{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:16:20Z","timestamp":1791951380958,"version":"4.3.4"},"reference-count":70,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["2015M3D6A1065094"],"award-info":[{"award-number":["2015M3D6A1065094"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI15C3518"],"award-info":[{"award-number":["HI15C3518"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jpain.2023.07.007","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T21:22:11Z","timestamp":1689110531000},"page":"2211-2227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Combination Gene Delivery Reduces Spinal Cord Pathology in Rats With Peripheral Neuropathic Pain"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3113-7849","authenticated-orcid":false,"given":"Hyelin","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Ran","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang-Joon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Youn","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-9075","authenticated-orcid":false,"given":"Yeomoon","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0489-2662","authenticated-orcid":false,"given":"Heonsik","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2023.07.007_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.18773\/austprescr.2018.022","article-title":"Neuropathic pain: Current definition and review of drug treatment","volume":"41","author":"Murnion","year":"2018","journal-title":"Aust Prescr"},{"key":"10.1016\/j.jpain.2023.07.007_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4110\/in.2012.12.2.41","article-title":"Glia as a link between neuroinflammation and neuropathic pain","volume":"12","author":"Jha","year":"2012","journal-title":"Immune Netw"},{"key":"10.1016\/j.jpain.2023.07.007_bib3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11916-017-0629-5","article-title":"Neuropathic pain: Central vs. peripheral mechanisms","volume":"21","author":"Meacham","year":"2017","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.jpain.2023.07.007_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.051508.135531","article-title":"Neuropathic pain: A maladaptive response of the nervous system to damage","volume":"32","author":"Costigan","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.jpain.2023.07.007_bib5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S1082-3174(96)80050-X","article-title":"Gate control theory: On the evolution of pain concepts","volume":"5","author":"Melzack","year":"1996","journal-title":"Pain Forum"},{"key":"10.1016\/j.jpain.2023.07.007_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1177\/204946370700100102","article-title":"Normal pain transmission","volume":"1","author":"Urch","year":"2007","journal-title":"Rev Pain"},{"key":"10.1016\/j.jpain.2023.07.007_bib7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/cns.13192","article-title":"Mechanism of dorsal root ganglion stimulation for pain relief in painful diabetic polyneuropathy is not dependent on GABA release in the dorsal horn of the spinal cord","volume":"26","author":"Koetsier","year":"2020","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.jpain.2023.07.007_bib8","doi-asserted-by":"crossref","DOI":"10.5812\/aapm.113020","article-title":"Dorsal root ganglion (DRG) and chronic pain","volume":"11","author":"Berger","year":"2021","journal-title":"Anesth Pain Med"},{"key":"10.1016\/j.jpain.2023.07.007_bib9","first-page":"S209","article-title":"Transforaminal epidural steroid injections: A systematic review and meta-analysis of efficacy and safety","volume":"24","author":"Helm","year":"2021","journal-title":"Pain Physician"},{"key":"10.1016\/j.jpain.2023.07.007_bib10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.omtm.2020.06.018","article-title":"AAV-mediated combination gene therapy for neuropathic pain: GAD65, GDNF, and IL-10","volume":"18","author":"Kim","year":"2020","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.jpain.2023.07.007_bib11","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/sj.gt.3300680","article-title":"Adeno-associated virus vectors can be efficiently produced without helper virus","volume":"5","author":"Matsushita","year":"1998","journal-title":"Gene Ther"},{"key":"10.1016\/j.jpain.2023.07.007_bib12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-61779-561-9_15","article-title":"The spared nerve injury model of neuropathic pain","volume":"851","author":"Pertin","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jpain.2023.07.007_bib13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroscience.2014.09.032","article-title":"Spinal presynaptic inhibition in pain control","volume":"283","author":"Guo","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpain.2023.07.007_bib14","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1016\/j.celrep.2017.06.018","article-title":"Peripheral sensory deprivation restores critical-period-like plasticity to adult somatosensory thalamocortical inputs","volume":"19","author":"Chung","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.jpain.2023.07.007_bib15","doi-asserted-by":"crossref","first-page":"6724","DOI":"10.1523\/JNEUROSCI.22-15-06724.2002","article-title":"Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord","volume":"22","author":"Moore","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2023.07.007_bib16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1385-299X(03)00068-0","article-title":"In vivo single unit extracellular recordings from spinal cord neurones of rats","volume":"12","author":"Urch","year":"2003","journal-title":"Brain Res Brain Res Protoc"},{"issue":"11","key":"10.1016\/j.jpain.2023.07.007_bib17","first-page":"11","article-title":"In vivo electrophysiological recording techniques for the study of neuropathic pain in rodent models","volume":"66","author":"Zhao","year":"2014","journal-title":"Curr Protoc Pharmacol"},{"key":"10.1016\/j.jpain.2023.07.007_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","article-title":"Spared nerve injury: An animal model of persistent peripheral neuropathic pain","volume":"87","author":"Decosterd","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2023.07.007_bib19","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.1523\/JNEUROSCI.23-25-08752.2003","article-title":"A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input","volume":"23","author":"Lu","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2023.07.007_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1113\/jphysiol.2006.126912","article-title":"Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat","volume":"581","author":"Santos","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.jpain.2023.07.007_bib21","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0896-6273(01)00494-9","article-title":"Glutamate and GABA: A painful combination","volume":"32","author":"MacDermott","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.jpain.2023.07.007_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1152\/jn.1994.72.1.169","article-title":"The contribution of GABAA and glycine receptors to central sensitization: Disinhibition and touch-evoked allodynia in the spinal cord","volume":"72","author":"Sivilotti","year":"1994","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2023.07.007_bib23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0361-9230(80)90012-X","article-title":"On the role of glial gaba uptake: Studies with dorsal root ganglia","volume":"5","author":"Headley","year":"1980","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jpain.2023.07.007_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0006-8993(74)90147-4","article-title":"The characterisation of [3H]GABA uptake into the satellite glial cells of rat sensory ganglia","volume":"66","author":"Schon","year":"1974","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jpain.2023.07.007_bib25","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: A generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2023.07.007_bib26","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1523\/JNEUROSCI.19-15-06497.1999","article-title":"Isolectin B(4)-positive and -negative nociceptors are functionally distinct","volume":"19","author":"Stucky","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2023.07.007_bib27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.expneurol.2009.01.014","article-title":"Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat","volume":"217","author":"Casals-Diaz","year":"2009","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jpain.2023.07.007_bib28","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1152\/jn.00945.2003","article-title":"Characterization of wide dynamic range neurons in the deep dorsal horn of the spinal cord in preprotachykinin-a null mice in vivo","volume":"91","author":"Martin","year":"2004","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpain.2023.07.007_bib29","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1097\/j.pain.0000000000001632","article-title":"Alterations in evoked and spontaneous activity of dorsal horn wide dynamic range neurons in pathological pain: A systematic review and analysis","volume":"160","author":"Zain","year":"2019","journal-title":"Pain."},{"key":"10.1016\/j.jpain.2023.07.007_bib30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1742-2094-8-33","article-title":"Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1","volume":"8","author":"Berger","year":"2011","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jpain.2023.07.007_bib31","article-title":"Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis","volume":"5","author":"Chen","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jpain.2023.07.007_bib32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fncel.2017.00235","article-title":"Microglia morphological categorization in a rat model of neuroinflammation by hierarchical cluster and principal components analysis","volume":"11","author":"Fernandez-Arjona","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jpain.2023.07.007_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41420-019-0166-6","article-title":"Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge","volume":"5","author":"Acaz-Fonseca","year":"2019","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jpain.2023.07.007_bib34","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s13311-018-0633-4","article-title":"Neuropathic pain after spinal cord injury: Challenges and research perspectives","volume":"15","author":"Shiao","year":"2018","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jpain.2023.07.007_bib35","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central sensitization: Implications for the diagnosis and treatment of pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2023.07.007_bib36","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S2665-9913(21)00032-1","article-title":"Central sensitisation in chronic pain conditions: Latest discoveries and their potential for precision medicine","volume":"3","author":"Nijs","year":"2021","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.jpain.2023.07.007_bib37","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1016\/j.celrep.2018.04.107","article-title":"NMDA receptor activation underlies the loss of spinal dorsal horn neurons and the transition to persistent pain after peripheral nerve injury","volume":"23","author":"Inquimbert","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.jpain.2023.07.007_bib38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ibror.2018.11.003","article-title":"Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system","volume":"5","author":"Hashimoto-Torii","year":"2018","journal-title":"IBRO Rep"},{"key":"10.1016\/j.jpain.2023.07.007_bib39","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918797032","article-title":"Mitochondrial superoxide increases excitatory synaptic strength in spinal dorsal horn neurons of neuropathic mice","volume":"14","author":"Bae","year":"2018","journal-title":"Mol Pain"},{"key":"10.1016\/j.jpain.2023.07.007_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073370","article-title":"Impaired excitatory drive to spinal GABAergic neurons of neuropathic mice","volume":"8","author":"Leitner","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jpain.2023.07.007_bib41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1744-8069-1-12","article-title":"New players tip the scales in the balance between excitatory and inhibitory synapses","volume":"1","author":"Levinson","year":"2005","journal-title":"Mol Pain"},{"key":"10.1016\/j.jpain.2023.07.007_bib42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0006-8993(93)90167-L","article-title":"GABA decreases in the spinal cord dorsal horn after peripheral neurectomy","volume":"620","author":"Castro-Lopes","year":"1993","journal-title":"Brain Res"},{"key":"10.1016\/j.jpain.2023.07.007_bib43","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/physrev.00025.2008","article-title":"Models and mechanisms of hyperalgesia and allodynia","volume":"89","author":"Sandkuhler","year":"2009","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jpain.2023.07.007_bib44","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1152\/physrev.00043.2010","article-title":"Fast synaptic inhibition in spinal sensory processing and pain control","volume":"92","author":"Zeilhofer","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jpain.2023.07.007_bib45","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1460-9568.2006.04602.x","article-title":"A local GABAergic system within rat trigeminal ganglion cells","volume":"23","author":"Hayasaki","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jpain.2023.07.007_bib46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neures.2020.08.007","article-title":"gamma-Aminobutyric acid (GABA) from satellite glial cells tonically depresses the excitability of primary afferent fibers","volume":"170","author":"Vargas-Parada","year":"2021","journal-title":"Neurosci Res"},{"key":"10.1016\/j.jpain.2023.07.007_bib47","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1113\/jphysiol.2014.278754","article-title":"Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition","volume":"592","author":"Yoon","year":"2014","journal-title":"J Physiol"},{"key":"10.1016\/j.jpain.2023.07.007_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2020.101952","article-title":"IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake","volume":"199","author":"Patel","year":"2021","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jpain.2023.07.007_bib49","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s13311-020-00936-0","article-title":"Central nervous system targets: Inhibitory interneurons in the spinal cord","volume":"17","author":"Hughes","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jpain.2023.07.007_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1054-3589(06)54001-3","article-title":"The role of GABA in the mediation and perception of pain","volume":"54","author":"Enna","year":"2006","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.jpain.2023.07.007_bib51","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3959(00)00383-3","article-title":"GABAergic modulation of descending inhibitory systems from the rostral ventromedial medulla (RVM). Dose-response analysis of nociception and neurological deficits","volume":"90","author":"Gilbert","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2023.07.007_bib52","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/j.pain.2011.04.017","article-title":"Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord","volume":"152","author":"Quintero","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2023.07.007_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2480689","article-title":"Neuronal-Glial interactions maintain chronic neuropathic pain after spinal cord injury","volume":"2017","author":"Gwak","year":"2017","journal-title":"Neural Plast"},{"key":"10.1016\/j.jpain.2023.07.007_bib54","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1017\/S1740925X08000100","article-title":"Do glial cells control pain?","volume":"3","author":"Suter","year":"2007","journal-title":"Neuron Glia Biol"},{"key":"10.1016\/j.jpain.2023.07.007_bib55","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41583-019-0218-1","article-title":"Astrocytes in chronic pain and itch","volume":"20","author":"Ji","year":"2019","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jpain.2023.07.007_bib56","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12974-019-1524-2","article-title":"An update on reactive astrocytes in chronic pain","volume":"16","author":"Li","year":"2019","journal-title":"J Neuroinflamm"},{"key":"10.1016\/j.jpain.2023.07.007_bib57","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3390\/molecules25030762","article-title":"Therapeutic potential of flavonoids in pain and inflammation: Mechanisms of action, pre-clinical and clinical data, and pharmaceutical development","volume":"25","author":"Ferraz","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jpain.2023.07.007_bib58","article-title":"Oral nonsteroidal anti-inflammatory drugs for neuropathic pain","volume":"2015","author":"Moore","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jpain.2023.07.007_bib59","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.bbi.2016.02.001","article-title":"Inhibiting neuroinflammation: The role and therapeutic potential of GABA in neuro-immune interactions","volume":"54","author":"Crowley","year":"2016","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jpain.2023.07.007_bib60","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.neuropharm.2018.04.009","article-title":"Peripheral GABAA receptor-mediated signaling facilitates persistent inflammatory hypersensitivity","volume":"135","author":"Lee","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpain.2023.07.007_bib61","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1136\/svn-2016-000012","article-title":"Neurotransmitter receptors on microglia","volume":"1","author":"Liu","year":"2016","journal-title":"Stroke Vasc Neurol"},{"key":"10.1016\/j.jpain.2023.07.007_bib62","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1089\/dna.2019.5308","article-title":"Hippo\/YAP pathway plays a critical role in effect of GDNF against abeta-induced inflammation in microglial cells","volume":"39","author":"Qing","year":"2020","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.jpain.2023.07.007_bib63","first-page":"10","article-title":"Glial cell line-derived neurotrophic factor family members reduce microglial activation via inhibiting p38MAPKs-mediated inflammatory responses","volume":"2014","author":"Rickert","year":"2014","journal-title":"J Neurodegener Dis"},{"key":"10.1016\/j.jpain.2023.07.007_bib64","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fphys.2019.00486","article-title":"Effects of neurotrophic factors in glial cells in the central nervous system: Expression and properties in neurodegeneration and injury","volume":"10","author":"Poyhonen","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.jpain.2023.07.007_bib65","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/glia.21087","article-title":"Astrocytes are GABAergic cells that modulate microglial activity","volume":"59","author":"Lee","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.jpain.2023.07.007_bib66","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12974-016-0763-8","article-title":"Balancing the immune response in the brain: IL-10 and its regulation","volume":"13","author":"Lobo-Silva","year":"2016","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jpain.2023.07.007_bib67","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fncel.2019.00430","article-title":"Loss of IL-10 promotes differentiation of microglia to a M1 phenotype","volume":"13","author":"Laffer","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jpain.2023.07.007_bib68","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3389\/fimmu.2020.01416","article-title":"Crosstalk between astrocytes and microglia: An overview","volume":"11","author":"Matejuk","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jpain.2023.07.007_bib69","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.neuron.2018.11.009","article-title":"Microglia in pain: Detrimental and protective roles in pathogenesis and resolution of pain","volume":"100","author":"Chen","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.jpain.2023.07.007_bib70","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1523\/JNEUROSCI.16-09-02945.1996","article-title":"Attenuation of astroglial reactivity by interleukin-10","volume":"16","author":"Balasingam","year":"1996","journal-title":"J Neurosci"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590023004686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590023004686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:13:08Z","timestamp":1761509588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590023004686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1526590023004686"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2023.07.007","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination Gene Delivery Reduces Spinal Cord Pathology in Rats With Peripheral Neuropathic Pain","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2023.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of United States Association for the Study of Pain, Inc","name":"copyright","label":"Copyright"}]}}