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(Sci)"},{"key":"10.1016\/j.jot.2026.101189_bib73","article-title":"LCN2-ACOD1 signalling affects the post-injury regeneration of skeletal muscle through mediating ferroptosis","author":"Hao","year":"2025","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jot.2026.101189_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2024.103958","article-title":"N-acetylcysteine stimulates the proliferation and differentiation in heat-stressed skeletal muscle cells","volume":"124","author":"Lu","year":"2024","journal-title":"J Therm Biol"},{"key":"10.1016\/j.jot.2026.101189_bib75","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41419-022-04775-z","article-title":"Interaction between macrophages and ferroptosis","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jot.2026.101189_bib76","article-title":"Skeletal muscle regeneration in cardiotoxin-induced muscle injury 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HIF-1alpha\/SLC7A11 pathway","volume":"10","author":"Ju","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jot.2026.101189_bib98","doi-asserted-by":"crossref","first-page":"405","DOI":"10.33549\/physiolres.935317","article-title":"Dihydromyricetin inhibits ferroptosis to attenuate cisplatin-induced muscle atrophy","volume":"73","author":"You","year":"2024","journal-title":"Physiol Res"},{"key":"10.1016\/j.jot.2026.101189_bib99","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.1051866","article-title":"Ferroptosis and its role in skeletal muscle diseases","volume":"9","author":"Wang","year":"2022","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.jot.2026.101189_bib100","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1089\/ars.2022.0208","article-title":"Nuclear factor erythroid 2-Related factor 2 and its targets in skeletal muscle repair and regeneration","volume":"38","author":"Loboda","year":"2023","journal-title":"Antioxid Redox 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role in the treatment of sepsis-related organ injury: mechanisms and potential therapeutic approaches","volume":"17","author":"Zhang","year":"2024","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.jot.2026.101189_bib108","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40779-025-00665-5","article-title":"The emerging role of ferroptosis in the pathological development and progression of sepsis","volume":"12","author":"Zhou","year":"2025","journal-title":"Milit Med Res"},{"key":"10.1016\/j.jot.2026.101189_bib109","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1089\/ars.2024.0556","article-title":"Ferroptosis-modulating natural products for targeting inflammation-related diseases: challenges and opportunities in manipulating redox signaling","volume":"41","author":"Liang","year":"2024","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jot.2026.101189_bib110","article-title":"SAT1\/ALOX15 signaling pathway is involved in ferroptosis after 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myasthenia gravis rats","volume":"8","author":"Song","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jot.2026.101189_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121368","article-title":"Qiangji Jianli decoction attenuates skeletal muscle injury in rats with experimental autoimmune myasthenia gravis via the GRP78\/IRE1alpha\/GPX4 signaling pathway","volume":"362","author":"Cai","year":"2026","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jot.2026.101189_bib142","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000546096","article-title":"Aerobic exercise alleviates doxorubicin-induced cardiotoxicity via inhibition of ferroptosis","volume":"70","author":"Liu","year":"2025","journal-title":"Chemotherapy"},{"key":"10.1016\/j.jot.2026.101189_bib143","article-title":"HIF1A transcriptionally activates CDKN1A to drive ferroptosis in skeletal muscle ischaemia-reperfusion injury","volume":"57","author":"Zhou","year":"2026","journal-title":"J 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