{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T03:08:43Z","timestamp":1761966523548,"version":"build-2065373602"},"reference-count":13,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpagonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric and Adolescent Gynecology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.jpag.2011.06.007","type":"journal-article","created":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T08:03:02Z","timestamp":1314604982000},"page":"365-367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Insight: Prolonged Vaginal Bleeding during Central Precocious Puberty Therapy with a Long-acting Gonadotropin-Releasing Hormone Agonist: A\u00a0Proposed Mechanism and Management Plan"],"prefix":"10.1016","volume":"24","author":[{"given":"Arieh","family":"Kauschansky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul","family":"Orvieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie","family":"Yeshaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Shterntal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Naor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpag.2011.06.007_bib1","first-page":"327","article-title":"Prolonged vaginal bleeding during central precocious puberty therapy with a long-acting gonadotropin-releasing hormone agonist","volume":"77","author":"Yeshaya","year":"1998","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.jpag.2011.06.007_bib2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1159\/000308172","article-title":"Effect of treatment with cyproterone acetate on uterine bleeding at the beginning of GnRH analogue therapy in girls with idiopathic central precocious puberty","volume":"73","author":"Seminara","year":"2010","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.jpag.2011.06.007_bib3","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000182145","article-title":"Long-term results of long-acting luteinizing-hormone-releasing hormone agonist in central precocious puberty","volume":"36","author":"Swaenepoel","year":"1991","journal-title":"Horm Res"},{"key":"10.1016\/j.jpag.2011.06.007_bib4","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1210\/me.2006-0253","article-title":"Reciprocal cross talk between gonadotropin-releasing hormone (GnRH) and prostaglandin receptors regulates GnRH receptor expression and differential gonadotropin secretion","volume":"21","author":"Naor","year":"2007","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jpag.2011.06.007_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1730001","article-title":"Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors","volume":"173","author":"McArdle","year":"2002","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jpag.2011.06.007_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yfrne.2008.07.001","article-title":"Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor","volume":"30","author":"Naor","year":"2009","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.jpag.2011.06.007_bib7","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.tem.2004.08.006","article-title":"Prostaglandin receptor signalling and function in human endometrial pathology","volume":"15","author":"Jabbour","year":"2004","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jpag.2011.06.007_bib8","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1471-0528.1981.tb01009.x","article-title":"Prostaglandin synthesis in the endometrium of women with ovular dysfunctional uterine bleeding","volume":"88","author":"Smith","year":"1981","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.jpag.2011.06.007_bib9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1471-0528.1984.tb04829.x","article-title":"Prostaglandins in menstrual fluid in menorrhagia and dysmenorrhoea","volume":"91","author":"Rees","year":"1984","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.jpag.2011.06.007_bib10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1530\/rep.0.1260559","article-title":"Cyclooxygenase enzymes and prostaglandins in pathology of the endometrium","volume":"126","author":"Sales","year":"2003","journal-title":"Reproduction"},{"key":"10.1016\/j.jpag.2011.06.007_bib11","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1210\/jcem.87.8.8719","article-title":"Expression and localization of endothelial monocyte-activating polypeptide II in the human endometrium across the menstrual cycle: regulation of expression by prostaglandin E(2)","volume":"87","author":"Battersby","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2011.06.007_bib12","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1210\/en.2003-0986","article-title":"Cyclooxygenase-2 overexpression inhibits cathepsin D-mediated cleavage of plasminogen to the potent antiangiogenic factor angiostatin","volume":"144","author":"Perchick","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.jpag.2011.06.007_bib13","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1095\/biolreprod43.6.1012","article-title":"Effects of gonadotropin-releasing hormone agonists on meiotic maturation of follicle-enclosed oocytes in rabbits","volume":"43","author":"Yoshimura","year":"1990","journal-title":"Biol Reprod"}],"container-title":["Journal of Pediatric and Adolescent Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108331881100283X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108331881100283X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:38:15Z","timestamp":1761053895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108331881100283X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S108331881100283X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpag.2011.06.007","relation":{},"ISSN":["1083-3188"],"issn-type":[{"type":"print","value":"1083-3188"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insight: Prolonged Vaginal Bleeding during Central Precocious Puberty Therapy with a Long-acting Gonadotropin-Releasing Hormone Agonist: A\u00a0Proposed Mechanism and Management Plan","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric and Adolescent Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpag.2011.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}