{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:13:48Z","timestamp":1761509628109,"version":"build-2065373602"},"reference-count":53,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK51413"],"award-info":[{"award-number":["DK51413"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jpain.2022.08.005","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T03:31:41Z","timestamp":1662694301000},"page":"2167-2178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Double Insult of Neonatal Cystitis Plus Adult Somatic Inflammation Results in Corticotropin Releasing Factor Type II Receptor-Dependent Bladder Hypersensitivity in Female Rats"],"prefix":"10.1016","volume":"23","author":[{"given":"Timothy J.","family":"Ness","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cary","family":"DeWitte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Randich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2022.08.005_bib0001","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuropharm.2013.04.016","article-title":"Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors","volume":"72","author":"Abdelhamid","year":"2013","journal-title":"Neuropharmacol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0002","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/WNR.0000000000001161","article-title":"The role of transient receptor potential vanilloid receptor 1 and peroxisome proliferator-activated receptors-alpha in mediating the antinocieptive effects of palmitoylethanolamine in rats","volume":"30","author":"Aldossary","year":"2019","journal-title":"Neuroreport"},{"key":"10.1016\/j.jpain.2022.08.005_bib0003","unstructured":"Anonymous. Causes of IC. ichelp.org\/about-ic\/causes-of-ic, 2021"},{"key":"10.1016\/j.jpain.2022.08.005_bib0004","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bcp.2015.04.013","article-title":"The role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain","volume":"97","author":"Bagdas","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0005","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.juro.2011.03.132","article-title":"Prevalence of symptoms of bladder pain syndrome\/interstitial cystitis among adult females in the United States","volume":"186","author":"Berry","year":"2011","journal-title":"J Urol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0006","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.juro.2006.09.032","article-title":"Symptoms of interstitial cystitis, painful bladder syndrome and similar diseases in women: A systematic review","volume":"177","author":"Bogart","year":"2007","journal-title":"J Urol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0007","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.autneu.2009.07.006","article-title":"Visceral organ cross-sensitization: An integrated perspective","volume":"153","author":"Brumovsky","year":"2010","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.jpain.2022.08.005_bib0008","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0304-3940(01)01886-9","article-title":"Vigor of visceromotor responses to urinary bladder distension in rats increases withrepeated trials and stimulus intensity","volume":"306","author":"Castroman","year":"2001","journal-title":"Neurosci Letts"},{"key":"10.1016\/j.jpain.2022.08.005_bib0009","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00702-019-02103-y","article-title":"The emergence of animal models of chronic pain and logistical and methodological issues concerning their use","volume":"127","author":"Coderre","year":"2020","journal-title":"J Neural Trans"},{"key":"10.1016\/j.jpain.2022.08.005_bib0010","first-page":"4","article-title":"Models of inflammation: Carrageenan- or complete Freund's adjuvant-induced edema and hypersensitivity in the rat","volume":"5","author":"Fehrenbacher","year":"2012","journal-title":"Curr Protoc Pharmacol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0011","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0022-5347(17)69067-0","article-title":"Interstitial cystitis: Report of 223 cases (204 women and 19 men)","volume":"61","author":"Hand","year":"1949","journal-title":"J Urol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0012","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/jnc.14677","article-title":"Endogenous transient receptor potential ankyrin 1 and vanilloid1 activity potentials glutamatergic input to spinal lamina I neurons in inflammatory pain","volume":"149","author":"Huang","year":"2019","journal-title":"J Neurochem"},{"key":"10.1016\/j.jpain.2022.08.005_bib0013","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/bja\/83.3.442","article-title":"Inflammation of the rat urinary bladder is associated with a referred thermal hyperalgesia which is nerve growth factor dependent","volume":"83","author":"Jaggar","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jpain.2022.08.005_bib0014","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.3892\/etm.2015.2407","article-title":"Analgesic roles of perineural intrinsic met-enkephalin and dynorphin in long-lasting inflammatory pain induced by complete Freund's adjuvant in rats","volume":"9","author":"Jiang","year":"2015","journal-title":"Exp Ther Med"},{"issue":"Suppl 5A","key":"10.1016\/j.jpain.2022.08.005_bib0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0090-4295(99)80327-6","article-title":"Epidemiology of interstitial cystitis","volume":"49","author":"Jones","year":"1997","journal-title":"Urol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0016","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neuroscience.2017.01.021","article-title":"Neonatal bladder inflammation induces long-term visceral pain and altered responses of spinal neurons in adult rats","volume":"346","author":"Kannampalli","year":"2017","journal-title":"Neurosci"},{"key":"10.1016\/j.jpain.2022.08.005_bib0017","first-page":"R1697","article-title":"Impact of state of arousal and stress neuropeptides on urodynamic function in freely moving rats","volume":"290","author":"Kiddoo","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0018","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.bbrc.2019.09.040","article-title":"The role of peripheral corticotropin-releasing factor signaling in a rat model of stress-induced gastric hyperalgesia","volume":"519","author":"Kozaki","year":"2019","journal-title":"Biochem Biophys Res Comms"},{"key":"10.1016\/j.jpain.2022.08.005_bib0019","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0022-5347(17)36120-7","article-title":"The natural history of interstitial cystitis: A survey of 374 patients","volume":"149","author":"Koziol","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0020","first-page":"G451","article-title":"Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways","volume":"290","author":"Lamb","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0021","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1111\/ejn.13060","article-title":"Intrathecal urocortin I in the spinal cord as a murine model of stress hormone-induced musculoskeletal and tactile hyperalgesia","volume":"42","author":"Larson","year":"2015","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jpain.2022.08.005_bib0022","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.peptides.2004.05.025","article-title":"Urocortins and the regulation of gastrointestinal motor function and visceral pain","volume":"25","author":"Martinez","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.jpain.2022.08.005_bib0023","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.peptides.2005.02.004","article-title":"Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female rats","volume":"26","author":"Million","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.jpain.2022.08.005_bib0024","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/gut.2004.051391","article-title":"CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1\/2 phosphorylation in rats","volume":"55","author":"Million","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.jpain.2022.08.005_bib0025","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1007\/s12035-021-02481-z","article-title":"Functional and anatomical characterization of corticotropin-releasing factor receptor subtypes of the rat spinal cord involved in somatic pain relief","volume":"58","author":"Mousa","year":"2021","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0026","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/cns.12486","article-title":"Preclinical assessment of inflammatory pain","volume":"22","author":"Muley","year":"2016","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.jpain.2022.08.005_bib0027","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0006-8993(01)03216-4","article-title":"Evidence for two populations of rat spinal dorsal horn neurons excited by urinary bladder distension","volume":"923","author":"Ness","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2022.08.005_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fpain.2021.791045","article-title":"A model in female rats with phenotypic features similar to interstitial cystitis\/bladder pain syndrome","volume":"2","author":"Ness","year":"2021","journal-title":"Front Pain Res"},{"key":"10.1016\/j.jpain.2022.08.005_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.147927","article-title":"Neonatal cystitis leads to alterations in spinal corticotropin releasing factor receptor-type 2 content and function in adult rats following bladder re-inflammation","volume":"1788","author":"Ness","year":"2022","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2022.08.005_bib0030","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0006-8993(89)90516-7","article-title":"Characterization of superficial T13-L2 dorsal horn neurons encoding for colorectal distension in the rat: Comparison with neurons in deep laminae","volume":"486","author":"Ness","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2022.08.005_bib0031","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1152\/jn.1991.66.1.20","article-title":"Interactions between visceral and cutaneous nociception in the rat. I. Noxious cutaneous stimuli inhibit visceral nociceptive neurons and reflexes","volume":"66","author":"Ness","year":"1991","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0032","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/S0022-5347(05)66586-X","article-title":"Characterization of pressor and visceromotor reflex responses to bladder distension in rats: Sources of variability and effect of analgesics","volume":"165","author":"Ness","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0033","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neulet.2010.02.007","article-title":"Neonatal bladder inflammation alters activity of adult rat spinal visceral nociceptive neurons","volume":"472","author":"Ness","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2022.08.005_bib0034","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-2982.2005.00644.x","article-title":"Divergent role for CRF1 and CRF2 receptors in the modulation of visceral pain","volume":"17","author":"Nijsen","year":"2005","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpain.2022.08.005_bib0035","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1210\/en.2014-1421","article-title":"A balance theory of peripheral corticotropin-releasing factor receptor Type 1 and type 2 signaling to induce colonic contractions and visceral hyperalgesia in rats","volume":"155","author":"Nozu","year":"2014","journal-title":"Endocrinol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0036","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00192-008-0573-3","article-title":"Incidence and clinical characteristics of interstitial cystitis in the community","volume":"19","author":"Patel","year":"2008","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"10.1016\/j.jpain.2022.08.005_bib0037","first-page":"36","article-title":"The neurobiology of infant pain: Development of excitatory and inhibitory neurotransmission in the spinal cord","volume":"29","author":"Pattinson","year":"2004","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.jpain.2022.08.005_bib0038","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.urology.2008.09.014","article-title":"Childhood symptoms and events in women with interstitial cystitis\/painful bladder syndrome","volume":"73","author":"Peters","year":"2009","journal-title":"Urology"},{"key":"10.1016\/j.jpain.2022.08.005_bib0039","doi-asserted-by":"crossref","DOI":"10.1177\/1744806917737934","article-title":"Group I metabotropic glutamate receptor plasticity after peripheral inflammation alters nociceptive transmission in the dorsal horn of the spinal cord in adult rats","volume":"13","author":"Radwani","year":"2017","journal-title":"Mol Pain"},{"key":"10.1016\/j.jpain.2022.08.005_bib0040","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neulet.2008.07.031","article-title":"Serotonergic and noradrenergic facilitation of the visceromotor reflex evoked by urinary bladder distension in rats with inflamed bladders","volume":"442","author":"Randich","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2022.08.005_bib0041","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jpain.2006.01.450","article-title":"Neonatal urinary bladder inflammation produces adult bladder hypersensitivity","volume":"7","author":"Randich","year":"2006","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2022.08.005_bib0042","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1021\/jm0202122","article-title":"Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists","volume":"45","author":"Rivier","year":"2002","journal-title":"J Med Chem"},{"key":"10.1016\/j.jpain.2022.08.005_bib0043","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/ejn.12414","article-title":"The consequences of pain in early life: Injury-induced plasticity in developing pain pathways","volume":"39","author":"Rivier","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jpain.2022.08.005_bib0044","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pain.2012.09.002","article-title":"MicroRNA-mediated GABAAa-1 receptor subunit downregulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats","volume":"154","author":"Sengupta","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2022.08.005_bib0045","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.juro.2012.08.190","article-title":"Early in life bladder inflammation alters opioid peptide content in the spinal cord and bladder of adult female rats","volume":"189","author":"Shaffer","year":"2013","journal-title":"J Urol"},{"key":"10.1016\/j.jpain.2022.08.005_bib0046","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neulet.2012.11.035","article-title":"Early-in-life bladder inflammation alters U50,488H but not morphine-induced inhibition of visceromotor responses to urinary bladder distension","volume":"534","author":"Shaffer","year":"2013","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2022.08.005_bib0047","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.bbrc.2019.03.051","article-title":"Animal models of chronic pain increase spontaneous glutamatergic transmission in adult rat spinal dorsal horn in vitro and in vivo","volume":"512","author":"Uta","year":"2019","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1016\/j.jpain.2022.08.005_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107753","article-title":"Chronic pain models amplify transient receptor potential vanilloid 1 (TRPV1) receptor responses in adult rat spinal dorsal horn","volume":"160","author":"Uta","year":"2019","journal-title":"Neuropharm"},{"key":"10.1016\/j.jpain.2022.08.005_bib0049","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/j.pain.0000000000000823","article-title":"Spinal intracellular metabotropic glutamate receptor 5 (mGluR5) contributes to pain and c-fos expression in a rat model of inflammatory pain","volume":"158","author":"Vincent","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2022.08.005_bib0050","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.urology.2007.12.091","article-title":"Urinary tract infection and inflammation at onset of interstitial cystitis\/painful bladder syndrome","volume":"71","author":"Warren","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.jpain.2022.08.005_bib0051","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1744-8069-4-61","article-title":"The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nocicep0tioin induced by complete Freund's adjuvant","volume":"4","author":"Yu","year":"2008","journal-title":"Mol Pain"},{"key":"10.1016\/j.jpain.2022.08.005_bib0052","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s11011-015-9695-8","article-title":"Chronic inflammatory pain upregulates expression of P2Y2 receptor in small-diameter sensory neurons","volume":"30","author":"Zhu","year":"2015","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.jpain.2022.08.005_bib0053","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590022003881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590022003881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:07:46Z","timestamp":1761509266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590022003881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S1526590022003881"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2022.08.005","relation":{},"ISSN":["1526-5900"],"issn-type":[{"type":"print","value":"1526-5900"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Double Insult of Neonatal Cystitis Plus Adult Somatic Inflammation Results in Corticotropin Releasing Factor Type II Receptor-Dependent Bladder Hypersensitivity in Female Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2022.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by United States Association for the Study of Pain, Inc.","name":"copyright","label":"Copyright"}]}}