{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:20:54Z","timestamp":1787602854623,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016879","name":"UCB SA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","award":["GPP 2022"],"award-info":[{"award-number":["GPP 2022"]}],"id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jot.2026.101135","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:41:25Z","timestamp":1780447285000},"page":"101135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Romosozumab increases bone mineral density in postmenopausal Chinese women with osteoporosis: A randomised phase three study"],"prefix":"10.1016","volume":"59","author":[{"given":"Zhang","family":"Zhenlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Qingyun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Decai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Aijun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huo","family":"Yanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Youjia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Qun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Huilin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Xiaoyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yujie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6669-9579","authenticated-orcid":false,"given":"Jiang","family":"Jun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"LingLing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario-Jansen","family":"Theresa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bauer","family":"Lars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Weibo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9773","key":"10.1016\/j.jot.2026.101135_bib1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"issue":"14","key":"10.1016\/j.jot.2026.101135_bib2","first-page":"1671","article-title":"Guidelines for the diagnosis and treatment of primary osteoporosis(2022)","volume":"26","year":"2023","journal-title":"Chinese General Practice"},{"issue":"8","key":"10.1016\/j.jot.2026.101135_bib3","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.21106","article-title":"Prevalence of osteoporosis and fracture in China: the China osteoporosis prevalence study","volume":"4","author":"Wang","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"14","key":"10.1016\/j.jot.2026.101135_bib5","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1097\/CM9.0000000000000332","article-title":"Prevalence of osteoporotic vertebral fracture among community-dwelling elderly in Shanghai","volume":"132","author":"Gao","year":"2019","journal-title":"Chin Med J (Engl)"},{"issue":"10","key":"10.1016\/j.jot.2026.101135_bib4","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1359\/jbmr.2000.15.10.2019","article-title":"Vertebral fractures in Beijing, China: the Beijing Osteoporosis Project","volume":"15","author":"Ling","year":"2000","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.jot.2026.101135_bib6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s11657-022-01158-x","article-title":"Prevalent vertebral fractures among urban-dwelling Chinese postmenopausal women: a population-based, randomized-sampling, cross-sectional study","volume":"17","author":"Xia","year":"2022","journal-title":"Arch Osteoporos"},{"issue":"8","key":"10.1016\/j.jot.2026.101135_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003180","article-title":"Incidence of and trends in hip fracture among adults in urban China: a nationwide retrospective cohort study","volume":"17","author":"Zhang","year":"2020","journal-title":"PLoS Med"},{"issue":"5","key":"10.1016\/j.jot.2026.101135_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00198-008-0742-8","article-title":"Secular trends in hip fracture incidence and recurrence","volume":"20","author":"Melton","year":"2009","journal-title":"Osteoporos Int"},{"issue":"8","key":"10.1016\/j.jot.2026.101135_bib9","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s00198-018-4502-0","article-title":"Characteristics of recurrent fractures","volume":"29","author":"Kanis","year":"2018","journal-title":"Osteoporos Int"},{"issue":"2","key":"10.1016\/j.jot.2026.101135_bib10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bone.2004.03.024","article-title":"A meta-analysis of previous fracture and subsequent fracture risk","volume":"35","author":"Kanis","year":"2004","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jot.2026.101135_bib11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s001980050218","article-title":"Vertebral fractures predict subsequent fractures","volume":"10","author":"Melton","year":"1999","journal-title":"Osteoporos Int"},{"issue":"3","key":"10.1016\/j.jot.2026.101135_bib12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00198-016-3868-0","article-title":"Imminent risk of fracture after fracture","volume":"28","author":"Johansson","year":"2017","journal-title":"Osteoporos Int"},{"issue":"6","key":"10.1016\/j.jot.2026.101135_bib13","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/s11914-018-0487-z","article-title":"Importance of recent fracture as predictor of imminent fracture risk","volume":"16","author":"Schnell","year":"2018","journal-title":"Curr Osteoporos Rep"},{"issue":"12","key":"10.1016\/j.jot.2026.101135_bib14","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1007\/s00198-022-06473-0","article-title":"The imminent risk of a fracture-existing worldwide data: a systematic review and meta-analysis","volume":"33","author":"Wong","year":"2022","journal-title":"Osteoporos Int"},{"issue":"3","key":"10.1016\/j.jot.2026.101135_bib15","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1046\/j.1532-5415.2003.51110.x","article-title":"Estimating hip fracture morbidity, mortality and costs","volume":"51","author":"Braithwaite","year":"2003","journal-title":"J Am Geriatr Soc"},{"issue":"10","key":"10.1016\/j.jot.2026.101135_bib16","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/gerona\/glt093","article-title":"Public health impact of osteoporosis","volume":"68","author":"Cauley","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"10.1016\/j.jot.2026.101135_bib17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bone.2004.03.035","article-title":"Health care costs of women with symptomatic vertebral fractures","volume":"35","author":"Puffer","year":"2004","journal-title":"Bone"},{"issue":"16","key":"10.1016\/j.jot.2026.101135_bib18","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal women with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.jot.2026.101135_bib19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1056\/NEJMoa1305224","article-title":"Romosozumab in postmenopausal women with low bone mineral density","volume":"370","author":"McClung","year":"2014","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.jot.2026.101135_bib20","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1056\/NEJMoa1708322","article-title":"Romosozumab or alendronate for fracture prevention in women with osteoporosis","volume":"377","author":"Saag","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jot.2026.101135_bib21","article-title":"FDA approves EVENITY\u2122 (romosozumab-aqqg) for the treatment of osteoporosis in postmenopausal women at high risk for","year":"2019","journal-title":"Fracture"},{"key":"10.1016\/j.jot.2026.101135_bib22","article-title":"European commission approves EVENITY\u00ae (romosozumab) for the treatment of severe osteoporosis in postmenopausal women at high risk of","year":"2019","journal-title":"Fracture"},{"key":"10.1016\/j.jot.2026.101135_bib23","first-page":"1","article-title":"Efficacy and safety of romosozumab: a meta-analysis of placebo-controlled trials","author":"Kobayashi","year":"2024","journal-title":"J Bone Miner Metabol"},{"issue":"5","key":"10.1016\/j.jot.2026.101135_bib24","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s001980050093","article-title":"Updated data on proximal femur bone mineral levels of US adults","volume":"8","author":"Looker","year":"1998","journal-title":"Osteoporos Int"},{"issue":"4","key":"10.1016\/j.jot.2026.101135_bib26","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00198-020-05324-0","article-title":"Romosozumab or alendronate for fracture prevention in East Asian patients: a subanalysis of the phase III, randomized ARCH study","volume":"31","author":"Lau","year":"2020","journal-title":"Osteoporos Int"},{"issue":"1","key":"10.1016\/j.jot.2026.101135_bib27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3803\/EnM.2020.848","article-title":"Romosozumab in postmenopausal Korean women with osteoporosis: a randomized, Double-Blind, placebo-controlled efficacy and safety Study","volume":"36","author":"Baek","year":"2021","journal-title":"Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.jot.2026.101135_bib28","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/ejendo\/lvaf211","article-title":"Efficacy comparison of 6-month romosozumab plus denosumab versus 12-month romosozumab in Koreans","volume":"193","author":"Lee","year":"2025","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jot.2026.101135_bib29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2017.07.005","article-title":"Romosozumab increases bone mineral density in postmenopausal Japanese women with osteoporosis: a phase 2 study","volume":"103","author":"Ishibashi","year":"2017","journal-title":"Bone"},{"issue":"10","key":"10.1016\/j.jot.2026.101135_bib30","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1093\/jbmr\/zjae126","article-title":"The relationship between treatment-related changes in total hip BMD measured after 12, 18, and 24 mo and fracture risk reduction in osteoporosis clinical trials: the FNIH-ASBMR-SABRE project","volume":"39","author":"Vilaca","year":"2024","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2026.101135_bib31","series-title":"FDA qualifies total hip Bone Mineral Density (BMD) as surrogate endpoint for osteoporosis drug development","year":"2025"},{"issue":"3","key":"10.1016\/j.jot.2026.101135_bib32","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1210\/endrev\/bnac031","article-title":"Bone turnover markers: basic biology to clinical applications","volume":"44","author":"Schini","year":"2023","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jot.2026.101135_bib33","doi-asserted-by":"crossref","first-page":"782","DOI":"10.3389\/fendo.2018.00782","article-title":"Prevalence of vitamin D inadequacy among Chinese postmenopausal women: a nationwide, multicenter, cross-sectional Study","volume":"9","author":"Xie","year":"2018","journal-title":"Front Endocrinol"},{"issue":"8","key":"10.1016\/j.jot.2026.101135_bib34","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1185\/030079907X219562","article-title":"Prevalence of vitamin D inadequacy in European postmenopausal women","volume":"23","author":"Bruy\u00e8re","year":"2007","journal-title":"Curr Med Res Opin"},{"issue":"8","key":"10.1016\/j.jot.2026.101135_bib35","article-title":"Chinese bone turnover marker study: reference ranges for C-terminal telopeptide of type I collagen and procollagen I N-terminal peptide by age and gender","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jot.2026.101135_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2014.9","article-title":"The Chinese skeleton: insights into microstructure that help to explain the epidemiology of fracture","volume":"2","author":"Cong","year":"2014","journal-title":"Bone Res"},{"issue":"1","key":"10.1016\/j.jot.2026.101135_bib40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/jbmr.4433","article-title":"Validation of the surrogate threshold effect for change in bone mineral density as a surrogate endpoint for fracture outcomes: the FNIH-ASBMR SABRE Project","volume":"37","author":"Eastell","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"3","key":"10.1016\/j.jot.2026.101135_bib41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.afos.2016.07.001","article-title":"Osteoporosis in East Asia: current issues in assessment and management","volume":"2","author":"Cheung","year":"2016","journal-title":"Osteoporos Sarcopenia"},{"issue":"1","key":"10.1016\/j.jot.2026.101135_bib42","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11657-018-0549-y","article-title":"The epidemiology of osteoporosis, associated fragility fractures, and management gap in China","volume":"14","author":"Yu","year":"2019","journal-title":"Arch Osteoporos"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26000914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26000914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:25:47Z","timestamp":1787599547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X26000914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":38,"alternative-id":["S2214031X26000914"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2026.101135","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Romosozumab increases bone mineral density in postmenopausal Chinese women with osteoporosis: A randomised phase three study","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2026.101135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}],"article-number":"101135"}}