{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:24:02Z","timestamp":1761956642646,"version":"build-2065373602"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpagonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric and Adolescent Gynecology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.jpag.2008.08.005","type":"journal-article","created":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T04:34:10Z","timestamp":1238992450000},"page":"91-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Pioglitazone on Menstrual Frequency, Hyperandrogenism and Insulin Resistance in Adoloscents and Young Adults with Polycystic Ovary Syndrome"],"prefix":"10.1016","volume":"22","author":[{"given":"Laddiperla","family":"Narsing Rao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jubbin Jagan","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas V.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Rajarathinam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandalam S.","family":"Seshadri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpag.2008.08.005_bib1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jpag.2008.08.005_bib2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/09513599809015601","article-title":"Insulin and polycystic ovary syndrome: a new look to an old subject","volume":"12","author":"Ciampelli","year":"1998","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.jpag.2008.08.005_bib3","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0026-0495(94)90209-7","article-title":"Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy","volume":"43","author":"Velazquez","year":"1994","journal-title":"Metabolism"},{"key":"10.1016\/j.jpag.2008.08.005_bib4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1056\/NEJM199608293350902","article-title":"Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome","volume":"335","author":"Nestler","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpag.2008.08.005_bib5","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1056\/NEJM199806253382603","article-title":"Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome","volume":"338","author":"Nestler","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpag.2008.08.005_bib6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1365-2265.1999.00786.x","article-title":"The effects of metformin on insulin resistance and ovarian steroidogenesis in women with polycystic ovary syndrome","volume":"51","author":"Unluhizarci","year":"1999","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jpag.2008.08.005_bib7","first-page":"3299","article-title":"The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome","volume":"81","author":"Dunaif","year":"1996","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2008.08.005_bib8","first-page":"2108","article-title":"Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome","volume":"82","author":"Ehrmann","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2008.08.005_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0015-0282(98)00454-3","article-title":"Effect of troglitazone on endocrine and ovulatory performance in women with insulin resistance-related polycystic ovary syndrome","volume":"71","author":"Hasegawa","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpag.2008.08.005_bib10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2165\/00003495-200060020-00009","volume":"60","author":"Gillies","year":"2000","journal-title":"Pioglitazone. Drugs"},{"key":"10.1016\/j.jpag.2008.08.005_bib11","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1093\/humrep\/deg264","article-title":"Selective effects of pioglitazone on insulin and androgen abnormalities in normo- and hyperinsulinaemic obese patients with polycystic ovary syndrome","volume":"18","author":"Romualdi","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jpag.2008.08.005_bib12","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0002-9378(81)90746-8","article-title":"Hirsutism: implications, etiology, and management","volume":"140","author":"Hatch","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpag.2008.08.005_bib13","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2337\/diacare.22.10.1655","article-title":"A quantitative scale of acanthosis nigricans","volume":"22","author":"Burke","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpag.2008.08.005_bib14","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1210\/jc.2003-031737","article-title":"Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome","volume":"89","author":"Brettenthaler","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2008.08.005_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1471-0528.2000.tb11572.x","article-title":"Polycystic ovary syndrome: a risk factor for cardiovascular disease?","volume":"107","author":"Rajkhowa","year":"2000","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.jpag.2008.08.005_bib16","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/humrep\/deh145","article-title":"Effect of pioglitazone treatment on the adrenal androgen response to corticotrophin in obese patients with polycystic ovary syndrome","volume":"19","author":"Guido","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jpag.2008.08.005_bib17","first-page":"2694","article-title":"A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome","volume":"83","author":"Legro","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2008.08.005_bib18","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1210\/jc.2004-1965","article-title":"Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome","volume":"90","author":"Ortega-Gonzalez","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2008.08.005_bib19","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1056\/NEJMoa072761","article-title":"Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes","volume":"356","author":"Nissen","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpag.2008.08.005_bib20","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0140-6736(05)67528-9","article-title":"PROactive investigators. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial","volume":"366","author":"Dormandy","year":"2005","journal-title":"Lancet"}],"container-title":["Journal of Pediatric and Adolescent Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318808002763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318808002763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:37:14Z","timestamp":1761053834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083318808002763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S1083318808002763"],"URL":"https:\/\/doi.org\/10.1016\/j.jpag.2008.08.005","relation":{},"ISSN":["1083-3188"],"issn-type":[{"type":"print","value":"1083-3188"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Pioglitazone on Menstrual Frequency, Hyperandrogenism and Insulin Resistance in Adoloscents and Young Adults with Polycystic Ovary Syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric and Adolescent Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpag.2008.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}