{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:49:35Z","timestamp":1777546175577,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":6919,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.jpain.2004.06.008","type":"journal-article","created":{"date-parts":[[2004,10,23]],"date-time":"2004-10-23T23:07:12Z","timestamp":1098572832000},"page":"413-419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine"],"prefix":"10.1016","volume":"5","author":[{"given":"Carla","family":"Ghelardini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Galeotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Grazioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Uslenghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2004.06.008_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/nrc.10009","article-title":"NMDA receptor mediates the response of trigeminovascular neurons of rats","volume":"29","author":"Ahn","year":"2001","journal-title":"Neurosci Res Comm"},{"key":"10.1016\/j.jpain.2004.06.008_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0022-510X(98)00023-9","article-title":"Plasma levels of neuroexcitatory amino acids in patients with migraine or tension headache","volume":"156","author":"Alam","year":"1998","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jpain.2004.06.008_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1046\/j.1468-2982.2000.00070.x","article-title":"Central sensitization in tension-type headache: Possible pathophysiological mechanisms","volume":"20","author":"Bendtsen","year":"2000","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jpain.2004.06.008_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3959(00)00478-4","article-title":"Deconstructing migraine headache into peripheral and central sensitization","volume":"89","author":"Burstein","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2004.06.008_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ana.10786","article-title":"Defeating migraine pain with triptans: A race against the development of cutaneous allodynia","volume":"55","author":"Burstein","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jpain.2004.06.008_bib6","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/brain\/123.8.1703","article-title":"The development of cutaneous allodynia during a migraine attack: Clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine","volume":"123","author":"Burstein","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.jpain.2004.06.008_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/ana.10785","article-title":"Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization","volume":"55","author":"Burstein","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jpain.2004.06.008_bib8","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/1531-8249(200005)47:5<614::AID-ANA9>3.0.CO;2-N","article-title":"An association between migraine and cutaneous allodynia","volume":"47","author":"Burstein","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jpain.2004.06.008_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1046\/j.1468-2982.1991.1104197.x","article-title":"Platelet glycine, glutamate and aspartate in primary headache","volume":"11","author":"D'Andrea","year":"1991","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jpain.2004.06.008_bib10","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1046\/j.1526-4610.2003.03161.x","article-title":"Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine versus sumatriptan in acute treatment of multiple migraine attacks: A multicenter, randomized, crossover trial","volume":"43","author":"Di Monda","year":"2003","journal-title":"Headache"},{"key":"10.1016\/j.jpain.2004.06.008_bib11","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1001\/archneur.60.11.1524","article-title":"Advances in neuropathic pain","volume":"60","author":"Dworkin","year":"2003","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jpain.2004.06.008_bib12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1468-2982.2002.00404.x","article-title":"Triptans (serotonin, 5-HT1B\/1D agonists) in migraine: Detailed results and methods of a meta-analysis of 53 trials","volume":"22","author":"Ferrari","year":"2002","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jpain.2004.06.008_bib13","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1212\/WNL.40.10.1582","article-title":"Neuroexcitatory plasma amino acids are elevated in migraine","volume":"40","author":"Ferrari","year":"1990","journal-title":"Neurology"},{"key":"10.1016\/j.jpain.2004.06.008_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1043-6618(02)00126-3","article-title":"Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in \u201cin vivo\u201d models of migraine","volume":"46","author":"Galeotti","year":"2002","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jpain.2004.06.008_bib15","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/PL00005094","article-title":"Caffeine induces central cholinergic analgesia","volume":"356","author":"Ghelardini","year":"1997","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jpain.2004.06.008_bib16","unstructured":"Ghelardini C, Galeotti N, Di Cesare Mannelli L, Uslenghi C, Grazioli I, Bartolini A: Investigation into the analgesic effect of prochlorperazine. 30th Annual Meeting Society for Neuroscience, New Orleans, LA, Nov 2000, p 2155"},{"key":"10.1016\/j.jpain.2004.06.008_bib17","first-page":"192","article-title":"Prevention by sumatriptan of hyperalgesia induced by morphine withdrawal","volume":"10","author":"Ghelardini","year":"1996","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.jpain.2004.06.008_bib18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0304-3959(99)00118-9","article-title":"Parenterally administered kainic acid induces a persistent hyperalgesia in the mouse and rat","volume":"83","author":"Giovengo","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2004.06.008_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0014-2999(94)90522-3","article-title":"Central mechanism of indomethacin analgesia","volume":"263","author":"Hu","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpain.2004.06.008_bib20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-2999(80)90515-4","article-title":"Intrathecal morphine in mice: A new technique","volume":"67","author":"Hylden","year":"1980","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpain.2004.06.008_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(92)90790-E","article-title":"Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse","volume":"148","author":"Kitto","year":"1992","journal-title":"Neurosci Lett"},{"issue":"3","key":"10.1016\/j.jpain.2004.06.008_bib22","first-page":"28","article-title":"Peripheral and central sensitization during migraine","volume":"15","author":"Malick","year":"2000","journal-title":"Funct Neurol"},{"key":"10.1016\/j.jpain.2004.06.008_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1046\/j.1468-2982.1993.1302089.x","article-title":"Neuroexcitatory amino acids levels in plasma and cerebrospinal fluid during migraine attacks","volume":"13","author":"Martinez","year":"1993","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jpain.2004.06.008_bib24","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0022-3565(25)30089-3","article-title":"Quantification of the analgesic activity of narcotic antagonists by a modified hot plate procedure","volume":"192","author":"O'Callaghan","year":"1975","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2004.06.008_bib25","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1211\/0022357001774039","article-title":"The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats","volume":"52","author":"Park","year":"2000","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jpain.2004.06.008_bib26","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1046\/j.1526-4610.1999.3909644.x","article-title":"Amino acids in the saliva of patients with migraine","volume":"39","author":"Rajda","year":"1999","journal-title":"Headache"},{"key":"10.1016\/j.jpain.2004.06.008_bib27","doi-asserted-by":"crossref","first-page":"6611","DOI":"10.1523\/JNEUROSCI.17-17-06611.1997","article-title":"Glutamate receptor Subunits GluR5 and KA-2 are coexpressed in rat trigeminal ganglion neurons","volume":"17","author":"Sahara","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2004.06.008_bib28","unstructured":"Sicuteri F, Nicolodi M: The holistic hypothesis of migraine. Ann Ital Med Int 12:3-32, 1997 (Suppl 1)"},{"key":"10.1016\/j.jpain.2004.06.008_bib29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-2999(00)00129-1","article-title":"Activation of cGMP-dependent protein kinase I\u03b1 is required for N-methyl-D-aspartate- or nitric oxide-produced spinal thermal hyperalgesia","volume":"392","author":"Tao","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpain.2004.06.008_bib30","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0733-8619(18)30319-0","article-title":"The concept of migraine as a state of central neuronal hyperexcitability","volume":"8","author":"Welch","year":"1990","journal-title":"Neurol Clin"},{"key":"10.1016\/j.jpain.2004.06.008_bib31","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(99)01307-0","article-title":"Neuropathic pain: Aetiology, symptoms, mechanisms, and management","volume":"353","author":"Woolf","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jpain.2004.06.008_bib32","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1097\/00001756-199812010-00019","article-title":"COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA","volume":"9","author":"Yamamoto","year":"1998","journal-title":"Neuroreport"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590004008806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590004008806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:40:33Z","timestamp":1761507633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590004008806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S1526590004008806"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2004.06.008","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2004.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Pain Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}