{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:42:23Z","timestamp":1776166943140,"version":"3.50.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,13]],"date-time":"2027-02-13T00:00:00Z","timestamp":1802476800000},"content-version":"am","delay-in-days":318,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31 DK12148401"],"award-info":[{"award-number":["F31 DK12148401"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK115478"],"award-info":[{"award-number":["R01 DK115478"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15 NS128624"],"award-info":[{"award-number":["R15 NS128624"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jpain.2026.106199","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:46:10Z","timestamp":1769013970000},"page":"106199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Amygdalar calcitonin gene-related peptide driven effects of cold sensitivity induced by peripheral neuropathy in mice"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7603-6268","authenticated-orcid":false,"given":"Alexis D.","family":"Trail","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0771-1959","authenticated-orcid":false,"given":"Heather N.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8314-4461","authenticated-orcid":false,"given":"Blesson","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6675-4820","authenticated-orcid":false,"given":"Tyler S.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6213-751X","authenticated-orcid":false,"given":"James A.","family":"Widner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakeisha","family":"Lewter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"See H.","family":"Tack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael Miller","family":"Neilan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-1805","authenticated-orcid":false,"given":"Benedict J.","family":"Kolber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jpain.2026.106199_bib1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1526-4637.2009.00588.x","article-title":"The prevalence of neuropathic pain: clinical evaluation compared with screening tools in a community population","volume":"10","author":"Yawn","year":"2009","journal-title":"Pain Med"},{"issue":"2","key":"10.1016\/j.jpain.2026.106199_bib2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1124\/pr.117.014399","article-title":"Etiology and pharmacology of neuropathic pain","volume":"70","author":"Alles","year":"2018","journal-title":"Pharm Rev"},{"key":"10.1016\/j.jpain.2026.106199_bib3","doi-asserted-by":"crossref","DOI":"10.1177\/2058738419838383","article-title":"The neuropathic pain: an overview of the current treatment and future therapeutic approaches","volume":"33","author":"Cavalli","year":"2019","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"10","key":"10.1016\/j.jpain.2026.106199_bib4","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jpain.2015.06.009","article-title":"Comorbidity of mental disorders and chronic pain: chronology of onset in adolescents of a national representative cohort","volume":"16","author":"Tegethoff","year":"2015","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2026.106199_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neubiorev.2017.09.017","article-title":"The role of central and medial amygdala in normal and abnormal aggression: a review of classical approaches","volume":"85","author":"Haller","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"10.1016\/j.jpain.2026.106199_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0959-4388(96)80076-6","article-title":"The amygdala and emotion","volume":"6","author":"Gallagher","year":"1996","journal-title":"Curr Opin Neurobiol"},{"issue":"6","key":"10.1016\/j.jpain.2026.106199_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/biom11060823","article-title":"Understanding emotions: origins and roles of the amygdala","volume":"11","author":"\u0160imi\u0107","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jpain.2026.106199_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2020.101891","article-title":"Left and right hemispheric lateralization of the amygdala in pain","volume":"196","author":"Allen","year":"2021","journal-title":"Prog Neurobiol"},{"issue":"2","key":"10.1016\/j.jpain.2026.106199_bib9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1046\/j.0953-816x.2001.01640.x","article-title":"Projections from the nociceptive area of the central nucleus of the amygdala to the forebrain: a PHA-L study in the rat","volume":"14","author":"Bourgeais","year":"2001","journal-title":"Eur J Neurosci"},{"issue":"4","key":"10.1016\/j.jpain.2026.106199_bib10","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.neures.2008.10.004","article-title":"Neuroanatomical and neurochemical organization of projections from the central amygdaloid nucleus to the nucleus retroambiguus via the periaqueductal gray in the rat","volume":"62","author":"Oka","year":"2008","journal-title":"Neurosci Res"},{"issue":"42","key":"10.1016\/j.jpain.2026.106199_bib11","doi-asserted-by":"crossref","first-page":"8225","DOI":"10.1523\/JNEUROSCI.1162-19.2019","article-title":"Parabrachial complex: a hub for pain and aversion","volume":"39","author":"Chiang","year":"2019","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.jpain.2026.106199_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1506","article-title":"The central nucleus of the amygdala lesion attenuates orthodontic pain during experimental tooth movement in rats","volume":"10","author":"Qiao","year":"2020","journal-title":"Brain Behav"},{"key":"10.1016\/j.jpain.2026.106199_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.brainres.2015.01.008","article-title":"The amygdala central nucleus is required for acute stress-induced bladder hyperalgesia in a rat visceral pain model","volume":"1606","author":"DeBerry","year":"2015","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.jpain.2026.106199_bib14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0304-3959(95)00027-P","article-title":"The central nucleus of the amygdala contributes to the production of morphine antinociception in the formalin test","volume":"63","author":"Manning","year":"1995","journal-title":"Pain"},{"issue":"12","key":"10.1016\/j.jpain.2026.106199_bib15","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.1523\/JNEUROSCI.15-12-08199.1995","article-title":"The central nucleus of the amygdala contributes to the production of morphine antinociception in the rat tail-flick test","volume":"15","author":"Manning","year":"1995","journal-title":"J Neurosci"},{"issue":"20","key":"10.1016\/j.jpain.2026.106199_bib16","doi-asserted-by":"crossref","first-page":"8238","DOI":"10.1523\/JNEUROSCI.21-20-08238.2001","article-title":"Reduction in opioid- and cannabinoid-induced antinociception in rhesus monkeys after bilateral lesions of the amygdaloid complex","volume":"21","author":"Manning","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2026.106199_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2017.08.032","article-title":"Lesions of the central amygdala and ventromedial medulla reduce bladder hypersensitivity produced by acute but not chronic foot shock","volume":"1675","author":"Randich","year":"2017","journal-title":"Brain Res"},{"issue":"1-2","key":"10.1016\/j.jpain.2026.106199_bib18","first-page":"13","article-title":"Post-stress analgesia after lesions to the central nucleus of the amygdala in rats","volume":"50","author":"Werka","year":"1990","journal-title":"Acta Neurobiol Exp (Wars)"},{"issue":"3","key":"10.1016\/j.jpain.2026.106199_bib19","doi-asserted-by":"crossref","first-page":"e463","DOI":"10.1097\/j.pain.0000000000002389","article-title":"Neuronal basis for pain-like and anxiety-like behaviors in the central nucleus of the amygdala","volume":"163","author":"Chen","year":"2022","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.jpain.2026.106199_bib20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/j.pain.0000000000000830","article-title":"Divergent functions of the left and right central amygdala in visceral nociception","volume":"158","author":"Sadler","year":"2017","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.jpain.2026.106199_bib21","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41593-020-0632-8","article-title":"General anesthetics activate a potent central pain-suppression circuit in the amygdala","volume":"23","author":"Hua","year":"2020","journal-title":"Nat Neurosci"},{"issue":"4","key":"10.1016\/j.jpain.2026.106199_bib22","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0306-4522(03)00356-7","article-title":"The rodent amygdala contributes to the production of cannabinoid-induced antinociception","volume":"120","author":"Manning","year":"2003","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.jpain.2026.106199_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31962-w","article-title":"The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy","volume":"8","author":"Seno","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jpain.2026.106199_bib24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neulet.2018.08.013","article-title":"The left central nucleus of the amygdala contributes to mechanical allodynia and hyperalgesia following right-sided peripheral nerve injury","volume":"684","author":"Cooper","year":"2018","journal-title":"Neurosci Lett"},{"issue":"22","key":"10.1016\/j.jpain.2026.106199_bib25","doi-asserted-by":"crossref","first-page":"9453","DOI":"10.1523\/JNEUROSCI.18-22-09453.1998","article-title":"A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala","volume":"18","author":"Manning","year":"1998","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.jpain.2026.106199_bib26","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.celrep.2019.09.011","article-title":"Dual and opposing functions of the central amygdala in the modulation of pain","volume":"29","author":"Wilson","year":"2019","journal-title":"Cell Rep"},{"issue":"4","key":"10.1016\/j.jpain.2026.106199_bib27","first-page":"339","article-title":"Amygdalar involvement in pain","volume":"39","author":"Mena","year":"1995","journal-title":"Indian J Physiol Pharm"},{"key":"10.1016\/j.jpain.2026.106199_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1874210601307010027","article-title":"The endogenous opioids related with antinociceptive effects induced by electrical stimulation into the amygdala","volume":"7","author":"Nakamura","year":"2013","journal-title":"Open Dent J"},{"key":"10.1016\/j.jpain.2026.106199_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109029","article-title":"Acetaminophen and pregabalin attenuate central sensitization in rodent models of nociplastic widespread pain","volume":"210","author":"Yajima","year":"2022","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.jpain.2026.106199_bib30","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1097\/j.pain.0000000000002224","article-title":"Active role of the central amygdala in widespread mechanical sensitization in rats with facial inflammatory pain","volume":"162","author":"Sugimoto","year":"2021","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.jpain.2026.106199_bib31","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.biopsych.2022.09.010","article-title":"A parabrachial-to-amygdala circuit that determines hemispheric lateralization of somatosensory processing","volume":"93","author":"Allen","year":"2023","journal-title":"Biol Psychiatry"},{"issue":"12","key":"10.1016\/j.jpain.2026.106199_bib32","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.jpain.2010.05.004","article-title":"Corticotropin-releasing factor in the rat amygdala differentially influences sensory-discriminative and emotional-like pain response in peripheral neuropathy","volume":"11","author":"Bourbia","year":"2010","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2026.106199_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108052","article-title":"Amygdala, neuropeptides, and chronic pain-related affective behaviors","volume":"170","author":"Neugebauer","year":"2020","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.jpain.2026.106199_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/nmo.12495","article-title":"Corticotrophin-releasing factor 1 activation in the central amygdale and visceral hyperalgesia","volume":"27","author":"Tach\u00e9","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpain.2026.106199_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109031","article-title":"Optogenetic manipulations of CeA-CRF neurons modulate pain- and anxiety-like behaviors in neuropathic pain and control rats","volume":"210","author":"Mazzitelli","year":"2022","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.jpain.2026.106199_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpain.2024.02.009","article-title":"Activation of CRF\/CRFR1 Signaling in the Central Nucleus of the Amygdala Contributes to Chronic Stress-Induced Exacerbation of Neuropathic Pain by Enhancing GluN2B-NMDA Receptor-Mediated Synaptic Plasticity in Adult Male Rats","volume":"25","author":"Tian","year":"2024","journal-title":"J Pain"},{"key":"10.1016\/j.jpain.2026.106199_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.660792","article-title":"Amygdalar corticotropin-releasing factor signaling is required for later-life behavioral dysfunction following neonatal pain","volume":"12","author":"Davis","year":"2021","journal-title":"Front Physiol"},{"issue":"3","key":"10.1016\/j.jpain.2026.106199_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.16","article-title":"Knockdown of corticotropin-releasing factor in the central amygdala reverses persistent viscerosomatic hyperalgesia","volume":"5","author":"Johnson","year":"2015","journal-title":"Transl Psychiatry"},{"issue":"10","key":"10.1016\/j.jpain.2026.106199_bib39","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1038\/npp.2016.44","article-title":"Traumatic Stress Promotes Hyperalgesia via Corticotropin-Releasing Factor-1 Receptor (CRFR1) Signaling in Central Amygdala","volume":"41","author":"Itoga","year":"2016","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.jpain.2026.106199_bib40","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/j.pain.0000000000000759","article-title":"Amygdala-mediated mechanisms regulate visceral hypersensitivity in adult females following early life stress: importance of the glucocorticoid receptor and corticotropin-releasing factor","volume":"158","author":"Prusator","year":"2017","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.jpain.2026.106199_bib41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.brainres.2003.09.050","article-title":"Role of corticotropin-releasing factor and its receptor in nociceptive modulation in the central nucleus of amygdala in rats","volume":"995","author":"Cui","year":"2004","journal-title":"Brain Res"},{"issue":"5","key":"10.1016\/j.jpain.2026.106199_bib42","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2982.2012.01899.x","article-title":"B. Importance of stress receptor-mediated mechanisms in the amygdala on visceral pain perception in an intrinsically anxious rat","volume":"24","author":"Johnson","year":"2012","journal-title":"Neurogastroenterol Motil"},{"issue":"11","key":"10.1016\/j.jpain.2026.106199_bib43","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.3346\/jkms.2010.25.11.1646","article-title":"The expression of corticotropin-releasing factor in the central nucleus of the amygdala, induced by colorectal distension, is attenuated by general anesthesia","volume":"25","author":"Kim","year":"2010","journal-title":"J Korean Med Sci"},{"issue":"8","key":"10.1016\/j.jpain.2026.106199_bib44","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.biopsych.2016.08.025","article-title":"Parabrachial Pituitary Adenylate Cyclase-Activating Polypeptide Activation of Amygdala Endosomal Extracellular Signal-Regulated Kinase Signaling Regulates the Emotional Component of Pain","volume":"81","author":"Missig","year":"2017","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jpain.2026.106199_bib45","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuropharm.2014.06.022","article-title":"Parabrachial nucleus (PBn) pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the amygdala: implication for the sensory and behavioral effects of pain","volume":"86","author":"Missig","year":"2014","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.jpain.2026.106199_bib46","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-022-01531-8","article-title":"CGRP-dependent sensitization of PKC-\u03b4 positive neurons in central amygdala mediates chronic migraine","volume":"23","author":"Chou","year":"2022","journal-title":"J Headache Pain"},{"issue":"1","key":"10.1016\/j.jpain.2026.106199_bib47","article-title":"Facilitation of Synaptic Transmission and Pain Responses by CGRP in the Amygdala of Normal Rats","volume":"6","author":"Han","year":"2010","journal-title":"Mol Pain"},{"issue":"46","key":"10.1016\/j.jpain.2026.106199_bib48","doi-asserted-by":"crossref","first-page":"10717","DOI":"10.1523\/JNEUROSCI.4112-05.2005","article-title":"Critical Role of Calcitonin Gene-Related Peptide 1 Receptors in the Amygdala in Synaptic Plasticity and Pain Behavior","volume":"25","author":"Han","year":"2005","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.jpain.2026.106199_bib49","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0306-4522(03)00069-1","article-title":"Antinociceptive effect of calcitonin gene-related peptide in the central nucleus of amygdala: activating opioid receptors through amygdala-periaqueductal gray pathway","volume":"118","author":"Xu","year":"2003","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.jpain.2026.106199_bib50","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1111\/ejn.13662","article-title":"Essential role of endogenous calcitonin gene-related peptide in pain-associated plasticity in the central amygdala","volume":"46","author":"Shinohara","year":"2017","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jpain.2026.106199_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.928587","article-title":"Sex Differences in CGRP Regulation and Function in the Amygdala in a Rat Model of Neuropathic Pain","volume":"15","author":"Presto","year":"2022","journal-title":"Front Mol Neurosci"},{"issue":"2","key":"10.1016\/j.jpain.2026.106199_bib52","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/bj2550377","article-title":"Peptides from the calcitonin genes: molecular genetics, structure and function","volume":"255","author":"Breimer","year":"1988","journal-title":"Biochem J"},{"issue":"1","key":"10.1016\/j.jpain.2026.106199_bib53","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0306-4522(88)90018-8","article-title":"Differential expression of alpha-CGRP and beta-CGRP by primary sensory neurons and enteric autonomic neurons of the rat","volume":"25","author":"Mulderry","year":"1988","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.jpain.2026.106199_bib54","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1152\/physrev.00034.2013","article-title":"Calcitonin gene-related peptide: physiology and pathophysiology","volume":"94","author":"Russell","year":"2014","journal-title":"Physiol Rev"},{"issue":"3","key":"10.1016\/j.jpain.2026.106199_bib55","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/0333102418765787","article-title":"Molecular studies of CGRP and the CGRP family of peptides in the central nervous system","volume":"39","author":"Hendrikse","year":"2019","journal-title":"Cephalalgia"},{"issue":"4","key":"10.1016\/j.jpain.2026.106199_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114057","article-title":"Parabrachial Calca neurons drive nociplasticity","volume":"43","author":"Condon","year":"2024","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.jpain.2026.106199_bib57","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cell.2015.05.057","article-title":"Elucidating an Affective Pain Circuit that Creates a Threat Memory","volume":"162","author":"Han","year":"2015","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jpain.2026.106199_bib58","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tins.2018.03.007","article-title":"The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm","volume":"41","author":"Palmiter","year":"2018","journal-title":"Trends Neurosci"},{"issue":"1","key":"10.1016\/j.jpain.2026.106199_bib59","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/cne.20618","article-title":"Calcitonin gene-related peptide-containing pathways in the rat forebrain","volume":"489","author":"Dobolyi","year":"2005","journal-title":"J Comp Neurol"},{"issue":"5","key":"10.1016\/j.jpain.2026.106199_bib60","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0149-7634(96)00023-1","article-title":"Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors","volume":"21","author":"van Rossum","year":"1997","journal-title":"Neurosci Biobehav Rev"},{"issue":"10","key":"10.1016\/j.jpain.2026.106199_bib61","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1523\/JNEUROSCI.1137-21.2022","article-title":"A female-specific role for calcitonin gene-related peptide (CGRP) in rodent pain models","volume":"42","author":"Paige","year":"2022","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpain.2026.106199_bib62","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-6-10","article-title":"Facilitation of synaptic transmission and pain responses by CGRP in the amygdala of normal rats","volume":"6","author":"Han","year":"2010","journal-title":"Mol Pain"},{"issue":"4","key":"10.1016\/j.jpain.2026.106199_bib63","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.biopsych.2022.09.010","article-title":"A parabrachial-to-amygdala circuit that determines hemispheric lateralization of somatosensory processing","volume":"93","author":"Allen","year":"2023","journal-title":"Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.jpain.2026.106199_bib64","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1523\/JNEUROSCI.2661-18.2018","article-title":"Nociceptor translational profiling reveals the ragulator-Rag GTPase complex as a critical generator of neuropathic pain","volume":"39","author":"Megat","year":"2019","journal-title":"J Neurosci"},{"issue":"8","key":"10.1016\/j.jpain.2026.106199_bib65","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1021\/acsabm.9b00380","article-title":"Covalent poly(lactic acid) nanoparticles for the sustained delivery of naloxone","volume":"2","author":"Kassick","year":"2019","journal-title":"ACS Appl Bio Mater"},{"issue":"2","key":"10.1016\/j.jpain.2026.106199_bib66","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","article-title":"Spared nerve injury: an animal model of persistent peripheral neuropathic pain","volume":"87","author":"Decosterd","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.jpain.2026.106199_bib67","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"3","key":"10.1016\/j.jpain.2026.106199_bib68","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0304-3959(94)90023-X","article-title":"Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain","volume":"59","author":"Yoon","year":"1994","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.jpain.2026.106199_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103524","article-title":"The mGluR5 antagonist fenobam induces analgesic conditioned place preference in mice with spared nerve injury","volume":"9","author":"Lax","year":"2014","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.jpain.2026.106199_bib70","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/s42003-024-07198-y","article-title":"Widespread co-release of glutamate and GABA throughout the mouse brain","volume":"7","author":"Ceballos","year":"2024","journal-title":"Commun Biol"},{"issue":"6","key":"10.1016\/j.jpain.2026.106199_bib71","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jpain.2012.02.009","article-title":"Estimating efficacy and drug ED50's Using von Frey thresholds: impact of Weber's law and log transformation","volume":"13","author":"Mills","year":"2012","journal-title":"J Pain"},{"issue":"8090","key":"10.1016\/j.jpain.2026.106199_bib72","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41586-025-09602-x","article-title":"A parabrachial hub for need-state control of enduring pain","volume":"647","author":"Goldstein","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jpain.2026.106199_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pain.2005.10.036","article-title":"Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse","volume":"122","author":"Bourquin","year":"2006","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.jpain.2026.106199_bib74","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00280-012-2047-z","article-title":"Persistent chemoneuropathy in patients receiving the plant alkaloids paclitaxel and vincristine","volume":"71","author":"Boyette-Davis","year":"2013","journal-title":"Cancer Chemother Pharm"},{"issue":"21","key":"10.1016\/j.jpain.2026.106199_bib75","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1016\/j.lfs.2004.01.002","article-title":"Paclitaxel-induced neuropathic hypersensitivity in mice: Responses in 10 inbred mouse strains","volume":"74","author":"Smith","year":"2004","journal-title":"Life Sci"},{"key":"10.1016\/j.jpain.2026.106199_bib76","doi-asserted-by":"crossref","first-page":"S141","DOI":"10.1016\/S0304-3959(99)00148-7","article-title":"Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients","volume":"82","author":"Woolf","year":"1999","journal-title":"PAIN"},{"issue":"4","key":"10.1016\/j.jpain.2026.106199_bib77","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11892-012-0282-7","article-title":"Neuropathic pain: is quantitative sensory testing helpful?","volume":"12","author":"Krumova","year":"2012","journal-title":"Curr Diab Rep"},{"issue":"23","key":"10.1016\/j.jpain.2026.106199_bib78","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1093\/jnci\/87.23.1804-a","article-title":"Does paclitaxel penetrate into brain tumor tissue?","volume":"87","author":"Heiman","year":"1995","journal-title":"JNCI J Natl Cancer Inst"},{"issue":"1-2","key":"10.1016\/j.jpain.2026.106199_bib79","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00685646","article-title":"The distribution of systemically administered [3H]-paclitaxel in rats: a quantitative autoradiographic study","volume":"37","author":"Lesser","year":"1995","journal-title":"Cancer Chemother Pharmacol"},{"issue":"11","key":"10.1016\/j.jpain.2026.106199_bib80","first-page":"1866","article-title":"Estimation of paclitaxel biodistribution and uptake in human-derived xenografts in vivo with (18)F-fluoropaclitaxel","volume":"46","author":"Gangloff","year":"2005","journal-title":"J Nucl Med"},{"issue":"3","key":"10.1016\/j.jpain.2026.106199_bib81","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1177\/0333102417739584","article-title":"Gender aspects of CGRP in migraine","volume":"39","author":"Labastida-Ram\u00edrez","year":"2019","journal-title":"Cephalalgia"},{"issue":"4","key":"10.1016\/j.jpain.2026.106199_bib82","doi-asserted-by":"crossref","DOI":"10.5214\/ans.0972.7531.190403","article-title":"Effects of estrogen on the serotonergic system and calcitonin gene-related peptide in Trigeminal Ganglia of rats","volume":"19","author":"Aggarwal","year":"2012","journal-title":"Ann Neurosci"},{"issue":"6","key":"10.1016\/j.jpain.2026.106199_bib83","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0143-4179(96)90037-2","article-title":"CGRP in the trigeminal nucleus, spinal cord and hypothalamus: effect of gonadal steroids","volume":"30","author":"Moussaoui","year":"1996","journal-title":"Neuropeptides"},{"issue":"1-2","key":"10.1016\/j.jpain.2026.106199_bib84","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jns.2014.08.002","article-title":"Deficiency of female sex hormones augments PGE2 and CGRP levels within midbrain periaqueductal gray","volume":"346","author":"Wang","year":"2014","journal-title":"J Neurol Sci"},{"issue":"9","key":"10.1016\/j.jpain.2026.106199_bib85","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1111\/j.1460-9568.2012.08235.x","article-title":"Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation","volume":"36","author":"Gon\u00e7alves","year":"2012","journal-title":"Eur J Neurosci"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590026000179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590026000179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:38:22Z","timestamp":1776163102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590026000179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":85,"alternative-id":["S1526590026000179"],"URL":"https:\/\/doi.org\/10.1016\/j.jpain.2026.106199","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amygdalar calcitonin gene-related peptide driven effects of cold sensitivity induced by peripheral neuropathy in mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpain.2026.106199","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 Published by Elsevier Inc. on behalf of United States Association for the Study of Pain, Inc","name":"copyright","label":"Copyright"}],"article-number":"106199"}}