{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:57:04Z","timestamp":1783573024229,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":3450,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.jpain.2013.12.002","type":"journal-article","created":{"date-parts":[[2013,12,25]],"date-time":"2013-12-25T17:30:20Z","timestamp":1387992620000},"page":"387.e1-387.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mechanistic Insights Into the Analgesic Efficacy of A-1264087, a Novel Neuronal Ca2+ Channel Blocker That Reduces Nociception in Rat Preclinical Pain Models"],"prefix":"10.1016","volume":"15","author":[{"given":"Chang Z.","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Vortherms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Swensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wende","family":"Niforatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Neelands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Milicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La Geisha","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Gauvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Mikusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cenchen","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavi","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Roderwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine L.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Bespalov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia B.","family":"Searle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"McGaraughty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Bitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony W.","family":"Bannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailen K.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria E.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2013.12.002_bib1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1124\/jpet.110.166363","article-title":"Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker","volume":"334","author":"Abbadie","year":"2010","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2013.12.002_bib2","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.ejpain.2011.04.005","article-title":"Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury","volume":"15","author":"Anand","year":"2011","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0022-3565(24)37423-3","article-title":"ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In\u00a0vivo characterization","volume":"285","author":"Bannon","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2013.12.002_bib4","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1016\/j.bmcl.2013.06.074","article-title":"Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain","volume":"23","author":"Beebe","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jpain.2013.12.002_bib5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.emboj.7600515","article-title":"Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception","volume":"24","author":"Bourinet","year":"2005","journal-title":"EMBO J"},{"key":"10.1016\/j.jpain.2013.12.002_bib7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pain.2006.10.019","article-title":"Voltage-gated calcium channels and pain","volume":"126","author":"Cao","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.cellbio.16.1.521","article-title":"Structure and regulation of voltage-gated Ca2+ channels","volume":"16","author":"Catterall","year":"2000","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.jpain.2013.12.002_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejphar.2009.04.009","article-title":"Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis","volume":"613","author":"Chandran","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpain.2013.12.002_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jpain.2013.12.002_bib11","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1124\/mol.111.073205","article-title":"TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent","volume":"80","author":"Choe","year":"2011","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jpain.2013.12.002_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neulet.2004.09.025","article-title":"Increased WDR spontaneous activity and receptive field size in rats following a neuropathic or inflammatory injury: Implications for mechanical sensitivity","volume":"372","author":"Chu","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2013.12.002_bib13","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/sj.bjp.0705103","article-title":"Identification of MEK1 as a novel target for the treatment of neuropathic pain","volume":"138","author":"Ciruela","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jpain.2013.12.002_bib14","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s00221-002-1217-3","article-title":"Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury","volume":"147","author":"Cizkova","year":"2002","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.jpain.2013.12.002_bib15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jpain.2013.12.002_bib16","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1124\/jpet.105.084103","article-title":"A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid","volume":"314","author":"El Kouhen","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2013.12.002_bib17","doi-asserted-by":"crossref","first-page":"20171","DOI":"10.1074\/jbc.M300581200","article-title":"Determinants of inhibition of transiently expressed voltage-gated calcium channels by omega-conotoxins GVIA and MVIIA","volume":"278","author":"Feng","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpain.2013.12.002_bib18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1089\/adt.2010.0311","article-title":"An integrated multiassay approach to the discovery of small-molecule N-type voltage-gated calcium channel antagonists","volume":"8","author":"Finley","year":"2010","journal-title":"Assay Drug Dev Technol"},{"key":"10.1016\/j.jpain.2013.12.002_bib19","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1096\/fj.00-0562fje","article-title":"Dystonia and cerebellar atrophy in Cacna1a null mice lacking P\/Q calcium channel activity","volume":"15","author":"Fletcher","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.jpain.2013.12.002_bib20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.pain.2009.11.017","article-title":"The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition","volume":"148","author":"Gao","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib21","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1097\/00001756-200108080-00027","article-title":"Differential nociceptive responses in mice lacking the alpha(1B) subunit of N-type Ca(2+) channels","volume":"12","author":"Hatakeyama","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.jpain.2013.12.002_bib22","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.pain.2010.12.035","article-title":"A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain","volume":"152","author":"Hildebrand","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib23","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1152\/jn.01031.2007","article-title":"Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve","volume":"99","author":"Jagodic","year":"2008","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2013.12.002_bib24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1601-183X.2006.00267.x","article-title":"Impaired long-term memory and long-term potentiation in N-type Ca2+ channel-deficient mice","volume":"6","author":"Jeon","year":"2007","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.jpain.2013.12.002_bib25","doi-asserted-by":"crossref","first-page":"15245","DOI":"10.1073\/pnas.96.26.15245","article-title":"Ablation of P\/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit","volume":"96","author":"Jun","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpain.2013.12.002_bib26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1523\/JNEUROSCI.22-01-00082.2002","article-title":"Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site","volume":"22","author":"Kaneko","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2013.12.002_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/mcne.2001.1013","article-title":"Altered nociceptive response in mice deficient in the alpha(1B) subunit of the voltage-dependent calcium channel","volume":"18","author":"Kim","year":"2001","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.jpain.2013.12.002_bib28","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1097\/00001756-200212200-00021","article-title":"Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury","volume":"13","author":"Kim","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.jpain.2013.12.002_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1744-8069-7-39","article-title":"Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord","volume":"7","author":"Lee","year":"2011","journal-title":"Mol Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib30","doi-asserted-by":"crossref","first-page":"35335","DOI":"10.1074\/jbc.M002252200","article-title":"Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes","volume":"275","author":"Lewis","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpain.2013.12.002_bib31","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.neuroscience.2006.06.049","article-title":"Pain sensitivity in mice lacking the Ca(v)2.1alpha1 subunit of P\/Q-type Ca2+ channels","volume":"142","author":"Luvisetto","year":"2006","journal-title":"Neurosci"},{"key":"10.1016\/j.jpain.2013.12.002_bib32","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0304-3959(02)00097-0","article-title":"Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus","volume":"99","author":"Ma","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0304-3959(01)00255-X","article-title":"Effects of spinally delivered N- and P-type voltage-dependent calcium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy","volume":"92","author":"Matthews","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib34","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.neuroscience.2008.11.015","article-title":"A CB(2) receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: Contributions of spinal and peripheral CB(2) receptors","volume":"158","author":"McGaraughty","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpain.2013.12.002_bib35","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2174\/1568007043336743","article-title":"Voltage-gated calcium channels as targets for the treatment of chronic pain","volume":"3","author":"McGivern","year":"2004","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"10.1016\/j.jpain.2013.12.002_bib36","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jpain.2012.02.009","article-title":"Estimating efficacy and drug ED50's using von Frey thresholds: Impact of Weber's law and log transformation","volume":"13","author":"Mills","year":"2012","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib37","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.brainres.2004.07.066","article-title":"Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice","volume":"1024","author":"Murakami","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2013.12.002_bib38","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbr.2009.11.042","article-title":"Behavioral and neurochemical characterization of mice deficient in the N-type Ca2+ channel alpha1B subunit","volume":"208","author":"Nakagawasai","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jpain.2013.12.002_bib39","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.bmcl.2010.01.008","article-title":"Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors","volume":"20","author":"Pajouhesh","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jpain.2013.12.002_bib40","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.conb.2005.05.010","article-title":"Function and dysfunction of synaptic calcium channels: Insights from mouse models","volume":"15","author":"Pietrobon","year":"2005","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.jpain.2013.12.002_bib41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jpainsymman.2005.10.003","article-title":"A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain","volume":"31","author":"Rauck","year":"2006","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.jpain.2013.12.002_bib42","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0304-3959(92)90039-E","article-title":"The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation","volume":"50","author":"Ren","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib43","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/emboj\/20.10.2349","article-title":"Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel","volume":"20","author":"Saegusa","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.jpain.2013.12.002_bib44","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bcp.2011.10.019","article-title":"A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats","volume":"83","author":"Scott","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jpain.2013.12.002_bib45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0304-3959(01)00436-5","article-title":"The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices","volume":"96","author":"Smith","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib46","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1602\/neurorx.2.4.662","article-title":"Targeting chronic and neuropathic pain: The N-type calcium channel comes of age","volume":"2","author":"Snutch","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.jpain.2013.12.002_bib47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jama.291.1.63","article-title":"Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: A randomized controlled trial","volume":"291","author":"Staats","year":"2004","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jpain.2013.12.002_bib48","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1523\/JNEUROSCI.19-06-01895.1999","article-title":"Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels","volume":"19","author":"Talley","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2013.12.002_bib49","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1476-5381.2011.01256.x","article-title":"T-type voltage-gated calcium channels as targets for the development of novel pain therapies","volume":"163","author":"Todorovic","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jpain.2013.12.002_bib50","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00011-011-0322-9","article-title":"Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels","volume":"60","author":"Vortherms","year":"2011","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jpain.2013.12.002_bib51","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1586\/14737175.6.10.1423","article-title":"Ziconotide: A new nonopioid intrathecal analgesic for the treatment of chronic pain","volume":"6","author":"Wallace","year":"2006","journal-title":"Exp Rev Neurother"},{"key":"10.1016\/j.jpain.2013.12.002_bib52","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3959(99)00197-9","article-title":"Effects of intrathecal administration of ziconotide, a selective neuronal N-type calcium channel blocker, on mechanical allodynia and heat hyperalgesia in a rat model of postoperative pain","volume":"84","author":"Wang","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2013.12.002_bib53","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.bcp.2005.04.035","article-title":"Use-dependent blockade of Cav2.2 voltage-gated calcium channels for neuropathic pain","volume":"70","author":"Winquist","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jpain.2013.12.002_bib54","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: Increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jpain.2013.12.002_bib55","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1152\/jn.00463.2013","article-title":"A mixed Ca2+ channel blocker, A-1264087, utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain","volume":"111","author":"Xu","year":"2014","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2013.12.002_bib56","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1016\/j.bmcl.2009.09.008","article-title":"Scaffold-based design and synthesis of potent N-type calcium channel blockers","volume":"19","author":"Zamponi","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jpain.2013.12.002_bib57","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pain.2004.12.022","article-title":"ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model","volume":"114","author":"Zhuang","year":"2005","journal-title":"Pain"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152659001301434X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152659001301434X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:56:17Z","timestamp":1761508577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152659001301434X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S152659001301434X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2013.12.002","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic Insights Into the Analgesic Efficacy of A-1264087, a Novel Neuronal Ca2+ Channel Blocker That Reduces Nociception in Rat Preclinical Pain Models","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2013.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Pain Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}