{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:23:21Z","timestamp":1790061801792,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpagonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric and Adolescent Gynecology"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.jpag.2008.10.003","type":"journal-article","created":{"date-parts":[[2009,6,17]],"date-time":"2009-06-17T04:43:33Z","timestamp":1245213813000},"page":"173-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["No Activating Mutations of FSH Receptor in Four Children with Ovarian Juvenile Granulosa Cell Tumors and the Association of These Tumors with Central Precocious Puberty"],"prefix":"10.1016","volume":"22","author":[{"given":"Firdevs","family":"Bas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ora Hirsch","family":"Pescovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Steinmetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpag.2008.10.003_bib1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00000478-198408000-00002","article-title":"Juvenile granulosa cell tumor of the ovary: A clinicopathological analysis of 125 cases","volume":"8","author":"Young","year":"1984","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jpag.2008.10.003_bib2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00000478-198209000-00002","article-title":"Granulosa tumors of the ovary in children: A clinical and pathologic study of 32 cases","volume":"6","author":"Zaloudek","year":"1982","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jpag.2008.10.003_bib3","first-page":"281","article-title":"Pathology of ovarian neoplasms in childhood and adolescence","volume":"27","author":"Lack","year":"1992","journal-title":"Path Annu"},{"key":"10.1016\/j.jpag.2008.10.003_bib4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/00006254-199804000-00022","article-title":"Granulosa and theca cell tumors in children: A report of 17 cases and literature review","volume":"53","author":"Cronje","year":"1998","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.jpag.2008.10.003_bib5","first-page":"40","article-title":"Juvenile granulosa cell tumors of the ovary","volume":"113","author":"Biscotti","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jpag.2008.10.003_bib6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/1097-0142(197209)30:3<713::AID-CNCR2820300319>3.0.CO;2-G","article-title":"Relative frequency of neoplasm in children and adolescents","volume":"30","author":"Norris","year":"1972","journal-title":"Cancer"},{"key":"10.1016\/j.jpag.2008.10.003_bib7","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1200\/JCO.1988.6.6.990","article-title":"Juvenile granulosa cell tumor of the ovary in children: A clinical study of 15 cases","volume":"6","author":"Vassal","year":"1988","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jpag.2008.10.003_bib8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1006\/gyno.1997.4695","article-title":"Juvenile granulosa cell tumors of the ovary in children and adolescents: Results from 33 patients registered in a prospective cooperative study","volume":"65","author":"Calaminus","year":"1997","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jpag.2008.10.003_bib9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/BF02072508","article-title":"Precocious puberty due to a lipid cell tumor of the ovary","volume":"152","author":"Dengg","year":"1993","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpag.2008.10.003_bib10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000184639","article-title":"Central precocious puberty following feminizing right ovarian granulosa cell tumor","volume":"44","author":"Kukuvitis","year":"1995","journal-title":"Horm Res"},{"key":"10.1016\/j.jpag.2008.10.003_bib11","first-page":"292","article-title":"An association of hypothalamic hamartoma, central precocious puberty and juvenile granulosa cell tumor in early childhood","volume":"49","author":"Feilberg Jorgensen","year":"1998","journal-title":"Horm Res"},{"key":"10.1016\/j.jpag.2008.10.003_bib12","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1056\/NEJM199409223311204","article-title":"Ovarian tumors in a cohort of infertile women","volume":"331","author":"Rossing","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpag.2008.10.003_bib13","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/0140-6736(93)91071-S","article-title":"Ovarian stimulation and granulosa cell tumour","volume":"341","author":"Willemsen","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.jpag.2008.10.003_bib14","first-page":"739","article-title":"The follicle stimulating hormone receptor: Biochemistry, molecular biology, physiology, and pathophysiology","volume":"18","author":"Simoni","year":"1997","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jpag.2008.10.003_bib15","first-page":"1020","article-title":"A mutation in the follicle stimulating hormone receptor occurs frequently in human ovarian sex cord tumors","volume":"82","author":"Kotlar","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2008.10.003_bib16","first-page":"274","article-title":"No evidence of a role for mutations or polymorphisms of the follicle-stimulating hormone receptor in ovarian granulosa cell tumors","volume":"83","author":"Fuller","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2008.10.003_bib17","first-page":"2233","article-title":"Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors","volume":"84","author":"Ligtenberg","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2008.10.003_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variation in pattern of pubertal changes in girls","volume":"44","author":"Marshall","year":"1969","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpag.2008.10.003_bib19","first-page":"553","article-title":"Growth standards for Turkish children","volume":"29","author":"Neyzi","year":"1979","journal-title":"Courrier"},{"key":"10.1016\/j.jpag.2008.10.003_bib20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1210\/jcem-59-3-441","article-title":"Investigation of binding sites for follicle-stimulating hormone and chorionic gonadotropin in human ovarian cancers","volume":"59","author":"Stouffer","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2008.10.003_bib21","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0002-9378(89)90749-7","article-title":"Localization of gonadotropin binding sites in human ovarian neoplasms","volume":"161","author":"Nakano","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpag.2008.10.003_bib22","first-page":"2074","article-title":"Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors","volume":"83","author":"Villares- Fragoso","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2008.10.003_bib23","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/mgme.1997.2650","article-title":"Molecular genetic, biochemical, and clinical implications of gonadotropin receptor mutations","volume":"63","author":"Chan","year":"1998","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jpag.2008.10.003_bib24","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/0006-291X(91)91682-3","article-title":"Cloning and sequencing of human FSH receptor cDNA","volume":"175","author":"Minegish","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jpag.2008.10.003_bib25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0303-7207(92)90220-Z","article-title":"The cloning of the human follicle-stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells","volume":"89","author":"Kelton","year":"1992","journal-title":"Mol and Cell Endocrinol"},{"key":"10.1016\/j.jpag.2008.10.003_bib26","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0092-8674(95)90275-9","article-title":"Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure","volume":"82","author":"Aittomaki","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.jpag.2008.10.003_bib27","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0015-0282(98)00151-4","article-title":"Identification of allelic variants in the follicle-stimulating hormone receptor genes of females with or without hypergonadotropic amenorrhea","volume":"70","author":"Liu","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpag.2008.10.003_bib28","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0015-0282(16)57786-3","article-title":"The follicle-stimulating hormone receptor gene is polymorphic in premature ovarian failure and normal controls","volume":"64","author":"Whitney","year":"1995","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpag.2008.10.003_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2265.1999.00745.x","article-title":"Mutation screening and isoform prevalence of the follicle-stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndrome","volume":"51","author":"Conway","year":"1999","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jpag.2008.10.003_bib30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0015-0282(99)00520-8","article-title":"Mutation analysis of the follicle-stimulating hormone receptor gene in girls with gonadotropin-independent precocious puberty resulting from autonomous cystic ovaries","volume":"73","author":"Batista","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpag.2008.10.003_bib31","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1126\/science.2116665","article-title":"Two G protein oncogenes in endocrine tumors","volume":"249","author":"Lyons","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.jpag.2008.10.003_bib32","first-page":"4159","article-title":"Absence of the previously reported G protein oncogene (gip2) in ovarian granulosa cell tumors","volume":"81","author":"Shen","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"issue":"suppl 3","key":"10.1016\/j.jpag.2008.10.003_bib33","first-page":"891","article-title":"Premature thelarche and granulosa cell tumors: A search for FSH receptor and Gs\u03b1 activating muations","volume":"15","author":"Hannon","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.jpag.2008.10.003_bib34","first-page":"425","article-title":"Rapid induction of ovarian granulosa cell tumors by 7,12-dimethylbenz (a) anthracene in neonatally estrogenized mice","volume":"48","author":"Taguchi","year":"1988","journal-title":"Cancer Res"},{"key":"10.1016\/j.jpag.2008.10.003_bib35","first-page":"721","article-title":"Plasma gonadotropin levels during early stages of ovarian tumorigenesis in mice of the Wx\/Wu genotype","volume":"33","author":"Murphy","year":"1973","journal-title":"Cancer Res"},{"key":"10.1016\/j.jpag.2008.10.003_bib36","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1651-2227.1992.tb12178.x","article-title":"Cystic adult granulosa cell tumor causing precocious pseudopuberty in a six-year-old girl","volume":"81","author":"Arisaka","year":"1992","journal-title":"Acta Pediatr"},{"key":"10.1016\/j.jpag.2008.10.003_bib37","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1651-2227.1997.tb15193.x","article-title":"Precocious pseudopuberty due to a granulosa cell tumour in seven-month-old female","volume":"86","author":"Cameron","year":"1997","journal-title":"Acta Pediatr"},{"key":"10.1016\/j.jpag.2008.10.003_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3476(86)80767-3","article-title":"The NIH experience with precocious puberty: Diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analog therapy","volume":"108","author":"Pescovitz","year":"1986","journal-title":"J Pediatr"}],"container-title":["Journal of Pediatric and Adolescent Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318808002933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318808002933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:36:52Z","timestamp":1761053812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083318808002933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S1083318808002933"],"URL":"https:\/\/doi.org\/10.1016\/j.jpag.2008.10.003","relation":{},"ISSN":["1083-3188"],"issn-type":[{"value":"1083-3188","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"No Activating Mutations of FSH Receptor in Four Children with Ovarian Juvenile Granulosa Cell Tumors and the Association of These Tumors with Central Precocious Puberty","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric and Adolescent Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpag.2008.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}