{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:30:09Z","timestamp":1782779409082,"version":"3.54.5"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":3389,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.jpain.2014.02.008","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T02:18:32Z","timestamp":1395022712000},"page":"656-663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Exercise-Induced Modulation of Pain in Adults With and Without Painful Diabetic Neuropathy"],"prefix":"10.1016","volume":"15","author":[{"given":"Matthew T.","family":"Knauf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli F.","family":"Koltyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2014.02.008_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/dmrr.848","article-title":"Practical guidelines on the management and prevention of the diabetic foot","volume":"24","author":"Apelqvist","year":"2008","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.jpain.2014.02.008_bib2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0025-6196(11)61474-2","article-title":"Diabetic peripheral neuropathic pain: Clinical and quality-of-life issues","volume":"81","author":"Argoff","year":"2006","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jpain.2014.02.008_bib3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1634\/theoncologist.2009-S502","article-title":"Future directions in neuropathic pain therapy: Closing the translational loop","volume":"15","author":"Backonja","year":"2010","journal-title":"Oncologist"},{"key":"10.1016\/j.jpain.2014.02.008_bib4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00002508-200006001-00004","article-title":"Peripheral neuropathic pain: From mechanisms to symptoms","volume":"16","author":"Baron","year":"2000","journal-title":"Clin J Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/02640419608727718","article-title":"Post-exercise analgesia: Replication and extension","volume":"14","author":"Bartholomew","year":"1996","journal-title":"J Sports Sci"},{"key":"10.1016\/j.jpain.2014.02.008_bib6","doi-asserted-by":"crossref","first-page":"s114","DOI":"10.1080\/02701367.2000.11082794","article-title":"Assessment of physical activity: An international perspective","volume":"71","author":"Booth","year":"2000","journal-title":"Res Q Exerc Sport"},{"key":"10.1016\/j.jpain.2014.02.008_bib7","series-title":"Borg's Perceived Exertion and Pain Scales","first-page":"29","article-title":"The Borg RPE Scale","author":"Borg","year":"1998"},{"key":"10.1016\/j.jpain.2014.02.008_bib8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.pain.2003.12.024","article-title":"Development and validation of the Neuropathic Pain Screening Inventory","volume":"108","author":"Bouhassira","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib9","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0306-4522(03)00486-X","article-title":"Altered temporal pattern of mechanically evoked C-fiber activity in a model of diabetic neuropathy in the rat","volume":"121","author":"Chen","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpain.2014.02.008_bib10","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1097\/00005768-199708000-00004","article-title":"Naturally occurring muscle pain during exercise: Assessment and experimental evidence","volume":"29","author":"Cook","year":"1997","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jpain.2014.02.008_bib11","first-page":"256","article-title":"Pain and exercise","volume":"31","author":"Cook","year":"2000","journal-title":"Int J Sport Psychol"},{"key":"10.1016\/j.jpain.2014.02.008_bib12","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jpain.2009.11.010","article-title":"Exercise alters pain sensitivity in gulf war veterans with chronic musculoskeletal pain","volume":"11","author":"Cook","year":"2010","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib13","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International Physical Activity Questionnaire: 12-country reliability and validity","volume":"35","author":"Craig","year":"2003","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jpain.2014.02.008_bib14","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1185\/030079906X132488","article-title":"painDETECT: A new screening questionnaire to identify neuropathic components in patients with back pain","volume":"22","author":"Freynhagen","year":"2006","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.jpain.2014.02.008_bib15","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1079\/PHN2005898","article-title":"The International Physical Activity Questionnaire: A study of concurrent and construct validity","volume":"9","author":"Hagstr\u00f6mer","year":"2006","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.jpain.2014.02.008_bib16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1177\/014107689608900706","article-title":"Pain sensitivity, exercise and stoicism","volume":"89","author":"Janal","year":"1996","journal-title":"J R Soc Med"},{"key":"10.1016\/j.jpain.2014.02.008_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(01)01302-4","article-title":"The clinical picture of neuropathic pain","volume":"429","author":"Jensen","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpain.2014.02.008_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejpain.2005.12.013","article-title":"The effects of static muscular contraction on blood pressure, heart rate, pain ratings, and pressure pain thresholds in healthy individuals and patients with fibromyalgia","volume":"11","author":"Kadetoff","year":"2007","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib19","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jdiacomp.2012.05.007","article-title":"The effect of exercise on neuropathic symptoms, nerve fiber function, and cutaneous innervations in people with diabetic peripheral neuropathy","volume":"26","author":"Kluding","year":"2012","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.jpain.2014.02.008_bib20","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1249\/01.MSS.0000385842.83723.bb","article-title":"Exercise-induced modulation of pain","volume":"42","author":"Knauf","year":"2010","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jpain.2014.02.008_bib21","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.jpain.2012.01.137","article-title":"Exercise-induced pain modulation in adults with painful diabetic peripheral neuropathy","volume":"13","author":"Knauf","year":"2012","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/bjsm.32.1.20","article-title":"Perception of pain after resistance exercise","volume":"32","author":"Koltyn","year":"1998","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jpain.2014.02.008_bib23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2165\/00007256-200029020-00002","article-title":"Analgesia following exercise: A review","volume":"29","author":"Koltyn","year":"2000","journal-title":"Sports Med"},{"key":"10.1016\/j.jpain.2014.02.008_bib24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2165\/00007256-200232080-00001","article-title":"Exercise-induced hypoalgesia and intensity of exercise","volume":"32","author":"Koltyn","year":"2002","journal-title":"Sports Med"},{"key":"10.1016\/j.jpain.2014.02.008_bib25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2165\/00007256-200636030-00003","article-title":"Exercise, hypoalgesia, and blood pressure","volume":"36","author":"Koltyn","year":"2006","journal-title":"Sports Med"},{"key":"10.1016\/j.jpain.2014.02.008_bib26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0304-3959(95)00112-3","article-title":"Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls","volume":"64","author":"Kosek","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib27","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/00002508-200309000-00004","article-title":"Development of a neuropathic pain questionnaire","volume":"19","author":"Krause","year":"2003","journal-title":"Clin J Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jpain.2007.08.001","article-title":"Extended swimming exercise reduces inflammatory and peripheral neuropathic pain in rodents","volume":"8","author":"Kuphal","year":"2007","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pain.2010.06.021","article-title":"Dysfunction of endogenous pain inhibition during exercise with painful muscles in patients with shoulder myalgia and fibromyalgia","volume":"151","author":"Lannersten","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib30","series-title":"Profile of Mood States","author":"McNair","year":"1971"},{"key":"10.1016\/j.jpain.2014.02.008_bib31","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0304-3959(87)91074-8","article-title":"The Short-Form McGill Pain Questionnaire","volume":"30","author":"Melzack","year":"1987","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/AJP.0b013e318162eaf4","article-title":"Experimental pain sensitivity in women with temporomandibular disorders and pain-free controls: The relationship to orofacial muscular contraction and cardiovascular responses","volume":"24","author":"Mohn","year":"2008","journal-title":"Clin J Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2337\/dc06-1128","article-title":"Physical activity in U.S. adults with diabetes and at risk for developing diabetes, 2003","volume":"30","author":"Morrato","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpain.2014.02.008_bib34","doi-asserted-by":"crossref","first-page":"ES205","DOI":"10.36076\/ppj.2012\/15\/ES205","article-title":"Dysfunctional endogenous analgesia during exercise in patients with chronic pain: Exercise or not to exercise?","volume":"15","author":"Nijs","year":"2012","journal-title":"Pain Physician"},{"key":"10.1016\/j.jpain.2014.02.008_bib35","first-page":"119","article-title":"Exercise and pain: The neurobiology, measurement, and laboratory study of pain in relation to exercise in humans","volume":"27","author":"O\u2019Connor","year":"1999","journal-title":"Exerc Sport Sci Rev"},{"key":"10.1016\/j.jpain.2014.02.008_bib36","doi-asserted-by":"crossref","first-page":"11287","DOI":"10.1523\/JNEUROSCI.2659-06.2006","article-title":"Abnormal function of C-fibers in patients with diabetic neuropathy","volume":"26","author":"\u00d8rstavik","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2014.02.008_bib37","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1590\/S1807-59322011000900019","article-title":"Exercise training attenuates acute hyperalgesia streptozotocin-induced diabetic female rats","volume":"66","author":"Rossi","year":"2011","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1016\/j.jpain.2014.02.008_bib38","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1471-4159.2011.07302.x","article-title":"Forced-exercise delays neuropathic pain in experimental diabetes effects on voltage-activated calcium channels","volume":"118","author":"Shankarappa","year":"2011","journal-title":"J Neurochem"},{"key":"10.1016\/j.jpain.2014.02.008_bib39","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/108107301750254457","article-title":"A comparison of views of individuals with type 2 diabetes mellitus and diabetes educators about barriers to diet and exercise","volume":"6","author":"Shultz","year":"2001","journal-title":"J Health Commun"},{"key":"10.1016\/j.jpain.2014.02.008_bib40","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/ALN.0b013e318210f880","article-title":"Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: Role of endogenous opioids","volume":"114","author":"Stagg","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpain.2014.02.008_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0304-3959(03)00208-2","article-title":"Ratings of experimental pain and pain-related negative affect predict clinical pain in patients with fibromyalgia syndrome","volume":"105","author":"Staud","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib42","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pain.2005.08.007","article-title":"Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls","volume":"118","author":"Staud","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib43","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jpain.2006.02.005","article-title":"Advanced continuous-contact heat pulse design for efficient temporal summation of second pain (windup)","volume":"7","author":"Staud","year":"2006","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib44","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1136\/pgmj.2003.010553","article-title":"Barriers to physical activity in patients with diabetes","volume":"80","author":"Thomas","year":"2004","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.jpain.2014.02.008_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00007256-200434010-00001","article-title":"How many steps\/day are enough? Preliminary pedometer indices for public health","volume":"34","author":"Tudor-Locke","year":"2004","journal-title":"Sports Med"},{"key":"10.1016\/j.jpain.2014.02.008_bib46","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1249\/01.mss.0000321961.02829.76","article-title":"Examination of the dose-response relationship between pain perception and blood pressure following isometric exercise","volume":"40","author":"Umeda","year":"2008","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jpain.2014.02.008_bib47","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/j.1532-2149.2012.00193.x","article-title":"Evidence for central sensitization in chronic whiplash: A systematic literature review","volume":"17","author":"Van Oosterwijck","year":"2012","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib48","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1526-4637.2007.00347.x","article-title":"Painful diabetic neuropathy: Epidemiology, natural history, early diagnosis, and treatment options","volume":"9","author":"Veves","year":"2008","journal-title":"Pain Med"},{"key":"10.1016\/j.jpain.2014.02.008_bib49","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1054\/jpai.2001.25533","article-title":"The effect of maximal exercise on temporal summation of second pain (windup) in patients with fibromyalgia syndrome","volume":"2","author":"Vierck","year":"2001","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0304-3959(02)00421-9","article-title":"Differential recruitment of endogenous pain inhibitory systems in neuropathic pain patients","volume":"103","author":"Witting","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.008_bib51","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0304-3959(96)03082-5","article-title":"Effects of systematic morphine on responses of primates to first or second pain sensations","volume":"66","author":"Yeomans","year":"1996","journal-title":"Pain"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590014006075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590014006075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:57:14Z","timestamp":1761508634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590014006075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S1526590014006075"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2014.02.008","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise-Induced Modulation of Pain in Adults With and Without Painful Diabetic Neuropathy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2014.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Pain Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}