{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:54:34Z","timestamp":1790776474498,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":5001,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.jpain.2009.05.003","type":"journal-article","created":{"date-parts":[[2009,9,27]],"date-time":"2009-09-27T04:19:26Z","timestamp":1254025166000},"page":"13-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["A Single Nitrous Oxide (N2O) Exposure Leads to Persistent Alleviation of Neuropathic Pain in Rats"],"prefix":"10.1016","volume":"11","author":[{"given":"Baptiste","family":"Bessi\u00e8re","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Laboureyras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Chateauraynaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Laulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Simonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2009.05.003_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0304-3959(02)00350-0","article-title":"Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: Responses to early and late infusions","volume":"103","author":"Araujo","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/rapm-00115550-200805000-00004","article-title":"Contralateral neuropathic pain following a surgical model of unilateral nerve injury in rats","volume":"33","author":"Arguis","year":"2008","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.jpain.2009.05.003_bib3","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1468-1331.2006.01511.x","article-title":"EFNS guidelines on pharmacological treatment of neuropathic pain","volume":"13","author":"Attal","year":"2006","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jpain.2009.05.003_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib5","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.982058","article-title":"Nitrous oxide \u201canalgesia\u201d: Resemblance to opiate action","volume":"194","author":"Berkowitz","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.jpain.2009.05.003_bib6","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.neuropharm.2007.08.003","article-title":"Nitrous oxide (N(2)O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats","volume":"53","author":"Bessiere","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpain.2009.05.003_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0304-3940(01)02154-1","article-title":"Contralateral treatment with lidocaine reduces spinal neuronal activity in mononeuropathic rats","volume":"311","author":"Bileviciute-Ljungar","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2009.05.003_bib8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2006.09.021","article-title":"Mechanisms of neuropathic pain","volume":"52","author":"Campbell","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.jpain.2009.05.003_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0006-8993(99)01998-8","article-title":"Evidence for opiate-activated NMDA processes masking opiate analgesia in rats","volume":"847","author":"C\u00e9l\u00e8rier","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2009.05.003_bib11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/00000542-200002000-00029","article-title":"Long-lasting hyperalgesia induced by fentanyl in rats: Preventive effect of ketamine","volume":"92","author":"C\u00e9l\u00e8rier","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpain.2009.05.003_bib12","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.2174\/1381612054865082","article-title":"NMDA antagonists and neuropathic pain: Multiple drug targets and multiple uses","volume":"11","author":"Chizh","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jpain.2009.05.003_bib13","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0165-6147(00)01863-0","article-title":"NMDA receptor antagonists as analgesics: Focus on the NR2B subtype","volume":"22","author":"Chizh","year":"2001","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jpain.2009.05.003_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuropharm.2006.02.007","article-title":"The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism","volume":"51","author":"Christoph","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpain.2009.05.003_bib15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-3959(93)90161-H","article-title":"Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence","volume":"52","author":"Coderre","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1526-4637.2004.04043.x","article-title":"Subanesthetic ketamine infusion therapy: A retrospective analysis of a novel therapeutic approach to complex regional pain syndrome","volume":"5","author":"Correll","year":"2004","journal-title":"Pain Med"},{"key":"10.1016\/j.jpain.2009.05.003_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0304-3959(97)00198-X","article-title":"Can patients with chronic neuropathic pain be cured by acute administration of the NMDA receptor antagonist amantadine?","volume":"74","author":"Eisenberg","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2344\/0003-3006(2007)54[9:AIUTAO]2.0.CO;2","article-title":"Advances in understanding the actions of nitrous oxide","volume":"54","author":"Emmanouil","year":"2007","journal-title":"Anesth Prog"},{"key":"10.1016\/j.jpain.2009.05.003_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.pain.2005.08.013","article-title":"Algorithm for neuropathic pain treatment: An evidence based proposal","volume":"118","author":"Finnerup","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1385\/MN:25:2:167","article-title":"Neurobiology of nitrous oxide-induced antinociceptive effects","volume":"25","author":"Fujinaga","year":"2002","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jpain.2009.05.003_bib21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pain.2007.03.026","article-title":"Nitrous oxide inhibits glutamatergic transmission in spinal dorsal horn neurons","volume":"134","author":"Georgiev","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1124\/mol.65.2.443","article-title":"Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane","volume":"65","author":"Gruss","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jpain.2009.05.003_bib23","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1152\/jn.1990.64.5.1537","article-title":"Neuronal responsiveness in the ventrobasal thalamic complex of rats with an experimental peripheral mononeuropathy","volume":"64","author":"Guilbaud","year":"1990","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2009.05.003_bib24","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nm0498-460","article-title":"Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin","volume":"4","author":"Jevtovic-Todorovic","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.jpain.2009.05.003_bib25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.tins.2003.09.017","article-title":"Central sensitization and LTP: Do pain and memory share similar mechanisms?","volume":"26","author":"Ji","year":"2003","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jpain.2009.05.003_bib26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0006-8993(87)91338-2","article-title":"Paradoxical hyperalgesic effect of exceedingly low doses of systemic morphine in an animal model of persistent pain (Freund's adjuvant- induced arthritic rats)","volume":"414","author":"Kayser","year":"1987","journal-title":"Brain Res"},{"issue":"Suppl","key":"10.1016\/j.jpain.2009.05.003_bib27","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/nn936","article-title":"NMDA receptor pathways as drug targets","volume":"5","author":"Kemp","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jpain.2009.05.003_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejpain.2007.02.002","article-title":"Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia","volume":"12","author":"Klein","year":"2008","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib29","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0166-2236(98)01302-2","article-title":"Does the right side know what the left is doing?","volume":"22","author":"Koltzenburg","year":"1999","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jpain.2009.05.003_bib30","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1152\/jn.1993.70.2.470","article-title":"Spatial patterns of increased spinal cord membrane-bound protein kinase C and their relation to increases in 14C-2-deoxyglucose metabolic activity in rats with painful peripheral mononeuropathy","volume":"70","author":"Mao","year":"1993","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2009.05.003_bib31","doi-asserted-by":"crossref","first-page":"9716","DOI":"10.1523\/JNEUROSCI.18-23-09716.1998","article-title":"Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures","volume":"18","author":"Mennerick","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2009.05.003_bib32","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1523\/JNEUROSCI.23-03-01026.2003","article-title":"Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats","volume":"23","author":"Milligan","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2009.05.003_bib33","doi-asserted-by":"crossref","first-page":"8791","DOI":"10.1073\/pnas.0402825101","article-title":"Nitrous oxide (N(2)O) requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans","volume":"101","author":"Nagele","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpain.2009.05.003_bib34","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/ana.410440513","article-title":"Unilateral postherpetic neuralgia is associated with bilateral sensory neuron damage","volume":"44","author":"Oaklander","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jpain.2009.05.003_bib35","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/00000542-200310000-00030","article-title":"Brain stem opioidergic and GABAergic neurons mediate the antinociceptive effect of nitrous oxide in Fischer rats","volume":"99","author":"Ohashi","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpain.2009.05.003_bib36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-2999(01)01307-3","article-title":"NMDA receptors as targets for drug action in neuropathic pain","volume":"429","author":"Parsons","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpain.2009.05.003_bib37","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0166-2236(02)02157-4","article-title":"Chronic pain and medullary descending facilitation","volume":"25","author":"Porreca","year":"2002","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jpain.2009.05.003_bib38","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0304-3959(98)00014-1","article-title":"The NMDA receptor antagonist amantadine reduces surgical neuropathic pain in cancer patients: A double blind, randomized, placebo controlled trial","volume":"75","author":"Pud","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib39","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/S0022-3565(24)38236-9","article-title":"Prolonged analgesic effect of ketamine, an N-methyl-D-aspartate receptor inhibitor, in patients with chronic pain","volume":"289","author":"Rabben","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2009.05.003_bib40","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.neuropharm.2006.09.021","article-title":"Nitrous oxide (N2O) pre- and postsynaptically attenuates NMDA receptor-mediated neurotransmission in the amygdala","volume":"52","author":"Ranft","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpain.2009.05.003_bib41","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1097\/ACO.0b013e32830edbdf","article-title":"Neuron-glia crosstalk gets serious: Role in pain hypersensitivity","volume":"21","author":"Ren","year":"2008","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1016\/j.jpain.2009.05.003_bib42","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/00000542-200510000-00024","article-title":"Nitrous oxide revisited: Evidence for potent antihyperalgesic properties","volume":"103","author":"Richebe","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpain.2009.05.003_bib43","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00000542-200502000-00028","article-title":"Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats","volume":"102","author":"Richebe","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpain.2009.05.003_bib44","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1038\/sj.npp.1301340","article-title":"Non-nociceptive environmental stress induces hyperalgesia, not analgesia, in pain and opioid-experienced rats","volume":"32","author":"Rivat","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpain.2009.05.003_bib45","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00000542-200202000-00025","article-title":"Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: Prevention by the N-methyl-D-aspartate receptor antagonist ketamine","volume":"96","author":"Rivat","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpain.2009.05.003_bib46","first-page":"318","article-title":"Cellular neuroplasticity mechanisms mediating pain persistence","volume":"18","author":"Salter","year":"2004","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib47","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/00000542-200503000-00013","article-title":"Effect of N-methyl-D-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice","volume":"102","author":"Sato","year":"2005","journal-title":"Anesthesiology"},{"issue":"Suppl","key":"10.1016\/j.jpain.2009.05.003_bib48","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nn942","article-title":"Can we conquer pain?","volume":"5","author":"Scholz","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jpain.2009.05.003_bib49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/08990220070274","article-title":"Contribution of central sensitization to the pain-related abnormal activity in neuropathic rats","volume":"17","author":"Sotgiu","year":"2000","journal-title":"Somatosens Mot Res"},{"key":"10.1016\/j.jpain.2009.05.003_bib50","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0166-2236(00)01854-3","article-title":"Glial activation: A driving force for pathological pain","volume":"24","author":"Watkins","year":"2001","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jpain.2009.05.003_bib51","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(99)01307-0","article-title":"Neuropathic pain: Aetiology, symptoms, mechanisms, and management","volume":"353","author":"Woolf","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jpain.2009.05.003_bib52","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: Increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jpain.2009.05.003_bib53","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pain.2005.04.017","article-title":"Neuropathic pain: Early spontaneous afferent activity is the trigger","volume":"116","author":"Xie","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib54","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00000542-200107000-00025","article-title":"Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels","volume":"95","author":"Yamakura","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpain.2009.05.003_bib55","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pain.2005.02.026","article-title":"Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy","volume":"115","author":"Yasuda","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2009.05.003_bib56","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1476-5381.1996.tb15152.x","article-title":"Intrathecal CGRP8-37-induced bilateral increase in hindpaw withdrawal latency in rats with unilateral inflammation","volume":"117","author":"Yu","year":"1996","journal-title":"Br J Pharmacol"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590009005641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590009005641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:48:06Z","timestamp":1761508086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590009005641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S1526590009005641"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2009.05.003","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Single Nitrous Oxide (N2O) Exposure Leads to Persistent Alleviation of Neuropathic Pain in Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2009.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Pain Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}