{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:08:57Z","timestamp":1762160937376,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpagonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric and Adolescent Gynecology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jpag.2012.04.001","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T02:54:48Z","timestamp":1343184888000},"page":"262-266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Ameliorative Effects of Resveratrol on Acute Ovarian Toxicity Induced by Total Body Irradiation in Young Adult Rats"],"prefix":"10.1016","volume":"25","author":[{"given":"Yavuz","family":"Simsek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simay","family":"Gurocak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Turkoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nusret","family":"Akpolat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onder","family":"Celik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ozer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ercan","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Turhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Ozyalin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"48 Suppl 1","key":"10.1016\/j.jpag.2012.04.001_bib1","first-page":"S102","article-title":"New strategies for cancer therapy in the 21st century","author":"Saito","year":"2001","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.jpag.2012.04.001_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0163-7258(01)00159-0","article-title":"The machinery of programmed cell death","volume":"92","author":"Zimmermann","year":"2001","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jpag.2012.04.001_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0167-8140(96)01732-X","article-title":"Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells","volume":"39","author":"N\u00fa\u00f1ez","year":"1996","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.jpag.2012.04.001_bib4","first-page":"489","article-title":"[The redox homeostasis system in radiation-induced genomic instability]","volume":"41","author":"Burlakova","year":"2001","journal-title":"Radiats Biol Radioecol"},{"key":"10.1016\/j.jpag.2012.04.001_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10495-005-3346-1","article-title":"Cellular and molecular effects of protons: apoptosis induction and potential implications for cancer therapy","volume":"11","author":"Di Pietro","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.jpag.2012.04.001_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF01727413","article-title":"Long-term gonadal toxicity after therapy for Hodgkin's and non-Hodgkin's lymphoma","volume":"68","author":"Bokemeyer","year":"1994","journal-title":"Ann Hematol"},{"key":"10.1016\/j.jpag.2012.04.001_bib7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/GRF.0b013e3181f96b54","article-title":"Toxicity of chemotherapy and radiation on female reproduction","volume":"53","author":"Meirow","year":"2010","journal-title":"Clin Obstet Gynecol"},{"issue":"29 Suppl B","key":"10.1016\/j.jpag.2012.04.001_bib8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.placenta.2008.07.007","article-title":"Pregnancy and assisted reproduction techniques in men and women after cancer treatment","author":"Gurgan","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.jpag.2012.04.001_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000207616","article-title":"Alterations in pubertal timing following therapy for childhood malignancies","volume":"15","author":"Armstrong","year":"2009","journal-title":"Endocr Dev"},{"key":"10.1016\/j.jpag.2012.04.001_bib10","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/jnci\/djj243","article-title":"Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study","volume":"98","author":"Sklar","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jpag.2012.04.001_bib11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF02743581","article-title":"The effect of melatonin on lipid peroxidation during radiotherapy in female rats","volume":"175","author":"Kaya","year":"1999","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.jpag.2012.04.001_bib12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/(SICI)1098-2825(1997)11:5<287::AID-JCLA6>3.0.CO;2-4","article-title":"Wine as a biological fluid: history, production, and role in disease prevention","volume":"11","author":"Soleas","year":"1997","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.jpag.2012.04.001_bib13","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: the in\u00a0vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jpag.2012.04.001_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1527-3466.2004.tb00139.x","article-title":"Cardiovascular protective effects of resveratrol","volume":"22","author":"Bradamante","year":"2004","journal-title":"Cardiovasc Drug Rev"},{"key":"10.1016\/j.jpag.2012.04.001_bib15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/978-1-61779-210-6_24","article-title":"Laboratory guidelines for animal care","volume":"770","author":"Couto","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jpag.2012.04.001_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0018-506X(77)90047-2","article-title":"A technique for sustained synchronization of hamster estrous cycles by hormonal means","volume":"9","author":"Gross","year":"1977","journal-title":"Horm Behav"},{"issue":"4A","key":"10.1016\/j.jpag.2012.04.001_bib17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1590\/S1519-69842002000400008","article-title":"Determination of the estrous cycle phases of rats: some helpful considerations","volume":"62","author":"Marcondes","year":"2002","journal-title":"Braz J Biol"},{"key":"10.1016\/j.jpag.2012.04.001_bib18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jss.2005.01.024","article-title":"Protective effect of resveratrol against oxidative stress in cholestasis","volume":"127","author":"Ara","year":"2005","journal-title":"J Surg Res"},{"key":"10.1016\/j.jpag.2012.04.001_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2010.03.043","article-title":"Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation","volume":"636","author":"Zhang","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpag.2012.04.001_bib20","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.fertnstert.2007.03.065","article-title":"Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?","volume":"89","author":"Kaya","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpag.2012.04.001_bib21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Rad Biol Med"},{"key":"10.1016\/j.jpag.2012.04.001_bib22","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.2174\/092986710792231950","article-title":"A review of natural and synthetic antioxidants important for health and longevity","volume":"17","author":"Wojcik","year":"2010","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.jpag.2012.04.001_bib23","series-title":"Methods of Enzymatic Analysis","first-page":"673","author":"Aebi","year":"1974"},{"key":"10.1016\/j.jpag.2012.04.001_bib24","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Pagia","year":"1967","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.jpag.2012.04.001_bib25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0076-6879(90)86134-H","article-title":"Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal","volume":"186","author":"Esterbauer","year":"1990","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jpag.2012.04.001_bib26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0890-6238(91)90097-Y","article-title":"Comparison of random and serial sections in assessment of ovarian toxicity","volume":"5","author":"Smith","year":"1991","journal-title":"Reprod Toxicol"},{"issue":"5","key":"10.1016\/j.jpag.2012.04.001_bib27","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0015-0282(01)02859-X","article-title":"The physiology of folliculogenesis: the role of novel growth factors","volume":"76","author":"Erickson","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpag.2012.04.001_bib28","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1530\/jrf.0.0170555","article-title":"Proposal for a classification of oocytes and follicles in the mouse ovary","volume":"17","author":"Pedersen","year":"1968","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.jpag.2012.04.001_bib29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0891-5849(95)00033-T","article-title":"Whole body X-ray irradiation to mice decreases ascorbic acid concentrations in bone marrow: comparison between ascorbic acid and vitamin E","volume":"19","author":"Umegaki","year":"1995","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jpag.2012.04.001_bib30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0891-5849(94)90170-8","article-title":"Decrease in vitamin E levels in the bone marrow of mice receiving whole-body X-ray irradiation","volume":"17","author":"Umegaki","year":"1994","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jpag.2012.04.001_bib31","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/sj.cdd.4402052","article-title":"Caspase-2 involvement during ionizing radiation-induced oocyte death in the mouse ovary","volume":"14","author":"Hanoux","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jpag.2012.04.001_bib32","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0891-5849(02)01360-6","article-title":"The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults","volume":"34","author":"Yant","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jpag.2012.04.001_bib33","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1210\/endo.139.9.6289","article-title":"Ovarian function in superoxide dismutase 1 and 2 knockout mice","volume":"139","author":"Matzuk","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.jpag.2012.04.001_bib34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejphar.2008.06.067","article-title":"Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and\u00a0augmented activities of antioxidant enzymes","volume":"591","author":"Rubiolo","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpag.2012.04.001_bib35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.phrs.2005.08.002","article-title":"Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress","volume":"53","author":"Li","year":"2006","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jpag.2012.04.001_bib36","first-page":"e374","article-title":"Resveratrol, an effective regulator of ovarian development and oocyte apoptosis","volume":"34","author":"Kong","year":"2011","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.jpag.2012.04.001_bib37","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1158\/1078-0432.CCR-03-0105","article-title":"Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats","volume":"10","author":"Tseng","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jpag.2012.04.001_bib38","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.275.5297.218","article-title":"Cancer chemopreventive activity of resveratrol, a natural product derived from grapes","volume":"275","author":"Jang","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jpag.2012.04.001_bib39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4143\/crt.2006.38.1.48","article-title":"Resveratrol at high doses acts as an apoptotic inducer in endothelial cells","volume":"38","author":"In","year":"2006","journal-title":"Cancer Res Treat"},{"key":"10.1016\/j.jpag.2012.04.001_bib40","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1471-0528.1999.tb08180.x","article-title":"Ovarian and uterine characteristics after total body irradiation in childhood and adolescence: response to sex steroid replacement","volume":"106","author":"Bath","year":"1999","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.jpag.2012.04.001_bib41","doi-asserted-by":"crossref","first-page":"3207S","DOI":"10.1093\/jn\/134.11.3207S","article-title":"Antioxidants and radiation therapy","volume":"134","author":"Borek","year":"2004","journal-title":"J Nutr"}],"container-title":["Journal of Pediatric and Adolescent Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318812000551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318812000551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:39:01Z","timestamp":1761053941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083318812000551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1083318812000551"],"URL":"https:\/\/doi.org\/10.1016\/j.jpag.2012.04.001","relation":{},"ISSN":["1083-3188"],"issn-type":[{"type":"print","value":"1083-3188"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ameliorative Effects of Resveratrol on Acute Ovarian Toxicity Induced by Total Body Irradiation in Young Adult Rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric and Adolescent Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpag.2012.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}