{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:35:24Z","timestamp":1770906924166,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":6431,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.jpain.2005.09.013","type":"journal-article","created":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T13:25:25Z","timestamp":1139405125000},"page":"134-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pain Behaviors Produced by Capsaicin: Influence of Inflammatory Mediators and Nerve Injury"],"prefix":"10.1016","volume":"7","author":[{"given":"Jana","family":"Sawynok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Meisner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2005.09.013_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0306-4522(02)00009-X","article-title":"Different peripheral mechanisms mediate enhanced nociception in metabolic\/toxic and traumatic painful peripheral neuropathies in the rat","volume":"11","author":"Aley","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpain.2005.09.013_bib2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0006-8993(02)03972-0","article-title":"Local inflammation increases vanilloid receptor 1 expression within distinct subgroups of DRG neurons","volume":"963","author":"Amaya","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2005.09.013_bib3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(01)02093-6","article-title":"Peripheral capsaicin receptors increase in the inflamed rat hindpaw","volume":"310","author":"Carlton","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2005.09.013_bib4","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.pain.2004.04.042","article-title":"Somatostatin modulates the transient receptor potential vanilloid 1 (TRPV1) ion channel","volume":"110","author":"Carlton","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.neuro.24.1.487","article-title":"The vanilloid receptor","volume":"24","author":"Caterina","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.jpain.2005.09.013_bib6","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/35082088","article-title":"Bradykinin and nerve growth factor release the capsaicin receptor from Ptdins(4,5)P2-mediated receptor inhibition","volume":"411","author":"Chuang","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jpain.2005.09.013_bib7","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1111\/j.1432-1033.2004.04082.x","article-title":"Biochemical pharmacology of the vanilloid receptor TRPV1","volume":"271","author":"Cortright","year":"2004","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jpain.2005.09.013_bib8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0304-3959(93)90059-X","article-title":"Streptozotocin-induced diabetic rats","volume":"53","author":"Courteix","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0304-3959(00)00331-6","article-title":"Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy","volume":"88","author":"Cui","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1213\/01.ANE.0000131967.69309.4F","article-title":"Differential analgesic sensitivity of two distinct neuropathic pain models","volume":"99","author":"Decosterd","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jpain.2005.09.013_bib11","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0304-3959(98)00261-9","article-title":"Acute amitriptyline in a rat model of neuropathic pain","volume":"80","author":"Esser","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib12","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1124\/jpet.105.084103","article-title":"A-425619 [I-isoquinolin-5-yl-3-(4trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid","volume":"314","author":"El Kouhen","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2005.09.013_bib13","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/sj.bjp.0705546","article-title":"Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice","volume":"141","author":"Ferreira","year":"2004","journal-title":"Brit J Pharmacol"},{"key":"10.1016\/j.jpain.2005.09.013_bib14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1385\/MN:26:1:057","article-title":"Contribution of the spared primary afferent neurons to the pathomechanisms of neuropathic pain","volume":"26","author":"Fukuoka","year":"2002","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jpain.2005.09.013_bib15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3959(02)00067-2","article-title":"VR1, but not P2X3, increases in the spared L4 DRG in rats with L5 spinal nerve ligation","volume":"99","author":"Fukuoka","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib16","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1124\/jpet.104.079855","article-title":"AMG 9810 [(E)-3-(4-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties","volume":"313","author":"Gavva","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2005.09.013_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0304-3959(96)03104-1","article-title":"Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of capsaicin in rats","volume":"67","author":"Gilchrist","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib18","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1073\/pnas.93.3.1108","article-title":"Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors","volume":"93","author":"Gold","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpain.2005.09.013_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0028-3908(03)00305-8","article-title":"Identification and characterization of SB-3666791, a potent and selective vanilloid receptor (VR1\/TRPV1) antagonist","volume":"46","author":"Gunthorpe","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpain.2005.09.013_bib20","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0306-4522(94)90527-4","article-title":"Behavioural effects of intraplantar injection of inflammatory mediators in the rat","volume":"63","author":"Hong","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpain.2005.09.013_bib21","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1046\/j.0953-816x.2001.01591.x","article-title":"VR1 protein expression increases in undamaged DRG neurons after partial nerve injury","volume":"13","author":"Hudson","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jpain.2005.09.013_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0896-6273(02)00908-X","article-title":"p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia","volume":"36","author":"Ji","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.jpain.2005.09.013_bib23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pain.2004.02.032","article-title":"Pro-nociceptive role of peripheral galanin in inflammatory pain","volume":"110","author":"Jiminez-Andrade","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1523\/JNEUROSCI.19-02-00529.1999","article-title":"Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel","volume":"19","author":"Jung","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2005.09.013_bib25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","article-title":"An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat","volume":"50","author":"Kim","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0304-3959(93)90187-T","article-title":"Effects of sympathectomy on a rat model of peripheral neuropathy","volume":"55","author":"Kim","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0306-4522(94)00474-J","article-title":"Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat","volume":"65","author":"Kinnman","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpain.2005.09.013_bib28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/00001756-200003200-00002","article-title":"An animal model of neuropathic pain employing injury to the sciatic nerve branches","volume":"11","author":"Lee","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.jpain.2005.09.013_bib29","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1021\/jm030089u","article-title":"N-(3-acyloxy-2-benzyl-propyl)-N\u2032-[4(methylsulfonylamino)benzyl]thiourea analogues","volume":"46","author":"Lee","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.jpain.2005.09.013_bib30","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/jn.00568.2002","article-title":"Sympathetic modulation of acute cutaneous flare induced by intradermal injection of capsaicin in anesthetized rats","volume":"89","author":"Lin","year":"2003","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2005.09.013_bib31","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1523\/JNEUROSCI.18-16-06081.1998","article-title":"The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons","volume":"18","author":"Lopshire","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2005.09.013_bib32","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pain.2004.11.018","article-title":"Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased \u03b12C-adrenoceptor co-expression and functional inhibition by clonidine","volume":"113","author":"Ma","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib33","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1136\/bmj.38042.506748.EE","article-title":"Systematic review of topical capsaicin for the treatment of chronic pain","volume":"328","author":"Mason","year":"2004","journal-title":"Brit Med J"},{"key":"10.1016\/j.jpain.2005.09.013_bib34","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1523\/JNEUROSCI.19-05-01844.1999","article-title":"Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy","volume":"19","author":"Michael","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2005.09.013_bib35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2174\/1568007043336789","article-title":"Nociception and TRP channels","volume":"3","author":"Numazaki","year":"2004","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"10.1016\/j.jpain.2005.09.013_bib36","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0306-4522(00)00396-1","article-title":"Hyperalgesia due to nerve injury","volume":"101","author":"Perkins","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpain.2005.09.013_bib37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3940(91)90444-X","article-title":"Prostaglandins sensitize nociceptors in cell culture","volume":"132","author":"Pitchford","year":"1991","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2005.09.013_bib38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1124\/jpet.102.046268","volume":"306","author":"Pomonis","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2005.09.013_bib39","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1124\/jpet.102.046250","article-title":"Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain","volume":"304","author":"Rashid","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2005.09.013_bib40","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1124\/jpet.103.050948","article-title":"Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice","volume":"306","author":"Rashid","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2005.09.013_bib41","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1124\/jpet.103.060335","article-title":"Switching of bradykinin-mediated nociception following partial sciatic nerve injury in mice","volume":"308","author":"Rashid","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2005.09.013_bib42","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/jn.00804.2004","article-title":"Sympathetic modulation of activity in A\u03b4- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats","volume":"93","author":"Ren","year":"2005","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2005.09.013_bib43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3959(98)00199-7","article-title":"Spinal nerve ligation-induced neuropathy in the rat","volume":"80","author":"R\u00f6ytta","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib44","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/0028-3908(92)90057-V","article-title":"The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord","volume":"31","author":"Sakurada","year":"1992","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpain.2005.09.013_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.55.1.1","article-title":"Topical and peripherally acting analgesics","volume":"5","author":"Sawynok","year":"2003","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jpain.2005.09.013_bib46","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3727\/000000003783992982","article-title":"The formalin test","volume":"7","author":"Sawynok","year":"2004","journal-title":"Rev Analg"},{"key":"10.1016\/j.jpain.2005.09.013_bib47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(90)91074-S","article-title":"A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve surgery","volume":"43","author":"Seltzer","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2005.09.013_bib48","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0006-8993(01)02743-3","article-title":"Anti-TNF\u2013neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy","volume":"913","author":"Sommer","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2005.09.013_bib49","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1152\/jn.2002.88.1.544","article-title":"Bradykinin lowers threshold temperature for heat activation of vanilloid receptor 1","volume":"88","author":"Sugiura","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2005.09.013_bib50","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1021\/jm030560j","article-title":"Vanilloid receptor TRPV1 antagonists as the next generation of pain killers","volume":"47","author":"Szallasi","year":"2004","journal-title":"J Med Chem"},{"key":"10.1016\/j.jpain.2005.09.013_bib51","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0031-6997(24)01403-0","article-title":"Vanilloid (capsaicin) receptors and mechanisms","volume":"51","author":"Szallasi","year":"1999","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jpain.2005.09.013_bib52","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1073\/pnas.111025298","article-title":"Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia","volume":"98","author":"Tominaga","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpain.2005.09.013_bib53","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1124\/jpet.102.045674","article-title":"N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl) tetrahydropyrazine-1(2H)carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties. I. In vitro characterization and pharmacokinetic properties","volume":"306","author":"Valenzano","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2005.09.013_bib54","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.pain.2003.09.002","article-title":"The effects of protein phosphatase inhibitors on nociceptive behavioral responses of rats following intradermal injection of capsaicin","volume":"106","author":"Zhang","year":"2003","journal-title":"Pain"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590005008977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590005008977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:41:54Z","timestamp":1761507714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590005008977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S1526590005008977"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2005.09.013","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pain Behaviors Produced by Capsaicin: Influence of Inflammatory Mediators and Nerve Injury","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2005.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Pain Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}