Advancements in surface coatings for enhancing longevity in hip implants: a review","volume":"7","author":"Nikam","year":"2025","journal-title":"Prosthesis"},{"key":"10.1016\/j.jot.2026.101122_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2024.112850","article-title":"Titanium-based alloys and composites for orthopedic implants applications: a comprehensive review","volume":"241","author":"Abd-Elaziem","year":"2024","journal-title":"Mater Des"},{"key":"10.1016\/j.jot.2026.101122_bib138","article-title":"Prospective applications of bioactive materials in orthopedic therapies: a review","volume":"10","author":"Liang","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jot.2026.101122_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123493","article-title":"A soft-hard hybrid scaffold for osteochondral regeneration through integration of composite hydrogel and biodegradable magnesium","volume":"324","author":"Pei","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101122_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2025.214292","article-title":"Bionic ECM scaffolds for directional articular hyaline cartilage regeneration and long-term homeostasis maintenance","volume":"173","author":"Li","year":"2025","journal-title":"Biomater Adv"},{"key":"10.1016\/j.jot.2026.101122_bib141","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1021\/acsbiomaterials.5c00048","article-title":"Dual-phase degradation and hydroxyapatite Formation in bioactive glass ceramic-coated aluminum titanate scaffolds for bone applications","volume":"11","author":"B","year":"2025","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.jot.2026.101122_bib142","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1039\/D4MA00752B","article-title":"Monitoring of the dissolution\/precipitation behavior of bioglass with simulated body fluid buffered by HEPES","volume":"6","author":"Horkavcov\u00e1","year":"2025","journal-title":"Mater Adv"},{"key":"10.1016\/j.jot.2026.101122_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2024.106010","article-title":"In-depth review of synthesis of hydroxyapatite biomaterials from natural resources and chemical regents for biomedical applications","volume":"17","author":"Etinosa","year":"2024","journal-title":"Arab J Chem"},{"key":"10.1016\/j.jot.2026.101122_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2025.117457","article-title":"DXA-based 3D finite element models predict hip fractures better than areal BMD in elderly women","volume":"195","author":"Grassi","year":"2025","journal-title":"Bone"},{"key":"10.1016\/j.jot.2026.101122_bib145","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.radi.2024.08.009","article-title":"The accuracy and clinical utility of spectral CT bone density measurement in the lumbar spine of unenhanced images: a narrative review","volume":"30","author":"Hepburn","year":"2024","journal-title":"Radiography"},{"key":"10.1016\/j.jot.2026.101122_bib146","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.medengphy.2016.03.006","article-title":"The influence of the modulus-density relationship and the material mapping method on the simulated mechanical response of the proximal femur in side-ways fall loading configuration","volume":"38","author":"Helgason","year":"2016","journal-title":"Med Eng Phys"},{"key":"10.1016\/j.jot.2026.101122_bib147","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1538460","article-title":"Biomechanical perspectives on image-based hip fracture risk assessment: advances and challenges","volume":"16","author":"Luo","year":"2025","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jot.2026.101122_bib148","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s11657-025-01579-4","article-title":"Opportunistic computed tomography (CT) assessment of osteoporosis in patients undergoing transcatheter aortic valve replacement (TAVR)","volume":"20","author":"Paukovitsch","year":"2025","journal-title":"Arch Osteoporosis"},{"key":"10.1016\/j.jot.2026.101122_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2023.106299","article-title":"QCT-based 3D finite element modeling to assess patient-specific hip fracture risk and risk factors","volume":"150","author":"Awal","year":"2024","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.jot.2026.101122_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2025.117621","article-title":"Empirical quantification of bone mineral and organic phase attenuation coefficients using CT imaging and controlled thermal processing","volume":"200","author":"Luo","year":"2025","journal-title":"Bone"},{"key":"10.1016\/j.jot.2026.101122_bib151","doi-asserted-by":"crossref","DOI":"10.1093\/jbmrpl\/ziaf066","article-title":"A three-material model for dual-layer detector spectral computed tomography measurements of marrow adipose tissue and bone mineral density","volume":"9","author":"Zhou","year":"2025","journal-title":"JBMR Plus"},{"key":"10.1016\/j.jot.2026.101122_bib152","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1302\/2046-3758.146.BJR-2024-0118.R3","article-title":"Increasing reaming depth enhances implant stability while minimizing bone strain","volume":"14","author":"Karia","year":"2025","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.jot.2026.101122_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinbiomech.2025.106539","article-title":"Finite element analysis of primary stability in cementless tibial components with varying interference fits","volume":"126","author":"S\u00e1nchez","year":"2025","journal-title":"Clin BioMech"},{"key":"10.1016\/j.jot.2026.101122_bib154","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jor.25671","article-title":"Corroboration of coupled musculoskeletal model and finite element predictions with in vivo RSA migration of an uncemented acetabular component","volume":"42","author":"Fallahnezhad","year":"2024","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jot.2026.101122_bib155","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.3390\/app14083200","article-title":"Finite element models to predict the risk of aseptic loosening in cementless femoral stems: a literature review","volume":"14","author":"Sun","year":"2024","journal-title":"Appl Sci"},{"key":"10.1016\/j.jot.2026.101122_bib156","doi-asserted-by":"crossref","DOI":"10.1177\/24730114241308577","article-title":"Finite element analysis of the influence that bone density and implant fixation features have on total ankle tibial component stability","volume":"9","author":"Johnson","year":"2024","journal-title":"Foot & Ankle Orthopaedics"},{"key":"10.1016\/j.jot.2026.101122_bib157","doi-asserted-by":"crossref","first-page":"5719","DOI":"10.1038\/s41598-024-56327-4","article-title":"Development of a density-based topology optimization of homogenized lattice structures for individualized hip endoprostheses and validation using micro-FE","volume":"14","author":"M\u00fcller","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jot.2026.101122_bib158","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3390\/jcs8070254","article-title":"A finite element analysis study of influence of femoral stem material in stress shielding in a model of uncemented total hip arthroplasty: Ti-6Al-4V versus carbon fibre-reinforced PEEK composite","volume":"8","author":"Ceddia","year":"2024","journal-title":"J Compos Sci"},{"key":"10.1016\/j.jot.2026.101122_bib159","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41598-018-36503-z","article-title":"Anatomic grooved stem mitigates strain shielding compared to established total hip arthroplasty stem designs in finite-element models","volume":"9","author":"Heyland","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jot.2026.101122_bib160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0300270","article-title":"Finite element modeling of stress distribution and safety factors in a Ti-27Nb alloy hip implant under real-world physiological loading scenarios","volume":"19","author":"Amjad","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.jot.2026.101122_bib161","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1177\/09544119211021675","article-title":"Endurance testing and finite element simulation of a modified hip stem for integration of an energy harvesting system","volume":"235","author":"Lange","year":"2021","journal-title":"Proc Inst Mech Eng H"},{"key":"10.1016\/j.jot.2026.101122_bib162","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2025.110574","article-title":"An in silico study reveals how architectural and mechanical cues jointly regulate angiogenesis and bone regeneration in 3D printed scaffolds","volume":"195","author":"Dazzi","year":"2025","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.jot.2026.101122_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2025.117688","article-title":"A review of bone fracture healing modelling: from mechanobiological theory to personalized rehabilitation protocols","volume":"202","author":"Li","year":"2026","journal-title":"Bone"},{"key":"10.1016\/j.jot.2026.101122_bib164","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.actbio.2022.04.008","article-title":"An in silico model predicts the impact of scaffold design in large bone defect regeneration","volume":"145","author":"Perier-Metz","year":"2022","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2026.101122_bib165","author":"Entezari"},{"key":"10.1016\/j.jot.2026.101122_bib166","first-page":"51524","article-title":"An overview of developments in computational modeling of bone healing processes","volume":"59","author":"Bazyar","year":"2024","journal-title":"BJSTR"},{"key":"10.1016\/j.jot.2026.101122_bib167","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s10237-025-01985-0","article-title":"Finite element analysis of stem migration after total hip replacement","volume":"24","author":"Reiber","year":"2025","journal-title":"Biomech Model Mechanobiol"},{"key":"10.1016\/j.jot.2026.101122_bib168","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/jor.25808","article-title":"Influence of offset on osseointegration in cementless total hip arthroplasty: a finite element study","volume":"42","author":"Meisterhans","year":"2024","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jot.2026.101122_bib169","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1177\/09544119241286958","article-title":"Prediction of bone ingrowth into a porous novel hip-stem: a finite element analysis integrated with mechanoregulatory algorithm","volume":"238","author":"Loha","year":"2024","journal-title":"Proc Inst Mech Eng H"},{"key":"10.1016\/j.jot.2026.101122_bib170","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s42235-019-0122-4","article-title":"Finite element analysis of porous titanium alloy hip stem to evaluate the biomechanical performance during walking and stair climbing","volume":"16","author":"Alkhatib","year":"2019","journal-title":"J Bionic Eng"},{"key":"10.1016\/j.jot.2026.101122_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.medengphy.2025.104369","article-title":"Effects of mechanical stimuli on bone cells for regenerative medicine: a review of recent experimental and computational methods","volume":"142","author":"Wiedemann-Fod\u00e9","year":"2025","journal-title":"Med Eng Phys"},{"key":"10.1016\/j.jot.2026.101122_bib172","doi-asserted-by":"crossref","DOI":"10.1016\/j.engmed.2025.100057","article-title":"Biomechanics in bone regeneration and mechanobiology in osteoblasts: fundamental concepts and recent progress","volume":"2","author":"Cai","year":"2025","journal-title":"EngMedicine"},{"key":"10.1016\/j.jot.2026.101122_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.compstruct.2024.117923","article-title":"Multi-objective optimization for designing porous scaffolds with controllable mechanics and permeability: a case study on triply periodic minimal surface scaffolds","volume":"333","author":"Li","year":"2024","journal-title":"Compos Struct"},{"key":"10.1016\/j.jot.2026.101122_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2024.106864","article-title":"Developing porous hip implants implementing topology optimization based on the bone remodelling model and fatigue failure","volume":"163","author":"Ziaie","year":"2025","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.jot.2026.101122_bib175","doi-asserted-by":"crossref","DOI":"10.1007\/s10409-025-24486-x","article-title":"Multi-objective optimization design of biomimetic porous scaffolds based on cancellous bone structure","volume":"42","author":"Tian","year":"2026","journal-title":"Acta Mech Sin"},{"key":"10.1016\/j.jot.2026.101122_bib176","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbaf032","article-title":"Magnesium as an emerging bioactive material for orthopedic applications: bedside needs lead the way from innovation to clinical translation","volume":"12","author":"Zhang","year":"2025","journal-title":"Regen Biomater"},{"key":"10.1016\/j.jot.2026.101122_bib177","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/35015116","article-title":"Effects of mechanical forces on maintenance and adaptation of form in trabecular bone","volume":"405","author":"Huiskes","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jot.2026.101122_bib178","first-page":"124","article-title":"The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials","author":"Huiskes","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jot.2026.101122_bib179","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.actbio.2010.09.017","article-title":"Investigation of alendronate-doped apatitic cements as a potential technology for the prevention of osteoporotic hip fractures: critical influence of the drug introduction mode on the in vitro cement properties","volume":"7","author":"Schnitzler","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2026.101122_bib180","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jcot.2018.04.008","article-title":"Additive manufacturing applications in orthopaedics: a review","volume":"9","author":"Javaid","year":"2018","journal-title":"Journal of Clinical Orthopaedics & Trauma"},{"key":"10.1016\/j.jot.2026.101122_bib181","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0021-9290(96)00140-6","article-title":"Biophysical stimuli on cells during tissue differentiation at implant interfaces","volume":"30","author":"Prendergast","year":"1997","journal-title":"J Biomech"},{"key":"10.1016\/j.jot.2026.101122_bib182","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0021-9290(98)00153-5","article-title":"Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing","volume":"32","author":"Claes","year":"1999","journal-title":"J Biomech"},{"key":"10.1016\/j.jot.2026.101122_bib183","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.actbio.2011.10.029","article-title":"Sustained release of adiponectin improves osteogenesis around hydroxyapatite implants by suppressing osteoclast activity in ovariectomized rabbits","volume":"8","author":"Luo","year":"2012","journal-title":"Acta Biomater"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26000781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26000781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:34:03Z","timestamp":1783143243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X26000781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":183,"alternative-id":["S2214031X26000781"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2026.101122","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toward next-generation hip implants: From failure mechanisms to translational design","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2026.101122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}],"article-number":"101122"}}