{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:03:37Z","timestamp":1783739017628,"version":"3.55.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":2505,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jpain.2016.07.007","type":"journal-article","created":{"date-parts":[[2016,9,25]],"date-time":"2016-09-25T04:11:03Z","timestamp":1474776663000},"page":"1183-1197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["A Role for Bradykinin Signaling in Chronic Vulvar Pain"],"prefix":"10.1016","volume":"17","author":[{"given":"Megan L.","family":"Falsetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collynn F.","family":"Woeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Pollock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne D.","family":"Bonham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine G.","family":"Haidaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Phipps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2016.07.007_bib1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/01.AOG.0000199951.26822.27","article-title":"Vulvodynia: Characteristics and associations with comorbidities and quality of life","volume":"107","author":"Arnold","year":"2006","journal-title":"Obstetr Gynecol"},{"key":"10.1016\/j.jpain.2016.07.007_bib2","doi-asserted-by":"crossref","first-page":"101.e1","DOI":"10.1016\/j.ajog.2007.05.037","article-title":"Association between primary vulvar vestibulitis syndrome, defective induction of tumor necrosis factor-alpha, and carriage of the mannose-binding lectin codon 54 gene polymorphism","volume":"198","author":"Babula","year":"2008","journal-title":"Am J Obstetr Gynecol"},{"key":"10.1016\/j.jpain.2016.07.007_bib3","doi-asserted-by":"crossref","first-page":"28944","DOI":"10.1074\/jbc.M800685200","article-title":"The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB","volume":"283","author":"Baglole","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpain.2016.07.007_bib4","first-page":"115","article-title":"Isolation and phenotypic characterization of lung fibroblasts","volume":"117","author":"Baglole","year":"2005","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.jpain.2016.07.007_bib5","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1021\/jm2016057","article-title":"From bradykinin B2 receptor antagonists to orally active and selective bradykinin B1 receptor antagonists","volume":"55","author":"Barth","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.jpain.2016.07.007_bib6","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.peptides.2008.12.003","article-title":"Structure-activity relationships of novel peptide agonists of the human bradykinin B2 receptor","volume":"30","author":"Belanger","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.jpain.2016.07.007_bib7","first-page":"45","article-title":"Vulvar vestibulitis syndrome: Reliability of diagnosis and evaluation of current diagnostic criteria","volume":"98","author":"Bergeron","year":"2001","journal-title":"Obstetr Gynecol"},{"key":"10.1016\/j.jpain.2016.07.007_bib8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1160\/TH13-03-0258","article-title":"Plasma kallikrein: The bradykinin-producing enzyme","volume":"110","author":"Bjorkqvist","year":"2013","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jpain.2016.07.007_bib9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.peptides.2013.08.003","article-title":"Release of biologically active kinin peptides, Met-Lys-bradykinin and Leu-Met-Lys-bradykinin from human kininogens by two major secreted aspartic proteases of Candida parapsilosis","volume":"48","author":"Bras","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.jpain.2016.07.007_bib10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1515\/hsz-2012-0157","article-title":"Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides, Met-Lys-bradykinin and des-Arg(9)-Met-Lys-bradykinin","volume":"393","author":"Bras","year":"2012","journal-title":"Biol Chem"},{"key":"10.1016\/j.jpain.2016.07.007_bib11","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1172\/JCI42143","article-title":"Some new insights into the molecular mechanisms of pain perception","volume":"120","author":"Brown","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jpain.2016.07.007_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(00)00335-3","article-title":"Kinins in pain and inflammation","volume":"87","author":"Calixto","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2016.07.007_bib13","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bcp.2013.06.005","article-title":"Characterization of a novel proinflammatory effect mediated by BK and the kinin B(2) receptor in human preadipocytes","volume":"86","author":"Catalioto","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jpain.2016.07.007_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bcp.2015.07.034","article-title":"Enhanced Ca(2+) response and stimulation of prostaglandin release by the bradykinin B2 receptor in human retinal pigment epithelial cells primed with proinflammatory cytokines","volume":"97","author":"Catalioto","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jpain.2016.07.007_bib15","first-page":"512","volume":"74","author":"Cavalli","year":"1987","journal-title":"Radiol Med"},{"key":"10.1016\/j.jpain.2016.07.007_bib16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0304-3959(00)00331-6","article-title":"Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy","volume":"88","author":"Cui","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2016.07.007_bib17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1476-5381.1992.tb14503.x","article-title":"The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia","volume":"107","author":"Cunha","year":"1992","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jpain.2016.07.007_bib18","first-page":"135","article-title":"Childhood sexual and physical abuse. Incidence in patients with vulvodynia","volume":"42","author":"Edwards","year":"1997","journal-title":"J Reprod Med"},{"key":"10.1016\/j.jpain.2016.07.007_bib19","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bbi.2009.01.012","article-title":"The role of IL-6 and IL-1beta in painful perineural inflammatory neuritis","volume":"23","author":"Eliav","year":"2009","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jpain.2016.07.007_bib20","doi-asserted-by":"crossref","first-page":"38.e1","DOI":"10.1016\/j.ajog.2015.02.002","article-title":"Identification of novel mechanisms involved in generating localized vulvodynia pain","volume":"213","author":"Falsetta","year":"2015","journal-title":"Am J Obstetr Gynecol"},{"key":"10.1016\/j.jpain.2016.07.007_bib21","doi-asserted-by":"crossref","first-page":"101ra191","DOI":"10.1126\/scitranslmed.3002613","article-title":"Repeated vulvovaginal fungal infections cause persistent pain in a mouse model of vulvodynia","volume":"3","author":"Farmer","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jpain.2016.07.007_bib22","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.4049\/jimmunol.144.9.3347","article-title":"Quantitative analysis of cytokine gene expression in rheumatoid arthritis","volume":"144","author":"Firestein","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.jpain.2016.07.007_bib23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/01.j.pain.0000460320.95267.5d","article-title":"Site-specific mesenchymal control of inflammatory pain to yeast challenge in vulvodynia afflicted and pain-free women","volume":"156","author":"Foster","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2016.07.007_bib24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0029-7844(96)00447-4","article-title":"Elevated tissue levels of interleukin-1 beta and tumor necrosis factor-alpha in vulvar vestibulitis","volume":"89","author":"Foster","year":"1997","journal-title":"Obstetr Gynecol"},{"key":"10.1016\/j.jpain.2016.07.007_bib25","doi-asserted-by":"crossref","first-page":"346.e1","DOI":"10.1016\/j.ajog.2006.12.038","article-title":"Enhanced synthesis of proinflammatory cytokines by vulvar vestibular fibroblasts: Implications for vulvar vestibulitis","volume":"196","author":"Foster","year":"2007","journal-title":"Am J Obstetr Gynecol"},{"key":"10.1016\/j.jpain.2016.07.007_bib26","first-page":"503","article-title":"Impact of genetic variation in interleukin-1 receptor antagonist and melanocortin-1 receptor genes on vulvar vestibulitis syndrome","volume":"49","author":"Foster","year":"2004","journal-title":"J Reprod Med"},{"key":"10.1016\/j.jpain.2016.07.007_bib27","first-page":"G1","article-title":"Kinins as mediators of intestinal secretion","volume":"256","author":"Gaginella","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpain.2016.07.007_bib28","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1743-6109.2009.01642.x","article-title":"Pelvic floor muscle assessment outcomes in women with and without provoked vestibulodynia and the impact of a physical therapy program","volume":"7","author":"Gentilcore-Saulnier","year":"2010","journal-title":"J Sex Med"},{"key":"10.1016\/j.jpain.2016.07.007_bib29","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1093\/bioinformatics\/btr427","article-title":"Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq unified mapper (RUM)","volume":"27","author":"Grant","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jpain.2016.07.007_bib30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.det.2010.07.002","article-title":"Vulvodynia: New concepts and review of the literature","volume":"28","author":"Groysman","year":"2010","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.jpain.2016.07.007_bib31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/01.lgt.0000225898.37090.04","article-title":"Report of the International Society for the Study of Vulvovaginal Disease terminology and classification of vulvodynia","volume":"11","author":"Haefner","year":"2007","journal-title":"J Low Genit Tract Dis"},{"key":"10.1016\/j.jpain.2016.07.007_bib32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00128360-200501000-00009","article-title":"The vulvodynia guideline","volume":"9","author":"Haefner","year":"2005","journal-title":"J Low Genit Tract Dis"},{"key":"10.1016\/j.jpain.2016.07.007_bib33","doi-asserted-by":"crossref","first-page":"40.e1","DOI":"10.1016\/j.ajog.2013.09.033","article-title":"Prevalence of symptoms consistent with a diagnosis of vulvodynia: Population-based estimates from 2 geographic regions","volume":"210","author":"Harlow","year":"2014","journal-title":"Am J Obstetr Gynecol"},{"key":"10.1016\/j.jpain.2016.07.007_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fphar.2014.00017","article-title":"Female reproductive tract pain: Targets, challenges, and outcomes","volume":"5","author":"Jobling","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jpain.2016.07.007_bib35","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1128\/iai.58.7.2139-2143.1990","article-title":"Activation of the plasma kallikrein-kinin system by Candida albicans proteinase","volume":"58","author":"Kaminishi","year":"1990","journal-title":"Infect Immun"},{"key":"10.1016\/j.jpain.2016.07.007_bib36","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1016\/j.peptides.2011.10.021","article-title":"Molecular determinants of the interaction between human high molecular weight kininogen and Candida albicans cell wall: Identification of kininogen-binding proteins on fungal cell wall and mapping the cell wall-binding regions on kininogen molecule","volume":"32","author":"Karkowska-Kuleta","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.jpain.2016.07.007_bib37","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1248\/bpb.34.1170","article-title":"Prostaglandin E2 and pain\u2013an update","volume":"34","author":"Kawabata","year":"2011","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jpain.2016.07.007_bib38","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0002-9440(10)61768-3","article-title":"Fibroblast heterogeneity: Existence of functionally distinct Thy 1(+) and Thy 1(\u2212) human female reproductive tract fibroblasts","volume":"159","author":"Koumas","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jpain.2016.07.007_bib39","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12866-015-0394-8","article-title":"Kinin release from human kininogen by 10 aspartic proteases produced by pathogenic yeast Candida albicans","volume":"15","author":"Kozik","year":"2015","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jpain.2016.07.007_bib40","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1124\/mol.110.064840","article-title":"Bradykinin B2 receptor interacts with integrin alpha5beta1 to transactivate epidermal growth factor receptor in kidney cells","volume":"78","author":"Kramarenko","year":"2010","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jpain.2016.07.007_bib41","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jpain.2016.07.007_bib42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/LGT.0b013e3182a55591","article-title":"CD4-positive T-cell recruitment in primary-provoked localized vulvodynia: Potential insights into disease triggers","volume":"18","author":"Leclair","year":"2014","journal-title":"J Low Genit Tract Dis"},{"key":"10.1016\/j.jpain.2016.07.007_bib43","doi-asserted-by":"crossref","first-page":"C672","DOI":"10.1152\/ajpcell.00451.2009","article-title":"Novel anti-adipogenic activity produced by human fibroblasts","volume":"299","author":"Lehmann","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jpain.2016.07.007_bib44","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ejphar.2010.02.020","article-title":"Up-regulation of bradykinin receptors in rat bronchi via I kappa B kinase-mediated inflammatory signaling pathway","volume":"634","author":"Lei","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpain.2016.07.007_bib45","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1124\/jpet.106.105569","article-title":"Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity","volume":"319","author":"Lin","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2016.07.007_bib46","first-page":"390","article-title":"Vulvodynia as a somatoform disorder","volume":"53","author":"Lynch","year":"2008","journal-title":"J Reprod Med"},{"key":"10.1016\/j.jpain.2016.07.007_bib47","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrd1522","article-title":"Bradykinin receptor ligands: Therapeutic perspectives","volume":"3","author":"Marceau","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jpain.2016.07.007_bib48","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/j.1398-9995.2011.02686.x","article-title":"New topics in bradykinin research","volume":"66","author":"Maurer","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jpain.2016.07.007_bib49","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/j.1476-5381.2012.01830.x","article-title":"Inflammatory muscle pain is dependent on the activation of kinin B(1) and B(2) receptors and intracellular kinase pathways","volume":"166","author":"Meotti","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jpain.2016.07.007_bib50","first-page":"2010","article-title":"Pattern recognition via the toll-like receptor system in the human female genital tract","volume":"976024","author":"Nasu","year":"2010","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jpain.2016.07.007_bib51","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.2174\/138161206778743457","article-title":"Innate immunity in the mucosal immune system","volume":"12","author":"Nochi","year":"2006","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jpain.2016.07.007_bib52","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/j.1365-2133.2010.09684.x","article-title":"British Society for the Study of Vulval Disease Guideline (BSSVD) Guideline Group: Guidelines for the management of vulvodynia","volume":"162","author":"Nunns","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jpain.2016.07.007_bib53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3959(01)00420-1","article-title":"Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in\u00a0vivo","volume":"96","author":"Obreja","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2016.07.007_bib54","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1046\/j.1464-410X.2002.02655.x","article-title":"The cloacal plate: The missing link in anorectal and urogenital development","volume":"89","author":"Penington","year":"2002","journal-title":"BJU Int"},{"key":"10.1016\/j.jpain.2016.07.007_bib55","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1046\/j.1464-410X.2002.02656.x","article-title":"The urethral plate\u2013does it grow into the genital tubercle or within it?","volume":"89","author":"Penington","year":"2002","journal-title":"BJU Int"},{"key":"10.1016\/j.jpain.2016.07.007_bib56","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1152\/physrev.00048.2010","article-title":"Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors","volume":"92","author":"Petho","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jpain.2016.07.007_bib57","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1515\/bc.2010.083","article-title":"Degradation of human kininogens with the release of kinin peptides by extracellular proteinases of Candida spp","volume":"391","author":"Rapala-Kozik","year":"2010","journal-title":"Biol Chem"},{"key":"10.1016\/j.jpain.2016.07.007_bib58","doi-asserted-by":"crossref","first-page":"170.e1","DOI":"10.1016\/j.ajog.2011.08.012","article-title":"Prevalence and demographic characteristics of vulvodynia in a population-based sample","volume":"206","author":"Reed","year":"2012","journal-title":"Am J Obstetr Gynecol"},{"key":"10.1016\/j.jpain.2016.07.007_bib59","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/AOG.0000000000000066","article-title":"Factors associated with vulvodynia incidence","volume":"123","author":"Reed","year":"2014","journal-title":"Obstetr Gynecol"},{"key":"10.1016\/j.jpain.2016.07.007_bib60","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejphar.2012.07.051","article-title":"Bradykinin- and lipopolysaccharide-induced bradykinin B2 receptor expression, interleukin 8 release and \u201cnitrosative stress\u201d in bronchial epithelial cells BEAS-2B: Role for neutrophils","volume":"694","author":"Ricciardolo","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpain.2016.07.007_bib61","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jpain.2016.07.007_bib62","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00005392-199907000-00030","article-title":"Activation of the kallikrein kinin system in interstitial cystitis","volume":"162","author":"Rosamilia","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.jpain.2016.07.007_bib63","first-page":"679","article-title":"Clinical profile of vulvodynia patients. A prospective study of 300 patients","volume":"45","author":"Sadownik","year":"2000","journal-title":"J Reprod Med"},{"key":"10.1016\/j.jpain.2016.07.007_bib64","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2147\/IJWH.S37660","article-title":"Etiology, diagnosis, and clinical management of vulvodynia","volume":"6","author":"Sadownik","year":"2014","journal-title":"Int J Womens Health"},{"key":"10.1016\/j.jpain.2016.07.007_bib65","doi-asserted-by":"crossref","first-page":"691","DOI":"10.12891\/ceog17402014","article-title":"Elevated tissue levels of tumor necrosis factor-alpha in vulvar vestibulitis syndrome","volume":"41","author":"Seckin-Alac","year":"2014","journal-title":"Clin Exp Obstetr Gynecol"},{"key":"10.1016\/j.jpain.2016.07.007_bib66","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neulet.2003.12.007","article-title":"Recent findings on how proinflammatory cytokines cause pain: Peripheral mechanisms in inflammatory and neuropathic hyperalgesia","volume":"361","author":"Sommer","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2016.07.007_bib67","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.peptides.2003.10.016","article-title":"Bradykinin antagonists: Discovery and development","volume":"25","author":"Stewart","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.jpain.2016.07.007_bib68","doi-asserted-by":"crossref","first-page":"476.e1","DOI":"10.1016\/j.ajog.2014.10.1098","article-title":"Activation of vestibule-associated lymphoid tissue in localized provoked vulvodynia","volume":"212","author":"Tommola","year":"2015","journal-title":"Am J Obstetr Gynecol"},{"key":"10.1016\/j.jpain.2016.07.007_bib69","first-page":"533","article-title":"Association of human papillomavirus with vulvodynia and the vulvar vestibulitis syndrome","volume":"33","author":"Turner","year":"1988","journal-title":"J Reprod Med"},{"key":"10.1016\/j.jpain.2016.07.007_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1254\/jphs.93.1","article-title":"Roles for the kallikrein-kinin system in inflammatory exudation and pain: Lessons from studies on kininogen-deficient rats","volume":"93","author":"Ueno","year":"2003","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.jpain.2016.07.007_bib71","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s13760-014-0411-y","article-title":"Nociception and role of immune system in pain","volume":"115","author":"Verma","year":"2015","journal-title":"Acta Neurol Belg"},{"key":"10.1016\/j.jpain.2016.07.007_bib72","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1515\/BC.2006.003","article-title":"Bradykinin and peripheral sensitization","volume":"387","author":"Wang","year":"2006","journal-title":"Biol Chem"},{"key":"10.1016\/j.jpain.2016.07.007_bib73","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.jpain.2012.06.006","article-title":"Reliability and reproducibility of novel methodology for assessment of pressure pain sensitivity in pelvis","volume":"13","author":"Zolnoun","year":"2012","journal-title":"J Pain"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152659001630181X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152659001630181X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T23:17:10Z","timestamp":1694906230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152659001630181X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":73,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S152659001630181X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2016.07.007","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Role for Bradykinin Signaling in Chronic Vulvar Pain","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2016.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American Pain Society","name":"copyright","label":"Copyright"}]}}