{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:52:07Z","timestamp":1780573927098,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpagonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric and Adolescent Gynecology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jpag.2014.12.010","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T11:34:11Z","timestamp":1419852851000},"page":"441-446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Epithelial Tumors of the Ovary in Children and Teenagers: A Prospective Study from the Italian TREP Project"],"prefix":"10.1016","volume":"28","author":[{"given":"Calogero","family":"Virgone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Alaggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Dall\u2019Igna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Buffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Tonegatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Bisogno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cecchetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpag.2014.12.010_bib1","series-title":"Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament","article-title":"Atlas of tumor pathology","author":"Scully","year":"1996"},{"key":"10.1016\/j.jpag.2014.12.010_bib2","series-title":"World Health Organization Classifications of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs","first-page":"113","author":"Tavasso\u00e9li","year":"2003"},{"key":"10.1016\/j.jpag.2014.12.010_bib3","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/PAS.0b013e318273a9ff","article-title":"Ovarian surface epithelial neoplasms in the pediatric population: incidence, histologic subtype, and natural history","volume":"37","author":"Hazard","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jpag.2014.12.010_bib4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0031-3955(05)70138-3","article-title":"Evaluation of adnexial masses in adolescents","volume":"46","author":"Pfeifer","year":"1999","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.jpag.2014.12.010_bib5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1055\/s-2002-35959","article-title":"Mucinous cystadenoma: a rare abdominal mass in childhood","volume":"12","author":"Yazici","year":"2002","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.jpag.2014.12.010_bib6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1053\/jpsu.2003.50103","article-title":"Epitelial ovarian tumors in children: a retrospective analysis","volume":"38","author":"Morowitz","year":"2003","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpag.2014.12.010_bib7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s00383-005-1624-1","article-title":"Mucinous cystadenoma of the ovary in perimenarchal girls","volume":"22","author":"Sri Paran","year":"2006","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpag.2014.12.010_bib8","first-page":"281","article-title":"Pathology of ovarian neoplasms in childhood and adolescence","volume":"227","author":"Lack","year":"1992","journal-title":"Pathol Annu"},{"key":"10.1016\/j.jpag.2014.12.010_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1053\/j.sempedsurg.2005.01.004","article-title":"Benign ovarian masses","volume":"14","author":"Templeman","year":"2005","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jpag.2014.12.010_bib10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejogrb.2008.09.007","article-title":"Serous and seromucinous infantile ovarian cystadenomas: a study of 42 cases","volume":"142","author":"Massicot","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.jpag.2014.12.010_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0090-8258(92)90290-Y","article-title":"Ovarian borderline mucinous tumor in premenarchal girl: review on ovarian epithelial cancer in young girls","volume":"45","author":"Deprest","year":"1992","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jpag.2014.12.010_bib12","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/01.pas.0000164030.82810.db","article-title":"Ovarian serous tumors of low malignant potential (borderline tumors): outcome based study of 276 patients with long term (> or = 5 years) follow up","volume":"29","author":"Longacre","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jpag.2014.12.010_bib13","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ejca.2006.08.028","article-title":"The challenge of very rare tumors in childhood: the Italian TREP Project","volume":"43","author":"Ferrari","year":"2007","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jpag.2014.12.010_bib14","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/S0140-6736(98)04119-1","article-title":"\u201cICON2\u201d: Randomized trial of single agent carboplatin against three drugs combinations (CAP) in woman with ovarian cancer","volume":"352","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jpag.2014.12.010_bib15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/1097-0142(197209)30:3<713::AID-CNCR2820300319>3.0.CO;2-G","article-title":"Relative frequency of ovarian neoplasms in children and adolescents","volume":"30","author":"Norris","year":"1972","journal-title":"Cancer"},{"key":"10.1016\/j.jpag.2014.12.010_bib16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jpag.2012.04.007","article-title":"An extra-large ovarian mucinous cystadenoma in a premenarchal girl and a review of the literature","volume":"26","author":"Cevik","year":"2013","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2014.12.010_bib17","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jpag.2009.08.008","article-title":"Bilateral ovarian serous borderline tumor with a giant non-invasive peritoneal implant in a four-year-old girl","volume":"23","author":"Njim","year":"2010","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2014.12.010_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/pbc.20233","article-title":"Pediatric ovarian tumors: a review of 67 cases","volume":"44","author":"Schultz","year":"2005","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jpag.2014.12.010_bib19","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jpag.2011.07.011","article-title":"Epithelial ovarian tumors in adolescents: a retrospective pathologic study and a critical review of the literature","volume":"24","author":"Grapsa","year":"2011","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2014.12.010_bib20","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/1097-0142(20010601)91:11<2065::AID-CNCR1233>3.0.CO;2-R","article-title":"Diagnosis, pathology, staging, treatment, and outcome of epithelial ovarian neoplasia in patients age < 21 years","volume":"91","author":"Tsai","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.jpag.2014.12.010_bib21","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/j.jpedsurg.2010.06.012","article-title":"Pediatric borderline ovarian tumors: a retrospective analysis","volume":"45","author":"Song","year":"2010","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpag.2014.12.010_bib22","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/j.sempedsurg.2005.01.005","article-title":"Malignant lesions of the ovary in childhood","volume":"14","author":"von Allmen","year":"2005","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jpag.2014.12.010_bib23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1053\/jpsu.2001.21617","article-title":"Ovarian adenocarcinoma in premenarchal girls","volume":"36","author":"Shankar","year":"2001","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpag.2014.12.010_bib24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/MPH.0b013e3181984dd3","article-title":"Serous cystadenocarcinoma of the ovary in an 11-year-old girl with extensive dissemination and chylothorax: a case report and a brief review of literature","volume":"31","author":"Gupta","year":"2009","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.jpag.2014.12.010_bib25","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/0022-3468(92)90343-6","article-title":"Pediatric malignant ovarian tumors: a 43-year review","volume":"27","author":"Gribbon","year":"1992","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpag.2014.12.010_bib26","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/j.jpag.2009.09.011","article-title":"Ovarian mucinous cystadenoma of borderline malignancy in a premenarchal girl","volume":"23","author":"Iwasaki","year":"2010","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2014.12.010_bib27","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/pbc.22918","article-title":"Sex cord stromal tumors of the ovary in children: a clinicopathological report from the Italian TREP project","volume":"56","author":"Cecchetto","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jpag.2014.12.010_bib28","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/pbc.21459","article-title":"The challenges of clinical trials for adolescents and young adults with cancer","volume":"50","author":"Ferrari","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jpag.2014.12.010_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/08880018.2011.572963","article-title":"Upper age limits for accessing pediatric oncology centers in Italy: a barrier preventing adolescents with cancer from entering national cooperative AIEOP trials","volume":"29","author":"Ferrari","year":"2012","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.jpag.2014.12.010_bib30","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ejca.2004.10.023","article-title":"Use of paediatric versus adult oncology treatment centres by adolescents 15-19 years old: the Canadian Childhood Cancer Surveillance and Control Program","volume":"41","author":"Klein-Geltink","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jpag.2014.12.010_bib31","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/pbc.22049","article-title":"Evaluating access to pediatric cancer care centers of children and adolescents with rare tumors in Italy: the TREP project","volume":"53","author":"Pastore","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jpag.2014.12.010_bib32","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00404-011-1946-2","article-title":"Fertility sparing surgery for ovarian tumors in children and young adults","volume":"285","author":"Abdel-Hady el-S","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.jpag.2014.12.010_bib33","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.fertnstert.2008.02.116","article-title":"Advantage of conservative surgical management of large ovarian neoplasms in adolescents","volume":"91","author":"Reddy","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpag.2014.12.010_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00383-011-3004-3","article-title":"Surgical intervention strategies for pediatric ovarian tumors: experience with 60 cases at one institution","volume":"28","author":"Tajiri","year":"2012","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpag.2014.12.010_bib35","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.ygyno.2006.05.022","article-title":"Is complete surgical staging necessary in patients with stage I mucinous epithelial ovarian tumors?","volume":"103","author":"Cho","year":"2006","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jpag.2014.12.010_bib36","first-page":"671","article-title":"Surgical staging in patients with ovarian tumors of low malignant potential","volume":"100","author":"Winter","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpag.2014.12.010_bib37","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00404-010-1713-9","article-title":"Ten years experience in the management of borderline ovarian tumors at Tom Baker Cancer Centre","volume":"284","author":"Anfinan","year":"2011","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.jpag.2014.12.010_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1477-7819-11-13","article-title":"Incomplete staging surgery as a major predictor of relapse of borderline ovarian tumor","volume":"11","author":"Romeo","year":"2013","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.jpag.2014.12.010_bib39","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1097\/IGC.0b013e31825e5254","article-title":"Clinical significance of microinvasion in borderline ovarian tumors and its impact on surgical management","volume":"22","author":"Ferrero","year":"2012","journal-title":"Int J Gynecol Cancer"}],"container-title":["Journal of Pediatric and Adolescent Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318814004185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318814004185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:43:39Z","timestamp":1761054219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083318814004185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S1083318814004185"],"URL":"https:\/\/doi.org\/10.1016\/j.jpag.2014.12.010","relation":{},"ISSN":["1083-3188"],"issn-type":[{"value":"1083-3188","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epithelial Tumors of the Ovary in Children and Teenagers: A Prospective Study from the Italian TREP Project","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric and Adolescent Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpag.2014.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}