{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:48:04Z","timestamp":1781556484931,"version":"3.54.5"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpagonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric and Adolescent Gynecology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jpag.2026.04.004","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T23:13:03Z","timestamp":1776726783000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron Overload-Associated Premature Ovarian Insufficiency: A Case Report"],"prefix":"10.1016","author":[{"given":"Yosep","family":"Sutandar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulyanusa Amarullah","family":"Ritonga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Rachmawati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian","family":"Tjahyadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jpag.2026.04.004_bib0001","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1056\/NEJMcp2116488","article-title":"Primary ovarian insufficiency","volume":"388","author":"Stuenkel","year":"2023","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jpag.2026.04.004_bib0002","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1089\/ars.2007.1893","article-title":"Intracellular iron transport and storage: from molecular mechanisms to health implications","volume":"10","author":"MacKenzie","year":"2008","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"10.1016\/j.jpag.2026.04.004_bib0003","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell Signal"},{"issue":"1","key":"10.1016\/j.jpag.2026.04.004_bib0004","first-page":"1","article-title":"State of the art review in gonadal dysgenesis: challenges in diagnosis and management","volume":"4","author":"McCann-Crosby","year":"2014","journal-title":"Int J Pediatr Endocrinol"},{"key":"10.1016\/j.jpag.2026.04.004_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopha.2023.115415","article-title":"The emerging role of ferroptosis in female reproductive disorders","volume":"166","author":"Liu","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jpag.2026.04.004_bib0006","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.freeradbiomed.2022.12.105","article-title":"Iron overload modulates follicular microenvironment via ROS\/HIF-1\u03b1\/FSHR signaling","volume":"196","author":"Wu","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jpag.2026.04.004_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2023.1174817","article-title":"Iron overload triggering ECM-mediated Hippo\/YAP pathway in follicle development: a hypothetical model endowed with therapeutic implications","volume":"14","author":"Xia","year":"2023","journal-title":"Front Endocrinol"},{"issue":"6","key":"10.1016\/j.jpag.2026.04.004_bib0008","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1080\/13697137.2024.2408922","article-title":"Evidence-based guideline: premature ovarian insufficiency(\u2020)(\u2021)","volume":"27","author":"Panay","year":"2024","journal-title":"Climacteric"},{"key":"10.1016\/j.jpag.2026.04.004_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.109031","article-title":"Chronic iron overload disrupts the reproductive tract and leads to infertility: from a clinical case report to the experimental study of reproduction in female mice","volume":"137","author":"da Costa","year":"2025","journal-title":"Reprod Toxicol"},{"issue":"1","key":"10.1016\/j.jpag.2026.04.004_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000541171","article-title":"Ovarian insufficiency in adolescent females with transfusion-dependent \u03b2-thalassemia: pituitary versus Ovarian iron overload","volume":"99","author":"Matter","year":"2024","journal-title":"Horm Res Paediatr"},{"issue":"6","key":"10.1016\/j.jpag.2026.04.004_bib0011","doi-asserted-by":"crossref","DOI":"10.1530\/EJE-22-0073","article-title":"Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline","volume":"186","author":"Nordenstr\u00f6m","year":"2022","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"10.1016\/j.jpag.2026.04.004_bib0012","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/archdischild-2016-311372","article-title":"Hormone supplementation for pubertal induction in girls","volume":"102","author":"Matthews","year":"2017","journal-title":"Arch Dis Child"},{"issue":"1","key":"10.1016\/j.jpag.2026.04.004_bib0013","doi-asserted-by":"crossref","DOI":"10.1186\/1687-9856-2014-12","article-title":"A randomized trial of transdermal and oral estrogen therapy in adolescent girls with hypogonadism","volume":"12","author":"Shah","year":"2014","journal-title":"Int J Pediatr Endocrinol"},{"issue":"1","key":"10.1016\/j.jpag.2026.04.004_bib0014","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1530\/EJE-20-0702","article-title":"Cancer occurrence in Turner syndrome and the effect of sex hormone substitution therapy","volume":"184","author":"Viuff","year":"2021","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.jpag.2026.04.004_bib0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13052-022-01242-5","article-title":"Current clinical management of constitutional delay of growth and puberty","volume":"48","author":"Gaudino","year":"2022","journal-title":"Ital J Pediatr"}],"container-title":["Journal of Pediatric and Adolescent Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318826003670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318826003670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:49:16Z","timestamp":1781552956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083318826003670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":15,"alternative-id":["S1083318826003670"],"URL":"https:\/\/doi.org\/10.1016\/j.jpag.2026.04.004","relation":{},"ISSN":["1083-3188"],"issn-type":[{"value":"1083-3188","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iron Overload-Associated Premature Ovarian Insufficiency: A Case Report","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric and Adolescent Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpag.2026.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}