{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:14:36Z","timestamp":1778055276854,"version":"3.51.4"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011117","name":"Coastal Ocean Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011117","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"US Food and Drug Administration","doi-asserted-by":"publisher","award":["FDA-BAA-75F40119C10099"],"award-info":[{"award-number":["FDA-BAA-75F40119C10099"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jpain.2024.104759","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T01:49:10Z","timestamp":1734227350000},"page":"104759","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Methodology for determining minimally clinically important differences in acute pain intensity with the double stopwatch technique"],"prefix":"10.1016","volume":"30","author":[{"given":"Christopher J.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Farrar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jpain.2024.104759_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0304-3959(96)03306-4","article-title":"Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics: use of pain intensity and visual analogue scales","volume":"69","author":"Moore","year":"1997","journal-title":"Pain"},{"issue":"12","key":"10.1016\/j.jpain.2024.104759_bib2","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1136\/rapm-2020-101670","article-title":"Is the minimal clinically important difference (MCID) in acute pain a good measure of analgesic efficacy in regional anesthesia?","volume":"45","author":"Mu\u00f1oz-Leyva","year":"2020","journal-title":"Regional Anesthesia & Pain Medicine"},{"issue":"2","key":"10.1016\/j.jpain.2024.104759_bib3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(01)00349-9","article-title":"Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale","volume":"94","author":"Farrar","year":"2001","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.jpain.2024.104759_bib4","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1056\/NEJMe2305480","article-title":"Trials for managing acute pain \u2013 a clinically meaningful small effect size?","volume":"389","author":"Wallace","year":"2023","journal-title":"The New England Journal of Medicine"},{"issue":"4","key":"10.1016\/j.jpain.2024.104759_bib5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.pmn.2006.09.001","article-title":"Determination of clinically meaningful levels of pain reduction in patients experiencing acute postoperative pain","volume":"7","author":"Sloman","year":"2006","journal-title":"Pain Management Nursing"},{"issue":"6","key":"10.1016\/j.jpain.2024.104759_bib6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1155\/2013\/742468","article-title":"What constitutes a clinically important pain reduction in patients after third molar surgery?","volume":"18","author":"Martin","year":"2013","journal-title":"Pain Research and Management"},{"issue":"2","key":"10.1016\/j.jpain.2024.104759_bib7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/sj.clpt.1996.21","article-title":"Onset of analgesia: further validation of a new stopwatch methodology","volume":"59","author":"Desjardins","year":"1996","journal-title":"Clinical Pharmacology & Therapeutics"},{"key":"10.1016\/j.jpain.2024.104759_bib8","unstructured":"Food and Drug Administration. Development of non-opioid analgesics for acute pain: guidance for industry \u2013 draft guidance; Published February 7, 2022. \u3008https:\/\/www.fda.gov\/media\/156063\/download\u3009. [Accessed 13 November 2024]."},{"issue":"2","key":"10.1016\/j.jpain.2024.104759_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2344\/0003-3006-58.2.73","article-title":"A double-blind placebo-controlled comparison of a novel formulation of intravenous diclofenac and ketorolac for postoperative third molar extraction pain","volume":"58","author":"Christensen","year":"2011","journal-title":"Anesthesia Progress"},{"issue":"4","key":"10.1016\/j.jpain.2024.104759_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/scientificamerican1000-82","article-title":"Better decisions through science","volume":"283","author":"Swets","year":"2000","journal-title":"Scientific American"},{"issue":"4","key":"10.1016\/j.jpain.2024.104759_bib11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/clinchem\/39.4.561","article-title":"Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine","volume":"39","author":"Zweig","year":"1993","journal-title":"Clinical Chemistry"},{"issue":"1","key":"10.1016\/j.jpain.2024.104759_bib12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","article-title":"Index for rating diagnostic tests","volume":"3","author":"Youden","year":"1950","journal-title":"Cancer"},{"issue":"7","key":"10.1016\/j.jpain.2024.104759_bib13","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/aje\/kwj063","article-title":"The inconsistency of \"optimal\" cutpoints obtained using two criteria based on the receiver operating characteristic curve","volume":"163","author":"Perkins","year":"2006","journal-title":"American Journal of Epidemiology"},{"issue":"1","key":"10.1016\/j.jpain.2024.104759_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1214\/aos\/1176344552","article-title":"Bootstrap methods: another look at the jackknife","volume":"7","author":"Efron","year":"1979","journal-title":"The Annals of Statistics"},{"key":"10.1016\/j.jpain.2024.104759_bib15","series-title":"Bootstrap Methods and Their Application","first-page":"385","article-title":"Complex Dependence","author":"Davison","year":"1997"},{"issue":"5","key":"10.1016\/j.jpain.2024.104759_bib16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0885-3924(03)00162-3","article-title":"Clinically important changes in acute pain outcome measures: a validation study","volume":"25","author":"Farrar","year":"2003","journal-title":"Journal of Pain and Symptom Management"},{"issue":"3","key":"10.1016\/j.jpain.2024.104759_bib17","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0304-3959(00)00339-0","article-title":"Defining the clinically important difference in pain outcome measures","volume":"88","author":"Farrar","year":"2000","journal-title":"Pain"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590024007375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590024007375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:31:14Z","timestamp":1778052674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590024007375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":17,"alternative-id":["S1526590024007375"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2024.104759","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methodology for determining minimally clinically important differences in acute pain intensity with the double stopwatch technique","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2024.104759","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc. on behalf of United States Association for the Study of Pain, Inc","name":"copyright","label":"Copyright"}],"article-number":"104759"}}