{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:04:50Z","timestamp":1784754290629,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpagonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric and Adolescent Gynecology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jpag.2026.05.010","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:20:23Z","timestamp":1780503623000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Serum Betatrophin Levels in Normal-Weight and Overweight Adolescents with Polycystic Ovary Syndrome"],"prefix":"10.1016","author":[{"given":"Merve Didem","family":"E\u015fkin Tanr\u0131verdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aytekin","family":"Tokmak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpag.2026.05.010_bib0001","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1080\/09513590.2016.1252743","article-title":"Association of betatrophin with metabolic characteristics in overweight\/obese and lean women with PCOS","volume":"33","author":"Li","year":"2017","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0002","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1210\/jc.2019-00234","article-title":"Depression over the lifespan in a population-based cohort of women with polycystic ovary syndrome: longitudinal analysis","volume":"104","author":"Greenwood","year":"2019","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0003","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.2337\/db12-0963","article-title":"miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance","volume":"62","author":"Chen","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.jpag.2026.05.010_bib0004","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1210\/jc.2005-1329","article-title":"Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome","volume":"91","author":"Ehrmann","year":"2006","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0005","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11886-024-02050-5","article-title":"Polycystic ovary syndrome, insulin resistance, and cardiovascular disease","volume":"26","author":"Dubey","year":"2024","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.jpag.2026.05.010_bib0006","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.2337\/dc12-2071","article-title":"How metformin acts in PCOS pregnant women: insights into insulin secretion and peripheral action at each trimester of gestation","volume":"36","author":"Romualdi","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpag.2026.05.010_bib0007","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1210\/jc.2014-2544","article-title":"Elevated circulating levels of irisin and the effect of metformin treatment in women with polycystic ovary syndrome","volume":"100","author":"Li","year":"2015","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0008","doi-asserted-by":"crossref","first-page":"96604","DOI":"10.18632\/oncotarget.21852","article-title":"Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studies in vivo and in vitro","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jpag.2026.05.010_bib0009","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1210\/jc.2018-02086","article-title":"Adipose insulin resistance in normal-weight women with polycystic ovary syndrome","volume":"104","author":"Dumesic","year":"2019","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0010","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1253164","article-title":"Adipose insulin resistance and circulating betatrophin levels in women with PCOS","volume":"2020","author":"He","year":"2020","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.jpag.2026.05.010_bib0011","doi-asserted-by":"crossref","first-page":"E334","DOI":"10.1152\/ajpendo.00084.2012","article-title":"Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism","volume":"303","author":"Ren","year":"2012","journal-title":"Am J Physiol Endocrinol Metabol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0012","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cmet.2013.06.006","article-title":"Betatrophin fuels \u03b2 cell proliferation: first step toward regenerative therapy?","volume":"18","author":"Lickert","year":"2013","journal-title":"Cell Metabol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0013","doi-asserted-by":"crossref","unstructured":"Zhang R: Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem Biophys Res Commun 2012; 424:786-792","DOI":"10.1016\/j.bbrc.2012.07.038"},{"key":"10.1016\/j.jpag.2026.05.010_bib0014","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00125-013-3071-1","article-title":"Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes","volume":"57","author":"Espes","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.jpag.2026.05.010_bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/323407","article-title":"Increased circulating betatrophin concentrations in patients with type 2 diabetes","volume":"2014","author":"Espes","year":"2014","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0016","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.2337\/dc14-0602","article-title":"Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients","volume":"37","author":"Hu","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpag.2026.05.010_bib0017","doi-asserted-by":"crossref","first-page":"E2004","DOI":"10.1210\/jc.2014-1568","article-title":"Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes","volume":"99","author":"G\u00f3mez-Ambrosi","year":"2014","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0018","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1038\/srep05013","article-title":"Elevated circulating lipasin\/betatrophin in human type 2 diabetes and obesity","volume":"4","author":"Fu","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.jpag.2026.05.010_bib0019","unstructured":"WHO, Adolescents: health risks and solutions. Available: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/adolescents-health-risks-and-solutions, 2022."},{"key":"10.1016\/j.jpag.2026.05.010_bib0020","doi-asserted-by":"crossref","first-page":"G43","DOI":"10.1093\/ejendo\/lvad096","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"189","author":"Teede","year":"2023","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0021","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12020-016-0875-z","article-title":"Elevated circulating levels of betatrophin are associated with polycystic ovary syndrome","volume":"53","author":"Calan","year":"2016","journal-title":"Endocrine"},{"key":"10.1016\/j.jpag.2026.05.010_bib0022","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/09513590.2018.1536736","article-title":"Circulating angiopoietin-like 8 protein (ANGPTL8\/Betatrophin) in patients with polycystic ovary syndrome: a systematic review and multi effect size meta-analysis","volume":"35","author":"Varikasuvu","year":"2019","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0023","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6321427","article-title":"Circulating ANGPTL8 is associated with the presence of metabolic syndrome and insulin resistance in polycystic ovary syndrome young women","volume":"2019","author":"Pu","year":"2019","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.jpag.2026.05.010_bib0024","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/0300060516680441","article-title":"Serum betatrophin levels are increased and associated with insulin resistance in patients with polycystic ovary syndrome","volume":"45","author":"Qu","year":"2017","journal-title":"J Int Med Res"},{"key":"10.1016\/j.jpag.2026.05.010_bib0025","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s40618-018-0831-2","article-title":"Association of serum betatrophin with fibroblast growth factor-21 in women with polycystic ovary syndrome","volume":"41","author":"Kahraman","year":"2018","journal-title":"J Endocrinol Investig"},{"key":"10.1016\/j.jpag.2026.05.010_bib0026","first-page":"20","article-title":"Relationship between betatrophin levels and metabolic parameters in patients with polycystic ovary syndrome","volume":"62","author":"Erbag","year":"2016","journal-title":"Cell Mol Biol"},{"issue":"8","key":"10.1016\/j.jpag.2026.05.010_bib0027","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.2919","article-title":"ANGPTL8 (betatrophin) role in diabetes and metabolic diseases","volume":"33","author":"Abu-Farha","year":"2017","journal-title":"Diabetes\/Metabol Res Rev"},{"key":"10.1016\/j.jpag.2026.05.010_bib0028","article-title":"The effects of serum ANGPTL8\/betatrophin on the risk of developing the metabolic syndrome - a prospective study","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jpag.2026.05.010_bib0029","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12933-016-0461-y","article-title":"Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome","volume":"15","author":"Fu","year":"2016","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jpag.2026.05.010_bib0030","article-title":"Evaluation of adiponectin and ANGPTL8 in women with metabolic syndrome in the Madinah Region of Saudi Arabia","volume":"15","author":"Mohammedsaeed","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.jpag.2026.05.010_bib0031","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5096860","article-title":"The relationship between circulating ANGPTL8\/betatrophin concentrations and adult obesity: a meta-analysis","volume":"2019","author":"Ye","year":"2019","journal-title":"Dis Markers"},{"key":"10.1016\/j.jpag.2026.05.010_bib0032","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3390\/metabo12100925","article-title":"Betatrophin and insulin resistance","volume":"12","author":"Guo","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.jpag.2026.05.010_bib0033","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12902-020-0531-8","article-title":"Circulating betatrophin\/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders","volume":"20","author":"Zheng","year":"2020","journal-title":"BMC Endocr Disord"},{"key":"10.1016\/j.jpag.2026.05.010_bib0034","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/oby.21038","article-title":"Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals","volume":"23","author":"Guo","year":"2015","journal-title":"Obesity"},{"key":"10.1016\/j.jpag.2026.05.010_bib0035","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4274\/jcrpe.2183","article-title":"Reference values for weight, height, head circumference, and body mass index in Turkish children","volume":"7","author":"Neyzi","year":"2015","journal-title":"J Clin Res Pediatr Endocrinol"}],"container-title":["Journal of Pediatric and Adolescent Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318826004080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083318826004080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:26:25Z","timestamp":1784751985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083318826004080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":35,"alternative-id":["S1083318826004080"],"URL":"https:\/\/doi.org\/10.1016\/j.jpag.2026.05.010","relation":{},"ISSN":["1083-3188"],"issn-type":[{"value":"1083-3188","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of Serum Betatrophin Levels in Normal-Weight and Overweight Adolescents with Polycystic Ovary Syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric and Adolescent Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpag.2026.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}