{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:35:06Z","timestamp":1790714106448,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372397"],"award-info":[{"award-number":["82372397"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["CSTB2025TIAD-STX0001"],"award-info":[{"award-number":["CSTB2025TIAD-STX0001"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024T171107"],"award-info":[{"award-number":["2024T171107"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M720611"],"award-info":[{"award-number":["2022M720611"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017501","name":"Science-Health Joint Medical Scientific Research Project of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jot.2026.101166","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:35:59Z","timestamp":1782200159000},"page":"101166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Semaglutide alleviates osteoarthritis independent of weight loss via GLP-1R\u2013mediated activation of autophagy through AKT\/mTOR inhibition"],"prefix":"10.1016","volume":"59","author":[{"given":"Junming","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengliang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexi","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongliang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8082-096X","authenticated-orcid":false,"given":"Xianding","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jot.2026.101166_bib1","doi-asserted-by":"crossref","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the global Burden of Disease Study 2021","volume":"5","year":"2023","journal-title":"Lancet Rheumatol"},{"issue":"7","key":"10.1016\/j.jot.2026.101166_bib2","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/art.42089","article-title":"Prevalence Trends of Site-Specific Osteoarthritis from 1990 to 2019: findings from the Global Burden of Disease Study 2019","volume":"74","author":"Long","year":"2022","journal-title":"Arthritis Rheumatol"},{"issue":"11","key":"10.1016\/j.jot.2026.101166_bib3","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.joca.2010.08.016","article-title":"Circulating levels of IL-6 and TNF-\u03b1 are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults","volume":"18","author":"Stannus","year":"2010","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jot.2026.101166_bib4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41413-019-0070-y","article-title":"Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis","volume":"7","author":"Mazur","year":"2019","journal-title":"Bone Res"},{"issue":"3","key":"10.1016\/j.jot.2026.101166_bib5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","article-title":"OARSI guidelines for the non-surgical management of knee osteoarthritis","volume":"22","author":"McAlindon","year":"2014","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.jot.2026.101166_bib6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jphys.2020.11.009","article-title":"Critically appraised paper: physiotherapy improved pain and functional disability more than glucocorticoid injection in people with knee osteoarthritis [commentary]","volume":"67","author":"Lemes","year":"2021","journal-title":"J Physiother"},{"issue":"5","key":"10.1016\/j.jot.2026.101166_bib7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nrrheum.2017.50","article-title":"The role of metabolism in the pathogenesis of osteoarthritis","volume":"13","author":"Mobasheri","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jot.2026.101166_bib8","article-title":"Unraveling the shared genetic architecture of osteoarthritis and metabolic traits through multi-omics insights","volume":"28","author":"Liao","year":"2025","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"10.1016\/j.jot.2026.101166_bib9","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/annrheumdis-2019-216713","article-title":"Metformin limits osteoarthritis development and progression through activation of AMPK signalling","volume":"79","author":"Li","year":"2020","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.jot.2026.101166_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41413-023-00301-9","article-title":"Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms","volume":"11","author":"Wei","year":"2023","journal-title":"Bone Res"},{"issue":"20","key":"10.1016\/j.jot.2026.101166_bib11","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1001\/jama.2025.3471","article-title":"Metformin for knee osteoarthritis in patients with overweight or obesity: a randomized clinical trial","volume":"333","author":"Pan","year":"2025","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.jot.2026.101166_bib12","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.joca.2022.05.005","article-title":"Metformin as a potential disease-modifying drug in osteoarthritis: a systematic review of pre-clinical and human studies","volume":"30","author":"Lim","year":"2022","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jot.2026.101166_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105285","article-title":"Exploring antidiabetic drug targets as potential disease-modifying agents in osteoarthritis","volume":"107","author":"Fu","year":"2024","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.jot.2026.101166_bib14","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jbmr.4256","article-title":"Skeletal biology and disease modeling in zebrafish","volume":"36","author":"Dietrich","year":"2021","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.jot.2026.101166_bib15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41467-019-14169-z","article-title":"Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1\/TFEB pathway","volume":"11","author":"Sun","year":"2020","journal-title":"Nat Commun"},{"issue":"17","key":"10.1016\/j.jot.2026.101166_bib16","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1056\/NEJMoa2403664","article-title":"Once-Weekly semaglutide in persons with obesity and knee osteoarthritis","volume":"391","author":"Bliddal","year":"2024","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jot.2026.101166_bib17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tem.2016.03.017","article-title":"Perspectives in GLP-1 research: new targets, new receptors","volume":"27","author":"Cantini","year":"2016","journal-title":"Trends Endocrinol Metabol"},{"key":"10.1016\/j.jot.2026.101166_bib18","doi-asserted-by":"crossref","DOI":"10.1177\/20420188231222367","article-title":"Anti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications","volume":"15","author":"Alharbi","year":"2024","journal-title":"Ther Adv Endocrinol Metab"},{"key":"10.1016\/j.jot.2026.101166_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jot.2022.02.001","article-title":"Targeting the GLP-1\/GLP-1R axis to treat osteoarthritis: a new opportunity?","volume":"32","author":"Meurot","year":"2022","journal-title":"J Orthop Translat"},{"issue":"9","key":"10.1016\/j.jot.2026.101166_bib20","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jot.2026.101166_bib21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"7","key":"10.1016\/j.jot.2026.101166_bib22","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/s43587-025-00907-0","article-title":"Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy","volume":"5","author":"Xiang","year":"2025","journal-title":"Nat Aging"},{"issue":"1","key":"10.1016\/j.jot.2026.101166_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12951-024-02336-4","article-title":"M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis","volume":"22","author":"Qian","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.jot.2026.101166_bib24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jot.2022.09.009","article-title":"Exogenous Indian hedgehog antagonist damages intervertebral discs homeostasis in adult mice","volume":"36","author":"Chen","year":"2022","journal-title":"J Orthop Translat"},{"issue":"5","key":"10.1016\/j.jot.2026.101166_bib25","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.joca.2008.09.018","article-title":"ADAMTS5-\/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes","volume":"17","author":"Botter","year":"2009","journal-title":"Osteoarthr Cartil"},{"issue":"Suppl 3","key":"10.1016\/j.jot.2026.101166_bib26","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"10.1016\/j.jot.2026.101166_bib27","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"issue":"16","key":"10.1016\/j.jot.2026.101166_bib28","article-title":"LIPUS promotes calcium oscillation and enhances calcium dependent autophagy of chondrocytes to alleviate osteoarthritis","volume":"12","author":"Guan","year":"2025","journal-title":"Adv Sci (Weinh)"},{"issue":"15","key":"10.1016\/j.jot.2026.101166_bib29","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.7150\/ijbs.64152","article-title":"Long term usage of dexamethasone accelerating accelerates the initiation of osteoarthritis via enhancing chondrocyte apoptosis and the extracellular matrix calcification and apoptosis of chondrocytes","volume":"17","author":"Chen","year":"2021","journal-title":"Int J Biol Sci"},{"issue":"1","key":"10.1016\/j.jot.2026.101166_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.jot.2026.101166_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jot.2026.101166_bib32","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/dvdy.21100","article-title":"Conditional targeted cell ablation in zebrafish: a new tool for regeneration studies","volume":"236","author":"Curado","year":"2007","journal-title":"Dev Dyn"},{"issue":"9","key":"10.1016\/j.jot.2026.101166_bib33","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1080\/15548627.2023.2186112","article-title":"The role of autophagy in bone metabolism and clinical significance","volume":"19","author":"Wang","year":"2023","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.jot.2026.101166_bib34","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s13679-023-00520-5","article-title":"Obesity, metabolic syndrome, and Osteoarthritis-An updated review","volume":"12","author":"Sampath","year":"2023","journal-title":"Curr Obes Rep"},{"issue":"12","key":"10.1016\/j.jot.2026.101166_bib35","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrrheum.2012.135","article-title":"Metabolic syndrome meets osteoarthritis","volume":"8","author":"Zhuo","year":"2012","journal-title":"Nat Rev Rheumatol"},{"issue":"6742","key":"10.1016\/j.jot.2026.101166_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/science.adt0548","article-title":"Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling","volume":"388","author":"Yang","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.jot.2026.101166_bib37","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jot.2025.09.002","article-title":"Tirzepatide, a dual GLP-1 and GIP receptor agonist, promotes bone loss in obese mice via gut microbial-related metabolites","volume":"55","author":"Chen","year":"2025","journal-title":"J Orthop Translat"},{"issue":"10278","key":"10.1016\/j.jot.2026.101166_bib38","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(21)00213-0","article-title":"Semaglutide 2\u00b74 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial","volume":"397","author":"Davies","year":"2021","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jot.2026.101166_bib39","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S2213-8587(17)30092-X","article-title":"Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial","volume":"5","author":"Ahr\u00e9n","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"11","key":"10.1016\/j.jot.2026.101166_bib40","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S2213-8587(25)00226-8","article-title":"Once-weekly semaglutide 7.2 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial","volume":"13","author":"Wharton","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"11","key":"10.1016\/j.jot.2026.101166_bib41","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/nm1196-1254","article-title":"Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene","volume":"2","author":"Scrocchi","year":"1996","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.jot.2026.101166_bib42","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1172\/JCI43615","article-title":"Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis","volume":"121","author":"Ali","year":"2011","journal-title":"J Clin Investig"},{"issue":"1","key":"10.1016\/j.jot.2026.101166_bib43","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41413-022-00226-9","article-title":"Current understanding of osteoarthritis pathogenesis and relevant new approaches","volume":"10","author":"Tong","year":"2022","journal-title":"Bone Res"},{"issue":"12","key":"10.1016\/j.jot.2026.101166_bib44","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.cmet.2025.10.014","article-title":"Body-wide multi-omic counteraction of aging with GLP-1R agonism","volume":"37","author":"Huang","year":"2025","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.jot.2026.101166_bib45","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41419-017-0217-y","article-title":"Glucagon-like peptide-1 receptor regulates endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and the progression of osteoarthritis in rat","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis"},{"issue":"3","key":"10.1016\/j.jot.2026.101166_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabet.2025.101625","article-title":"Semaglutide 2.4 mg in French people living with Class 3 obesity and comorbidities: baseline characteristics and real-world safety data","volume":"51","author":"Disse","year":"2025","journal-title":"Diabetes Metab"},{"issue":"9","key":"10.1016\/j.jot.2026.101166_bib47","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S2213-8587(24)00182-7","article-title":"Efficacy and safety of once-weekly semaglutide 2.4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial","volume":"12","author":"McGowan","year":"2024","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"8","key":"10.1016\/j.jot.2026.101166_bib48","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.cmet.2025.07.004","article-title":"Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice","volume":"37","author":"Karasawa","year":"2025","journal-title":"Cell Metab"},{"key":"10.1016\/j.jot.2026.101166_bib49","article-title":"Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism","volume":"9","author":"Qin","year":"2026","journal-title":"Cell Metab"},{"issue":"9","key":"10.1016\/j.jot.2026.101166_bib50","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41584-024-01126-4","article-title":"Clinical phenotypes, molecular endotypes and theratypes in OA therapeutic development","volume":"20","author":"Mobasheri","year":"2024","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"10.1016\/j.jot.2026.101166_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2025.100567","article-title":"Effect of glucagon-like peptide-1 receptor agonists in osteoarthritis: a systematic review of pre-clinical and human studies","volume":"7","author":"Cheng","year":"2025","journal-title":"Osteoarthr Cartil Open"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26001245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26001245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:23:15Z","timestamp":1787599395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X26001245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":51,"alternative-id":["S2214031X26001245"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2026.101166","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Semaglutide alleviates osteoarthritis independent of weight loss via GLP-1R\u2013mediated activation of autophagy through AKT\/mTOR inhibition","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2026.101166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}],"article-number":"101166"}}