{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:00:03Z","timestamp":1786993203279,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpagonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric and Adolescent Gynecology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.jpag.2018.02.130","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T01:19:08Z","timestamp":1520471948000},"page":"451-458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Treatment Modalities in Adolescents Who Present with Heavy Menstrual Bleeding"],"prefix":"10.1016","volume":"31","author":[{"given":"Tasneem S.","family":"Alaqzam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela C.","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pippa M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica H.","family":"Flood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpag.2018.02.130_bib1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1079\/PHN19980041","article-title":"Reducing iron deficiency anemia due to heavy menstrual blood loss in Nigerian rural adolescents","volume":"1","author":"Barr","year":"1998","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.jpag.2018.02.130_bib2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/00016340500342912","article-title":"Bleeding disorders among young women: a population-based prevalence study","volume":"85","author":"Friberg","year":"2006","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.jpag.2018.02.130_bib3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jpag.2009.11.008","article-title":"Menorrhagia in adolescents with inherited bleeding disorders","volume":"23","author":"Chi","year":"2010","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1365-2516.2010.02315.x","article-title":"Women and bleeding disorders","volume":"16","author":"James","year":"2010","journal-title":"Hemophilia"},{"key":"10.1016\/j.jpag.2018.02.130_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-2516.2005.01108.x","article-title":"More than menorrhagia: a review of the obstetric and gynecological manifestations of bleeding disorders","volume":"11","author":"James","year":"2005","journal-title":"Hemophilia"},{"key":"10.1016\/j.jpag.2018.02.130_bib6","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1182\/blood-2010-08-302984","article-title":"The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia","volume":"117","author":"Neunert","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jpag.2018.02.130_bib7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/GCO.0b013e3283562bcb","article-title":"Management of heavy menstrual bleeding in adolescents","volume":"24","author":"Sokkary","year":"2012","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib8","doi-asserted-by":"crossref","first-page":"12.e1","DOI":"10.1016\/j.ajog.2009.04.024","article-title":"Von Willebrand disease and other bleeding disorders in women: consensus on diagnosis and management from an international expert panel","volume":"201","author":"James","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib9","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.jpag.2010.08.004","article-title":"Obstetric management of adolescents with bleeding disorders","volume":"23","author":"James","year":"2010","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jpag.2017.01.002","article-title":"Heavy menstrual bleeding in adolescents","volume":"30","author":"Haamid","year":"2017","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib11","series-title":"Iron deficiency anaemia assessment, prevention, and control: a guide for programme managers","author":"WHO\/UNICEF\/UNU","year":"2001"},{"key":"10.1016\/j.jpag.2018.02.130_bib12","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1097\/01.AOG.0000428646.67925.9a","article-title":"ACOG committee opinion no. 557: management of acute abnormal uterine bleeding in nonpregnant reproductive-aged women","volume":"121","author":"American College of Obstetricians and Gynecologists","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib13","first-page":"2114","article-title":"Iron deficiency\u2013United States, 1999-2000","volume":"288","author":"From the Centers for Disease Control and Prevention","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jpag.2018.02.130_bib14","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1542\/peds.107.6.1381","article-title":"Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States","volume":"107","author":"Halterman","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpag.2018.02.130_bib15","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0140-6736(96)02341-0","article-title":"Randomised study of cognitive effects of iron supplementation in non-anemic iron-deficient adolescent girls","volume":"348","author":"Bruner","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.jpag.2018.02.130_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jpag.2016.10.010","article-title":"Iron deficiency anemia in adolescents who present with heavy menstrual bleeding","volume":"30","author":"Cooke","year":"2017","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/blood-2009-10-249102","article-title":"Common VWF exon 28 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor","volume":"116","author":"Flood","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jpag.2018.02.130_bib18","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1365-2516.2007.01496.x","article-title":"The prevalence of disorders of hemostasis in adolescents with menorrhagia referred to a hemophilia treatment center","volume":"13","author":"Mikhail","year":"2007","journal-title":"Hemophilia"},{"key":"10.1016\/j.jpag.2018.02.130_bib19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0031-3955(16)34002-0","article-title":"Dysfunctional uterine bleeding in the adolescent","volume":"28","author":"Claessens","year":"1981","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.jpag.2018.02.130_bib20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.1351-8216.2003.00832.x","article-title":"Trends in clinical management of women with von Willebrand disease: a survey of 75 women enrolled in hemophilia treatment centers in the United States","volume":"10","author":"Kirtava","year":"2004","journal-title":"Hemophilia"},{"key":"10.1016\/j.jpag.2018.02.130_bib21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/hae.12046","article-title":"Iron deficiency and fatigue in adolescent females with heavy menstrual bleeding","volume":"19","author":"Wang","year":"2013","journal-title":"Hemophilia"},{"key":"10.1016\/j.jpag.2018.02.130_bib22","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1046\/j.1365-2516.1998.00208.x","article-title":"Quality of life during menstruation in patients with inherited bleeding disorders","volume":"4","author":"Kadir","year":"1998","journal-title":"Hemophilia"},{"key":"10.1016\/j.jpag.2018.02.130_bib23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/ajh.10327","article-title":"Health status and health-related quality of life associated with von Willebrand disease","volume":"73","author":"Barr","year":"2003","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jpag.2018.02.130_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2516.2007.01586.x","article-title":"Review of quality of life: menorrhagia in women with or without inherited bleeding disorders","volume":"14","author":"Shanker","year":"2008","journal-title":"Hemophilia"},{"key":"10.1016\/j.jpag.2018.02.130_bib25","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1471-0528.1990.tb16249.x","article-title":"Assessment of menstrual blood loss using a pictorial chart","volume":"97","author":"Higham","year":"1990","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ajog.2007.08.070","article-title":"Development of a screening tool for identifying women with menorrhagia for hemostatic evaluation","volume":"198","author":"Philipp","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib27","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/08880018.2012.699165","article-title":"Quantifying the PBAC in a pediatric and adolescent gynecology population","volume":"29","author":"Sanchez","year":"2012","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.jpag.2018.02.130_bib28","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0029-7844(95)00062-V","article-title":"A simple visual assessment technique to discriminate between menorrhagia and normal menstrual blood loss","volume":"85","author":"Janssen","year":"1995","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib29","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1471-0528.2000.tb13225.x","article-title":"Assessment of menstrual blood loss using a pictorial chart: a validation study","volume":"107","author":"Reid","year":"2000","journal-title":"BJOG"},{"key":"10.1016\/j.jpag.2018.02.130_bib30","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1097\/01.AOG.0000438961.38979.19","article-title":"Committee on Gynecologic Practice: Committee Opinion No.580: von Willebrand disease in women","volume":"122","author":"Committee on Adolescent Health Care","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib31","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jpag.2016.05.009","article-title":"Iron deficiency without anemia: a common yet under-recognized diagnosis in young women with heavy menstrual bleeding","volume":"29","author":"Johnson","year":"2016","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/AOG.0b013e3181809c0d","article-title":"ACOG Practice Bulletin No. 95: anemia in pregnancy","volume":"112","author":"American College of Obstetricians and Gynecologists","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib33","first-page":"98","article-title":"Iron deficiency anemia: evaluation and management","volume":"87","author":"Short","year":"2013","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.jpag.2018.02.130_bib34","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1542\/peds.2015-2567","article-title":"Screening for iron deficiency anemia in young children: USPSTF recommendation statement","volume":"136","author":"Siu","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpag.2018.02.130_bib35","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1542\/peds.2014-3979","article-title":"Screening and routine supplementation for iron deficiency anemia: a systematic review","volume":"135","author":"McDonagh","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpag.2018.02.130_bib36","first-page":"1","article-title":"Recommendations to prevent and control iron deficiency in the United States Centers for Disease Control and Prevention","volume":"47","year":"1998","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.jpag.2018.02.130_bib37","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jpag.2015.10.021","article-title":"Treatment of acute abnormal uterine bleeding in adolescents: what are providers doing in various specialties","volume":"29","author":"Huguelet","year":"2016","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib38","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jpag.2015.03.001","article-title":"Menstrual patterns and treatment of heavy menstrual bleeding in adolescents with bleeding disorders","volume":"28","author":"Dowlut-McElroy","year":"2015","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib39","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.jpag.2010.08.007","article-title":"Management of abnormal uterine bleeding in adolescents","volume":"23","author":"Wilkinson","year":"2010","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.jpag.2018.02.130_bib40","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jpag.2010.08.005","article-title":"Von Willebrand disease in the pediatric and adolescent population","volume":"23","author":"Mikhail","year":"2010","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"2 Suppl 2","key":"10.1016\/j.jpag.2018.02.130_bib41","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0015-0282(01)03261-7","article-title":"Pharmacokinetic overview of Ortho Evra\/Evra","volume":"77","author":"Abrams","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jpag.2018.02.130_bib42","author":"CDC"},{"issue":"6 Suppl","key":"10.1016\/j.jpag.2018.02.130_bib43","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/j.contraception.2007.01.005","article-title":"Levonorgestrel intrauterine system: bleeding disorders and anticoagulation therapy","volume":"755","author":"Kadir","year":"2007","journal-title":"Contraception"},{"key":"10.1016\/j.jpag.2018.02.130_bib44","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.ajog.2005.05.002","article-title":"The use of the levonorgestrel-releasing intrauterine system in the management of menorrhagia in women with hemostatic disorders","volume":"193","author":"Schaedel","year":"2005","journal-title":"Am J Obstet Gynecol"}],"container-title":["Journal of Pediatric and Adolescent Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318818301712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318818301712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:45:05Z","timestamp":1761054305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083318818301712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S1083318818301712"],"URL":"https:\/\/doi.org\/10.1016\/j.jpag.2018.02.130","relation":{},"ISSN":["1083-3188"],"issn-type":[{"value":"1083-3188","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment Modalities in Adolescents Who Present with Heavy Menstrual Bleeding","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric and Adolescent Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpag.2018.02.130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}