{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:32:41Z","timestamp":1792801961141,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":3359,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["FA9550-10-1-0177"],"award-info":[{"award-number":["FA9550-10-1-0177"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["2R01MH076136"],"award-info":[{"award-number":["2R01MH076136"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01DA027794-01"],"award-info":[{"award-number":["R01DA027794-01"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.jpain.2014.02.010","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T03:27:59Z","timestamp":1398310079000},"page":"734-746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["The Dynamics of Pain: Evidence for Simultaneous Site-Specific Habituation and Site-Nonspecific Sensitization in Thermal Pain"],"prefix":"10.1016","volume":"15","author":[{"given":"Marieke","family":"Jepma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor D.","family":"Wager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2014.02.010_bib1","doi-asserted-by":"crossref","first-page":"12964","DOI":"10.1523\/JNEUROSCI.0057-10.2010","article-title":"Brain mediators of predictive cue effects on perceived pain","volume":"30","author":"Atlas","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2014.02.010_bib2","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/(SICI)1522-2594(199905)41:5<1044::AID-MRM25>3.0.CO;2-M","article-title":"Human brain activation under controlled thermal stimulation and habituation to noxious heat: An fMRI study","volume":"41","author":"Becerra","year":"1999","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jpain.2014.02.010_bib3","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.pain.2011.02.027","article-title":"Operant learning of perceptual sensitization and habituation is impaired in fibromyalgia patients with and without irritable bowel syndrome","volume":"152","author":"Becker","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pain.2005.08.027","article-title":"Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network","volume":"120","author":"Bingel","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib5","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1152\/jn.2001.85.2.951","article-title":"Temporal and spatial dynamics of human forebrain activity during heat pain: Analysis by positron emission tomography","volume":"85","author":"Casey","year":"2001","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2014.02.010_bib6","doi-asserted-by":"crossref","first-page":"e1002719","DOI":"10.1371\/journal.pcbi.1002719","article-title":"Predictive dynamics of human pain perception","volume":"8","author":"Cecchi","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.jpain.2014.02.010_bib7","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1137\/0806023","article-title":"An interior trust region approach for nonlinear minimization subject to bounds","volume":"6","author":"Coleman","year":"1996","journal-title":"Siam J Optimiz"},{"key":"10.1016\/j.jpain.2014.02.010_bib8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0304-3959(81)90004-X","article-title":"Habituation to bearable experimental pain elicited by tooth pulp electrical stimulation","volume":"11","author":"Condes-Lara","year":"1981","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib9","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1111\/j.1468-2982.2007.01500.x","article-title":"Is the cerebral cortex hyperexcitable or hyperresponsive in migraine?","volume":"27","author":"Coppola","year":"2007","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jpain.2014.02.010_bib10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pain.2010.03.004","article-title":"Reply to the topical review entitled \u201cThe phenomenon of changes in cortical excitability in migraine is not migraine-specific\u2013A unifying thesis\u201d by Anne Stankewitz and Arne May published in Pain 2009;145:14\u20137","volume":"149","author":"Coppola","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10194-005-0183-0","article-title":"Habituation of single CO2 laser-evoked responses during interictal phase of migraine","volume":"6","author":"de Tommaso","year":"2005","journal-title":"J Headache Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib12","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.ejpain.2007.12.015","article-title":"Interactions between spatial summation, 2-point discrimination and habituation of heat pain","volume":"12","author":"Defrin","year":"2008","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib13","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/0028-3908(87)90275-9","article-title":"Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation","volume":"26","author":"Dickenson","year":"1987","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpain.2014.02.010_bib14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-3959(86)90077-1","article-title":"Pain perception decrement produced through repeated stimulation","volume":"26","author":"Ernst","year":"1986","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neulet.2003.12.064","article-title":"Peripheral and electrocortical responses to painful and non-painful stimulation in chronic pain patients, tension headache patients and healthy controls","volume":"361","author":"Flor","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2014.02.010_bib16","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm.2235","article-title":"Nociceptor sensitization in pain pathogenesis","volume":"16","author":"Gold","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.jpain.2014.02.010_bib17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pain.2006.02.003","article-title":"Contact heat-evoked temporal summation: Tonic versus repetitive-phasic stimulation","volume":"122","author":"Granot","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pain.2007.04.026","article-title":"Peripheral and central components of habituation of heat pain perception and evoked potentials in humans","volume":"132","author":"Greffrath","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib19","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1152\/jn.00730.2001","article-title":"Transient analgesia evoked by noxious stimulus offset","volume":"87","author":"Grill","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2014.02.010_bib20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1037\/h0029810","article-title":"Habituation: A dual-process theory","volume":"77","author":"Groves","year":"1970","journal-title":"Psychol Rev"},{"key":"10.1016\/j.jpain.2014.02.010_bib21","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1152\/jappl.1965.20.5.1014","article-title":"Skin temperature and cutaneous pain during warm water immersion","volume":"20","author":"Hardy","year":"1965","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jpain.2014.02.010_bib22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.pain.2009.07.002","article-title":"Women experience greater heat pain adaptation and habituation than men","volume":"145","author":"Hashmi","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.pain.2010.08.046","article-title":"Effects of temperature on heat pain adaptation and habituation in men and women","volume":"151","author":"Hashmi","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0301-0082(99)00051-9","article-title":"Wind-up of spinal cord neurones and pain sensation: Much ado about something?","volume":"61","author":"Herrero","year":"2000","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jpain.2014.02.010_bib25","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.pain.2011.02.049","article-title":"Changes in pain from a repetitive thermal stimulus: The roles of adaptation and sensitization","volume":"152","author":"Hollins","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib26","first-page":"201","article-title":"Lack of habituation of pain evoked potentials after naloxone","volume":"31","author":"Janicki","year":"1979","journal-title":"Pol J Pharmacol Pharm"},{"key":"10.1016\/j.jpain.2014.02.010_bib27","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.neuroimage.2011.08.083","article-title":"Turning on the alarm: The neural mechanisms of the transition from innocuous to painful sensation","volume":"59","author":"Johnstone","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.jpain.2014.02.010_bib28","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1152\/jn.1978.41.2.509","article-title":"Comparison of responses of warm and nociceptive C-fiber afferents in monkey with human judgments of thermal pain","volume":"41","author":"LaMotte","year":"1978","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2014.02.010_bib29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0304-3959(98)00154-7","article-title":"Windup leads to characteristics of central sensitization","volume":"79","author":"Li","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib30","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.neuroimage.2011.07.077","article-title":"Estimating and testing variance components in a multi-level GLM","volume":"59","author":"Lindquist","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.jpain.2014.02.010_bib31","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3758\/BF03210951","article-title":"Using confidence intervals in within-subject designs","volume":"1","author":"Loftus","year":"1994","journal-title":"Psychon Bull Rev"},{"key":"10.1016\/j.jpain.2014.02.010_bib32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pain.2008.02.034","article-title":"Chronic pain may change the structure of the brain","volume":"137","author":"May","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/j.1532-2149.2011.00023.x","article-title":"Within-session sensitization and between-session habituation: A robust physiological response to repetitive painful heat stimulation","volume":"16","author":"May","year":"2012","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib34","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0014-4886(66)90068-9","article-title":"Physiological properties of unmyelinated fiber projection to the spinal cord","volume":"16","author":"Mendell","year":"1966","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jpain.2014.02.010_bib35","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/BF00231861","article-title":"Habituation to repeated painful and non-painful cutaneous stimuli: A quantitative psychophysical study","volume":"87","author":"Milne","year":"1991","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.jpain.2014.02.010_bib36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijpsycho.2009.10.008","article-title":"Brain activation patterns underlying fast habituation to painful laser stimuli","volume":"75","author":"Mobascher","year":"2010","journal-title":"Int J Psychophysiol"},{"key":"10.1016\/j.jpain.2014.02.010_bib37","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1467-9280.1996.tb00352.x","article-title":"Mechanisms of placebo pain reduction: An empirical investigation","volume":"7","author":"Montgomery","year":"1996","journal-title":"Psychol Sci"},{"key":"10.1016\/j.jpain.2014.02.010_bib38","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1523\/JNEUROSCI.23-11-04766.2003","article-title":"Fatigue and paradoxical enhancement of heat response in C-fiber nociceptors from cross-modal excitation","volume":"23","author":"Peng","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2014.02.010_bib39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0304-3959(89)90176-0","article-title":"Chronic low-back pain and the reaction to repeated acute pain stimulation","volume":"39","author":"Peters","year":"1989","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib40","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.neuroimage.2009.04.028","article-title":"Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo\/nocebo factors: Evidence from human psychophysics, animal models, and neuroimaging","volume":"47","author":"Price","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.jpain.2014.02.010_bib41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0304-3959(77)90035-5","article-title":"Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses","volume":"3","author":"Price","year":"1977","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0304-3959(94)90069-8","article-title":"The N-methyl-d-aspartate receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man","volume":"59","author":"Price","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-3959(83)90126-4","article-title":"The validation of visual analogue scales as ratio scale measures for chronic and experimental pain","volume":"17","author":"Price","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib44","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1152\/jn.1989.62.6.1270","article-title":"Spatial summation of heat-induced pain: Influence of stimulus area and spatial separation of stimuli on perceived pain sensation intensity and unpleasantness","volume":"62","author":"Price","year":"1989","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2014.02.010_bib45","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jpain.2005.12.011","article-title":"Peripheral and central contributions to hyperalgesia in irritable bowel syndrome","volume":"7","author":"Price","year":"2006","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.nlm.2008.09.012","article-title":"Habituation revisited: An updated and revised description of the behavioral characteristics of habituation","volume":"92","author":"Rankin","year":"2009","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.jpain.2014.02.010_bib47","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.pain.2009.12.014","article-title":"Habituation to pain: Further support for a central component","volume":"148","author":"Rennefeld","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib48","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0079-6123(08)60382-9","article-title":"Functional contributions of the primate pulvinar","volume":"95","author":"Robinson","year":"1993","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.jpain.2014.02.010_bib49","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.conb.2009.05.007","article-title":"Gain control in the visual thalamus during perception and cognition","volume":"19","author":"Saalmann","year":"2009","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.jpain.2014.02.010_bib50","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.pain.2008.09.018","article-title":"Habituation and sensitization to heat and cold pain in women with fibromyalgia and healthy controls","volume":"140","author":"Smith","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib51","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pain.2009.03.010","article-title":"The phenomenon of changes in cortical excitability in migraine is not migraine-specific\u2014A unifying thesis","volume":"145","author":"Stankewitz","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib52","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/0333102412470215","article-title":"Neuronal correlates of impaired habituation in response to repeated trigemino-nociceptive but not to olfactory input in migraineurs: An fMRI study","volume":"33","author":"Stankewitz","year":"2013","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jpain.2014.02.010_bib53","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.pain.2013.05.019","article-title":"Pain sensitisers exhibit grey matter changes after repetitive pain exposure: A longitudinal voxel-based morphometry study","volume":"154","author":"Stankewitz","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib54","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pain.2006.10.010","article-title":"Brain activity related to temporal summation of C-fiber evoked pain","volume":"129","author":"Staud","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib55","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pain.2009.05.020","article-title":"Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: A randomized, double-blind, placebo-controlled study","volume":"145","author":"Staud","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib56","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1037\/h0022681","article-title":"Habituation: A model phenomenon for the study of neuronal substrates of behavior","volume":"73","author":"Thompson","year":"1966","journal-title":"Psychol Rev"},{"key":"10.1016\/j.jpain.2014.02.010_bib57","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1152\/jn.2001.86.3.1499","article-title":"Differential coding of pain intensity in the human primary and secondary somatosensory cortex","volume":"86","author":"Timmermann","year":"2001","journal-title":"J Neurophysiol"},{"issue":"Pt 3","key":"10.1016\/j.jpain.2014.02.010_bib58","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1113\/jphysiol.1995.sp020619","article-title":"Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin","volume":"483","author":"Treede","year":"1995","journal-title":"J Physiol"},{"key":"10.1016\/j.jpain.2014.02.010_bib59","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3959(03)00137-4","article-title":"Reduced habituation to experimental pain in migraine patients: A CO2 laser evoked potential study","volume":"105","author":"Valeriani","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib60","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0304-3959(03)00210-0","article-title":"Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patients","volume":"105","author":"Verne","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib61","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.neuroimage.2009.05.043","article-title":"Brain mediators of cardiovascular responses to social threat, Part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity","volume":"47","author":"Wager","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.jpain.2014.02.010_bib62","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/306686a0","article-title":"Evidence for a central component of post-injury pain hypersensitivity","volume":"306","author":"Woolf","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.jpain.2014.02.010_bib63","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central sensitization: Implications for the diagnosis and treatment of pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2014.02.010_bib64","doi-asserted-by":"crossref","first-page":"10264","DOI":"10.1523\/JNEUROSCI.4648-08.2009","article-title":"Temporal filtering of nociceptive information by dynamic activation of endogenous pain modulatory systems","volume":"29","author":"Yelle","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2014.02.010_bib65","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.pain.2007.04.014","article-title":"Offset analgesia: A temporal contrast mechanism for nociceptive information","volume":"134","author":"Yelle","year":"2008","journal-title":"Pain"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590014006932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590014006932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:58:11Z","timestamp":1786132691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590014006932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":65,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1526590014006932"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2014.02.010","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Dynamics of Pain: Evidence for Simultaneous Site-Specific Habituation and Site-Nonspecific Sensitization in Thermal Pain","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2014.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Pain Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}