{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:39:28Z","timestamp":1790696368155,"version":"4.1.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000945","name":"Pittsburgh Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["AA020889"],"award-info":[{"award-number":["AA020889"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["AA024836"],"award-info":[{"award-number":["AA024836"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["AA029942"],"award-info":[{"award-number":["AA029942"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["AA030257"],"award-info":[{"award-number":["AA030257"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["DA037621"],"award-info":[{"award-number":["DA037621"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS045954"],"award-info":[{"award-number":["NS045954"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS073548"],"award-info":[{"award-number":["NS073548"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS112632"],"award-info":[{"award-number":["NS112632"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jpain.2023.02.024","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T17:51:57Z","timestamp":1677693117000},"page":"1262-1274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Mechanical and Heat Hyperalgesia upon Withdrawal From Chronic Intermittent Ethanol Vapor Depends on Sex, Exposure Duration, and Blood Alcohol Concentration in Mice"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1600-5183","authenticated-orcid":false,"given":"Adam J.","family":"Brandner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7227-2388","authenticated-orcid":false,"given":"Annalisa M.","family":"Baratta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa S.","family":"Rathod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley K.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Farris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2023.02.024_bib0001","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.drugalcdep.2016.08.017","article-title":"Involvement of delta opioid receptors in alcohol withdrawal-induced mechanical allodynia in male C57BL\/6 mice","volume":"167","author":"Alongkronrusmee","year":"2016","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.jpain.2023.02.024_bib0002","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pbb.2013.09.008","article-title":"Neural mechanisms of pain and alcohol dependence","volume":"112","author":"Apkarian","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.jpain.2023.02.024_bib0003","doi-asserted-by":"crossref","first-page":"7761","DOI":"10.1523\/JNEUROSCI.0483-18.2018","article-title":"Central amygdala circuits mediate hyperalgesia in alcohol-dependent rats","volume":"38","author":"Avegno","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2023.02.024_bib0004","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s13311-020-00887-6","article-title":"Central nervous system targets: Supraspinal mechanisms of analgesia","volume":"17","author":"Bannister","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jpain.2023.02.024_bib0005","first-page":"348","article-title":"Alcohol dependence, withdrawal, and relapse","volume":"31","author":"Becker","year":"2008","journal-title":"Alcohol Res Health"},{"key":"10.1016\/j.jpain.2023.02.024_bib0006","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0741-8329(97)87949-9","article-title":"Repeated ethanol withdrawal experience increases the severity and duration of subsequent withdrawal seizures in mice","volume":"14","author":"Becker","year":"1997","journal-title":"Alcohol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0007","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1097\/01.ALC.0000149977.95306.3A","article-title":"Increased ethanol drinking after repeated chronic ethanol exposure and withdrawal experience in C57BL\/6 mice","volume":"28","author":"Becker","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0008","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1124\/pr.115.011163","article-title":"Sex differences in animal models: Focus on addiction","volume":"68","author":"Becker","year":"2016","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jpain.2023.02.024_bib0009","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/adb.12784","article-title":"Reduced sensitivity to ethanol and excessive drinking in a mouse model of neuropathic pain","volume":"24","author":"Bilbao","year":"2019","journal-title":"Addict Biol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1124\/mol.63.1.53","article-title":"Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABA A receptors","volume":"63","author":"Cagetti","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0011","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainres.2006.04.054","article-title":"Antinociceptive effects of alcohol and nicotine: involvement of the opioid system","volume":"1097","author":"Campbell","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0012","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0140-6736(19)31775-1","article-title":"Alcohol use disorders","volume":"394","author":"Carvalho","year":"2019","journal-title":"Lancet North Am Ed"},{"key":"10.1016\/j.jpain.2023.02.024_bib0013","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jpain.2023.02.024_bib0014","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ejpain.2004.01.003","article-title":"Sex differences in pain and analgesia: The role of gonadal hormones","volume":"8","author":"Craft","year":"2004","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpain.2023.02.024_bib0015","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1530-0277.1999.tb04131.x","article-title":"Gender differences in blood levels, but not brain levels, of ethanol in rats","volume":"23","author":"Crippens","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.136119","article-title":"Alcohol amplifies cingulate cortex signaling and facilitates immobilization-induced hyperalgesia in female rats","volume":"761","author":"Cucinello-Ragland","year":"2021","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpain.2023.02.024_bib0017","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1172\/JCI128022","article-title":"Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice","volume":"129","author":"De Logu","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jpain.2023.02.024_bib0018","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fnmol.2017.00284","article-title":"Methods used to evaluate pain behaviors in rodents","volume":"10","author":"Deuis","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.jpain.2023.02.024_bib0019","doi-asserted-by":"crossref","first-page":"8614","DOI":"10.1523\/JNEUROSCI.20-22-08614.2000","article-title":"Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat","volume":"20","author":"Dina","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2023.02.024_bib0020","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev-clinpsy-050718-095440","article-title":"A reciprocal model of pain and substance use: Transdiagnostic considerations, clinical implications, and future directions","volume":"15","author":"Ditre","year":"2019","journal-title":"Annu Rev Clin Psychol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0021","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0022","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2217\/fnl.10.14","article-title":"Neurobiology of dysregulated motivational systems in drug addiction","volume":"5","author":"Edwards","year":"2010","journal-title":"Future Neurol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0023","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/acer.14260","article-title":"Alcohol and pain: a translational review of preclinical and clinical findings to inform future treatment strategies","volume":"44","author":"Edwards","year":"2020","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0024","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.neuropharm.2011.11.006","article-title":"Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: Alleviation by CRF1 receptor antagonism","volume":"62","author":"Edwards","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpain.2023.02.024_bib0025","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/j.neubiorev.2012.07.010","article-title":"Alcohol dependence as a chronic pain disorder","volume":"36","author":"Egli","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jpain.2023.02.024_bib0026","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/acer.12686","article-title":"Chronic intermittent ethanol exposure in mice leads to an up-regulation of CRH\/CRHR1 signaling","volume":"39","author":"Eisenhardt","year":"2015","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0027","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0149-7634(00)00017-8","article-title":"Sex-related hormonal influences on pain and analgesic responses","volume":"24","author":"Fillingim","year":"2000","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jpain.2023.02.024_bib0028","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1177\/2167696817740453","article-title":"The gender risk-severity paradox for alcohol use disorder from adolescence through young adulthood","volume":"6","author":"Foster","year":"2018","journal-title":"Emerg Adulthood"},{"key":"10.1016\/j.jpain.2023.02.024_bib0029","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1017\/S0033291715001014","article-title":"Gender differences in the structure of risk for alcohol use disorder in adolescence and young adulthood","volume":"45","author":"Foster","year":"2015","journal-title":"Psychol Med"},{"key":"10.1016\/j.jpain.2023.02.024_bib0030","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1056\/NEJM199001113220205","article-title":"High blood alcohol levels in women","volume":"322","author":"Frezza","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpain.2023.02.024_bib0031","first-page":"136","article-title":"Chronic intermittent voluntary alcohol drinking induces hyperalgesia in Sprague-Dawley rats","volume":"7","author":"Fu","year":"2015","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0032","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1530-0277.1999.tb04118.x","article-title":"Effects of ethanol and ethanol withdrawal on nociception in rats","volume":"23","author":"Gatch","year":"1999","journal-title":"Alcoholism Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0033","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/alcalc\/37.4.313","article-title":"Theophylline blocks ethanol withdrawal-induced hyperalgesia","volume":"37","author":"Gatch","year":"2002","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0034","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1111\/j.1530-0277.2007.00509.x","article-title":"The impact of gonadectomy and adrenalectomy on acute withdrawal severity in male and female C57BL\/6J and DBA\/2J mice following a single high dose of ethanol","volume":"31","author":"Gililland","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/0471142301.ns0929s44","article-title":"Vapor inhalation of alcohol in rats","volume":"44","author":"Gilpin","year":"2008","journal-title":"Curr Protoc Neurosci"},{"key":"10.1016\/j.jpain.2023.02.024_bib0036","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1111\/j.1530-0277.2009.01051.x","article-title":"Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats","volume":"33","author":"Gilpin","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0037","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0022-3565(25)29104-2","article-title":"Relationship of alcohol dose to intensity of withdrawal signs in mice","volume":"180","author":"Goldstein","year":"1972","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpain.2023.02.024_bib0038","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1126\/science.172.3980.288","article-title":"Alcohol dependence produced in mice by inhalation of ethanol: Grading the withdrawal reaction","volume":"172","author":"Goldstein","year":"1971","journal-title":"Science"},{"key":"10.1016\/j.jpain.2023.02.024_bib0039","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpain.2019.01.161","article-title":"Estrous cycle and sex differences in referred and visceral sensitivity in rodents","volume":"20","author":"Gonzalez","year":"2019","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2023.02.024_bib0040","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1111\/j.1530-0277.2009.01027.x","article-title":"Intensity and duration of chronic ethanol exposure is critical for subsequent escalation of voluntary ethanol drinking in mice","volume":"33","author":"Griffin","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0041","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00213-008-1324-3","article-title":"Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens","volume":"201","author":"Griffin","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jpain.2023.02.024_bib0042","article-title":"Heightened sensitivity to the disinhibiting effect of alcohol in women during the late follicular phase of the menstrual cycle","author":"Griffith","year":"2022","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0043","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1369-1600.2009.00194.x","article-title":"Acute withdrawal, protracted abstinence and negative affect in alcoholism: Are they linked?","volume":"15","author":"Heilig","year":"2010","journal-title":"Addict Biol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0044","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.drugalcdep.2015.11.020","article-title":"Reductions in physical pain predict lower risk of relapse following alcohol treatment","volume":"158","author":"Jakubczyk","year":"2016","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.jpain.2023.02.024_bib0045","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1038\/s41598-018-38393-7","article-title":"Downregulation of M-channels in lateral habenula mediates hyperalgesia during alcohol withdrawal in rats","volume":"9","author":"Kang","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jpain.2023.02.024_bib0046","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1097\/01.ALC.0000131976.40428.8F","article-title":"Anxiety-like behavior in mice in two apparatuses during withdrawal from chronic ethanol vapor inhalation","volume":"28","author":"Kliethermes","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0047","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.psych.59.103006.093548","article-title":"Addiction and the brain antireward system","volume":"59","author":"Koob","year":"2008","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0048","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/nm.2231","article-title":"Central mechanisms of pathological pain","volume":"16","author":"Kuner","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.jpain.2023.02.024_bib0049","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/BF01897894","article-title":"Liver cell necrosis in rats after prolonged ethanol ingestion under the influence of an alcohol-dehydrogenase inhibitor","volume":"25","author":"Lelbach","year":"1969","journal-title":"Experientia"},{"key":"10.1016\/j.jpain.2023.02.024_bib0050","first-page":"163","article-title":"Differences between male and female rats in alcohol drinking, negative affects and neuronal activity after acute and prolonged abstinence","volume":"11","author":"Li","year":"2019","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0051","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.2042-7158.1974.tb09230.x","article-title":"The induction of ethanol dependence and the ethanol withdrawal syndrome: The effects of pyrazole","volume":"26","author":"Littleton","year":"1974","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0052","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s00213-005-0026-3","article-title":"Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL\/6J mice","volume":"181","author":"Lopez","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jpain.2023.02.024_bib0053","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1037\/neu0000558","article-title":"At the intersection of alcohol use disorder and chronic pain","volume":"33","author":"Maleki","year":"2019","journal-title":"Neuropsychology"},{"key":"10.1016\/j.jpain.2023.02.024_bib0054","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.alcohol.2017.08.014","article-title":"An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice","volume":"68","author":"Metten","year":"2018","journal-title":"Alcohol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0055","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1601-183X.2006.00249.x","article-title":"Estrous cycle effects on behavior of C57BL\/6J and BALB\/cByJ female mice: Implications for phenotyping strategies","volume":"6","author":"Meziane","year":"2007","journal-title":"Genes, Brain and Behav"},{"key":"10.1016\/j.jpain.2023.02.024_bib0056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pain.2005.06.020","article-title":"The case for the inclusion of female subjects in basic science studies of pain","volume":"117","author":"Mogil","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2023.02.024_bib0057","first-page":"55","article-title":"Gender differences in moderate drinking effects","volume":"23","author":"Mumenthaler","year":"1999","journal-title":"Alcohol Res Health"},{"key":"10.1016\/j.jpain.2023.02.024_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107793","article-title":"Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain","volume":"160","author":"Neddenriep","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpain.2023.02.024_bib0059","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1038\/s41598-019-43493-z","article-title":"Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn","volume":"9","author":"Nelson","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jpain.2023.02.024_bib0060","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/SPC.0000000000000055","article-title":"Descending pain modulation and chronification of pain","volume":"8","author":"Ossipov","year":"2014","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1016\/j.jpain.2023.02.024_bib0061","first-page":"1","article-title":"The convergent neuroscience of affective pain and substance use disorder","volume":"41","author":"Pahng","year":"2021","journal-title":"Alcohol Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0062","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1526-4637.2008.00558.x","article-title":"Sex-based differences in pain perception and treatment","volume":"10","author":"Paller","year":"2009","journal-title":"Pain Med"},{"key":"10.1016\/j.jpain.2023.02.024_bib0063","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/j.1530-0277.2008.00653.x","article-title":"Ethanol and pain sensitivity: Effects in healthy subjects using an acute pain paradigm","volume":"32","author":"Perrino","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0064","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.pain.2010.05.013","article-title":"Gender differences in pain modulation by diffuse noxious inhibitory controls: A systematic review","volume":"150","author":"Popescu","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2023.02.024_bib0065","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/ijnp\/pyz031","article-title":"Effect of histone deacetylase inhibitor on ethanol withdrawal-induced hyperalgesia in rats","volume":"22","author":"Pradhan","year":"2019","journal-title":"Int J Neuropsychopharmacolog"},{"key":"10.1016\/j.jpain.2023.02.024_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108409","article-title":"The Sigma-2 receptor \/transmembrane protein 97 (\u03c32R\/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice","volume":"184","author":"Quadir","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpain.2023.02.024_bib0067","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1601-183X.2006.00210.x","article-title":"Mouse inbred strain differences in ethanol drinking to intoxication","volume":"6","author":"Rhodes","year":"2007","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.jpain.2023.02.024_bib0068","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1111\/j.1530-0277.1998.tb03950.x","article-title":"Estrous cycle effects on operant responding for ethanol in female rats","volume":"22","author":"Roberts","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0069","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/alcalc\/agz067","article-title":"From pleasure to pain, and back again: The intricate relationship between alcohol and nociception","volume":"54","author":"Robins","year":"2019","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0070","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0163-1047(79)92061-2","article-title":"Long-term ethanol administration methods for rats: Advantages of inhalation over intubation or liquid diets","volume":"27","author":"Rogers","year":"1979","journal-title":"Behav Neural Biol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0071","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/adb.12360","article-title":"Intra-cerebral and intra-nasal melanocortin-4 receptor antagonist blocks withdrawal hyperalgesia in alcohol-dependent rats","volume":"22","author":"Roltsch Hellard","year":"2017","journal-title":"Addict Biol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0072","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1523\/ENEURO.0087-17.2017","article-title":"Anterior cingulate cortex contributes to alcohol withdrawal- induced and socially transferred hyperalgesia","volume":"4","author":"Smith","year":"2017","journal-title":"eNeuro"},{"key":"10.1016\/j.jpain.2023.02.024_bib0073","first-page":"407","article-title":"Alcohol elimination and simulator performance of male and female aviators: a preliminary report","volume":"67","author":"Taylor","year":"1996","journal-title":"Aviat Space Environ Med"},{"key":"10.1016\/j.jpain.2023.02.024_bib0074","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jpain.2016.11.009","article-title":"Analgesic effects of alcohol: A systematic review and meta-analysis of controlled experimental studies in healthy participants","volume":"18","author":"Thompson","year":"2017","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2023.02.024_bib0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187698","article-title":"Estradiol increases the sensitivity of ventral tegmental area dopamine neurons to dopamine and ethanol","volume":"12","author":"Vandegrift","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jpain.2023.02.024_bib0076","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.alcohol.2013.08.006","article-title":"Operant alcohol self-administration in dependent rats: focus on the vapor model","volume":"48","author":"Vendruscolo","year":"2014","journal-title":"Alcohol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0077","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/acer.14883","article-title":"Analgesic effects of alcohol in adults with chronic jaw pain","volume":"46","author":"Vitus","year":"2022","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114087","article-title":"Thermal antinociceptive responses to alcohol in DBA\/2J and C57BL\/6J inbred male and female mouse strains","volume":"436","author":"White","year":"2023","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jpain.2023.02.024_bib0079","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/add.12964","article-title":"Pain as a predictor of heavy drinking and any drinking lapses in the COMBINE Study and the United Kingdom alcohol treatment trial","volume":"110","author":"Witkiewitz","year":"2015","journal-title":"Addiction"},{"key":"10.1016\/j.jpain.2023.02.024_bib0080","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.alcohol.2007.12.006","article-title":"Voluntary ethanol consumption in 22 inbred mouse strains","volume":"42","author":"Yoneyama","year":"2008","journal-title":"Alcohol"},{"key":"10.1016\/j.jpain.2023.02.024_bib0081","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cpr.2015.02.005","article-title":"Interrelations between pain and alcohol: An integrative review","volume":"37","author":"Zale","year":"2015","journal-title":"Clin Psychol Rev"},{"key":"10.1016\/j.jpain.2023.02.024_bib0082","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.650793","article-title":"Behaviors related to psychiatric disorders and pain perception in C57BL\/6J mice during different phases of estrous cycle","volume":"15","author":"Zhao","year":"2021","journal-title":"Front Neurosci"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590023000573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590023000573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:10:46Z","timestamp":1761509446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590023000573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":82,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1526590023000573"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2023.02.024","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.08.19.504595","asserted-by":"object"}]},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanical and Heat Hyperalgesia upon Withdrawal From Chronic Intermittent Ethanol Vapor Depends on Sex, Exposure Duration, and Blood Alcohol Concentration in Mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2023.02.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 Published by Elsevier Inc. on behalf of United States Association for the Study of Pain, Inc.","name":"copyright","label":"Copyright"}]}}