{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:51:47Z","timestamp":1791129107185,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jot.2026.101193","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:45:23Z","timestamp":1787629523000},"page":"101193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Combining polydioxanone-based scaffold and allogeneic adipose-derived mesenchymal stem cells enhances articular cartilage repair - a pre-clinical study"],"prefix":"10.1016","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-1203","authenticated-orcid":false,"given":"Emanuel Vitor","family":"Appolonio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria Guerra","family":"Altheman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7260-1081","authenticated-orcid":false,"given":"Fernanda","family":"de Castro Stievanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo dos Santos","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Barthelson","family":"Carvalho de Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9268-3528","authenticated-orcid":false,"given":"Natalia Camargo","family":"Faraldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Fonseca Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila C.","family":"Kaleka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0015-1223","authenticated-orcid":false,"given":"Pedro","family":"Debieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moises","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Liz","family":"Garcia Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2026.101193_bib1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.2106\/00004623-199704000-00021","article-title":"Articular cartilage: part I","volume":"79","author":"Buckwalter","year":"1997","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.jot.2026.101193_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bone.2012.03.023","article-title":"Effects of aging on articular cartilage homeostasis","volume":"51","author":"Lotz","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.jot.2026.101193_bib3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/1941738109350438","article-title":"The basic science of articular cartilage: structure, composition, and function","volume":"1","author":"Sophia Fox","year":"2009","journal-title":"Sports Health"},{"key":"10.1016\/j.jot.2026.101193_bib4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2106\/00004623-200300002-00008","article-title":"Evaluation of cartilage injuries and repair","volume":"85","author":"Brittberg","year":"2003","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.jot.2026.101193_bib5","first-page":"998","article-title":"Advanced hydrogels for the repair of cartilage defects and regeneration","volume":"6","author":"Wei","year":"2021","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jot.2026.101193_bib6","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1053\/joca.2002.0801","article-title":"Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects","volume":"10","author":"Hunziker","year":"2002","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jot.2026.101193_bib7","series-title":"V\u00edctor manuel","article-title":"Polydioxanone-based membranes for bone regeneration academic","author":"Saska","year":"2021"},{"key":"10.1016\/j.jot.2026.101193_bib8","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.progpolymsci.2007.05.017","article-title":"Biodegradable polymers as biomaterials","volume":"32","author":"Nair","year":"2007","journal-title":"Prog Polym Sci"},{"key":"10.1016\/j.jot.2026.101193_bib9","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jor.1100090504","article-title":"Mesenchymal stem cells","volume":"9","author":"Caplan","year":"1991","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jot.2026.101193_bib10","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/stem.3016","article-title":"Concise review: mesenchymal stem cells: from roots to boost","volume":"37","author":"Andrzejewska","year":"2019","journal-title":"Stem Cell"},{"key":"10.1016\/j.jot.2026.101193_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24129939","article-title":"Clinical trials with mesenchymal stem cell therapies for osteoarthritis: challenges in the regeneration of articular cartilage","volume":"24","author":"Carneiro","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2026.101193_bib12","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1002\/jbm.a.34896","article-title":"Adipose-derived mesenchymal stem cells for cartilage tissue engineering: State-of-the-art in in vivo studies","volume":"102","author":"Veronesi","year":"2014","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.jot.2026.101193_bib13","series-title":"Osteochondral repair combining therapeutics implant with mesenchymal stem cells","author":"Henri Favreau","year":"2020"},{"key":"10.1016\/j.jot.2026.101193_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2454168","article-title":"Umbilical cord mesenchymal stromal cells for cartilage regeneration applications","volume":"2022","author":"Russo","year":"2022","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.jot.2026.101193_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16121558","article-title":"Tissue engineering construct for articular cartilage restoration with stromal cells from synovium vs. dental pulp\u2014A pre-clinical study","volume":"16","author":"Fernandes","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jot.2026.101193_bib16","doi-asserted-by":"crossref","first-page":"6376","DOI":"10.3390\/ijms26136376","article-title":"Clinical safety and efficacy of allogeneic adipose stem cells: a systematic review of the clinical trials","volume":"26","author":"Asch","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2026.101193_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123303","article-title":"Evaluating the efficacy of intra-articular polydioxanone (PDO) injections as a novel viscosupplement in osteoarthritis treatment","volume":"361","author":"Le","year":"2025","journal-title":"Life Sci"},{"key":"10.1016\/j.jot.2026.101193_bib18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.vetimm.2009.06.014","article-title":"Isolation and immunophenotypic characterization of mesenchymal stem cells derived from equine species adipose tissue","volume":"132","author":"de Mattos Carvalho","year":"2009","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.jot.2026.101193_bib19","doi-asserted-by":"crossref","DOI":"10.1186\/1746-6148-8-169","article-title":"Isolation and characterization of ovine mesenchymal stem cells derived from peripheral blood","volume":"8","author":"Lyahyai","year":"2012","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.jot.2026.101193_bib20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/01478885.2020.1744316","article-title":"Isolation, culture, and induced multiple differentiation of Mongolian sheep adipose-derived mesenchymal stem cells","volume":"43","author":"Zhao","year":"2020","journal-title":"J Histotechnol"},{"key":"10.1016\/j.jot.2026.101193_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Tim e Quantitative PCR and the 2 C T Method","volume":"2","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jot.2026.101193_bib22","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1177\/0963689719880527","article-title":"Autologous micro-fragmented adipose tissue as stem cell-based natural scaffold for cartilage defect repair","volume":"28","author":"Xu","year":"2019","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jot.2026.101193_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015157","article-title":"Immunohistochemical analysis of knee chondral defect repair after autologous particulated cartilage and platelet-rich plasma treatment in sheep","volume":"24","author":"Alcaide-Ruggiero","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2026.101193_bib24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tvjl.2007.12.028","article-title":"The inter- and intra-observer reliability of a locomotion scoring scale for sheep","volume":"180","author":"Kaler","year":"2009","journal-title":"Vet J"},{"key":"10.1016\/j.jot.2026.101193_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.biomaterials.2018.09.044","article-title":"Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues","volume":"188","author":"Cunniffe","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2026.101193_bib26","series-title":"Synthetic polymers in drug and biotherapeutics delivery","first-page":"315","article-title":"Polydioxanone: applications in surgery and tissue engineering","author":"Mathews","year":"2025"},{"key":"10.1016\/j.jot.2026.101193_bib27","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1021\/acsabm.5c00263","article-title":"Tackling microbial contamination in polydioxanone-based membranes for regenerative therapy: bioengineering an antibiotic-loaded platform","volume":"8","author":"Abdo","year":"2025","journal-title":"ACS Appl Bio Mater"},{"key":"10.1016\/j.jot.2026.101193_bib28","article-title":"Performance of polydioxanone-based membrane in association with 3D-Printed bioceramic scaffolds in bone regeneration","volume":"15","author":"Pitol-Palin","year":"2023","journal-title":"Polymers"},{"key":"10.1016\/j.jot.2026.101193_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/polym15040868","article-title":"Polydioxanone membrane compared with collagen membrane for bone regeneration","volume":"15","author":"Quirino","year":"2023","journal-title":"Polymers"},{"key":"10.1016\/j.jot.2026.101193_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/biomimetics9050284","article-title":"Combination of a synthetic bioceramic associated with a polydioxanone-based membrane as an alternative to autogenous bone grafting","volume":"9","author":"Frig\u00e9rio","year":"2024","journal-title":"Biomimetics"},{"key":"10.1016\/j.jot.2026.101193_bib31","article-title":"Aligned laminin core-polydioxanone\/collagen shell fiber matrices effective for neuritogenesis","volume":"8","author":"Song","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jot.2026.101193_bib32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1001\/jamafacial.2016.1200","article-title":"Assessment of scaffolding properties for chondrogenic differentiation of adipose-derived mesenchymal stem cells in nasal reconstruction","volume":"19","author":"San-Marina","year":"2017","journal-title":"JAMA Facial Plast Surg"},{"key":"10.1016\/j.jot.2026.101193_bib33","article-title":"Recent advances in bionic scaffolds for cartilage tissue engineering","volume":"13","author":"Zhang","year":"2025","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jot.2026.101193_bib34","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1111\/j.1582-4934.2011.01509.x","article-title":"Immunogenicity of allogeneic mesenchymal stem cells","volume":"16","author":"Schu","year":"2012","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jot.2026.101193_bib35","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.arthro.2018.08.033","article-title":"A scaffold-free allogeneic construct from adipose-derived stem cells regenerates an osteochondral defect in a rabbit model","volume":"35","author":"Oshima","year":"2019","journal-title":"Arthrosc J Arthrosc Relat Surg"},{"key":"10.1016\/j.jot.2026.101193_bib36","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-023-03359-8","article-title":"Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial","volume":"14","author":"Sadri","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jot.2026.101193_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ani11082153","article-title":"Adipose tissue-and bone marrow-derived mesenchymal stem cells from sheep: culture characteristics","volume":"11","author":"Dar","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.jot.2026.101193_bib38","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2478\/aoas-2023-0055","article-title":"Multi-faceted characterization of mesenchymal stem cells and their application as a powerful tool for agrobiotechnology, assisted reproductive technologies, and veterinary and regenerative biomedicine - a review","volume":"24","author":"Romanek","year":"2024","journal-title":"Ann Anim Sci"},{"key":"10.1016\/j.jot.2026.101193_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171231","article-title":"Ovine mesenchymal stromal cells: morphologic, phenotypic and functional characterization for osteochondral tissue engineering","volume":"12","author":"Sanjurjo-Rodr\u00edguez","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jot.2026.101193_bib40","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/jcp.21670","article-title":"Characterisation and developmental potential of ovine bone marrow derived mesenchymal stem cells","volume":"219","author":"Mccarty","year":"2009","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jot.2026.101193_bib41","doi-asserted-by":"crossref","first-page":"10S","DOI":"10.1177\/0363546509350694","article-title":"Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture","volume":"37","author":"Saris","year":"2009","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jot.2026.101193_bib42","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00167-019-05359-9","article-title":"Microfracture for cartilage repair in the knee: a systematic review of the contemporary literature","volume":"28","author":"Orth","year":"2020","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.jot.2026.101193_bib43","doi-asserted-by":"crossref","first-page":"S362","DOI":"10.1097\/00003086-200110001-00033","article-title":"Microfracture: surgical technique and rehabilitation to treat chondral defects","volume":"391","author":"Steadman","year":"2001","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jot.2026.101193_bib44","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1177\/0363546508328414","article-title":"Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis","volume":"37","author":"Mithoefer","year":"2009","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jot.2026.101193_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12030815","article-title":"Subchondral bone cyst development in osteoarthritis: from pathophysiology to bone microarchitecture changes and clinical implementations","volume":"12","author":"Kaspiris","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.jot.2026.101193_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.248","article-title":"Cyst formation in the subchondral bone following cartilage repair","volume":"10","author":"Gao","year":"2020","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.jot.2026.101193_bib47","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1177\/0363546516645514","article-title":"Incidence, degree, and clinical effect of subchondral bone overgrowth after microfracture in the knee","volume":"44","author":"Mithoefer","year":"2016","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jot.2026.101193_bib48","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1177\/0363546516652619","article-title":"Treatment of articular cartilage defects with microfracture and autologous matrix-induced chondrogenesis leads to extensive subchondral bone cyst formation in a sheep model","volume":"44","author":"Beck","year":"2016","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jot.2026.101193_bib49","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jot.2023.09.004","article-title":"Combination of a human articular cartilage-derived extracellular matrix scaffold and microfracture techniques for cartilage regeneration: a proof of concept in a sheep model","volume":"44","author":"Peng","year":"2024","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jot.2026.101193_bib50","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.csm.2024.08.003","article-title":"Cartilage repair with autologous chondrocytes (ACI generations 1\u20134)","volume":"44","author":"Brittberg","year":"2025","journal-title":"Clin Sports Med"},{"key":"10.1016\/j.jot.2026.101193_bib51","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1530\/EOR-2024-0083","article-title":"Current trends in the treatment of focal cartilage lesions: a comprehensive review","volume":"10","author":"Kutaish","year":"2025","journal-title":"EFORT Open Rev"},{"key":"10.1016\/j.jot.2026.101193_bib52","article-title":"Emerging strategies in cartilage repair and joint preservation","volume":"61","author":"Focsa","year":"2025","journal-title":"Medicina (Lithuania)"},{"key":"10.1016\/j.jot.2026.101193_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/jeo2.12016","article-title":"Treatment of knee cartilage lesions in 2024: from hyaluronic acid to regenerative medicine","volume":"11","author":"Brittberg","year":"2024","journal-title":"J Exp Orthop"},{"key":"10.1016\/j.jot.2026.101193_bib54","doi-asserted-by":"crossref","DOI":"10.1177\/09636897231221882","article-title":"Safety and tolerability of intra-articular injection of adipose-derived mesenchymal stem cells GXCPC1 in 11 subjects with knee osteoarthritis: a nonrandomized pilot study without a control arm","volume":"33","author":"Chen","year":"2024","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jot.2026.101193_bib55","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.joca.2007.05.005","article-title":"International cartilage repair society (ICRS) and Oswestry macroscopic cartilage evaluation scores validated for use in Autologous Chondrocyte Implantation (ACI) and microfracture","volume":"15","author":"van den Borne","year":"2007","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.jot.2026.101193_bib56","doi-asserted-by":"crossref","DOI":"10.1177\/2325967120981872","article-title":"Autologous matrix-induced chondrogenesis for treatment of focal cartilage defects in the knee: a Follow-up study","volume":"9","author":"Gille","year":"2021","journal-title":"Orthop J Sports Med"},{"key":"10.1016\/j.jot.2026.101193_bib57","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-021-02684-z","article-title":"Surgical management of focal chondral defects of the knee: a Bayesian network meta-analysis","volume":"16","author":"Migliorini","year":"2021","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.jot.2026.101193_bib58","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.knee.2023.04.001","article-title":"Scaffold-associated procedures are superior to microfracture in managing focal cartilage defects in the knee: a systematic review & meta-analysis","volume":"42","author":"Seewoonarain","year":"2023","journal-title":"Knee"},{"key":"10.1016\/j.jot.2026.101193_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413329","article-title":"Main and minor types of collagens in the articular cartilage: the role of collagens in repair tissue evaluation in chondral defects","volume":"22","author":"Alcaide-Ruggiero","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jot.2026.101193_bib60","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1177\/03635465241230031","article-title":"Passaged articular chondrocytes from the superficial zone and deep zone can regain zone-specific properties after redifferentiation","volume":"52","author":"Davis","year":"2024","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.jot.2026.101193_bib61","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.actbio.2023.07.024","article-title":"Harnessing knee joint resident mesenchymal stem cells in cartilage tissue engineering","volume":"168","author":"Xu","year":"2023","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2026.101193_bib62","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1007\/s11999-011-1857-3","article-title":"The role of growth factors in cartilage repair","volume":"469","author":"Fortier","year":"2011","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jot.2026.101193_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-022-00239-4","article-title":"The role of TGF-beta3 in cartilage development and osteoarthritis","volume":"11","author":"Du","year":"2023","journal-title":"Bone Res"},{"key":"10.1016\/j.jot.2026.101193_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/cells8090969","article-title":"TGF\u03b2\/BMP signaling pathway in cartilage homeostasis","volume":"8","author":"Thielen","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jot.2026.101193_bib65","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1302\/2046-3758.108.BJR-2021-0086","article-title":"Follow us @BoneJointRes the role of TGF-\u03b22 in cartilage development and diseases","volume":"10","author":"Duan","year":"2021","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.jot.2026.101193_bib66","doi-asserted-by":"crossref","DOI":"10.1177\/19476035211069246","article-title":"Comparison between arthroscopic and histological international cartilage repair society scoring systems in porcine cartilage repair model","volume":"13","author":"Puhakka","year":"2022","journal-title":"Cartilage"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X2600152X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X2600152X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:53:45Z","timestamp":1791125625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X2600152X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":66,"alternative-id":["S2214031X2600152X"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2026.101193","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combining polydioxanone-based scaffold and allogeneic adipose-derived mesenchymal stem cells enhances articular cartilage repair - a pre-clinical study","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2026.101193","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}],"article-number":"101193"}}