{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:00:45Z","timestamp":1793412045847,"version":"4.5.0"},"reference-count":191,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jot.2026.101178","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:47:53Z","timestamp":1783705673000},"page":"101178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Signal-driven interplay between lipid peroxidation and ferroptosis orchestrates osteoarthritis degeneration"],"prefix":"10.1016","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9512-5230","authenticated-orcid":false,"given":"Md.F.","family":"Kulyar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolita","family":"Pachaleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Brazaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mehedi","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Kaboli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignas","family":"Lebedis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiva","family":"Bernotiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2_suppl","key":"10.1016\/j.jot.2026.101178_bib1","doi-asserted-by":"crossref","DOI":"10.1177\/19476035211063858","article-title":"Role of mitochondria in physiology of chondrocytes and diseases of osteoarthritis and rheumatoid arthritis","volume":"13","author":"Kan","year":"2021","journal-title":"Cartilage"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s10517-021-05365-3","article-title":"Morphological changes in articular cartilage and free-radical lipid peroxidation in rats with posttraumatic osteoarthrosis","volume":"172","author":"Zubavlenko","year":"2021","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.jot.2026.101178_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154330","article-title":"Naringenin protects against iron overload-induced osteoarthritis by suppressing oxidative stress","volume":"105","author":"Pan","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jot.2026.101178_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.freeradbiomed.2016.10.490","article-title":"Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders","volume":"111","author":"Di Domenico","year":"2017","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"10.1016\/j.jot.2026.101178_bib5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.exger.2009.07.003","article-title":"Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders","volume":"44","author":"Mattson","year":"2009","journal-title":"Exp Gerontol"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41420-023-01613-9","article-title":"Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Death Discov"},{"issue":"12","key":"10.1016\/j.jot.2026.101178_bib7","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/cdd.2013.138","article-title":"Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance","volume":"20","author":"Dalleau","year":"2013","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jot.2026.101178_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal Biochem"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0301341","article-title":"Integration of metabolomics and transcriptomics provides insights into the molecular mechanism of temporomandibular joint osteoarthritis","volume":"19","author":"Tuerxun","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.jot.2026.101178_bib10","doi-asserted-by":"crossref","first-page":"8471","DOI":"10.2147\/JIR.S493001","article-title":"Ferroptosis in osteoarthritis: current understanding","volume":"17","author":"Liu","year":"2024","journal-title":"J Inflamm Res"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res"},{"key":"10.1016\/j.jot.2026.101178_bib12","article-title":"Deferoxamine alleviates osteoarthritis by inhibiting chondrocyte ferroptosis and activating the Nrf2 pathway","volume":"13","author":"Guo","year":"2022","journal-title":"Front Pharmacol"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib13","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/17435390.2021.1879303","article-title":"Lipid peroxidation metabolites associated with biomarkers of inflammation and oxidation stress in workers handling carbon nanotubes and metal oxide nanoparticles","volume":"15","author":"Wu","year":"2021","journal-title":"Nanotoxicology"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib14","first-page":"189","article-title":"Applications of antioxidant nanoparticles and hydrogels in osteoarthritis: a review","volume":"13","author":"Chen","year":"2023","journal-title":"Mater Res"},{"key":"10.1016\/j.jot.2026.101178_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jare.2022.01.004","article-title":"Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx","volume":"41","author":"Wang","year":"2022","journal-title":"J Adv Res"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib16","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1038\/s41598-024-55629-x","article-title":"Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-\u03baB p65\/GPX4 signaling pathway","volume":"14","author":"Han","year":"2024","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/ar4679","article-title":"Exosomes from IL-1\u03b2 stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes","volume":"16","author":"Kato","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.jot.2026.101178_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/biom15060829","article-title":"Synovial fluid extracellular vesicles from patients with severe osteoarthritis differentially promote a pro-catabolic, inflammatory chondrocyte phenotype","volume":"15","author":"Ditchfield","year":"2025","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/art.10859","article-title":"High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine","volume":"48","author":"Taniguchi","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrrheum.2014.162","article-title":"Emerging regulators of the inflammatory process in osteoarthritis","volume":"11","author":"Liu-Bryan","year":"2015","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"10.1016\/j.jot.2026.101178_bib21","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.joca.2014.04.006","article-title":"In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis","volume":"22","author":"Lim","year":"2014","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/01.LAB.0000056999.08437.B2","article-title":"Matrix metalloproteinase production by COOH-terminal heparin-binding fibronectin fragment in rheumatoid synovial cells","volume":"83","author":"Yasuda","year":"2003","journal-title":"Lab Invest"},{"issue":"9","key":"10.1016\/j.jot.2026.101178_bib23","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/art.10502","article-title":"Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes","volume":"46","author":"Forsyth","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"6937","key":"10.1016\/j.jot.2026.101178_bib24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molmed.2005.11.007","article-title":"RANKL\u2013RANK signaling in osteoclastogenesis and bone disease","volume":"12","author":"Wada","year":"2006","journal-title":"Trends Mol Med"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.plipres.2007.12.003","article-title":"The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease","volume":"47","author":"Hikiji","year":"2008","journal-title":"Prog Lipid Res"},{"issue":"12","key":"10.1016\/j.jot.2026.101178_bib27","doi-asserted-by":"crossref","first-page":"11395","DOI":"10.1074\/jbc.M411189200","article-title":"Prostaglandin E2 enhances osteoclastic differentiation of precursor cells through protein kinase A-dependent phosphorylation of TAK1","volume":"280","author":"Kobayashi","year":"2005","journal-title":"J Biol Chem"},{"issue":"33","key":"10.1016\/j.jot.2026.101178_bib28","doi-asserted-by":"crossref","first-page":"22907","DOI":"10.1074\/jbc.274.33.22907","article-title":"Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase","volume":"274","author":"Halleen","year":"1999","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/annrheumdis-2020-218089","article-title":"Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis","volume":"80","author":"Hu","year":"2021","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.jot.2026.101178_bib30","doi-asserted-by":"crossref","DOI":"10.1186\/ar3839","article-title":"Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage","volume":"14","author":"Dejica","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41413-021-00183-9","article-title":"I\u03baB-\u03b6 signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology","volume":"10","author":"Arra","year":"2022","journal-title":"Bone Res"},{"issue":"3","key":"10.1016\/j.jot.2026.101178_bib32","doi-asserted-by":"crossref","DOI":"10.1186\/ar3884","article-title":"RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis","volume":"14","author":"Mart\u00ednez-Calatrava","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018689","article-title":"The critical role of IL-34 in osteoclastogenesis","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13075-016-0973-6","article-title":"Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis","volume":"18","author":"Garcia","year":"2016","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.jot.2026.101178_bib35","doi-asserted-by":"crossref","DOI":"10.1186\/ar2066","article-title":"Alterations of metabolic activity in human osteoarthritic osteoblasts by lipid peroxidation end product 4-hydroxynonenal","volume":"8","author":"Shi","year":"2006","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13018-025-05544-2","article-title":"Ferrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation","volume":"20","author":"Xu","year":"2025","journal-title":"J Orthop Surg Res"},{"issue":"6","key":"10.1016\/j.jot.2026.101178_bib37","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1021\/acs.biomac.2c00409","article-title":"Multivalent polypeptide and tannic acid cooperatively iron-coordinated nanohybrids for synergistic cancer photothermal ferroptosis therapy","volume":"23","author":"He","year":"2022","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jot.2026.101178_bib38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ceb.2021.05.006","article-title":"Decoding mechanical cues by molecular mechanotransduction","volume":"72","author":"Swaminathan","year":"2021","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41413-024-00317-9","article-title":"Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx","volume":"12","author":"Xiang","year":"2024","journal-title":"Bone Res"},{"key":"10.1016\/j.jot.2026.101178_bib40","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.948290","article-title":"Impact of abnormal mechanical stress on chondrocyte death in osteoarthritis","volume":"31","author":"Du","year":"2025","journal-title":"Med Sci Monit"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1749-6632.2010.05808.x","article-title":"Mechanical loading, cartilage degradation, and arthritis","volume":"1211","author":"Sun","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jot.2026.101178_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115552","article-title":"Mechanical stress abnormalities promote chondrocyte senescence - the pathogenesis of knee osteoarthritis","volume":"167","author":"Jiang","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/j.jot.2026.101178_bib43","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/187152710791292567","article-title":"Mechanisms of oxidative glutamate toxicity: the glutamate\/cystine antiporter system xc- as a neuroprotective drug target","volume":"9","author":"Albrecht","year":"2010","journal-title":"CNS Neurol Disord: Drug Targets"},{"issue":"3","key":"10.1016\/j.jot.2026.101178_bib44","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13779","article-title":"Ferroptosis in osteoarthritis: towards novel therapeutic strategy","volume":"58","author":"Zhang","year":"2025","journal-title":"Cell Prolif"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib45","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1111\/hae.12208","article-title":"Identification and expression of iron regulators in human synovium: evidence for upregulation in haemophilic arthropathy compared to rheumatoid arthritis, osteoarthritis, and healthy controls","volume":"19","author":"Nieuwenhuizen","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.jot.2026.101178_bib46","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.mehy.2017.02.017","article-title":"Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events","volume":"101","author":"Bertrand","year":"2017","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.jot.2026.101178_bib47","article-title":"Significance of mechanical loading in bone fracture healing, bone regeneration, and vascularization","volume":"14","author":"Ma","year":"2023","journal-title":"J Inflamm Res"},{"issue":"7\u20139","key":"10.1016\/j.jot.2026.101178_bib48","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1089\/ars.2023.0237","article-title":"LPCAT3 is transcriptionally regulated by YAP\/ZEB\/EP300 and collaborates with ACSL4 and YAP to determine ferroptosis sensitivity","volume":"39","author":"Cui","year":"2023","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib49","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13018-024-05055-6","article-title":"Mechanisms of chondrocyte cell death in osteoarthritis: implications for disease progression and treatment","volume":"19","author":"Guan","year":"2024","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.jot.2026.101178_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112010","article-title":"Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11\/GPX4 signaling","volume":"133","author":"Xiao","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"10.1016\/j.jot.2026.101178_bib51","first-page":"437","article-title":"The relationship between hemoglobin level and disease activity in patients with rheumatoid arthritis","volume":"54","author":"Ganna","year":"2014","journal-title":"Rev Bras Reumatol"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib52","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s12013-024-01534-z","article-title":"Chondrocyte ferritinophagy as a molecular mechanism of Arthritis\u2013A narrative review","volume":"83","author":"Liu","year":"2025","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.jot.2026.101178_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103255","article-title":"Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1\/TLR4\/STAT3 axis in M1 macrophages","volume":"75","author":"Feng","year":"2024","journal-title":"Redox Biol"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib54","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.14336\/AD.2023.0201","article-title":"Mitochondrial dynamics: working with the cytoskeleton and intracellular organelles to mediate mechanotransduction","volume":"14","author":"Huang","year":"2023","journal-title":"Aging Dis"},{"issue":"7203","key":"10.1016\/j.jot.2026.101178_bib55","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib56","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.redox.2012.10.003","article-title":"Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response","volume":"1","author":"Haberzettl","year":"2013","journal-title":"Redox Biol"},{"issue":"12","key":"10.1016\/j.jot.2026.101178_bib57","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1111\/jcmm.16581","article-title":"The detrimental effect of iron on OA chondrocytes: importance of pro-inflammatory cytokines induced iron influx and oxidative stress","volume":"25","author":"Jing","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jot.2026.101178_bib58","article-title":"Interplay between iron overload and osteoarthritis: clinical significance and cellular mechanisms","volume":"9","author":"Cai","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib59","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jot.2026.101178_bib60","article-title":"Iron overload is associated with accelerated progression of osteoarthritis: the role of DMT1 mediated iron homeostasis","volume":"8","author":"Jing","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"9","key":"10.1016\/j.jot.2026.101178_bib61","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.joca.2020.06.005","article-title":"Systemic iron overload exacerbates osteoarthritis in the strain 13 Guinea pig","volume":"28","author":"Burton","year":"2020","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib62","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/biof.1520","article-title":"Intracellular iron uptake is favored in Hfe-KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype","volume":"45","author":"Sim\u00e3o","year":"2019","journal-title":"Biofactors"},{"issue":"11","key":"10.1016\/j.jot.2026.101178_bib63","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.joca.2022.08.007","article-title":"Systemic iron reduction via an iron deficient diet decreases the severity of knee cartilage lesions in the Dunkin-Hartley Guinea pig model of osteoarthritis","volume":"30","author":"Radakovich","year":"2022","journal-title":"Osteoarthr Cartil"},{"issue":"43","key":"10.1016\/j.jot.2026.101178_bib64","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000040089","article-title":"Iron overload is positively associated with the incidence of osteoarthritis: a NHANES cross-sectional study","volume":"103","author":"Liu","year":"2024","journal-title":"Medicine"},{"issue":"3","key":"10.1016\/j.jot.2026.101178_bib65","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3899\/jrheum.2023-0654","article-title":"Association of serum soluble transferrin receptor concentration with markers of inflammation: analysis of 1001 patients from a tertiary rheumatology center","volume":"51","author":"G\u00fcnther","year":"2024","journal-title":"J Rheumatol"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib66","doi-asserted-by":"crossref","DOI":"10.1186\/ar2503","article-title":"4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase","volume":"10","author":"Vaillancourt","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jot.2026.101178_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2020.104024","article-title":"Identification of 4-hydroxynonenal-modified proteins in human osteoarthritic chondrocytes","volume":"232","author":"Geib","year":"2021","journal-title":"J Proteom"},{"key":"10.1016\/j.jot.2026.101178_bib68","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jare.2024.04.012","article-title":"Interplay between lipid dysregulation and ferroptosis in chondrocytes and the targeted therapy effect of metformin on osteoarthritis","volume":"69","author":"Zou","year":"2025","journal-title":"J Adv Res"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib69","doi-asserted-by":"crossref","DOI":"10.1186\/ar3173","article-title":"Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis","volume":"12","author":"El-Bikai","year":"2010","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib70","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.bbadis.2016.01.003","article-title":"ROS\/oxidative stress signaling in osteoarthritis","volume":"1862","author":"Lepetsos","year":"2016","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"9","key":"10.1016\/j.jot.2026.101178_bib71","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1002\/art.38704","article-title":"New evidence implicating 4-Hydroxynonenal in the pathogenesis of osteoarthritis in vivo","volume":"66","author":"Shi","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib72","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s11101-022-09809-0","article-title":"Naturally occurring glucosinolates and isothiocyanates as a weapon against chronic pain: potentials and limits","volume":"21","author":"Lucarini","year":"2022","journal-title":"Phytochem Rev"},{"issue":"8","key":"10.1016\/j.jot.2026.101178_bib73","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/2211-5463.13613","article-title":"Combined detection of serum CTX-II and C2C in a rat model of ACLT-induced osteoarthritis","volume":"13","author":"Yu","year":"2023","journal-title":"FEBS Open Bio"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib74","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3892\/etm.2011.196","article-title":"Evaluation of the effect of oxidative stress on articular cartilage in spontaneously osteoarthritic STR\/OrtCrlj mice by measuring the biomarkers for oxidative stress and type II collagen degradation\/synthesis","volume":"2","author":"Watari","year":"2011","journal-title":"Exp Ther Med"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib75","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12891-017-1637-7","article-title":"Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study","volume":"18","author":"Tantavisut","year":"2017","journal-title":"BMC Muscoskelet Disord"},{"key":"10.1016\/j.jot.2026.101178_bib76","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.freeradbiomed.2015.09.003","article-title":"Aldehyde-modified proteins as mediators of early inflammation in atherosclerotic disease","volume":"89","author":"Antoniak","year":"2015","journal-title":"Free Radic Biol Med"},{"issue":"14","key":"10.1016\/j.jot.2026.101178_bib77","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1097\/CM9.0000000000003169","article-title":"Iron metabolism and arthritis: exploring connections and therapeutic avenues","volume":"137","author":"Zhuo","year":"2024","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib78","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41413-023-00247-y","article-title":"Fighting age-related orthopedic diseases: focusing on ferroptosis","volume":"11","author":"Ru","year":"2023","journal-title":"Bone Res"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib79","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.imbio.2014.09.010","article-title":"\u2018Ride on the ferrous wheel\u2019 \u2013 the cycle of iron in macrophages in health and disease","volume":"220","author":"Nairz","year":"2015","journal-title":"Immunobiology"},{"key":"10.1016\/j.jot.2026.101178_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116386","article-title":"Ferroptosis mechanisms and its novel potential therapeutic targets for DLBCL","volume":"173","author":"Bian","year":"2024","journal-title":"Biomed Pharmacother"},{"issue":"12","key":"10.1016\/j.jot.2026.101178_bib81","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.3324\/haematol.2012.063974","article-title":"Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses","volume":"97","author":"Zhang","year":"2012","journal-title":"Haematologica"},{"issue":"19","key":"10.1016\/j.jot.2026.101178_bib82","doi-asserted-by":"crossref","first-page":"7554","DOI":"10.7150\/thno.99565","article-title":"Rc3h1 negatively regulates osteoclastogenesis by limiting energy metabolism","volume":"14","author":"Chen","year":"2024","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/tjb-2024-0185","article-title":"Targeting oxidative stress, iron overload and ferroptosis in bone-degenerative conditions","volume":"50","author":"Ren","year":"2025","journal-title":"Turk J Biochem"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib84","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","article-title":"Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts","volume":"89","author":"Komori","year":"1997","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib85","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00109-024-02495-9","article-title":"Effects of iron overload in human joint tissue explant cultures and animal models","volume":"103","author":"Prasadam","year":"2025","journal-title":"J Mol Med"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib86","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s12011-024-04149-w","article-title":"Dietary iron overload triggers hepatic metabolic disorders and inflammation in laying hen","volume":"203","author":"Li","year":"2025","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib87","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41413-022-00226-9","article-title":"Current understanding of osteoarthritis pathogenesis and relevant new approaches","volume":"10","author":"Tong","year":"2022","journal-title":"Bone Res"},{"issue":"null","key":"10.1016\/j.jot.2026.101178_bib88","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.2147\/IJN.S142122","article-title":"Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential","volume":"12","author":"Lee","year":"2017","journal-title":"Int J Nanomed"},{"issue":"9","key":"10.1016\/j.jot.2026.101178_bib89","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.7150\/ijms.107057","article-title":"Novel insights into the role of ferroptosis in temporomandibular joint osteoarthritis and knee osteoarthritis","volume":"22","author":"Zhang","year":"2025","journal-title":"Int J Med Sci"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib90","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1186\/s13018-023-04128-2","article-title":"Ferroptosis-related genes LPCAT3 and PGD are potential diagnostic biomarkers for osteoarthritis","volume":"18","author":"Wang","year":"2023","journal-title":"J Orthop Surg Res"},{"issue":"731","key":"10.1016\/j.jot.2026.101178_bib91","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf4590","article-title":"Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology","volume":"16","author":"Tang","year":"2024","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib92","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct Targeted Ther"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib93","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.berh.2019.04.004","article-title":"The role of ferritin and adiponectin as predictors of cartilage damage assessed by arthroscopy in patients with symptomatic knee osteoarthritis","volume":"32","author":"Nugzar","year":"2018","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"11","key":"10.1016\/j.jot.2026.101178_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22046","article-title":"The influence of zinc and iron intake on osteoarthritis patients' subchondral sclerosis progression: a prospective observational study using data from the osteoarthritis initiative","volume":"9","author":"Zheng","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jot.2026.101178_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113915","article-title":"Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2\/System xc-\/GPX4 axis","volume":"157","author":"He","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"Suppl 1","key":"10.1016\/j.jot.2026.101178_bib96","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.5152\/eurjrheum.2023.20193","article-title":"Sex difference in OA: should we blame estrogen?","volume":"11","author":"Nguyen","year":"2023","journal-title":"Eur J Rheumatol"},{"key":"10.1016\/j.jot.2026.101178_bib97","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2023.03.008","article-title":"JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy","volume":"200","author":"Sun","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jot.2026.101178_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110835","article-title":"Ruscogenin attenuates cartilage destruction in osteoarthritis through suppressing chondrocyte ferroptosis via Nrf2\/SLC7A11\/GPX4 signaling pathway","volume":"388","author":"Ruan","year":"2024","journal-title":"Chem Biol Interact"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib99","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10571-025-01593-7","article-title":"The crosstalk between ferritinophagy and ferroptosis in ischemic stroke: regulatory mechanisms and therapeutic implications","volume":"45","author":"Shi","year":"2025","journal-title":"Cell Mol Neurobiol"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib100","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00011-022-01547-5","article-title":"The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes","volume":"71","author":"Lv","year":"2022","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jot.2026.101178_bib101","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.freeradbiomed.2023.12.047","article-title":"P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability","volume":"212","author":"Zheng","year":"2024","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib102","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/s13018-022-03225-y","article-title":"Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis","volume":"17","author":"Yan","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.jot.2026.101178_bib103","first-page":"114","article-title":"XJB-5-131 protects chondrocytes from ferroptosis to alleviate osteoarthritis progression via restoring Pebp1 expression","volume":"44","author":"Sun","year":"2024","journal-title":"J Orthop Transl"},{"key":"10.1016\/j.jot.2026.101178_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110566","article-title":"Exosomes derived from mesenchymal stem cells rescue cartilage injury in osteoarthritis through ferroptosis by GOT1\/CCR2 expression","volume":"122","author":"Peng","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jot.2026.101178_bib109","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2023.12.038","article-title":"Apigenin-7-glucoside-loaded nanoparticle alleviates intestinal ischemia-reperfusion by ATF3\/SLC7A11-mediated ferroptosis","volume":"366","author":"Zhao","year":"2024","journal-title":"J Contr Release"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib110","doi-asserted-by":"crossref","first-page":"7598","DOI":"10.1038\/s41467-023-43308-w","article-title":"Targeting ferroptosis by poly(acrylic) acid coated Mn(3)O(4) nanoparticles alleviates acute liver injury","volume":"14","author":"Shan","year":"2023","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.jot.2026.101178_bib111","article-title":"Cardamonin attenuates inflammation and oxidative stress in Interleukin-1\u03b2-Stimulated osteoarthritis chondrocyte through the Nrf2 pathway","volume":"10","author":"Peng","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib112","doi-asserted-by":"crossref","first-page":"9332","DOI":"10.1080\/21655979.2021.2000742","article-title":"Stigmasterol alleviates interleukin-1beta-induced chondrocyte injury by down-regulatingsterol regulatory element binding transcription factor 2 to regulateferroptosis","volume":"12","author":"Mo","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.jot.2026.101178_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110148","article-title":"Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes","volume":"366","author":"Wang","year":"2022","journal-title":"Chem Biol Interact"},{"issue":"11","key":"10.1016\/j.jot.2026.101178_bib114","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13134","article-title":"D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2\u03b1-dependent manner","volume":"54","author":"Zhou","year":"2021","journal-title":"Cell Prolif"},{"issue":"8","key":"10.1016\/j.jot.2026.101178_bib105","doi-asserted-by":"crossref","first-page":"677","DOI":"10.14348\/molcells.2015.0200","article-title":"Epigenetic regulation of chondrocyte catabolism and anabolism in osteoarthritis","volume":"38","author":"Kim","year":"2015","journal-title":"Mol Cells"},{"key":"10.1016\/j.jot.2026.101178_bib106","article-title":"Editorial: novel insights about subchondral bone remodeling in arthropathies","volume":"15","author":"Yang","year":"2024","journal-title":"Front Physiol"},{"issue":"9","key":"10.1016\/j.jot.2026.101178_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110526","article-title":"Rosiglitazone retards the progression of iron overload-induced osteoarthritis by impeding chondrocyte ferroptosis","volume":"27","author":"Cao","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.jot.2026.101178_bib108","article-title":"Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies","volume":"14","author":"Cao","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jot.2026.101178_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150683","article-title":"The role of ferroptosis in osteoarthritis: progress and prospects","volume":"733","author":"Sheng","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jot.2026.101178_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149733","article-title":"Mechanisms of chondrocyte regulated cell death in osteoarthritis: focus on ROS-Triggered ferroptosis, parthanatos, and oxeiptosis","volume":"705","author":"Fan","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10.1016\/j.jot.2026.101178_bib117","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12062125","article-title":"The potential roles of ferroptosis in pathophysiology and treatment of musculoskeletal diseases\u2014opportunities, challenges, and perspectives","volume":"12","author":"Hu","year":"2023","journal-title":"J Clin Med"},{"issue":"8","key":"10.1016\/j.jot.2026.101178_bib118","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00011-013-0635-y","article-title":"Vitamin E protects chondrocytes against hydrogen peroxide-induced oxidative stress in vitro","volume":"62","author":"Bhatti","year":"2013","journal-title":"Inflamm Res"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib119","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/19476035221142011","article-title":"Ferroptosis plays a role in human chondrocyte of osteoarthritis induced by IL-1\u03b2 in vitro","volume":"14","author":"Xu","year":"2023","journal-title":"Cartilage"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib120","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/med.21330","article-title":"Redox regulation of inflammation: old elements, a new story","volume":"35","author":"Lei","year":"2015","journal-title":"Med Res Rev"},{"issue":"6","key":"10.1016\/j.jot.2026.101178_bib121","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2217\/nnm-2021-0172","article-title":"Ameliorative effect of cerium oxide nanoparticles against freund\u2019s complete adjuvant-induced arthritis","volume":"17","author":"Allawadhi","year":"2022","journal-title":"Nanomedicine"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib122","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-13914-3","article-title":"Cerium oxide nanoparticles prepared through Bio-combustion using ficus carica as effective antioxidant, anticancer and dye degrading agent","volume":"15","author":"Majani","year":"2025","journal-title":"Sci Rep"},{"issue":"n\/a","key":"10.1016\/j.jot.2026.101178_bib123","article-title":"Emerging applications of photodynamic and sonodynamic therapies in orthopedic disorders: mechanisms, challenges, and future directions","volume":"n\/a","author":"Wen","year":"2025","journal-title":"Adv Healthcare Mater"},{"issue":"10","key":"10.1016\/j.jot.2026.101178_bib124","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1007\/s12011-021-03022-4","article-title":"Progress of selenium deficiency in the pathogenesis of arthropathies and selenium supplement for their treatment","volume":"200","author":"Deng","year":"2022","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.jot.2026.101178_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101306","article-title":"Advanced oxidation protein products increase TNF-\u03b1 and IL-1\u03b2 expression in chondrocytes via NADPH oxidase 4 and accelerate cartilage degeneration in osteoarthritis progression","volume":"28","author":"Liao","year":"2020","journal-title":"Redox Biol"},{"issue":"n\/a","key":"10.1016\/j.jot.2026.101178_bib126","article-title":"Silymarin\/silybin-functionalized selenium nanoparticles suppress lipopolysaccharide-induced inflammation via PI3K\/AKT\/NF-\u03baB signaling pathway inhibition","author":"Abd-Rabou","year":"2025","journal-title":"Chem Biodiversity"},{"key":"10.1016\/j.jot.2026.101178_bib127","doi-asserted-by":"crossref","first-page":"991","DOI":"10.12659\/MSM.912545","article-title":"Selenium nanoparticles dispersed in phytochemical exert anti-inflammatory activity by modulating catalase, GPx1, and COX-2 gene expression in a rheumatoid arthritis rat model","volume":"25","author":"Ren","year":"2019","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.jot.2026.101178_bib128","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.joca.2019.02.115","article-title":"Manganese dioxide nanoparticles modulate oxidative stress and protect cartilage from interleukin-1\u03b2 induced degradation","volume":"27","author":"Kumar","year":"2019","journal-title":"Osteoarthr Cartil"},{"issue":"10","key":"10.1016\/j.jot.2026.101178_bib129","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1007\/s00210-021-02131-0","article-title":"The application prospect of metal\/metal oxide nanoparticles in the treatment of osteoarthritis","volume":"394","author":"Luo","year":"2021","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jot.2026.101178_bib130","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.rvsc.2019.02.002","article-title":"Antioxidant effects of gold nanoparticles on early stage of collagen-induced arthritis in rats","volume":"124","author":"Kirdaite","year":"2019","journal-title":"Res Vet Sci"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib131","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8857486","article-title":"The role of nanomaterials in stroke treatment: targeting oxidative stress","volume":"2021","author":"Song","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jot.2026.101178_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2023.103446","article-title":"Curcumin-gold nanoformulation: synthesis, characterizations and biomedical application","volume":"57","author":"Amini","year":"2024","journal-title":"Food Biosci"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib133","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/JLB.5MR0420-008RR","article-title":"Magnetic nanoparticles: a new diagnostic and treatment platform for rheumatoid arthritis","volume":"109","author":"Liu","year":"2021","journal-title":"J Leukoc Biol"},{"issue":"38","key":"10.1016\/j.jot.2026.101178_bib134","doi-asserted-by":"crossref","first-page":"8884","DOI":"10.1039\/D0TB01686A","article-title":"Highly biosafe biomimetic stem cell membrane-disguised nanovehicles for cartilage regeneration","volume":"8","author":"Zhang","year":"2020","journal-title":"J Mater Chem B"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib135","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s13205-023-03552-9","article-title":"Nanoantibiotic effect of carbon-based nanocomposites: epicentric on graphene, carbon nanotubes and fullerene composites: a review","volume":"13","author":"Hada","year":"2023","journal-title":"3 Biotech"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib136","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.biomaterials.2008.09.061","article-title":"The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials","volume":"30","author":"Yin","year":"2009","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib137","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s12951-024-02645-8","article-title":"Graphene oxide quantum dots-loaded sinomenine hydrochloride nanocomplexes for effective treatment of rheumatoid arthritis via inducing macrophage repolarization and arresting abnormal proliferation of fibroblast-like synoviocytes","volume":"22","author":"Lin","year":"2024","journal-title":"J Nanobiotechnol"},{"issue":"20","key":"10.1016\/j.jot.2026.101178_bib138","doi-asserted-by":"crossref","DOI":"10.3390\/nano13202803","article-title":"The impressive anti-inflammatory activity of cerium oxide nanoparticles: more than redox?","volume":"13","author":"Corsi","year":"2023","journal-title":"Nanomaterials (Basel)"},{"issue":"14","key":"10.1016\/j.jot.2026.101178_bib139","doi-asserted-by":"crossref","DOI":"10.3390\/nano14141179","article-title":"Harnessing magnetic nanoparticles for the effective removal of Micro- and nanoplastics: a critical review","volume":"14","author":"Vohl","year":"2024","journal-title":"Nanomaterials (Basel)"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11738-025-03805-5","article-title":"Nanotechnology in viticulture: alleviating lime stress in 1103 Paulsen Rootstock with iron oxide nanoparticles (Fe3O4-NPs)","volume":"47","author":"Daler","year":"2025","journal-title":"Acta Physiol Plant"},{"issue":"30","key":"10.1016\/j.jot.2026.101178_bib141","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.1016\/j.biomaterials.2009.07.027","article-title":"On the nature of biomaterials","volume":"30","author":"Williams","year":"2009","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib142","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainresrev.2008.12.020","article-title":"Role of interleukin-1\u03b2 during pain and inflammation","volume":"60","author":"Ren","year":"2009","journal-title":"Brain Res Rev"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib143","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1136\/ard.2003.007674","article-title":"Severity and extent of osteoarthritis and low grade systemic inflammation as assessed by high sensitivity C reactive protein","volume":"63","author":"St\u00fcrmer","year":"2004","journal-title":"Ann Rheum Dis"},{"issue":"35","key":"10.1016\/j.jot.2026.101178_bib144","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202401882","article-title":"An osteoimmunomodulatory biopatch potentiates stem cell therapies for bone regeneration by simultaneously regulating IL-17\/Ferroptosis signaling pathways","volume":"11","author":"Liu","year":"2024","journal-title":"Adv Sci"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib145","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202209466","article-title":"Stem cell-niche engineering via multifunctional hydrogel potentiates stem cell therapies for inflammatory bone loss","volume":"33","author":"Li","year":"2023","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.jot.2026.101178_bib146","series-title":"Biogenic nanomaterials","first-page":"83","article-title":"Nanostructured biomaterials for targeted drug delivery","author":"Islam","year":"2022"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib147","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s10311-020-01022-9","article-title":"Passive and active targeting strategies for the delivery of the camptothecin anticancer drug: a review","volume":"18","author":"Behera","year":"2020","journal-title":"Environ Chem Lett"},{"issue":"null","key":"10.1016\/j.jot.2026.101178_bib148","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.2147\/IJN.S416049","article-title":"Polydopamine modified ceria nanorods alleviate inflammation in colitis by scavenging ROS and regulating macrophage M2 polarization","volume":"18","author":"Zhang","year":"2023","journal-title":"Int J Nanomed"},{"issue":"27","key":"10.1016\/j.jot.2026.101178_bib149","doi-asserted-by":"crossref","first-page":"34705","DOI":"10.1021\/acsami.4c06231","article-title":"A reactive oxygen species \u201csweeper\u201d based on hollow mesopore cerium oxide nanospheres for targeted and anti-inflammatory management of osteoarthritis","volume":"16","author":"Chen","year":"2024","journal-title":"ACS Appl Mater Interfaces"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib150","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s40495-022-00296-7","article-title":"The potential role of bioactive plant-based polyphenolic compounds and their delivery Systems\u2014as a promising opportunity for a new therapeutic solution for acute and chronic wound healing","volume":"8","author":"Kaparekar","year":"2022","journal-title":"Curr Pharmacol Rep"},{"key":"10.1016\/j.jot.2026.101178_bib151","article-title":"Intra-articular administration of PLGA resveratrol sustained-release nanoparticles attenuates the development of rat osteoarthritis","volume":"24","author":"Wei","year":"2024","journal-title":"Mater Today Bio"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib152","doi-asserted-by":"crossref","DOI":"10.3390\/gels12010007","article-title":"A novel thermosensitive curcumin-loaded hydrogel that modulates macrophage M1\/M2 polarization for osteoarthritis therapy","volume":"12","author":"Zhou","year":"2025","journal-title":"Gels"},{"key":"10.1016\/j.jot.2026.101178_bib153","article-title":"Injectable hydrogel with selenium nanoparticles delivery for sustained glutathione peroxidase activation and enhanced osteoarthritis therapeutics","volume":"23","author":"Hu","year":"2023","journal-title":"Mater Today Bio"},{"issue":"3","key":"10.1016\/j.jot.2026.101178_bib154","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0142-9612(03)00539-8","article-title":"Nanotexturing of titanium-based surfaces upregulates expression of bone sialoprotein and osteopontin by cultured osteogenic cells","volume":"25","author":"de Oliveira","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101178_bib155","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.2147\/DDDT.S407122","article-title":"The protective effect of selenium nanoparticles in osteoarthritis: in vitro and in vivo studies","volume":"17","author":"Li","year":"2023","journal-title":"Drug Des Dev Ther"},{"issue":"5","key":"10.1016\/j.jot.2026.101178_bib156","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1634\/stemcells.2005-0117","article-title":"Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro","volume":"24","author":"Ebert","year":"2006","journal-title":"Stem Cell"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib157","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1038\/s41467-021-22565-7","article-title":"Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts","volume":"12","author":"Kim","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jot.2026.101178_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119467","article-title":"Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress","volume":"224","author":"Kumar","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101178_bib159","article-title":"A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM","volume":"26","author":"Liu","year":"2024","journal-title":"Mater Today Bio"},{"issue":"25","key":"10.1016\/j.jot.2026.101178_bib160","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1039\/D4TB00307A","article-title":"Nano-enzyme hydrogels for cartilage repair effectiveness based on ternary strategy therapy","volume":"12","author":"Deng","year":"2024","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.jot.2026.101178_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114366","article-title":"Epigallocatechin-3-gallate (EGCG) based metal-polyphenol nanoformulations alleviates chondrocytes inflammation by modulating synovial macrophages polarization","volume":"161","author":"Wei","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib162","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.fsi.2015.01.032","article-title":"Identification and analysis of icCu\/Zn-SOD, Mn-SOD and ecCu\/Zn-SOD in superoxide dismutase multigene family of pseudosciaena crocea","volume":"43","author":"Liu","year":"2015","journal-title":"Fish Shellfish Immunol"},{"issue":"3","key":"10.1016\/j.jot.2026.101178_bib163","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0891-5849(02)00905-X","article-title":"Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression","volume":"33","author":"Zelko","year":"2002","journal-title":"Free Radic Biol Med"},{"issue":"24","key":"10.1016\/j.jot.2026.101178_bib164","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202305116","article-title":"Mesenchymal stem cells-involved strategies for rheumatoid arthritis therapy","volume":"11","author":"Li","year":"2024","journal-title":"Adv Sci"},{"issue":"3","key":"10.1016\/j.jot.2026.101178_bib165","doi-asserted-by":"crossref","first-page":"931","DOI":"10.7150\/thno.78639","article-title":"Targeted and responsive biomaterials in osteoarthritis","volume":"13","author":"Li","year":"2023","journal-title":"Theranostics"},{"issue":"Pt 2","key":"10.1016\/j.jot.2026.101178_bib167","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.jcis.2021.09.016","article-title":"Microfluidic encapsulated manganese organic frameworks as enzyme mimetics for inflammatory bowel disease treatment","volume":"607","author":"Chen","year":"2022","journal-title":"J Colloid Interface Sci"},{"key":"10.1016\/j.jot.2026.101178_bib168","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.biomaterials.2016.08.010","article-title":"A superoxide dismutase\/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease","volume":"105","author":"Zhang","year":"2016","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.jot.2026.101178_bib169","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/iej.14055","article-title":"Anti-inflammatory cerium-containing nano-scaled mesoporous bioactive glass for promoting regenerative capability of dental pulp cells","volume":"57","author":"Duan","year":"2024","journal-title":"Int Endod J"},{"key":"10.1016\/j.jot.2026.101178_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2026.178563","article-title":"PEGylated cerium oxide nanoparticles alleviate osteoarthritis progression by inhibiting chondrocyte ferroptosis and maintaining cartilage homeostasis","volume":"1015","author":"Li","year":"2026","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"10.1016\/j.jot.2026.101178_bib170","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nri3863","article-title":"Iron homeostasis in host defence and inflammation","volume":"15","author":"Ganz","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jot.2026.101178_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101481","article-title":"Iron homeostasis in arthropathies: from pathogenesis to therapeutic potential","volume":"72","author":"Sun","year":"2021","journal-title":"Ageing Res Rev"},{"issue":"13","key":"10.1016\/j.jot.2026.101178_bib172","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2174\/1381612829666230406102935","article-title":"New generation smart drug delivery systems for rheumatoid arthritis","volume":"29","author":"Singh","year":"2023","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jot.2026.101178_bib173","series-title":"Smart drug delivery","article-title":"Smart drug-delivery systems in the treatment of rheumatoid arthritis: current, future perspectives","author":"Kamra","year":"2021"},{"issue":"2","key":"10.1016\/j.jot.2026.101178_bib174","article-title":"Nanotechnology for targeted rheumatoid arthritis therapy: innovations and challenges","volume":"29","author":"Abd","year":"2025","journal-title":"J Inflamm Dis"},{"issue":"12","key":"10.1016\/j.jot.2026.101178_bib175","doi-asserted-by":"crossref","first-page":"19665","DOI":"10.1021\/acsnano.2c06393","article-title":"Injectable drug delivery systems for osteoarthritis and rheumatoid arthritis","volume":"16","author":"Bruno","year":"2022","journal-title":"ACS Nano"},{"issue":"25","key":"10.1016\/j.jot.2026.101178_bib176","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1080\/10408398.2022.2045471","article-title":"Bioactive compounds: application of albumin nanocarriers as delivery systems","volume":"63","author":"Visentini","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jot.2026.101178_bib177","series-title":"Nanotechnology and drug delivery","first-page":"179","article-title":"Smart targeted novel nanocarriers-based treatment of arthritis","author":"Sindhu","year":"2024"},{"issue":"3","key":"10.1016\/j.jot.2026.101178_bib178","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s10787-022-00977-1","article-title":"Methotrexate-loaded biodegradable nanoparticles exert anti-arthritic effect by downregulating pro-inflammatory cytokines in Freund's complete adjuvant-induced arthritic rats","volume":"30","author":"Saleem","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jot.2026.101178_bib179","article-title":"Enhanced anti-rheumatic efficacy of PLGA-based methotrexate-loaded implants in adjuvant-induced arthritis rat model","volume":"88","author":"He","year":"2023","journal-title":"J Drug Deliv Sci Technol"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib180","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2023.2184307","article-title":"Formulation of a dual drug-loaded nanoparticulate co-delivery hydrogel system and its validation in rheumatoid arthritis animal model","volume":"30","author":"Haloi","year":"2023","journal-title":"Drug Deliv"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib181","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.15419\/bmrat.v10i1.789","article-title":"Magnetic nanomaterials: advanced tools for cartilage extracellular matrix regeneration","volume":"10","author":"Herea","year":"2023","journal-title":"Biomed Res Ther"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib182","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1021\/cbmi.3c00026","article-title":"Designing smart iron oxide nanoparticles for MR imaging of tumors","volume":"1","author":"Li","year":"2023","journal-title":"Chem Biomed Imaging"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib183","doi-asserted-by":"crossref","first-page":"424","DOI":"10.7150\/ntno.86467","article-title":"Magnetic resonance imaging and iron-oxide nanoparticles in the era of personalized medicine","volume":"7","author":"Rahman","year":"2023","journal-title":"Nanotheranostics"},{"issue":"4","key":"10.1016\/j.jot.2026.101178_bib184","doi-asserted-by":"crossref","DOI":"10.1002\/mba2.106","article-title":"Biomimetic nanosystems based on cell membranes (BNCMs) for cancer immunotherapy","volume":"3","author":"Wang","year":"2024","journal-title":"MedComm \u2013 Biomaterials and Applications"},{"issue":"14","key":"10.1016\/j.jot.2026.101178_bib185","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202308659","article-title":"Bridging smart nanosystems with clinically relevant models and advanced imaging for precision drug delivery","volume":"11","author":"Zhou","year":"2024","journal-title":"Adv Sci"},{"issue":"3","key":"10.1016\/j.jot.2026.101178_bib186","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/23808993.2020.1736942","article-title":"Toward gene therapy in rheumatoid arthritis","volume":"5","author":"Young","year":"2020","journal-title":"Expert Rev Preci Med Drug Dev"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib187","doi-asserted-by":"crossref","first-page":"23","DOI":"10.15212\/AMM-2022-0039","article-title":"Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment","volume":"2","author":"Li","year":"2023","journal-title":"Acta Materia Medica"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib188","article-title":"Passive and active targeting in cancer therapy by liposomes and lipid nanoparticles","volume":"34","author":"Alavi","year":"2019","journal-title":"Drug Metab Pers Ther"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib189","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13075-024-03304-x","article-title":"TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis","volume":"26","author":"Wang","year":"2024","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jot.2026.101178_bib190","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-025-01376-x","article-title":"siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and Guinea pigs","author":"Colazo","year":"2025","journal-title":"Nat Biomed Eng"},{"issue":"1","key":"10.1016\/j.jot.2026.101178_bib191","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.apsb.2024.11.007","article-title":"Synergistic metabolic modulation of fibroblast-like synoviocytes via targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis","volume":"15","author":"Li","year":"2025","journal-title":"Acta Pharm Sin B"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26001361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X26001361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:48:40Z","timestamp":1791125320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X26001361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":191,"alternative-id":["S2214031X26001361"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2026.101178","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Signal-driven interplay between lipid peroxidation and ferroptosis orchestrates osteoarthritis degeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2026.101178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}],"article-number":"101178"}}