{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:15:31Z","timestamp":1761992131170,"version":"build-2065373602"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpagonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric and Adolescent Gynecology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jpag.2016.06.010","type":"journal-article","created":{"date-parts":[[2016,7,3]],"date-time":"2016-07-03T09:07:46Z","timestamp":1467536866000},"page":"58-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Does the Oral Contraceptive Pill Increase Plasma Intercellular Adhesion Molecule-1, Monocyte Chemoattractant Protein-1, and Tumor Necrosis Factor-\u03b1 Levels in Women with Polycystic Ovary Syndrome: A Pilot Study"],"prefix":"10.1016","volume":"30","author":[{"given":"Syed Douhath","family":"Yousuf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fouzia","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahira","family":"Mattoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chander","family":"Shekhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed","family":"Mudassar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Afzal","family":"Zargar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Ashraf","family":"Ganie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpag.2016.06.010_bib1","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2016.06.010_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jpag.2011.03.002","article-title":"Prevalence of polycystic ovarian syndrome in Indian adolescents","volume":"24","author":"Nidhi","year":"2011","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2016.06.010_bib3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4103\/2230-8210.131162","article-title":"A cross-sectional study of polycystic ovarian syndrome among adolescent and young girls in Mumbai, India","volume":"18","author":"Joshi","year":"2014","journal-title":"Indian J Endocrinol Metab"},{"key":"10.1016\/j.jpag.2016.06.010_bib4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.steroids.2011.12.003","article-title":"Inflammation in polycystic ovary syndrome; underpinning of insulin resistance and ovarian dysfunction","volume":"77","author":"Gonzalez","year":"2012","journal-title":"Steroids"},{"key":"10.1016\/j.jpag.2016.06.010_bib5","first-page":"371","article-title":"Screening for insulin resistance in polycystic ovary syndrome: views of physician members of the American Society for Reproductive Medicine","volume":"60","author":"Asante","year":"2015","journal-title":"J Reprod Med"},{"key":"10.1016\/j.jpag.2016.06.010_bib6","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/1570161112666140423221008","article-title":"Endothelial dysfunction, obesity and insulin resistance","volume":"12","author":"Prieto","year":"2014","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.jpag.2016.06.010_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0021-9150(03)00097-2","article-title":"Adhesion molecules and atherosclerosis","volume":"170","author":"Blankenberg","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jpag.2016.06.010_bib8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF02786454","article-title":"The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions","volume":"17","author":"Hayflick","year":"1998","journal-title":"Immunol Res"},{"key":"10.1016\/j.jpag.2016.06.010_bib9","doi-asserted-by":"crossref","first-page":"26602","DOI":"10.1074\/jbc.M601284200","article-title":"Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance","volume":"281","author":"Kamei","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpag.2016.06.010_bib10","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1073\/pnas.1133870100","article-title":"Monocyte chemoattractant protein 1 in obesity and insulin resistance","volume":"100","author":"Sartipy","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpag.2016.06.010_bib11","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1210\/en.2005-0969","article-title":"Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle","volume":"147","author":"Sell","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.jpag.2016.06.010_bib12","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MOL.0b013e3281338546","article-title":"Monocyte chemotactic protein-1 and its role in insulin resistance","volume":"18","author":"Sell","year":"2007","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jpag.2016.06.010_bib13","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1080\/09513590400014313","article-title":"Plasma concentration of soluble intercellular adhesion molecule-1 in women with polycystic ovary syndrome","volume":"19","author":"Nasiek","year":"2004","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.jpag.2016.06.010_bib14","first-page":"76","article-title":"Intercellular cell adhesion molecule-1 in PCOS; relation to insulin resistance or obesity","volume":"9","author":"Vrbikova","year":"2005","journal-title":"Endocrine Abstract"},{"key":"10.1016\/j.jpag.2016.06.010_bib15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2362.2006.01712.x","article-title":"Inflammatory and endothelial markers in women with polycystic ovary syndrome","volume":"36","author":"Diamanti-Kandarakis","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jpag.2016.06.010_bib16","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.metabol.2009.02.022","article-title":"Evidence of proatherogenic inflammation in polycystic ovary syndrome","volume":"58","author":"Gonzalez","year":"2009","journal-title":"Metabolism"},{"key":"10.1016\/j.jpag.2016.06.010_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejogrb.2011.03.015","article-title":"Elevated C-reactive protein and monocyte chemoattractant protein-1 in patients with polycystic ovary syndrome","volume":"157","author":"Hu","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.jpag.2016.06.010_bib18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.fertnstert.2010.08.030","article-title":"Increased monocyte chemoattractant protein-1 levels indicating early vascular damage in lean young PCOS patients","volume":"95","author":"Atabekoglu","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpag.2016.06.010_bib19","first-page":"721","article-title":"Association of monocyte chemoattractant protein-1 and the clinical characteristics of polycystic ovary syndrome: analysis of 65 cases","volume":"87","author":"Hu","year":"2007","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.jpag.2016.06.010_bib20","first-page":"487","article-title":"Monocyte chemoattractant protein-1 and its correlation with lipoprotein in polycystic ovary syndrome","volume":"38","author":"Hu","year":"2006","journal-title":"Beijing Da Xue Xue Bao"},{"key":"10.1016\/j.jpag.2016.06.010_bib21","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1096\/fasebj.9.10.7542214","article-title":"Transcriptional regulation of endothelial cell adhesion molecules; NFKappa B and cytokine inducible enhancers","volume":"9","author":"Collins","year":"1995","journal-title":"FASEB J"},{"key":"10.1016\/j.jpag.2016.06.010_bib22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0026-0495(99)90100-2","article-title":"Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome","volume":"48","author":"Gonzalez","year":"1999","journal-title":"Metabolism"},{"key":"10.1016\/j.jpag.2016.06.010_bib23","first-page":"165","article-title":"Elevated serum TNF-alpha levels in normal-weight women with polycystic ovaries or the polycystic ovary syndrome","volume":"48","author":"Sayin","year":"2003","journal-title":"J Reprod Med"},{"key":"10.1016\/j.jpag.2016.06.010_bib24","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1089\/met.2006.4.122","article-title":"Association between circulating tumor necrosis factor-alpha, interleukin-6, and insulin resistance in normal-weight women with polycystic ovary syndrome","volume":"4","author":"Tarkun","year":"2006","journal-title":"Metab Syndr Relat Disord"},{"key":"10.1016\/j.jpag.2016.06.010_bib25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/IJWH.S11304","article-title":"Treatment options for polycystic ovary syndrome","volume":"8","author":"Badawy","year":"2011","journal-title":"Int J Womens Health"},{"key":"10.1016\/j.jpag.2016.06.010_bib26","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/S0140-6736(97)02358-1","article-title":"WHO Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Acute myocardial infarction and combined oral contraceptives; results of an international multicentre case\u2013control study","volume":"349","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jpag.2016.06.010_bib27","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1136\/bmj.318.7198.1579","article-title":"Oral contraceptives and myocardial infarction: results of the MICA case\u2013control study","volume":"318","author":"Dunn","year":"1999","journal-title":"BMJ"},{"key":"10.1016\/j.jpag.2016.06.010_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1067\/mob.2002.119179","article-title":"Different effects of oral contraceptives containing levonorgestrel or desogestrel on plasma lipoproteins and coagulation factor VII","volume":"186","author":"Van Rooijen","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpag.2016.06.010_bib29","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0140-6736(69)90477-2","article-title":"Some effects of oral contraceptives on carbohydrate metabolism","volume":"2","author":"Wynn","year":"1969","journal-title":"Lancet"},{"key":"10.1016\/j.jpag.2016.06.010_bib30","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1365-2265.2009.03523.x","article-title":"Plasma monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1a are increased in\u00a0patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment","volume":"5","author":"Glintborg","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jpag.2016.06.010_bib31","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1056\/NEJMoa003216","article-title":"Oral contraceptives and the risk of myocardial infarction","volume":"345","author":"Tanis","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpag.2016.06.010_bib32","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1210\/jc.2002-021688","article-title":"Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome","volume":"88","author":"Morin-Papunen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpag.2016.06.010_bib33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.atherosclerosis.2003.10.005","article-title":"Third generation oral contraceptive use and cardiovascular risk factors","volume":"172","author":"Doring","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jpag.2016.06.010_bib34","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/humupd\/7.6.522","article-title":"Polycystic ovary syndrome cancer","volume":"7","author":"Balen","year":"2001","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.jpag.2016.06.010_bib35","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1161\/01.CIR.60.3.486","article-title":"Oral contraceptive use and fasting triglyceride, plasma cholesterol and HDL cholesterol","volume":"60","author":"Hennekens","year":"1979","journal-title":"Circulation"},{"key":"10.1016\/j.jpag.2016.06.010_bib36","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3923\/pjbs.2012.947.950","article-title":"Lipid profile of women using oral contraceptive pills","volume":"15","author":"Naz","year":"2012","journal-title":"Pak J Biol Sci"},{"key":"10.1016\/j.jpag.2016.06.010_bib37","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0015-0282(00)00718-4","article-title":"Treatment of hirsutism with ethinyl estradiol-desogestrel contraceptive pills has beneficial effects on the lipid profile and improves insulin sensitivity","volume":"74","author":"Escobar-Morreale","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpag.2016.06.010_bib38","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1093\/humrep\/deg146","article-title":"Effects of short term transdermal hormone replacement therapy on glycaemic control, lipid metabolism, C-reactive protein and proteinuria in postmenopausal women with type 2 diabetes or hypertension","volume":"18","author":"Fenkci","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jpag.2016.06.010_bib39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0378-5122(02)00157-3","article-title":"Lack of stimulatory effect of dienogest on the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 by endothelial cell as compared with other synthetic progestins","volume":"42","author":"Tatsumi","year":"2002","journal-title":"Maturitas"},{"key":"10.1016\/j.jpag.2016.06.010_bib40","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/01.GME.0000153888.94399.AF","article-title":"Effects of transdermal and oral postmenopausal hormone therapy on vascular function: a randomized, placebo-controlled study in healthy postmenopausal women","volume":"12","author":"Hemelaar","year":"2005","journal-title":"Menopause"},{"key":"10.1016\/j.jpag.2016.06.010_bib41","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5414\/CPP40150","article-title":"Effect of two oral contraceptives containing ethinylestradiol and levonorgestrel on serum and urinary surrogate markers of endothelial function","volume":"40","author":"Seeger","year":"2002","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1016\/j.jpag.2016.06.010_bib42","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3132\/dvdr.2004.012","article-title":"Effects of low-dose continuous combined HRT on vascular function in women with type 2 diabetes","volume":"1","author":"Kernohan","year":"2004","journal-title":"Diab Vasc Dis Res"},{"key":"10.1016\/j.jpag.2016.06.010_bib43","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2169\/internalmedicine.48.2177","article-title":"The effect of ethinyl estradiol (EE)\/cyproterone acetate (CA) and EE\/CA plus metformin treatment on adhesion molecules in cases with polycystic ovary syndrome (PCOS)","volume":"48","author":"Bilgir","year":"2009","journal-title":"Intern Med"},{"key":"10.1016\/j.jpag.2016.06.010_bib44","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s40618-014-0103-8","article-title":"Adiponectin, interleukin-6, monocyte chemoattractant protein-1, and regional fat mass during 12-month randomized treatment with metformin and\/or oral contraceptives in polycystic ovary syndrome","volume":"37","author":"Glintborg","year":"2014","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.jpag.2016.06.010_bib45","first-page":"15","article-title":"Effect of short-term standard therapeutic regimens on neuropeptide Y and adipose tissue hormones in overweight insulin-resistant women with polycystic ovary syndrome","volume":"53","author":"Orbetzova","year":"2011","journal-title":"Folia Med (Plovdiv)"},{"key":"10.1016\/j.jpag.2016.06.010_bib46","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/humrep\/dep459","article-title":"Increased follistatin levels after oral contraceptive treatment in obese and non-obese women with polycystic ovary syndrome","volume":"25","author":"Chen","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jpag.2016.06.010_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1538-7836.2005.01690.x","article-title":"Treatment with combined oral contraceptives induces a rise in serum C-reactive protein in the absence of a general inflammatory response","volume":"4","author":"van Rooijen","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jpag.2016.06.010_bib48","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1530\/EJE-08-0725","article-title":"Effects of an antiandrogenic OCP's compared with metformin on blood coagulation tests and endothelial function in women with the PCOS, influence of obesity and smoking","volume":"160","author":"Luque-Ramirez","year":"2009","journal-title":"Eur J Endocrinol"}],"container-title":["Journal of Pediatric and Adolescent Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318816300912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318816300912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:44:25Z","timestamp":1761054265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083318816300912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S1083318816300912"],"URL":"https:\/\/doi.org\/10.1016\/j.jpag.2016.06.010","relation":{},"ISSN":["1083-3188"],"issn-type":[{"type":"print","value":"1083-3188"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does the Oral Contraceptive Pill Increase Plasma Intercellular Adhesion Molecule-1, Monocyte Chemoattractant Protein-1, and Tumor Necrosis Factor-\u03b1 Levels in Women with Polycystic Ovary Syndrome: A Pilot Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric and Adolescent Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpag.2016.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}