{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:34:35Z","timestamp":1793414075469,"version":"4.5.0"},"reference-count":118,"publisher":"Tsinghua University Press","issue":"4","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T00:00:00Z","timestamp":1473984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470706"],"award-info":[{"award-number":["81470706"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"crossref","award":["2015A030313180"],"award-info":[{"award-number":["2015A030313180"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Otology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.joto.2016.10.001","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T04:03:21Z","timestamp":1477541001000},"page":"145-156","source":"Crossref","is-referenced-by-count":128,"title":["Ototoxic effects and mechanisms of loop diuretics"],"prefix":"10.26599","volume":"11","author":[{"given":"Dalian","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11138","reference":[{"issue":"14 Suppl","key":"10.1016\/j.joto.2016.10.001_bib2","first-page":"185","article-title":"Effect of loop-diuretics on hair cells of the cochlea in Guinea pigs. Histological and histochemical study","author":"Akiyoshi","year":"1981","journal-title":"Scand. Audiol. Suppl."},{"key":"10.1016\/j.joto.2016.10.001_bib3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3109\/00016488109138521","article-title":"Ultrastructural histopathology in a case of human ototoxicity due to loop diuretics","volume":"91","author":"Arnold","year":"1981","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5527\/wjn.v2.i1.11","article-title":"Pericytes synthesize renin","volume":"2","author":"Berg","year":"2013","journal-title":"World J. Nephrol."},{"key":"10.1016\/j.joto.2016.10.001_bib5","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1215\/S1152851705000232","article-title":"The role of pericytes in blood-vessel formation and maintenance","volume":"7","author":"Bergers","year":"2005","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.joto.2016.10.001_bib6","first-page":"S11","article-title":"Mechanism of action of diuretics","volume":"59","author":"Bleich","year":"1997","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.joto.2016.10.001_bib7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1113\/jphysiol.1979.sp012892","article-title":"The nature of the negative endocochlear potentials produced by anoxia and ethacrynic acid in the rat and Guinea-pig","volume":"293","author":"Bosher","year":"1979","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.joto.2016.10.001_bib8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3109\/00016488009131696","article-title":"The nature of the ototoxic actions of ethacrynic acid upon the mammalian endolymph system. II. Structural-functional correlates in the stria vascularis","volume":"90","author":"Bosher","year":"1980","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib9","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0041-008X(72)90286-4","article-title":"Effects of intra-arterially and intravenously administered ethacrynic acid and furosemide on cochlear N 1 in cats","volume":"22","author":"Brown","year":"1972","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.joto.2016.10.001_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1152\/ajplegacy.1973.225.1.119","article-title":"Furosemide effect on isolated perfused tubules","volume":"225","author":"Burg","year":"1973","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.joto.2016.10.001_bib11","first-page":"843","article-title":"Optometric implications of systemic drug therapy","volume":"56","author":"Canon","year":"1985","journal-title":"J.\u00a0Am. Optom. Assoc."},{"key":"10.1016\/j.joto.2016.10.001_bib12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physiolgenomics.00302.2005","article-title":"Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene","volume":"25","author":"Castrop","year":"2006","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.joto.2016.10.001_bib13","article-title":"Experimental study on the therapeutic value of microwave on hearing loss due to ethacrynic acid ototoxicity","volume":"28","author":"Chen","year":"1993","journal-title":"Zhonghua er bi yan hou ke za zhi"},{"key":"10.1016\/j.joto.2016.10.001_bib14","first-page":"133","article-title":"Deafness, induced by sodium ethacrynate in Guinea pigs, alleviated by microwave treatment","volume":"113","author":"Chen","year":"1992","journal-title":"Rev. Laryngol. Otol. Rhinol."},{"key":"10.1016\/j.joto.2016.10.001_bib15","first-page":"1","article-title":"Cochlear summating potentials. Descriptive aspects","volume":"302","author":"Dallos","year":"1972","journal-title":"Acta Oto-Laryngol. Suppl."},{"key":"10.1016\/j.joto.2016.10.001_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1152\/ajplegacy.1958.195.2.251","article-title":"Summating potentials of the cochlea","volume":"195","author":"Davis","year":"1958","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.joto.2016.10.001_bib17","first-page":"4","article-title":"The changes of cochlear bioelectric potential in Guinea pigs during brief anoxia","volume":"12","author":"Ding","year":"1998","journal-title":"Acta Otorhinolaryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib18","first-page":"407","article-title":"Review of cellular changes in the cochlea due to aminoglycoside antibiotics","volume":"105","author":"Ding","year":"2005","journal-title":"Volta Rev."},{"key":"10.1016\/j.joto.2016.10.001_bib19","first-page":"173","article-title":"Histochemistry of stria vascularis in the inner ear of Guinea pigs","volume":"1","author":"Ding","year":"1987","journal-title":"J.\u00a0Clin. Otorhinolaryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib20","first-page":"1","article-title":"The microcirculation static quantitative observation of the stria vascularis","volume":"4","author":"Ding","year":"1990","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib21","first-page":"265","article-title":"Functional and morphological changes of the cochlea in Guinea pigs during anoxia","volume":"28","author":"Ding","year":"1993","journal-title":"Chin. J. Otorhinolaryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib22","first-page":"76","article-title":"Experimental study of concurrent ototoxicity between ethacrynic acid and gentamycin","volume":"3","author":"Ding","year":"1995","journal-title":"J.\u00a0Audiol. Speech Disord."},{"key":"10.1016\/j.joto.2016.10.001_bib23","first-page":"330","article-title":"The changes of cochlear bioelectric potential on Guinea pigs deafened with ethacrynic acid","volume":"10","author":"Ding","year":"1996","journal-title":"J.\u00a0Clin. Otorhinolaryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(02)00585-3","article-title":"Ethacrynic acid rapidly and selectively abolishes blood flow in vessels supplying the lateral wall of the cochlea","volume":"173","author":"Ding","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.joto.2016.10.001_bib25","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0378-5955(03)00258-2","article-title":"Late dosing with ethacrynic acid can reduce gentamicin concentration in perilymph and protect cochlear hair cells","volume":"185","author":"Ding","year":"2003","journal-title":"Hear. Res."},{"issue":"1","key":"10.1016\/j.joto.2016.10.001_bib26","first-page":"42","article-title":"Ethacrynic acid is the key for opening of the blood-labyrinth barrier","volume":"2","author":"Ding","year":"2004","journal-title":"Chin. J. Otol."},{"key":"10.1016\/j.joto.2016.10.001_bib27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.heares.2006.07.015","article-title":"Cell death after co-administration of cisplatin and ethacrynic acid","volume":"226","author":"Ding","year":"2007","journal-title":"Hear. Res."},{"key":"10.1016\/j.joto.2016.10.001_bib28","first-page":"468","article-title":"Hypoxia-induced inner ear damage","volume":"6","author":"Ding","year":"2008","journal-title":"Chin. J. Otol."},{"key":"10.1016\/j.joto.2016.10.001_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.heares.2009.08.008","article-title":"Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid","volume":"259","author":"Ding","year":"2010","journal-title":"Hear. Res."},{"key":"10.1016\/j.joto.2016.10.001_bib30","series-title":"Science of the inner ear","author":"Ding","year":"2010"},{"key":"10.1016\/j.joto.2016.10.001_bib31","series-title":"Cisplatin Ototoxicity","first-page":"39","author":"Ding","year":"2011"},{"key":"10.1016\/j.joto.2016.10.001_bib32","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/ar.22577","article-title":"Review: ototoxic characteristics of platinum antitumor drugs","volume":"295","author":"Ding","year":"2012","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.joto.2016.10.001_bib33","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/sj.jcbfm.9600272","article-title":"CNS microvascular pericytes exhibit multipotential stem cell activity","volume":"26","author":"Dore-Duffy","year":"2006","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.joto.2016.10.001_bib34","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1121\/1.423293","article-title":"Are inner or outer hair cells the source of summating potentials recorded from the round window?","volume":"104","author":"Durrant","year":"1998","journal-title":"J.\u00a0Acoust. Soc. Am."},{"key":"10.1016\/j.joto.2016.10.001_bib35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jss.2006.06.010","article-title":"Pericytes and their role in microvasculature homeostasis","volume":"135","author":"Edelman","year":"2006","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.joto.2016.10.001_bib36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/16512251.1974.11675742","article-title":"Basic principles for electrocochleography","volume":"316","author":"Eggermont","year":"1974","journal-title":"Acta Oto-Laryngol. Suppl."},{"key":"10.1016\/j.joto.2016.10.001_bib37","first-page":"195","article-title":"The cortilymph, the third lymph of the inner ear","volume":"3","author":"Engstrom","year":"1960","journal-title":"Acta Morphol. Neerl."},{"key":"10.1016\/j.joto.2016.10.001_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1044\/1059-0889(1999\/001)","article-title":"SP\/AP area ratio in the diagnosis of Meniere's disease","volume":"8","author":"Ferraro","year":"1999","journal-title":"Am. J. Audiol."},{"key":"10.1016\/j.joto.2016.10.001_bib39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1365-2273.1976.tb00879.x","article-title":"Observations on the stria vascularis of the Guinea pig cochlea and the changes resulting from the administration of the diuretic furosemide","volume":"1","author":"Forge","year":"1976","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"10.1016\/j.joto.2016.10.001_bib40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/03005368209081455","article-title":"Ultrastructural and electrophysiological studies of acute ototoxic effects of furosemide","volume":"16","author":"Forge","year":"1982","journal-title":"Br. J. Audiol."},{"key":"10.1016\/j.joto.2016.10.001_bib41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2165\/00003495-199141010-00008","article-title":"Torasemide. A review of its pharmacological properties and therapeutic potential","volume":"41","author":"Friedel","year":"1991","journal-title":"Drugs"},{"key":"10.1016\/j.joto.2016.10.001_bib42","doi-asserted-by":"crossref","first-page":"744","DOI":"10.7326\/0003-4819-91-5-744","article-title":"Furosemide-induced ototoxicity","volume":"91","author":"Gallagher","year":"1979","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.joto.2016.10.001_bib43","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1126\/science.173.3991.64","article-title":"Angiotensin-forming enzyme in brain tissue","volume":"173","author":"Ganten","year":"1971","journal-title":"Science"},{"key":"10.1016\/j.joto.2016.10.001_bib44","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3109\/00016489109128043","article-title":"The use of electrocochleography in the diagnosis of Meniere's disease","volume":"485","author":"Gibson","year":"1991","journal-title":"Acta Oto-Laryngol. Suppl."},{"key":"10.1016\/j.joto.2016.10.001_bib45","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1038\/onc.2013.514","article-title":"Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma","volume":"33","author":"Glenn","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.joto.2016.10.001_bib46","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1152\/ajplegacy.1954.178.2.331","article-title":"Analysis of summating potential in cochlear responses of Guinea pigs","volume":"178","author":"Goldstein","year":"1954","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.joto.2016.10.001_bib47","first-page":"536","article-title":"New insights into the molecular mechanism of the action of diuretics","volume":"14","author":"Greger","year":"1999","journal-title":"Nephrol. Dialysis Transplant Off. Publ. Eur. Dialysis Transpl. Assoc. Eur. Ren. Assoc."},{"key":"10.1016\/j.joto.2016.10.001_bib48","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/BF01537500","article-title":"Cellular mechanism of the action of loop diuretics on the thick ascending limb of Henle's loop","volume":"61","author":"Greger","year":"1983","journal-title":"Klin. Wochenschr."},{"key":"10.1016\/j.joto.2016.10.001_bib49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature13165","article-title":"Capillary pericytes regulate cerebral blood flow in health and disease","volume":"508","author":"Hall","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.joto.2016.10.001_bib50","series-title":"IIIrd Symposium on the Role of the Vestibular Organ in Space Exploration NASA SP-152:241","article-title":"Vascular pattern of the membranous labyrinth","author":"Hawkins","year":"1967"},{"key":"10.1016\/j.joto.2016.10.001_bib51","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1001\/archotol.1989.01860280098025","article-title":"Effect of albumin-bound furosemide on the endocochlear potential of the chinchilla. Alleviation of furosemide-induced ototoxicity","volume":"115","author":"Ikeda","year":"1989","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.joto.2016.10.001_bib52","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0378-5955(89)90104-4","article-title":"Electrochemical profile for calcium ions in the stria vascularis: cellular model of calcium transport mechanism","volume":"40","author":"Ikeda","year":"1989","journal-title":"Hear Res."},{"key":"10.1016\/j.joto.2016.10.001_bib53","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0378-5955(89)90047-6","article-title":"Electrochemical profiles for monovalent ions in the stria vascularis: cellular model of ion transport mechanisms","volume":"39","author":"Ikeda","year":"1989","journal-title":"Hear Res."},{"key":"10.1016\/j.joto.2016.10.001_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(97)00009-9","article-title":"Molecular and clinical implications of loop diuretic ototoxicity","volume":"107","author":"Ikeda","year":"1997","journal-title":"Hear Res."},{"key":"10.1016\/j.joto.2016.10.001_bib55","first-page":"73","article-title":"Ocular side effects of selected systemic drugs","volume":"2","author":"Jaanus","year":"1992","journal-title":"Optom. Clin. Off. Publ. Prentice Soc."},{"key":"10.1016\/j.joto.2016.10.001_bib56","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.anl.2003.07.002","article-title":"Electrocochleographic findings in cases of autoimmune disease with sensorineural deafness","volume":"30","author":"Kakigi","year":"2003","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.joto.2016.10.001_bib57","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/00206098209072755","article-title":"Electrocochleographic study of summating potentials in Meniere's disease","volume":"21","author":"Kanzaki","year":"1982","journal-title":"Audiology"},{"key":"10.1016\/j.joto.2016.10.001_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0385-8146(78)80002-9","article-title":"Changes of the stria vascularis induced by ethacrynic acid","volume":"5","author":"Kasajima","year":"1978","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.joto.2016.10.001_bib59","first-page":"1058","article-title":"Mechanism of action & indication for therapeutic use of anionic diuretics; organic mercurial preparations carbonic anhydrase inhibitors, chlorothiacide","volume":"13","author":"Kruck","year":"1958","journal-title":"Arztliche Wochenschr."},{"key":"10.1016\/j.joto.2016.10.001_bib60","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1681\/ASN.2006090953","article-title":"Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium","volume":"18","author":"Kurtz","year":"2007","journal-title":"J.\u00a0Am. Soc. Nephrol. JASN"},{"key":"10.1016\/j.joto.2016.10.001_bib61","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1288\/00005537-197601000-00025","article-title":"Effects of anoxia and ethacrynic acid upon ampullar endolymphatic potential and upon high energy phosphates in ampullar wall","volume":"86","author":"Kusakari","year":"1976","journal-title":"Laryngoscope"},{"key":"10.1016\/j.joto.2016.10.001_bib62","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/lary.1978.88.1.12","article-title":"Effect of ethacrynic acid, furosemide, and ouabain upon the endolymphatic potential and upon high energy phosphates of the stria vascularis","volume":"88","author":"Kusakari","year":"1978","journal-title":"Laryngoscope"},{"key":"10.1016\/j.joto.2016.10.001_bib63","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3109\/00016487809107512","article-title":"Reduction of the endocochlear potential by the new \u201cloop\u201d diuretic, bumetanide","volume":"86","author":"Kusakari","year":"1978","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib64","first-page":"1","article-title":"Vestibular destruction by slow infusion of gentamicin into semicircular canals","volume":"552","author":"Li","year":"2004","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib65","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s12640-011-9244-0","article-title":"Co-administration of cisplatin and furosemide causes rapid and massive loss of cochlear hair cells in mice","volume":"20","author":"Li","year":"2011","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.joto.2016.10.001_bib66","first-page":"105","article-title":"Determination of prostaglandin F (2\u03b1) and prostacyclindiuresis in the cochlear lateral wall after echacrynic acid injection to Guinea pigs","volume":"2","author":"Liu","year":"1994","journal-title":"Acta Univ. Medictnae Tangji"},{"key":"10.1016\/j.joto.2016.10.001_bib67","first-page":"26","article-title":"Ethacrynic acid-induced cochlear lesions in\u00a0vitro","volume":"34","author":"Liu","year":"2011","journal-title":"Abstr. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib68","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1631\/jzus.B1100040","article-title":"Ototoxic destruction by co-administration of kanamycin and ethacrynic acid in rats","volume":"12","author":"Liu","year":"2011","journal-title":"J.\u00a0Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.joto.2016.10.001_bib69","first-page":"95","article-title":"The teratological effect of certain thiadiazoles related to acetazolamide, with a note on sulfanilamide and thiazide diuretics","volume":"130","author":"Maren","year":"1972","journal-title":"Johns Hopkins Med. J."},{"issue":"14 Suppl","key":"10.1016\/j.joto.2016.10.001_bib70","first-page":"131","article-title":"Effects of ototoxic diuretics on cochlear Na+\/K+-ATPase and adenylate cyclase","author":"Marks","year":"1981","journal-title":"Scand. Audiol. Suppl."},{"key":"10.1016\/j.joto.2016.10.001_bib71","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1288\/00005537-197608000-00001","article-title":"The ototoxic effects of ethacrynic acid in man and animals","volume":"86","author":"Matz","year":"1976","journal-title":"Laryngoscope"},{"key":"10.1016\/j.joto.2016.10.001_bib72","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0378-5955(02)00697-4","article-title":"Chinchilla models of selective cochlear hair cell loss","volume":"174","author":"McFadden","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.joto.2016.10.001_bib73","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.brainres.2003.10.031","article-title":"Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla","volume":"997","author":"McFadden","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.joto.2016.10.001_bib1","first-page":"156","article-title":"Merbaphen (Novasurol) as Diuretic in Congestive Heart Failure","volume":"17","year":"1927","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.joto.2016.10.001_bib74","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/jama.1971.03180310033006","article-title":"Deafness following standard intravenous dose of ethacrynic acid","volume":"216","author":"Meriwether","year":"1971","journal-title":"JAMA"},{"key":"10.1016\/j.joto.2016.10.001_bib75","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1177\/019459989010200609","article-title":"Summating potential\/action potential ratio in perilymph fistula","volume":"102","author":"Meyerhoff","year":"1990","journal-title":"Otolaryngol. Head Neck Surg. Off. J. Am. Acad. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.joto.2016.10.001_bib76","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF00460282","article-title":"Compound action potential of the cochlear nerve evoked electrically. Electrophysiological study of the acoustic nerve (Guinea pig)","volume":"206","author":"Nagel","year":"1974","journal-title":"Arch. Oto-Rhino-Laryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib77","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.otohns.2003.12.016","article-title":"Extratympanic electrocochleographic changes on noise-induced temporary threshold shift","volume":"130","author":"Nam","year":"2004","journal-title":"Otolaryngol. Head Neck Surg. Off. J. Am. Acad. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.joto.2016.10.001_bib78","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1681\/ASN.2012050493","article-title":"The increasing complexity of the intratubular Renin-Angiotensin system","volume":"23","author":"Navar","year":"2012","journal-title":"J.\u00a0Am. Soc. Nephrol. JASN"},{"key":"10.1016\/j.joto.2016.10.001_bib79","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0140-6736(69)92032-7","article-title":"Deafness after ethacrynic acid","volume":"1","author":"Ng","year":"1969","journal-title":"Lancet"},{"key":"10.1016\/j.joto.2016.10.001_bib80","first-page":"133","article-title":"Gentamicin Cures vertigo, but what Happens to hearing?","volume":"3","author":"Odkvist","year":"1997","journal-title":"Int. tinnitus J."},{"key":"10.1016\/j.joto.2016.10.001_bib81","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3109\/00016489709124023","article-title":"When and how to use gentamicin in the treatment of Meniere's disease","volume":"526","author":"Odkvist","year":"1997","journal-title":"Acta Oto-Laryngol. Suppl."},{"key":"10.1016\/j.joto.2016.10.001_bib82","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000276065","article-title":"Clinical significance of SP\/AP ratio in inner ear diseases","volume":"51","author":"Ohashi","year":"1989","journal-title":"ORL J. Oto-Rhino-Laryngol. Relat. Specialties"},{"key":"10.1016\/j.joto.2016.10.001_bib83","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0021-5155(01)00412-9","article-title":"Increased expression of angiotensin-converting enzyme in retinas of diabetic rats","volume":"45","author":"Okada","year":"2001","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.joto.2016.10.001_bib84","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000052608","article-title":"Pericyte regulation of renal medullary blood flow","volume":"9","author":"Pallone","year":"2001","journal-title":"Exp. Nephrol."},{"key":"10.1016\/j.joto.2016.10.001_bib85","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/BF00465552","article-title":"Influence of \u201cloop\u201d diuretics upon Na+K+-ATPase and adenylate cyclase of the stria vascularis","volume":"217","author":"Paloheimo","year":"1977","journal-title":"Arch. Oto-Rhino-Laryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib86","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature05193","article-title":"Bidirectional control of CNS capillary diameter by pericytes","volume":"443","author":"Peppiatt","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.joto.2016.10.001_bib87","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/000348947508400114","article-title":"Permanent deafness associated with furosemide administration","volume":"84","author":"Quick","year":"1975","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib88","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0378-5955(82)90037-5","article-title":"A\u00a0comparison of compound action potential and cochlear microphonic two-tone suppression in the Guinea pig","volume":"8","author":"Remond","year":"1982","journal-title":"Hear Res."},{"key":"10.1016\/j.joto.2016.10.001_bib89","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00007611-197801000-00029","article-title":"Deafness associated with oral furosemide","volume":"71","author":"Rifkin","year":"1978","journal-title":"South. Med. J."},{"key":"10.1016\/j.joto.2016.10.001_bib90","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0030-6665(20)30770-2","article-title":"Ototoxicity of loop diuretics","volume":"26","author":"Rybak","year":"1993","journal-title":"Otolaryngol. Clin. North Am."},{"key":"10.1016\/j.joto.2016.10.001_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00016487909137133","article-title":"Morphological alteration of the stria vascularis after administration of the diuretic bumetanide","volume":"88","author":"Santi","year":"1979","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib92","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0378-5955(83)90103-X","article-title":"The effect of bumetanide on the stria vascularis: a stereological analysis of cell volume density","volume":"12","author":"Santi","year":"1983","journal-title":"Hear. Res."},{"key":"10.1016\/j.joto.2016.10.001_bib93","series-title":"Pathology of the Ear","author":"Schucnect","year":"1974"},{"key":"10.1016\/j.joto.2016.10.001_bib94","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1177\/000348946307200308","article-title":"Experimental observations on the fluid Physiology of the inner ear","volume":"72","author":"Schuknecht","year":"1963","journal-title":"Ann. Otol. Rhinol Laryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib95","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1021\/jm00292a033","article-title":"Structure of the diuretic merbaphen","volume":"14","author":"Schultz","year":"1971","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.joto.2016.10.001_bib96","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0301-0082(75)90015-5","article-title":"Production and role of inner ear fluid","volume":"5","author":"Sellick","year":"1975","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.joto.2016.10.001_bib97","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1534-5807(04)00134-0","article-title":"Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened","volume":"6","author":"Sequeira Lopez","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.joto.2016.10.001_bib98","first-page":"151","article-title":"Study of the action of 9370 MHz microwave on cochlea microcirculation","volume":"1","author":"Shi","year":"1994","journal-title":"Chin. Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.joto.2016.10.001_bib99","first-page":"52","article-title":"Effect of microwave on cochlear microcirculation","volume":"32","author":"Shi","year":"1997","journal-title":"Chin. J. Zool."},{"key":"10.1016\/j.joto.2016.10.001_bib100","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/10739680802047445","article-title":"The cochlear pericytes","volume":"15","author":"Shi","year":"2008","journal-title":"Microcirculation"},{"key":"10.1016\/j.joto.2016.10.001_bib101","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2170\/jjphysiol.42.617","article-title":"Dependence of endocochlear potential on basolateral Na+ and Cl- concentration: a study using vascular and perilymph perfusion","volume":"42","author":"Shindo","year":"1992","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.joto.2016.10.001_bib102","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1288\/00005537-197106000-00008","article-title":"The effect of diuretics on cochlear potentials and inner ear fluids","volume":"81","author":"Silverstein","year":"1971","journal-title":"Laryngoscope"},{"key":"10.1016\/j.joto.2016.10.001_bib103","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1053\/hn.1999.v120.a91763","article-title":"Direct round window membrane application of gentamicin in the treatment of Meniere's disease","volume":"120","author":"Silverstein","year":"1999","journal-title":"Otolaryngol. Head Neck Surg. Off. J. Am. Acad. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.joto.2016.10.001_bib104","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1288\/00005537-195111000-00002","article-title":"Capillary areas of the cochlea in the Guinea pig","volume":"61","author":"Smith","year":"1951","journal-title":"Laryngoscope"},{"key":"10.1016\/j.joto.2016.10.001_bib105","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0378-5955(85)90031-0","article-title":"The effect of loop diuretics upon summating potentials in the Guinea pig","volume":"20","author":"Syka","year":"1985","journal-title":"Hear. Res."},{"key":"10.1016\/j.joto.2016.10.001_bib106","doi-asserted-by":"crossref","first-page":"333","DOI":"10.5631\/jibirin.66.333","article-title":"A\u00a0suggestion on the Origin of cortilymph by Scanning Electron microscope","volume":"66","author":"Tanaka","year":"1973","journal-title":"Pract. Oto-Rhino-Laryngol."},{"key":"10.1016\/j.joto.2016.10.001_bib107","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1152\/jn.1959.22.2.149","article-title":"Stria vascularis as source of endocochlear potential","volume":"22","author":"Tasaki","year":"1959","journal-title":"J.\u00a0Neurophysiol."},{"issue":"26","key":"10.1016\/j.joto.2016.10.001_bib108","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1121\/1.1907415","article-title":"Exploration of cochlear potentials in Guinea pig with a microelectrode","volume":"765","author":"Tasaki","year":"1954","journal-title":"Acoust. Soc. Am."},{"key":"10.1016\/j.joto.2016.10.001_bib109","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1288\/00005537-198205000-00025","article-title":"Arguments against a mediating role of the adenylate cyclase\u2013cyclic AMP system in the ototoxic action of loop diuretics","volume":"92","author":"Thalmann","year":"1982","journal-title":"Laryngoscope"},{"key":"10.1016\/j.joto.2016.10.001_bib110","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1161\/01.RES.42.3.376","article-title":"The renin response to diuretic therapyl A limitation of antihypertensive potential","volume":"42","author":"Vaughan","year":"1978","journal-title":"Circulation Res."},{"key":"10.1016\/j.joto.2016.10.001_bib111","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/bjo.80.2.159","article-title":"Demonstration of renin mRNA, angiotensinogen mRNA, and angiotensin converting enzyme mRNA expression in the human eye: evidence for an intraocular renin-angiotensin system","volume":"80","author":"Wagner","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.joto.2016.10.001_bib112","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0378-5955(95)00009-S","article-title":"Ion transport mechanisms responsible for K+ secretion and the transepithelial voltage across marginal cells of stria vascularis in\u00a0vitro","volume":"84","author":"Wangemann","year":"1995","journal-title":"Hear Res."},{"key":"10.1016\/j.joto.2016.10.001_bib113","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1126\/science.71.1834.215","article-title":"Auditory nerve impulses","volume":"71","author":"Wever","year":"1930","journal-title":"Science"},{"key":"10.1016\/j.joto.2016.10.001_bib114","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1111\/bph.13461","article-title":"The brain renin-angiotensin system plays a crucial role in regulating body weight in diet-induced rat obesity","volume":"173","author":"Winkler","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.joto.2016.10.001_bib115","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1073\/pnas.91.6.2201","article-title":"Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter","volume":"91","author":"Xu","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.joto.2016.10.001_bib116","first-page":"65","article-title":"The influence of enthacrynic acid on the activity of enzyme in the stria vascularis in Guinea pigs","volume":"2","author":"Zhao","year":"1988","journal-title":"J.\u00a0Clin. Otorhinolaryngol"},{"key":"10.1016\/j.joto.2016.10.001_bib117","first-page":"34","article-title":"Influence of ethacrynic acid on microcirculation of stria vascularis of cochlea in Guinea pigs","volume":"8","author":"Zhao","year":"1988","journal-title":"Acta Univ. Med. Second. Shanghai"},{"key":"10.1016\/j.joto.2016.10.001_bib118","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0378-5955(97)00127-5","article-title":"Evidence that inner hair cells are the major source of cochlear summating potentials","volume":"113","author":"Zheng","year":"1997","journal-title":"Hear. Res."}],"container-title":["Journal of Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1672293016300629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1672293016300629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T04:30:11Z","timestamp":1742185811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1672293016300629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":118,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1672293016300629"],"URL":"https:\/\/doi.org\/10.1016\/j.joto.2016.10.001","relation":{},"ISSN":["1672-2930"],"issn-type":[{"value":"1672-2930","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}