{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:17:49Z","timestamp":1791422269797,"version":"4.3.3"},"reference-count":70,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["R01AG061325"],"award-info":[{"award-number":["R01AG061325"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["R01AG059861"],"award-info":[{"award-number":["R01AG059861"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["K23AG046379"],"award-info":[{"award-number":["K23AG046379"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["R21AG045735"],"award-info":[{"award-number":["R21AG045735"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["UL1 TR000445"],"award-info":[{"award-number":["UL1 TR000445"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA050334"],"award-info":[{"award-number":["R01DA050334"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jpain.2023.10.027","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T16:51:19Z","timestamp":1699721479000},"page":"1059-1069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Gender Differences in Pain Threshold, Unpleasantness, and Descending Pain Modulatory Activation Across the Adult Life Span: A Cross Sectional Study"],"prefix":"10.1016","volume":"25","author":[{"given":"Michelle D.","family":"Failla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Beach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Atalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary S.","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bruehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L.","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd B.","family":"Monroe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jpain.2023.10.027_bib1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41583-020-0310-6","article-title":"Qualitative sex differences in pain processing: emerging evidence of a biased literature","volume":"21","author":"Mogil","year":"2020","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jpain.2011.11.002","article-title":"Sex differences in reported pain across 11,000 patients captured in electronic medical records","volume":"13","author":"Ruau","year":"2012","journal-title":"J Pain"},{"issue":"5","key":"10.1016\/j.jpain.2023.10.027_bib3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jpain.2008.12.001","article-title":"Sex, gender, and pain: a review of recent clinical and experimental findings","volume":"10","author":"Fillingim","year":"2009","journal-title":"J Pain Off J Am Pain Soc"},{"issue":"Suppl 1","key":"10.1016\/j.jpain.2023.10.027_bib4","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/j.pain.2007.10.014","article-title":"Studying sex and gender differences in pain and analgesia: a consensus report","volume":"132","author":"Greenspan","year":"2007","journal-title":"Pain"},{"issue":"12","key":"10.1016\/j.jpain.2023.10.027_bib5","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrn3360","article-title":"Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon","volume":"13","author":"Mogil","year":"2012","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"10.1016\/j.jpain.2023.10.027_bib6","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/acr.22712","article-title":"Enhanced pain sensitivity among individuals with symptomatic knee osteoarthritis: potential sex differences in central sensitization","volume":"68","author":"Bartley","year":"2016","journal-title":"Arthritis Care Res"},{"issue":"1","key":"10.1016\/j.jpain.2023.10.027_bib7","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yhbeh.2009.09.012","article-title":"Sex differences in opioid analgesia, hyperalgesia, tolerance and withdrawal: central mechanisms of action and roles of gonadal hormones","volume":"58","author":"Bodnar","year":"2010","journal-title":"Horm Behav"},{"issue":"1","key":"10.1016\/j.jpain.2023.10.027_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pain.2010.06.012","article-title":"Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies","volume":"151","author":"Niesters","year":"2010","journal-title":"Pain"},{"issue":"8","key":"10.1016\/j.jpain.2023.10.027_bib9","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1097\/j.pain.0000000000002215","article-title":"Sex differences in neuroimmune and glial mechanisms of pain","volume":"162","author":"Gregus","year":"2021","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1212\/WNL.0b013e31823fcdee","article-title":"Periaqueductal gray: an interface for behavioral control","volume":"78","author":"Benarroch","year":"2012","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.jpain.2023.10.027_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.pain.2009.11.008","article-title":"Exploring the brain in pain: activations, deactivations and their relation","volume":"148","author":"Kong","year":"2010","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.jpain.2023.10.027_bib12","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.pain.2011.11.006","article-title":"Sex similarities and differences in pain-related periaqueductal gray connectivity","volume":"153","author":"Linnman","year":"2012","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.jpain.2023.10.027_bib13","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.neuroimage.2011.11.095","article-title":"Neuroimaging of the periaqueductal gray: state of the field","volume":"60","author":"Linnman","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.jpain.2023.10.027_bib14","series-title":"In: Textbook of Pain","first-page":"125","article-title":"Central nervous system mechanisms of pain modulation","author":"Fields","year":"2006"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuron.2007.07.012","article-title":"The cerebral signature for pain perception and its modulation","volume":"55","author":"Tracey","year":"2007","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib16","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.pain.2009.07.002","article-title":"Women experience greater heat pain adaptation and habituation than men","volume":"145","author":"Hashmi","year":"2009","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.jpain.2023.10.027_bib17","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.pain.2014.01.005","article-title":"Sex differences in connectivity of the subgenual anterior cingulate cortex","volume":"155","author":"Wang","year":"2014","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.jpain.2023.10.027_bib18","first-page":"R257","article-title":"Sex differences in the cerebral BOLD signal response to painful heat stimuli","volume":"291","author":"Moulton","year":"2006","journal-title":"Am J"},{"issue":"2","key":"10.1016\/j.jpain.2023.10.027_bib19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/hbm.20536","article-title":"Sex differences in brain activation to anticipated and experienced pain in the medial prefrontal cortex","volume":"30","author":"Straube","year":"2009","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/j.1532-2149.2011.00027.x","article-title":"Behavioural and neural correlates of visceral pain sensitivity in healthy men and women: does sex matter?","volume":"16","author":"Benson","year":"2012","journal-title":"Eur J Pain"},{"issue":"4","key":"10.1016\/j.jpain.2023.10.027_bib21","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.neuroimage.2007.10.045","article-title":"Gender differences in brain activity evoked by muscle and cutaneous pain: a retrospective study of single-trial fMRI data","volume":"39","author":"Henderson","year":"2008","journal-title":"NeuroImage"},{"issue":"9","key":"10.1016\/j.jpain.2023.10.027_bib22","first-page":"1737","article-title":"Sex differences in brain regions modulating pain among older adults: a cross-sectional resting state functional connectivity study","volume":"19","author":"Monroe","year":"2018","journal-title":"Pain Med Malden Mass"},{"key":"10.1016\/j.jpain.2023.10.027_bib23","doi-asserted-by":"crossref","DOI":"10.1186\/s13293-015-0041-y","article-title":"Sex differences in psychophysical and neurophysiological responses to pain in older adults: a cross-sectional study","volume":"6","author":"Monroe","year":"2015","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.jpain.2023.10.027_bib24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neubiorev.2017.01.039","article-title":"Age changes in pain perception: a systematic-review and meta-analysis of age effects on pain and tolerance thresholds","volume":"75","author":"Lautenbacher","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"issue":"suppl_2","key":"10.1016\/j.jpain.2023.10.027_bib25","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1111\/j.1526-4637.2011.01287.x","article-title":"Age-related changes in the structure and function of brain regions involved in pain processing","volume":"13","author":"Farrell","year":"2012","journal-title":"Pain Med"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0304-3959(01)00427-4","article-title":"Gender, coping and the perception of pain","volume":"97","author":"Keogh","year":"2002","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib27","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3233\/JAD-201293","article-title":"Could altered evoked pain responsiveness be a phenotypic biomarker for alzheimer\u2019s disease risk? A cross-sectional analysis of cognitively healthy individuals","volume":"79","author":"Romano","year":"2021","journal-title":"J Alzheimers Dis JAD"},{"key":"10.1016\/j.jpain.2023.10.027_bib28","unstructured":"Hollingshead, August B. Four factor index of social status. 1975. Accessed September 19, 2023. https:\/\/sociology.yale.edu\/sites\/default\/files\/files\/yjs_fall_2011.pdf#page=21."},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"5","key":"10.1016\/j.jpain.2023.10.027_bib30","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00002508-200409000-00005","article-title":"Validity of the brief pain inventory for use in documenting the outcomes of patients with noncancer pain","volume":"20","author":"Keller","year":"2004","journal-title":"Clin J Pain"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000376585","article-title":"The WHO-5 well-being index: a systematic review of the literature","volume":"84","author":"Topp","year":"2015","journal-title":"Psychother Psychosom"},{"key":"10.1016\/j.jpain.2023.10.027_bib32","series-title":"The State-Trait Anxiety Inventory Manual","author":"Spielberger","year":"1970"},{"issue":"11","key":"10.1016\/j.jpain.2023.10.027_bib33","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1136\/jnnp.39.11.1071","article-title":"Method for quantitative estimation of thermal thresholds in patients","volume":"39","author":"Fruhstorfer","year":"1976","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib34","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00000542-200003000-00014","article-title":"Effect of ambient temperature on human pain and temperature perception","volume":"92","author":"Strigo","year":"2000","journal-title":"Anesthesiology"},{"issue":"Pt 11","key":"10.1016\/j.jpain.2023.10.027_bib35","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/brain\/awl228","article-title":"Pain sensitivity and fMRI pain-related brain activity in Alzheimer\u2019s disease","volume":"129","author":"Cole","year":"2006","journal-title":"Brain J Neurol"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ejpain.2004.09.001","article-title":"Differences in unpleasantness induced by experimental pressure pain between patients with fibromyalgia and healthy controls","volume":"9","author":"Petzke","year":"2005","journal-title":"Eur J Pain"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib37","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3233\/JAD-190142","article-title":"Sex differences in associations of cognitive function with perceptions of pain in older adults","volume":"70","author":"Romano","year":"2019","journal-title":"J Alzheimers Dis JAD"},{"issue":"1","key":"10.1016\/j.jpain.2023.10.027_bib38","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3233\/JAD-161187","article-title":"The impact of Alzheimer\u2019s disease on the resting state functional connectivity of brain regions modulating pain: a cross sectional study","volume":"57","author":"Monroe","year":"2017","journal-title":"J Alzheimers Dis JAD"},{"issue":"4","key":"10.1016\/j.jpain.2023.10.027_bib39","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/(SICI)1097-0193(1997)5:4<238::AID-HBM6>3.0.CO;2-4","article-title":"Automated labeling of the human brain: a preliminary report on the development and evaluation of a forward-transform method","volume":"5","author":"Lancaster","year":"1997","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"10.1016\/j.jpain.2023.10.027_bib40","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.neuroimage.2003.09.032","article-title":"Precentral gyrus discrepancy in electronic versions of the Talairach atlas","volume":"21","author":"Maldjian","year":"2004","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib41","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S1053-8119(03)00169-1","article-title":"An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets","volume":"19","author":"Maldjian","year":"2003","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib42","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.pain.2012.11.018","article-title":"The importance of context: when relative relief renders pain pleasant","volume":"154","author":"Leknes","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2023.10.027_bib43","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.neuroimage.2013.12.058","article-title":"Cluster-extent based thresholding in fMRI analyses: Pitfalls and recommendations","volume":"91","author":"Woo","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.jpain.2023.10.027_bib44","unstructured":"Brett M., Anton J.L., Valabregue R., Poline J.B. Region of interest analysis using an SPM toolbox. Presented at: 8th International Conferance on Functional Mapping of the Human Brain, June 2\u20136, 2002, Sendai, Japan. Accessed October 4, 2023."},{"issue":"2","key":"10.1016\/j.jpain.2023.10.027_bib45","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1526-4610.2006.00708.x","article-title":"The influence of gender and sex steroids on craniofacial nociception","volume":"47","author":"Cairns","year":"2007","journal-title":"Headache J Head Face Pain"},{"issue":"2","key":"10.1016\/j.jpain.2023.10.027_bib46","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1089\/jwh.2012.3972","article-title":"Influence of patient sex and gender on medication use, adherence, and prescribing alignment with guidelines","volume":"23","author":"Manteuffel","year":"2014","journal-title":"J Womens Health"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib47","first-page":"193","article-title":"Inhibition in expressing pain. A qualitative study among Dutch surgical breast cancer patients","volume":"17","author":"Francke","year":"1994","journal-title":"Cancer Nurs"},{"issue":"1","key":"10.1016\/j.jpain.2023.10.027_bib48","first-page":"79","article-title":"Gender differences and pain medication","volume":"5","author":"Richardson","year":"2009","journal-title":"Womens Health"},{"issue":"2","key":"10.1016\/j.jpain.2023.10.027_bib49","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0304-3959(89)90240-6","article-title":"Measurements of human pressure-pain thresholds on fingers and toes","volume":"38","author":"Brennum","year":"1989","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.jpain.2023.10.027_bib50","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/BF02330587","article-title":"Evaluation of pain threshold using a simple pressure algometer","volume":"6","author":"Buchanan","year":"1987","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.jpain.2023.10.027_bib51","article-title":"The effects of sex and gender role on responses to pressure pain","volume":"9","author":"Kr\u00f6ner-Herwig","year":"2012","journal-title":"GMS Psycho-Soc-Med"},{"issue":"7","key":"10.1016\/j.jpain.2023.10.027_bib52","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1111\/j.1526-4637.2011.01157.x","article-title":"Individual differences in morphine and butorphanol analgesia: a laboratory pain study","volume":"12","author":"Sibille","year":"2011","journal-title":"Pain Med"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib53","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0304-3959(91)90094-E","article-title":"Sex differences in the perception of noxious heat stimuli","volume":"44","author":"Feine","year":"1991","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.jpain.2023.10.027_bib54","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3959(97)00214-5","article-title":"Sex differences in temporal summation but not sensory-discriminative processing of thermal pain","volume":"75","author":"Fillingim","year":"1998","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.jpain.2023.10.027_bib55","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00006842-200007000-00010","article-title":"Race and sex differences in cutaneous pain perception","volume":"62","author":"Sheffield","year":"2000","journal-title":"Psychosom Med"},{"issue":"2","key":"10.1016\/j.jpain.2023.10.027_bib56","first-page":"173","article-title":"Influence of sex and anxiety on pain threshold and tolerance","volume":"2","author":"Robin","year":"1987","journal-title":"Funct Neurol"},{"issue":"1","key":"10.1016\/j.jpain.2023.10.027_bib57","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/00002508-199303000-00003","article-title":"Gender differences in pain and cardiovascular responses to forearm ischemia","volume":"9","author":"Maixner","year":"1993","journal-title":"Clin J Pain"},{"issue":"9","key":"10.1016\/j.jpain.2023.10.027_bib58","first-page":"1779","article-title":"Thermal psychophysics and associated brain activation patterns along a continuum of healthy aging","volume":"21","author":"Beach","year":"2020","journal-title":"Pain Med Malden Mass"},{"issue":"4","key":"10.1016\/j.jpain.2023.10.027_bib59","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.3233\/JAD-170532","article-title":"Sex differences in the psychophysical response to contact heat in moderate cognitive impairment Alzheimer\u2019s disease: a cross-sectional brief report","volume":"60","author":"Cowan","year":"2017","journal-title":"J Alzheimers Dis JAD"},{"issue":"4","key":"10.1016\/j.jpain.2023.10.027_bib60","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1097\/j.pain.0000000000002104","article-title":"Sex differences in brain modular organization in chronic pain","volume":"162","author":"Fauchon","year":"2021","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib61","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/hbm.25245","article-title":"Sex-differences in network level brain dynamics associated with pain sensitivity and pain interference","volume":"42","author":"Kim","year":"2021","journal-title":"Hum Brain Mapp"},{"issue":"2","key":"10.1016\/j.jpain.2023.10.027_bib62","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/SPC.0000000000000055","article-title":"Descending pain modulation and chronification of pain","volume":"8","author":"Ossipov","year":"2014","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1016\/j.jpain.2023.10.027_bib63","series-title":"The Human Nervous System","first-page":"367","article-title":"Chapter 10\u2014periaqueductal gray","author":"Carrive","year":"2012"},{"issue":"2","key":"10.1016\/j.jpain.2023.10.027_bib64","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbr.2010.03.042","article-title":"Intrinsic functional connectivity of the periaqueductal gray, a resting fMRI study","volume":"211","author":"Kong","year":"2010","journal-title":"Behav Brain Res"},{"issue":"1","key":"10.1016\/j.jpain.2023.10.027_bib65","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1073\/pnas.0906186106","article-title":"Prestimulus functional connectivity determines pain perception in humans","volume":"107","author":"Ploner","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib66","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.pain.2010.08.046","article-title":"Effects of temperature on heat pain adaptation and habituation in men and women","volume":"151","author":"Hashmi","year":"2010","journal-title":"Pain"},{"issue":"15","key":"10.1016\/j.jpain.2023.10.027_bib67","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1056\/NEJMoa1204471","article-title":"An fMRI-Based neurologic signature of physical pain","volume":"368","author":"Wager","year":"2013","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jpain.2023.10.027_bib68","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/aur.2289","article-title":"Neural correlates of cardiac interoceptive focus across development: implications for social symptoms in autism spectrum disorder","volume":"13","author":"Failla","year":"2020","journal-title":"Autism Res Off J Int Soc Autism Res"},{"key":"10.1016\/j.jpain.2023.10.027_bib69","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1196\/annals.1379.024","article-title":"Age-related changes in nociceptive processing in the human brain","volume":"1097","author":"Quiton","year":"2007","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1016\/j.jpain.2023.10.027_bib70","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nn1008","article-title":"Mapping cortical change across the human life span","volume":"6","author":"Sowell","year":"2003","journal-title":"Nat Neurosci"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590023006077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590023006077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T04:00:18Z","timestamp":1729051218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590023006077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":70,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1526590023006077"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2023.10.027","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gender Differences in Pain Threshold, Unpleasantness, and Descending Pain Modulatory Activation Across the Adult Life Span: A Cross Sectional Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2023.10.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of United States Association for the Study of Pain, Inc","name":"copyright","label":"Copyright"}]}}