{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:08:09Z","timestamp":1790316489494,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpagonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric and Adolescent Gynecology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.jpag.2014.01.104","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T15:49:33Z","timestamp":1411487373000},"page":"356-359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Evaluation of the Pro-inflammatory Cytokine Tumor Necrosis Factor-\u03b1 in Adolescents with Polycystic Ovary Syndrome"],"prefix":"10.1016","volume":"27","author":[{"given":"Melissa","family":"Pawelczak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Milla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bina","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpag.2014.01.104_bib1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jpag.2014.01.104_bib2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199509283331307","article-title":"Polycystic ovary syndrome","volume":"333","author":"Franks","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpag.2014.01.104_bib3","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/jc.2013-2350","article-title":"Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline","volume":"98","author":"Legro","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2014.01.104_bib4","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3109\/09513590.2012.683082","article-title":"Mediators of chronic inflammation in polycystic ovarian syndrome","volume":"28","author":"Deligeoroglou","year":"2012","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.jpag.2014.01.104_bib5","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1021\/pr3000317","article-title":"Metabonomics reveals plasma metabolic changes and inflammatory marker in polycystic ovary syndrome patients","volume":"11","author":"Sun","year":"2012","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jpag.2014.01.104_bib6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejogrb.2011.07.012","article-title":"Low-grade chronic inflammation in the peripheral blood and ovaries of women with polycystic ovarian syndrome","volume":"159","author":"Xiong","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.jpag.2014.01.104_bib7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mce.2010.08.002","article-title":"The role of low-grade inflammation in the polycystic ovary syndrome","volume":"335","author":"Repaci","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jpag.2014.01.104_bib8","doi-asserted-by":"crossref","first-page":"758656","DOI":"10.1155\/2010\/758656","article-title":"Mediators of inflammation in polycystic ovary syndrome in relation to adiposity","volume":"2010","author":"Sathyapalan","year":"2010","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jpag.2014.01.104_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1196\/annals.1365.015","article-title":"Indices of low-grade inflammation in polycystic ovary syndrome","volume":"1092","author":"Diamanti-Kandarakis","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jpag.2014.01.104_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.fertnstert.2011.11.023","article-title":"Is PCOS an inflammatory process?","volume":"97","author":"Duleba","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpag.2014.01.104_bib11","doi-asserted-by":"crossref","first-page":"389317","DOI":"10.1155\/2011\/389317","article-title":"IL-6 serum levels and production is related to an altered immune response in polycystic ovary syndrome girls with insulin resistance","volume":"2011","author":"Fulghesu","year":"2011","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jpag.2014.01.104_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0163-7258(95)02064-0","article-title":"Cytokines in the ovary: pathophysiology and potential for pharmacological intervention","volume":"69","author":"Norman","year":"1996","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jpag.2014.01.104_bib13","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/oxfordjournals.humrep.a137929","article-title":"Involvement of leukocytes and cytokines in the ovulatory process and corpus luteum function","volume":"8","author":"Br\u00e4nnstr\u00f6m","year":"1993","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jpag.2014.01.104_bib14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-0897.1997.tb00192.x","article-title":"Review: cytokine involvement in ovarian processes","volume":"37","author":"Terranova","year":"1997","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.jpag.2014.01.104_bib15","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1095\/biolreprod61.6.1506","article-title":"Evidence for the presence of tumor necrosis factor alpha receptors during ovarian development in the rat","volume":"61","author":"Balchak","year":"1999","journal-title":"Biol Reprod"},{"key":"10.1016\/j.jpag.2014.01.104_bib16","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.lfs.2012.03.019","article-title":"Macrophage secretions modulate the steroidogenesis of polycystic ovary in rats: effect of testosterone on macrophage pro-inflammatory cytokines","volume":"90","author":"Figueroa","year":"2012","journal-title":"Life Sci"},{"key":"10.1016\/j.jpag.2014.01.104_bib17","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1210\/jcem.86.10.7952","article-title":"Limitations of the fasting glucose to insulin ratio as an index of insulin sensitivity","volume":"86","author":"Quon","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2014.01.104_bib18","doi-asserted-by":"crossref","first-page":"e500","DOI":"10.1542\/peds.2004-1921","article-title":"Homeostasis model assessment is more reliable than the fasting glucose\/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents","volume":"115","author":"Keskin","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpag.2014.01.104_bib19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00237-9","article-title":"The TNF and TNF receptor superfamilies: integrating mammalian biology","volume":"104","author":"Locksley","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.jpag.2014.01.104_bib20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/BF02918162","article-title":"MHC Class II-associated variation in the production of tumor necrosis factor in mice and humans: relevance to the pathogenesis of autoimmune diseases","volume":"10","author":"Jacob","year":"1991","journal-title":"Immunol Res"},{"key":"10.1016\/j.jpag.2014.01.104_bib21","doi-asserted-by":"crossref","first-page":"678","DOI":"10.7326\/0003-4819-114-8-678","article-title":"Mechanisms in human immunodeficiency virus (HIV) Infection","volume":"114","author":"Fauci","year":"1991","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jpag.2014.01.104_bib22","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1158\/1541-7786.MCR-05-0232","article-title":"Tumor necrosis factor-alpha differentially modulates CD44 expression in ovarian cancer cells","volume":"4","author":"Muthukumaran","year":"2006","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.jpag.2014.01.104_bib23","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1158\/1535-7163.MCT-05-0303","article-title":"Expression and regulation of tumor necrosis factor alpha in normal and malignant ovarian epithelium","volume":"5","author":"Szlosarek","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.jpag.2014.01.104_bib24","first-page":"5657","article-title":"Ovarian cancer-induced immunosuppression: relationship to tumor necrosis factor-alpha (TNF-alpha) release from ovarian tissue","volume":"19","author":"Hassan","year":"1990","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jpag.2014.01.104_bib25","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/ijc.25840","article-title":"Tumor necrosis factor (TNF)- \u03b1, soluble TNF receptors and endometrial cancer risk: the EPIC study","volume":"129","author":"Dossus","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jpag.2014.01.104_bib26","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S1472-6483(10)60175-7","article-title":"Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review","volume":"19","author":"Chittenden","year":"2009","journal-title":"Reprod Biomed Online"}],"container-title":["Journal of Pediatric and Adolescent Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318814001090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318814001090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:40:58Z","timestamp":1761054058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083318814001090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S1083318814001090"],"URL":"https:\/\/doi.org\/10.1016\/j.jpag.2014.01.104","relation":{},"ISSN":["1083-3188"],"issn-type":[{"value":"1083-3188","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the Pro-inflammatory Cytokine Tumor Necrosis Factor-\u03b1 in Adolescents with Polycystic Ovary Syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric and Adolescent Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpag.2014.01.104","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}