{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:37:42Z","timestamp":1792179462415,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jpain.2024.104529","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T12:49:21Z","timestamp":1712407761000},"page":"104529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tooth Loss and Chronic Pain: A Population-based Analysis of the National Health and Nutrition Examination Survey"],"prefix":"10.1016","volume":"25","author":[{"given":"Kevin Sheng-Kai","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8453-9892","authenticated-orcid":false,"given":"Shu-Yen","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiow-Ing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Cheng-Chung","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sait","family":"Ashina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpain.2024.104529_bib1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/jama.1978.03290060047012","article-title":"Chronic inflammatory gingival and periodontal disease","volume":"240","author":"Page","year":"1978","journal-title":"JAMA"},{"key":"10.1016\/j.jpain.2024.104529_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases: a global public health challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jpain.2024.104529_bib3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/annrheumdis-2020-216972","article-title":"Dysbiosis in the oral microbiomes of anti-CCP positive individuals at risk of developing rheumatoid arthritis","volume":"80","author":"Cheng","year":"2021","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.jpain.2024.104529_bib4","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.jfma.2022.01.017","article-title":"Severity of periodontitis and salivary interleukin-1\u03b2 are associated with psoriasis involvement","volume":"121","author":"Wu","year":"2022","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jpain.2024.104529_bib5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/JPER.21-0181","article-title":"Periodontitis in patients with systemic lupus erythematosus: a nationwide study of 1,990 patients","volume":"93","author":"Bolstad","year":"2022","journal-title":"J Periodontol"},{"key":"10.1016\/j.jpain.2024.104529_bib6","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3389\/fimmu.2017.01295","article-title":"Association between systemic lupus erythematosus and periodontitis: a systematic review and meta-analysis","volume":"8","author":"Rutter-Locher","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jpain.2024.104529_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jre.12936","article-title":"Periodontitis and systemic lupus erythematosus: a systematic review and meta-analysis","volume":"57","author":"Hussain","year":"2022","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jpain.2024.104529_bib8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0765.1977.tb00107.x","article-title":"Immunoglobulin bearing lymphocytes and plasma cells in human periodontal disease","volume":"12","author":"Mackler","year":"1977","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jpain.2024.104529_bib9","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/JPER.21-0256","article-title":"Fibromyalgia and periodontitis: bidirectional associations in population-based 15-year retrospective cohorts","volume":"93","author":"Ma","year":"2022","journal-title":"J Periodontol"},{"key":"10.1016\/j.jpain.2024.104529_bib10","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.3899\/jrheum.130493","article-title":"Chronic widespread pain in patients with rheumatoid arthritis and the relation between pain and disease activity measures over the first 5 years","volume":"40","author":"Andersson","year":"2013","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jpain.2024.104529_bib11","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/ejp.1432","article-title":"A diagnosis of rheumatoid arthritis, endometriosis or IBD is associated with later onset of fibromyalgia and chronic widespread pain","volume":"23","author":"Larrosa Pardo","year":"2019","journal-title":"Eur J Pain"},{"key":"10.1016\/j.jpain.2024.104529_bib12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/j.pain.0000000000000733","article-title":"Identifying patients with chronic widespread pain in primary care","volume":"158","author":"Mansfield","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2024.104529_bib13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.semarthrit.2020.10.008","article-title":"The Jak\/STAT pathway: a focus on pain in rheumatoid arthritis","volume":"51","author":"Simon","year":"2021","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.jpain.2024.104529_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/jicd.12087","article-title":"Relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain: a literature review","volume":"5","author":"de Avila","year":"2014","journal-title":"J Investig Clin Dent"},{"key":"10.1016\/j.jpain.2024.104529_bib15","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.2105\/AJPH.2021.306517","article-title":"The National Health and Nutrition Examination Survey (NHANES), 2021-2022: adapting data collection in a COVID-19 environment","volume":"111","author":"Paulose-Ram","year":"2021","journal-title":"Am J Public Health"},{"key":"10.1016\/j.jpain.2024.104529_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12903-019-0777-6","article-title":"Overview and quality assurance for the oral health component of the National Health and Nutrition Examination Survey (NHANES), 2011-2014","volume":"19","author":"Dye","year":"2019","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.jpain.2024.104529_bib17","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1001\/jama.2018.14854","article-title":"The physical activity guidelines for Americans","volume":"320","author":"Piercy","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jpain.2024.104529_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Afshin","year":"2017","journal-title":"N Engl J Med"},{"issue":"Suppl 20","key":"10.1016\/j.jpain.2024.104529_bib19","first-page":"S1","article-title":"A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification","volume":"45","author":"Caton","year":"2018","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jpain.2024.104529_bib20","doi-asserted-by":"crossref","first-page":"Itc33","DOI":"10.7326\/AITC202003030","article-title":"Fibromyalgia","volume":"172","author":"Bair","year":"2020","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jpain.2024.104529_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11916-016-0556-x","article-title":"Fibromyalgia pathogenesis and treatment options update","volume":"20","author":"Chinn","year":"2016","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.jpain.2024.104529_bib22","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1056\/NEJMra1915327","article-title":"Migraine","volume":"383","author":"Ashina","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpain.2024.104529_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41572-021-00257-2","article-title":"Tension-type headache","volume":"7","author":"Ashina","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jpain.2024.104529_bib24","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J Dent Res"},{"issue":"Suppl 18","key":"10.1016\/j.jpain.2024.104529_bib25","first-page":"S39","article-title":"Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP\/ORCA workshop on the boundaries between caries and periodontal diseases","volume":"44","author":"Chapple","year":"2017","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.jpain.2024.104529_bib26","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1186\/s12889-021-12392-2","article-title":"Multimorbidity and tooth loss: the Brazilian National Health Survey, 2019","volume":"21","author":"Bomfim","year":"2021","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jpain.2024.104529_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12011-016-0832-y","article-title":"Trace mineral micronutrients and chronic periodontitis-a review","volume":"176","author":"Gaur","year":"2017","journal-title":"Biol Trace Elem Res"},{"issue":"15","key":"10.1016\/j.jpain.2024.104529_bib28","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.3390\/nu14153010","article-title":"The efficacy of vitamin D supplementation in the treatment of fibromyalgia syndrome and chronic musculoskeletal pain","volume":"14","author":"Lombardo","year":"2022","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.jpain.2024.104529_bib29","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.3390\/nu12082177","article-title":"Vitamin D and periodontitis: a systematic review and meta-analysis","volume":"12","author":"Machado","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jpain.2024.104529_bib30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/jcpe.13384","article-title":"The impact of smoking on non-surgical periodontal therapy: a\u00a0systematic review and meta-analysis","volume":"48","author":"Chang","year":"2021","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jpain.2024.104529_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13075-019-1808-z","article-title":"Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: a case-control study","volume":"21","author":"Rodriguez-Lozano","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jpain.2024.104529_bib32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1600-051X.2007.01173.x","article-title":"A systematic review and meta-analyses on C-reactive protein in relation to periodontitis","volume":"35","author":"Paraskevas","year":"2008","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jpain.2024.104529_bib33","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: consensus report","volume":"47","author":"Sanz","year":"2020","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jpain.2024.104529_bib34","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/rheumatology\/kev388","article-title":"Multibiomarker disease activity score and C-reactive protein in a cross-sectional observational study of patients with rheumatoid arthritis with and without concomitant fibromyalgia","volume":"55","author":"Lee","year":"2016","journal-title":"Rheumatology"},{"key":"10.1016\/j.jpain.2024.104529_bib35","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1177\/0022034521995157","article-title":"Host modulation and treatment of periodontal disease","volume":"100","author":"Balta","year":"2021","journal-title":"J Dent Res"},{"key":"10.1016\/j.jpain.2024.104529_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2842.2012.02345.x","article-title":"The role of dental loss and denture status on clinical signs of temporomandibular disorders","volume":"40","author":"Sipil\u00e4","year":"2013","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.jpain.2024.104529_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bj.2018.12.001","article-title":"Association between periodontal pathogens and systemic disease","volume":"42","author":"Bui","year":"2019","journal-title":"Biomed J"},{"key":"10.1016\/j.jpain.2024.104529_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/prd.12385","article-title":"Periodontitis and rheumatoid arthritis: what have we learned about their connection and their treatment?","volume":"87","author":"Gonz\u00e1lez-Febles","year":"2021","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.jpain.2024.104529_bib39","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1902\/jop.2013.130336","article-title":"Altered antigenic profiling and infectivity of Porphyromonas gingivalis in smokers and non-smokers with periodontitis","volume":"85","author":"Zeller","year":"2014","journal-title":"J Periodontol"},{"key":"10.1016\/j.jpain.2024.104529_bib40","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1136\/annrheumdis-2020-217344","article-title":"EULAR definition of difficult-to-treat rheumatoid arthritis","volume":"80","author":"Nagy","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jpain.2024.104529_bib41","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1136\/annrheumdis-2018-213687","article-title":"Characteristics of difficult-to-treat rheumatoid arthritis: results of an international survey","volume":"77","author":"Roodenrijs","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jpain.2024.104529_bib42","article-title":"Role of interleukin-17A in the pathomechanisms of periodontitis and related systemic chronic inflammatory diseases","volume":"13","author":"Feng","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jpain.2024.104529_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.706432","article-title":"Serum C-reactive protein and periodontitis: a systematic review and meta-analysis","volume":"12","author":"Machado","year":"2021","journal-title":"Front Immunol"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590024004498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590024004498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T04:01:31Z","timestamp":1756699291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590024004498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S1526590024004498"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2024.104529","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tooth Loss and Chronic Pain: A Population-based Analysis of the National Health and Nutrition Examination Survey","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2024.104529","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc. on behalf of United States Association for the Study of Pain, Inc","name":"copyright","label":"Copyright"}],"article-number":"104529"}}