{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:50:30Z","timestamp":1778745030235,"version":"3.51.4"},"reference-count":71,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":2140,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.jpain.2017.06.007","type":"journal-article","created":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T06:32:22Z","timestamp":1499495542000},"page":"1354-1364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Synergistic Interaction Between Dexmedetomidine and Ulinastatin Against Vincristine-Induced Neuropathic Pain in Rats"],"prefix":"10.1016","volume":"18","author":[{"given":"Bilin","family":"Nie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuxi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxiu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaochao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weian","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-9653","authenticated-orcid":false,"given":"Handong","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2017.06.007_bib1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s12032-014-0405-x","article-title":"Protective effect of ulinastatin in patients with non-small cell lung cancer after radiation therapy: A randomized, placebo-controlled study","volume":"32","author":"Bao","year":"2015","journal-title":"Med Oncol"},{"key":"10.1016\/j.jpain.2017.06.007_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/ANA.0b013e31826318af","article-title":"The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery","volume":"25","author":"Bekker","year":"2013","journal-title":"J Neurosurg Anesthesiol"},{"key":"10.1016\/j.jpain.2017.06.007_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-2094-9-23","article-title":"TNF-alpha protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation","volume":"9","author":"Belarbi","year":"2012","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jpain.2017.06.007_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0031-6997(25)00026-2","article-title":"What is synergy?","volume":"41","author":"Berenbaum","year":"1989","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jpain.2017.06.007_bib5","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/bjp.2008.278","article-title":"Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice","volume":"155","author":"Bruzzone","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jpain.2017.06.007_bib6","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1399-6576.2009.02019.x","article-title":"Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury","volume":"53","author":"Can","year":"2009","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.jpain.2017.06.007_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jpain.2017.06.007_bib8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s11596-014-1277-1","article-title":"Differential expression of alpha-adrenoceptor subtypes in rat dorsal root ganglion after chronic constriction injury","volume":"34","author":"Cheng","year":"2014","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"10.1016\/j.jpain.2017.06.007_bib9","first-page":"488","article-title":"Action of antiproteases on the inflammatory response in acute pancreatitis","volume":"8","author":"Chen","year":"2007","journal-title":"JOP"},{"key":"10.1016\/j.jpain.2017.06.007_bib10","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1001\/jama.2015.0894","article-title":"Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia","volume":"313","author":"Diouf","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.jpain.2017.06.007_bib11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.pharmthera.2009.04.001","article-title":"Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis","volume":"123","author":"Fairbanks","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jpain.2017.06.007_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pharmthera.2010.01.002","article-title":"Chemokines, neuronal-glial interactions, and central processing of neuropathic pain","volume":"126","author":"Gao","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jpain.2017.06.007_bib13","first-page":"218","article-title":"Ulinastatin exerts synergistic effects with taxotere and inhibits invasion and metastasis of breast cancer by blocking angiogenesis and the epithelial-mesenchymal transition","volume":"28","author":"Gao","year":"2013","journal-title":"Cancer Biother Radiopharm"},{"key":"10.1016\/j.jpain.2017.06.007_bib14","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1093\/brain\/aww251","article-title":"Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice","volume":"139","author":"Geisler","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.jpain.2017.06.007_bib15","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s00520-014-2158-7","article-title":"A phase III randomized, placebo-controlled study of topical amitriptyline and ketamine for chemotherapy-induced peripheral neuropathy (CIPN): A University of Rochester CCOP study of 462 cancer survivors","volume":"22","author":"Gewandter","year":"2014","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jpain.2017.06.007_bib16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3344\/kjp.2015.28.2.156","article-title":"Combined use of intrathecal opioids and dexmedetomidine in the management of neuropathic pain","volume":"28","author":"Ghobadifar","year":"2015","journal-title":"Korean J Pain"},{"key":"10.1016\/j.jpain.2017.06.007_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0304-3959(02)00047-7","article-title":"Phase III evaluation of nortriptyline for alleviation of symptoms of cis-platinum-induced peripheral neuropathy","volume":"98","author":"Hammack","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2017.06.007_bib18","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/ALN.0b013e3181de6d2c","article-title":"Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function","volume":"113","author":"Hayashida","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpain.2017.06.007_bib19","first-page":"91","article-title":"A rat pain model of vincristine-induced neuropathy","volume":"99","author":"Higuera","year":"2004","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.jpain.2017.06.007_bib20","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.2165\/11207190-000000000-00000","article-title":"Dexmedetomidine: A review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation","volume":"71","author":"Hoy","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.jpain.2017.06.007_bib21","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1523\/JNEUROSCI.0646-16.2016","article-title":"mir-500-mediated GAD67 downregulation contributes to neuropathic pain","volume":"36","author":"Huang","year":"2016","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2017.06.007_bib22","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1161\/CIRCULATIONAHA.112.000936","article-title":"Perioperative dexmedetomidine improves outcomes of cardiac surgery","volume":"127","author":"Ji","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jpain.2017.06.007_bib23","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3344\/kjp.2013.26.4.356","article-title":"The effect of urinary trypsin inhibitor against neuropathic pain in rat models","volume":"26","author":"Jung","year":"2013","journal-title":"Korean J Pain"},{"key":"10.1016\/j.jpain.2017.06.007_bib24","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/aas.12039","article-title":"Effects of dexmedetomidine on inflammatory responses in patients undergoing laparoscopic cholecystectomy","volume":"57","author":"Kang","year":"2013","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.jpain.2017.06.007_bib25","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1097\/00000542-200306000-00027","article-title":"Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain","volume":"98","author":"Kawamata","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpain.2017.06.007_bib26","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1097\/01586154-201305000-00028","article-title":"Dexmedetomidine suppresses proinflammatory mediator production in human whole blood in\u00a0vitro","volume":"74","author":"Kawasaki","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jpain.2017.06.007_bib27","first-page":"1847","article-title":"Inhibition of tumor cell invasion through matrigel by a peptide derived from the domain II region in urinary trypsin inhibition","volume":"55","author":"Kobayashi","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.jpain.2017.06.007_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3959(99)00195-5","article-title":"Cytokine involvement in dynorphin-induced allodynia","volume":"84","author":"Laughlin","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2017.06.007_bib29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.36076\/ppj.2012\/15\/287","article-title":"The effect of epidural resiniferatoxin in the neuropathic pain rat model","volume":"15","author":"Lee","year":"2012","journal-title":"Pain Phys"},{"key":"10.1016\/j.jpain.2017.06.007_bib30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/j.pain.0000000000000312","article-title":"Regular physical activity prevents chronic pain by altering resident muscle macrophage phenotype and increasing interleukin-10 in mice","volume":"157","author":"Leung","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2017.06.007_bib31","first-page":"2015","article-title":"Dexmedetomidine analgesia effects in patients undergoing dental implant surgery and its impact on postoperative inflammatory and oxidative stress","volume":"186736","author":"Li","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jpain.2017.06.007_bib32","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1007\/s00134-014-3366-9","article-title":"An exciting candidate therapy for sepsis: Ulinastatin, a urinary protease inhibitor","volume":"40","author":"Linder","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jpain.2017.06.007_bib33","first-page":"375","article-title":"Negative immunoregulatory effects of noradrenaline through alpha2-adrenoceptor activation","volume":"21","author":"Maes","year":"2000","journal-title":"Neuro Endocrinol Lett"},{"key":"10.1016\/j.jpain.2017.06.007_bib34","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1017\/S0033291702005925","article-title":"Platelet\u00a0alpha2-adrenoceptor density in humans: Relationships to stress-induced anxiety, psychasthenic constitution, gender and stress-induced changes in the inflammatory response system","volume":"32","author":"Maes","year":"2002","journal-title":"Psychol Med"},{"key":"10.1016\/j.jpain.2017.06.007_bib35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jpain.2010.07.006","article-title":"Combination drug therapy for chronic pain: A call for more clinical studies","volume":"12","author":"Mao","year":"2011","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2017.06.007_bib36","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrn1700","article-title":"Role of the immune system in chronic pain","volume":"6","author":"Marchand","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jpain.2017.06.007_bib37","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/bja\/aem017","article-title":"Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients","volume":"98","author":"Memis","year":"2007","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jpain.2017.06.007_bib38","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1111\/j.1460-9568.2005.04057.x","article-title":"Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10","volume":"21","author":"Milligan","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jpain.2017.06.007_bib39","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pain.2006.07.009","article-title":"Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain","volume":"126","author":"Milligan","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2017.06.007_bib40","first-page":"2416","article-title":"Vincristine-induced peripheral neuropathy in pediatric cancer patients","volume":"6","author":"Mora","year":"2016","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.jpain.2017.06.007_bib41","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neulet.2015.01.070","article-title":"Urinary trypsin inhibitor attenuates the development of neuropathic pain following spinal nerve ligation","volume":"590","author":"Oh","year":"2015","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2017.06.007_bib42","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0302-2838(03)00383-X","article-title":"Amiloride and urinary trypsin inhibitor inhibit urothelial cancer invasion","volume":"44","author":"Oka","year":"2003","journal-title":"Eur Urol"},{"key":"10.1016\/j.jpain.2017.06.007_bib43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jpain.2011.09.008","article-title":"The antinociceptive activity of intrathecally administered amiloride and its interactions with morphine and clonidine in rats","volume":"13","author":"Ouyang","year":"2012","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2017.06.007_bib44","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916646785","article-title":"Ulinastatin attenuates neuropathic pain induced by L5-VRT via the calcineurin\/IL-10 pathway","volume":"12","author":"Ouyang","year":"2016","journal-title":"Mol Pain"},{"key":"10.1016\/j.jpain.2017.06.007_bib45","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1155\/2015\/902914","article-title":"Spinal antinociceptive action of amiloride and its interaction with tizanidine in the rat formalin test","volume":"20","author":"Ouyang","year":"2015","journal-title":"Pain Res Manag"},{"key":"10.1016\/j.jpain.2017.06.007_bib46","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3322\/caac.21204","article-title":"Chemotherapy-induced peripheral neurotoxicity: A critical analysis","volume":"63","author":"Park","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jpain.2017.06.007_bib47","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.3346\/jkms.2012.27.11.1411","article-title":"Analgesic effects of dexmedetomidine in vincristine-evoked painful neuropathic rats","volume":"27","author":"Park","year":"2012","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.jpain.2017.06.007_bib48","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1476-5381.2011.01791.x","article-title":"Involvement of alpha2- and beta2-adrenoceptors on breast cancer cell proliferation and tumour growth regulation","volume":"166","author":"Perez Pinero","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jpain.2017.06.007_bib49","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pneurobio.2006.08.001","article-title":"Noradrenergic pain modulation","volume":"80","author":"Pertovaara","year":"2006","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jpain.2017.06.007_bib50","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.immunol.22.012703.104622","article-title":"Interleukin-10 and related cytokines and receptors","volume":"22","author":"Pestka","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jpain.2017.06.007_bib51","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1056\/NEJMra052603","article-title":"Treatment of acute lymphoblastic leukemia","volume":"354","author":"Pui","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpain.2017.06.007_bib52","doi-asserted-by":"crossref","first-page":"R136","DOI":"10.1186\/cc8012","article-title":"Sedation improves early outcome in severely septic Sprague Dawley rats","volume":"13","author":"Qiao","year":"2009","journal-title":"Crit Care"},{"key":"10.1016\/j.jpain.2017.06.007_bib53","doi-asserted-by":"crossref","first-page":"8988","DOI":"10.1523\/JNEUROSCI.2995-05.2005","article-title":"Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain","volume":"25","author":"Romero-Sandoval","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2017.06.007_bib54","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbi.2017.03.006","article-title":"The effects of dexmedetomidine pretreatment on the pro- and anti-inflammation systems after spinal cord injury in rats","volume":"64","author":"Rong","year":"2017","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jpain.2017.06.007_bib55","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/bph.12774","article-title":"Ligand requirements for involvement of PKCepsilon in synergistic analgesic interactions between spinal mu and delta opioid receptors","volume":"172","author":"Schuster","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jpain.2017.06.007_bib56","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1177\/1060028013504082","article-title":"Comparison of dexmedetomidine and propofol for conscious sedation in awake craniotomy: A prospective, double-blind, randomized, and controlled clinical trial","volume":"47","author":"Shen","year":"2013","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jpain.2017.06.007_bib57","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nrneurol.2014.211","article-title":"Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain","volume":"10","author":"Sisignano","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jpain.2017.06.007_bib58","doi-asserted-by":"crossref","first-page":"e0120694","DOI":"10.1371\/journal.pone.0120694","article-title":"Ulinastatin reduces the resistance of liver cancer cells to epirubicin by inhibiting autophagy","volume":"10","author":"Song","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jpain.2017.06.007_bib59","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1111\/j.2042-7158.2010.01192.x","article-title":"Systemic daily morphine enhances the analgesic effect of intrathecal dexmedetomidine via up-regulation of alpha 2 adrenergic receptor subtypes A, B and C in dorsal root ganglion and dorsal horn","volume":"62","author":"Tamagaki","year":"2010","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jpain.2017.06.007_bib60","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1097\/01.CCM.0000128579.84228.2A","article-title":"Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats","volume":"32","author":"Taniguchi","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jpain.2017.06.007_bib61","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jclinane.2008.10.010","article-title":"Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis","volume":"21","author":"Tasdogan","year":"2009","journal-title":"J Cin Anesth"},{"key":"10.1016\/j.jpain.2017.06.007_bib62","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: Procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jpain.2017.06.007_bib63","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/bja\/aev549","article-title":"Dexmedetomidine post-treatment induces neuroprotection via activation of extracellular signal-regulated kinase in rats with subarachnoid haemorrhage","volume":"116","author":"Wang","year":"2016","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jpain.2017.06.007_bib64","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11011-016-9926-7","article-title":"Effects of ulinastatin on early postoperative cognitive function after one-lung ventilation surgery in elderly patients receiving neoadjuvant chemotherapy","volume":"32","author":"Wang","year":"2017","journal-title":"Metabol Brain Dis"},{"key":"10.1016\/j.jpain.2017.06.007_bib65","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1002\/tox.22011","article-title":"Different cellular responses of dexmedetomidine at infected site and peripheral blood of emdotoxemic BALB\/c mice","volume":"30","author":"Wu","year":"2015","journal-title":"Environ Toxicol"},{"key":"10.1016\/j.jpain.2017.06.007_bib66","first-page":"2013","article-title":"Dexmedetomidine reduced cytokine release during postpartum bleeding-induced multiple organ dysfunction syndrome in rats","volume":"627831","author":"Xianbao","year":"2013","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jpain.2017.06.007_bib67","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00011-013-0604-5","article-title":"Effects of dexmedetomidine on early and late cytokines during polymicrobial sepsis in mice","volume":"62","author":"Xu","year":"2013","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jpain.2017.06.007_bib68","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916657089","article-title":"EXPRESS: Methylcobalamin ameliorates neuropathic pain induced by vincristine in rats: Effect on loss of peripheral nerve fibers and imbalance of cytokines in the spinal dorsal horn","volume":"12","author":"Xu","year":"2016","journal-title":"Mol Pain"},{"key":"10.1016\/j.jpain.2017.06.007_bib69","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/j.pain.0000000000000805","article-title":"Epigenetic upregulation of CXCL12 expression mediates antitubulin chemotherapeutics-induced neuropathic pain","volume":"158","author":"Xu","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2017.06.007_bib70","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.canlet.2009.07.003","article-title":"Urinary trypsin inhibitor suppresses migration of malignant mesothelioma","volume":"288","author":"Yaguchi","year":"2010","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jpain.2017.06.007_bib71","doi-asserted-by":"crossref","first-page":"e3731","DOI":"10.1097\/MD.0000000000003731","article-title":"Preventive effects of ulinastatin on complications related to pancreaticoduodenectomy: A Consort-prospective, randomized, double-blind, placebo-controlled trial","volume":"95","author":"Zhang","year":"2016","journal-title":"Medicine"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590017306302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590017306302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T16:40:50Z","timestamp":1750524050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590017306302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":71,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1526590017306302"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2017.06.007","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic Interaction Between Dexmedetomidine and Ulinastatin Against Vincristine-Induced Neuropathic Pain in Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2017.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the American Pain Society","name":"copyright","label":"Copyright"}]}}