{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:06:26Z","timestamp":1789142786998,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"9-10","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":1105,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007292","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jpain.2020.01.007","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T17:10:47Z","timestamp":1593105047000},"page":"1060-1074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Electroacupuncture Alleviates Mechanical Allodynia in a Rat Model of Complex Regional Pain Syndrome Type-I via Suppressing Spinal CXCL12\/CXCR4 Signaling"],"prefix":"10.1016","volume":"21","author":[{"given":"Qimiao","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-584X","authenticated-orcid":false,"given":"Xiaoli","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3267-8556","authenticated-orcid":false,"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-6144","authenticated-orcid":false,"given":"Yi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2020.01.007_bib0001","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12264-015-0007-4","article-title":"Upregulation of chemokine CXCL12 in the dorsal root ganglia and spinal cord contributes to the development and maintenance of neuropathic pain following spared nerve injury in rats","volume":"32","author":"Bai","year":"2016","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.jpain.2020.01.007_bib0002","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrneurol.2018.20","article-title":"Complex regional pain syndrome - phenotypic characteristics and potential biomarkers","volume":"14","author":"Birklein","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jpain.2020.01.007_bib0003","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/ALN.0b013e3181e3db38","article-title":"An update on the pathophysiology of complex regional pain syndrome","volume":"113","author":"Bruehl","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpain.2020.01.007_bib0004","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.expneurol.2014.05.014","article-title":"Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2","volume":"261","author":"Cao","year":"2014","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jpain.2020.01.007_bib0005","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2598975","article-title":"Electroacupuncture alleviates pain responses and inflammation in a rat model of acute gout arthritis","volume":"2018","author":"Chai","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jpain.2020.01.007_bib0006","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jpain.2020.01.007_bib0007","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/j.1526-4637.2010.00911.x","article-title":"A hypothesis for the cause of complex regional pain syndrome-type I (reflex sympathetic dystrophy): pain due to deep-tissue microvascular pathology","volume":"11","author":"Coderre","year":"2010","journal-title":"Pain Med"},{"key":"10.1016\/j.jpain.2020.01.007_bib0008","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.pain.2004.08.001","article-title":"Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat","volume":"112","author":"Coderre","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2020.01.007_bib0009","article-title":"Evaluating the effects of acupuncture using a dental pain model in healthy subjects - a randomized, cross-over trial","author":"de Matos","year":"2019","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2020.01.007_bib0010","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jpain.2020.01.007_bib0011","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.lfs.2018.03.028","article-title":"Parameter-specific analgesic effects of electroacupuncture mediated by degree of regulation TRPV1 and P2X3 in inflammatory pain in rats","volume":"200","author":"Fang","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.jpain.2020.01.007_bib0012","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pharmthera.2010.01.002","article-title":"Chemokines, neuronal-glial interactions, and central processing of neuropathic pain","volume":"126","author":"Gao","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jpain.2020.01.007_bib0013","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.jpain.2018.04.006","article-title":"Oxidative stress contributes to fracture\/cast-induced inflammation and pain in a rat model of complex regional pain syndrome","volume":"19","author":"Guo","year":"2018","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2020.01.007_bib0014","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4097\/kjae.2012.63.2.149","article-title":"Effect of superoxide on the development and maintenance of mechanical allodynia in a rat model of chronic post-ischemia pain","volume":"63","author":"Han","year":"2012","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.jpain.2020.01.007_bib0015","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s11916-003-0072-7","article-title":"Complex regional pain syndrome: a review of evidence-supported treatment options","volume":"7","author":"Hord","year":"2003","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.jpain.2020.01.007_bib0016","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3389\/fphar.2019.00453","article-title":"TRPV1 channel contributes to the behavioral hypersensitivity in a rat model of complex regional pain syndrome Type 1","volume":"10","author":"Hu","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jpain.2020.01.007_bib0017","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1172\/JCI92117","article-title":"Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy","volume":"128","author":"Jayaraj","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jpain.2020.01.007_bib0018","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.aaf8924","article-title":"Pain regulation by non-neuronal cells and inflammation","volume":"354","author":"Ji","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jpain.2020.01.007_bib0019","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrd4334","article-title":"Emerging targets in neuroinflammation-driven chronic pain","volume":"13","author":"Ji","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jpain.2020.01.007_bib0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0304-3959(97)00049-3","article-title":"A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes","volume":"73","author":"Kingery","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2020.01.007_bib0021","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00424-015-1746-9","article-title":"Acute and chronic nociceptive phases observed in a rat hind paw ischemia\/reperfusion model depend on different mechanisms","volume":"468","author":"Klafke","year":"2016","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jpain.2020.01.007_bib0022","article-title":"Oxidized phospholipid OxPAPC activates TRPA1 and contributes to chronic inflammatory pain in mice","volume":"11","author":"Liu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jpain.2020.01.007_bib0023","article-title":"Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis","volume":"5","author":"Liu","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jpain.2020.01.007_bib0024","doi-asserted-by":"crossref","first-page":"24789","DOI":"10.1074\/jbc.M800649200","article-title":"SDF1alpha\/CXCR4 signaling, via ERKs and the transcription factor Egr1, induces expression of a 67-kDa form of glutamic acid decarboxylase in embryonic hippocampal neurons","volume":"283","author":"Luo","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpain.2020.01.007_bib0025","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916636385","article-title":"Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain","volume":"12","author":"Luo","year":"2016","journal-title":"Mol Pain"},{"key":"10.1016\/j.jpain.2020.01.007_bib0026","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1515\/revneuro-2015-0016","article-title":"CXCL12\/CXCR4 axis: an emerging neuromodulator in pathological pain","volume":"27","author":"Luo","year":"2016","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.jpain.2020.01.007_bib0027","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s00424-018-2192-2","article-title":"Electroacupuncture induces antihyperalgesic effect through endothelin-B receptor in the chronic phase of a mouse model of complex regional pain syndrome type I","volume":"470","author":"Mazzardo-Martins","year":"2018","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jpain.2020.01.007_bib0028","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2011.08.004","article-title":"The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia\/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy","volume":"1414","author":"Meng","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2020.01.007_bib0029","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12576-013-0297-0","article-title":"Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats","volume":"64","author":"Moon","year":"2014","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.jpain.2020.01.007_bib0030","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jpain.2018.01.004","article-title":"Signs and symptoms in 1,043 patients with complex regional pain syndrome","volume":"19","author":"Ott","year":"2018","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2020.01.007_bib0031","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.fcl.2011.03.001","article-title":"Complex regional pain syndrome","volume":"16","author":"Shah","year":"2011","journal-title":"Foot Ankle Clin"},{"key":"10.1016\/j.jpain.2020.01.007_bib0032","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11916-018-0667-7","article-title":"Complex regional pain syndrome, current concepts and treatment options","volume":"22","author":"Urits","year":"2018","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.jpain.2020.01.007_bib0033","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jpain.2017.11.005","article-title":"Acupuncture for chronic pain: update of an individual patient data meta-analysis","volume":"19","author":"Vickers","year":"2018","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2020.01.007_bib0034","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/j.1532-2149.2013.00325.x","article-title":"Long-term antinociception by electroacupuncture is mediated via peripheral opioid receptors in free-moving rats with inflammatory hyperalgesia","volume":"17","author":"Wang","year":"2013","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpain.2020.01.007_bib0035","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.02.010","article-title":"Electroacupuncture for reflex sympathetic dystrophy after stroke: a meta-analysis","volume":"28","author":"Wei","year":"2019","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jpain.2020.01.007_bib0036","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jneumeth.2009.06.020","article-title":"An improved method for protecting and fixing the lumbar catheters placed in the spinal subarachnoid space of rats","volume":"183","author":"Xu","year":"2009","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jpain.2020.01.007_bib0037","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12974-015-0441-2","article-title":"SDF1-CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation","volume":"12","author":"Yang","year":"2015","journal-title":"J Neuroinflamm"},{"key":"10.1016\/j.jpain.2020.01.007_bib0038","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.2147\/JPR.S184621","article-title":"Effect of dexmedetomidine on the development of mechanical allodynia and central sensitization in chronic post-ischemia pain rats","volume":"11","author":"Yeo","year":"2018","journal-title":"J Pain Res"},{"key":"10.1016\/j.jpain.2020.01.007_bib0039","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2147\/JPR.S188758","article-title":"Transcriptome profiling of dorsal root ganglia in a rat model of complex regional pain syndrome type-I reveals potential mechanisms involved in pain","volume":"12","author":"Yin","year":"2019","journal-title":"J Pain Res"},{"key":"10.1016\/j.jpain.2020.01.007_bib0040","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1007\/s00018-017-2513-1","article-title":"Chemokines in neuron-glial cell interaction and pathogenesis of neuropathic pain","volume":"74","author":"Zhang","year":"2017","journal-title":"Cell Mol Life Sci"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590020300080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590020300080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:03:16Z","timestamp":1761508996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590020300080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":40,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S1526590020300080"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2020.01.007","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electroacupuncture Alleviates Mechanical Allodynia in a Rat Model of Complex Regional Pain Syndrome Type-I via Suppressing Spinal CXCL12\/CXCR4 Signaling","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2020.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by United States Association for the Study of Pain, Inc.","name":"copyright","label":"Copyright"}]}}